Details of the Target

General Information of Target

Target ID LDTP10377
Target Name 4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2)
Gene Name COQ2
Gene ID 27235
Synonyms
CL640; 4-hydroxybenzoate polyprenyltransferase, mitochondrial; 4-HB polyprenyltransferase; EC 2.5.1.39; 4-hydroxybenzoate decaprenyltransferase; COQ2 homolog; hCOQ2; Para-hydroxybenzoate--polyprenyltransferase; PHB:PPT; PHB:polyprenyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPPLAPLPPRDPNGAGPEWREPGAVSFADVAVYFCREEWGCLRPAQRALYRDVMRETYG
HLSALGIGGNKPALISWVEEEAELWGPAAQDPEVAKCQTQTDPADSRNKKKERQREGTGA
LEKPDPVAAGSPGLKSPQAPSAGPPYGWEQLSKAPHRGRPSLCAHPPVPRADQRHGCYVC
GKSFAWRSTLVEHVYSHTGEKPFHCTDCGKGFGHASSLSKHRAIHRGERPHRCLECGRAF
TQRSALTSHLRVHTGEKPYGCADCGRRFSQSSALYQHRRVHSGETPFPCPDCGRAFAYPS
DLRRHVRTHTGEKPYPCPDCGRCFRQSSEMAAHRRTHSGEKPYPCPQCGRRFGQKSAVAK
HQWVHRPGAGGHRGRVAGRLSVTLTPGHGDLDPPVGFQLYPEIFQECG
Target Bioclass
Enzyme
Family
UbiA prenyltransferase family
Subcellular location
Mitochondrion inner membrane
Function
Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis. Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-decaprenyl diphosphate). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls (decaprenyl) producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9. However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10. Plays a central role in the biosynthesis of CoQ10. CoQ10 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes. CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway. Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner.
Uniprot ID
Q96H96
Ensemble ID
ENST00000311461.7
HGNC ID
HGNC:25223

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.G12V .
FUOV1 SNV: p.F333C .
MFE296 Deletion: p.L345Ter .
OCILY3 SNV: p.N336S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C48(1.03)  LDD1702  [1]
DBIA
 Probe Info  		C127(0.91)  LDD0531  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C127(0.91)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C127(0.85)  LDD1508  [3]
 LDCM0259  AC14 HEK-293T C127(1.26)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C127(1.01)  LDD1513  [3]
 LDCM0276  AC17 HCT 116 C127(1.14)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C127(1.06)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C127(1.11)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C127(0.91)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C127(1.18)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C127(0.96)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C127(1.01)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C127(1.20)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C127(1.05)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C127(1.28)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C127(1.46)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C127(1.26)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C127(0.78)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C127(1.41)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C127(0.94)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C127(1.69)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C127(1.25)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C127(1.02)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C127(1.11)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C127(2.45)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C127(0.85)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C127(1.01)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C127(0.92)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C127(0.83)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C127(0.89)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C127(0.91)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C127(1.01)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C127(0.98)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C127(0.77)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C127(0.91)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C127(1.14)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C127(1.36)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C127(0.95)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C127(0.95)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C127(0.87)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C127(0.97)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C127(0.92)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C127(0.97)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C127(0.60)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C127(0.77)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C127(1.06)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C127(0.95)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C127(1.10)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C127(1.23)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C127(0.72)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C127(0.96)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C127(1.13)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C127(0.92)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C127(0.91)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C127(0.99)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C127(0.89)  LDD1567  [3]
 LDCM0332  AC68 HCT 116 C127(0.91)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C127(1.29)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C127(1.08)  LDD1568  [3]
 LDCM0335  AC70 HCT 116 C127(1.14)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C127(1.13)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C127(1.12)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C127(1.40)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C127(1.30)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C127(1.42)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C127(1.11)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C127(1.21)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C127(1.09)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C127(1.29)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C127(0.90)  LDD1569  [3]
 LDCM0346  AC80 HCT 116 C127(1.03)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C127(0.96)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C127(1.46)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C127(1.16)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C127(1.27)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C127(1.39)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C127(1.48)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C127(0.82)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C127(1.46)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C127(1.71)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C127(0.99)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C127(1.15)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C127(1.30)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C127(1.09)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C127(0.98)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C127(1.12)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C127(1.00)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C127(0.89)  LDD0681  [2]
 LDCM0248  AKOS034007472 HEK-293T C127(1.07)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C127(1.09)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C127(0.94)  LDD1514  [3]
 LDCM0367  CL1 PaTu 8988t C127(1.12)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C127(1.53)  LDD1247  [2]
 LDCM0369  CL100 HCT 116 C127(0.93)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C127(0.98)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C127(1.17)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C127(1.11)  LDD1576  [3]
 LDCM0374  CL105 HCT 116 C127(1.17)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C127(1.10)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C127(1.21)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C127(1.21)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C127(1.30)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C127(1.13)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C127(1.40)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C127(1.00)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C127(1.30)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C127(0.99)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C127(1.53)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C127(1.31)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C127(1.22)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C127(1.27)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C127(1.16)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C127(1.06)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C127(1.19)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C127(0.98)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C127(0.88)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C127(1.09)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C127(0.97)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C127(1.15)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C127(1.13)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C127(0.87)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C127(0.98)  LDD1602  [3]
 LDCM0400  CL13 PaTu 8988t C127(1.68)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C127(1.60)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C127(1.09)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C127(1.16)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C127(0.96)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C127(1.03)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C127(1.26)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C127(1.11)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C127(1.37)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C127(2.21)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C127(1.99)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C127(1.24)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C127(1.18)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C127(1.19)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C127(1.31)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C127(1.09)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C127(1.15)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C127(1.27)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C127(1.24)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C127(1.07)  LDD0736  [2]
 LDCM0422  CL33 HEK-293T C127(5.85)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C127(1.25)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C127(0.96)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C127(1.20)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C127(1.45)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C127(1.27)  LDD1632  [3]
 LDCM0429  CL4 PaTu 8988t C127(1.16)  LDD1308  [2]
 LDCM0431  CL41 HEK-293T C127(1.16)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C127(0.84)  LDD1636  [3]
 LDCM0435  CL45 HEK-293T C127(1.27)  LDD1639  [3]
 LDCM0436  CL46 HCT 116 C127(0.84)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C127(0.87)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C127(0.92)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C127(0.96)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C127(1.69)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C127(1.00)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C127(0.75)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C127(0.77)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C127(0.73)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C127(0.71)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C127(0.78)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C127(0.78)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C127(1.04)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C127(0.72)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C127(0.76)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C127(1.58)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C127(0.64)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C127(0.95)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C127(0.91)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C127(1.08)  LDD1658  [3]
 LDCM0457  CL65 HEK-293T C127(0.71)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C127(0.83)  LDD1661  [3]
 LDCM0461  CL69 HEK-293T C127(1.32)  LDD1664  [3]
 LDCM0462  CL7 PaTu 8988t C127(1.27)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C127(1.34)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C127(1.00)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C127(1.24)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C127(1.17)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C127(0.78)  LDD1670  [3]
 LDCM0470  CL77 HEK-293T C127(1.24)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C127(0.75)  LDD1674  [3]
 LDCM0473  CL8 PaTu 8988t C127(1.26)  LDD1352  [2]
 LDCM0475  CL81 HEK-293T C127(1.07)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C127(1.35)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C127(1.18)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C127(1.16)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C127(1.00)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C127(0.78)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C127(1.00)  LDD1684  [3]
 LDCM0483  CL89 HEK-293T C127(0.56)  LDD1686  [3]
 LDCM0484  CL9 PaTu 8988t C127(1.28)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C127(4.37)  LDD1688  [3]
 LDCM0486  CL91 HCT 116 C127(1.01)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C127(0.87)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C127(0.88)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C127(0.93)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C127(0.97)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C127(0.92)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C127(0.98)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C127(1.00)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C127(0.83)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C127(1.17)  LDD1698  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C48(1.03)  LDD1702  [1]
 LDCM0468  Fragment33 HEK-293T C127(1.18)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C127(0.84)  LDD1631  [3]
 LDCM0022  KB02 A204 C127(2.24)  LDD2252  [4]
 LDCM0023  KB03 C-4-II C127(6.84)  LDD2699  [4]
 LDCM0024  KB05 C-4-II C127(5.37)  LDD3116  [4]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840