Details of the Target

General Information of Target

Target ID LDTP10287
Target Name Microspherule protein 1 (MCRS1)
Gene Name MCRS1
Gene ID 10445
Synonyms
INO80Q; MSP58; Microspherule protein 1; 58 kDa microspherule protein; Cell cycle-regulated factor p78; INO80 complex subunit J; MCRS2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVCGLGSRLGLGSRLGLRGCFGAARLLYPRFQSRGPQGVEDGDRPQPSSKTPRIPKIYT
KTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALELVTEKGHTFAEELQKIQCT
LQDVGSALATPCSSAREAHLKYTTFKAGPILELEQWIDKYTSQLPPLTAFILPSGGKISS
ALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSDYLFTLARYAAMKEGNQEKIYMK
NDPSAESEGL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homomer poly(G) and poly(U).
Uniprot ID
Q96EZ8
Ensemble ID
ENST00000343810.9
HGNC ID
HGNC:6960

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.E170D .
JURKAT SNV: p.A110T .
NCIH2286 SNV: p.M296V .
NUGC3 SNV: p.Q149H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.79  LDD0403  [1]
DBIA
 Probe Info  		C97(1.69); C202(8.01)  LDD3311  [2]
BTD
 Probe Info  		C189(0.75)  LDD2109  [3]
IA-alkyne
 Probe Info  		C84(0.00); C421(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C189(0.00); C421(0.00)  LDD0037  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C189(0.95)  LDD2117  [3]
 LDCM0214  AC1 HEK-293T C84(0.78); C189(1.00)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C84(1.11); C189(0.97); C421(0.99)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C84(1.12); C189(1.02); C421(1.04)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C84(1.14); C189(0.96); C421(1.06)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C84(1.15); C189(1.01); C421(1.01)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C84(1.29); C189(0.93)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C84(1.00); C189(0.91)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C84(1.15); C189(1.15); C421(1.02)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C84(1.50); C189(0.72); C421(0.99)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C84(0.95); C189(0.95); C421(1.08)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C84(0.89); C189(1.04); C421(1.00)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C84(1.06); C189(1.00)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C84(0.99); C189(0.98); C421(0.95)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C84(0.96); C189(1.02)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C84(1.03); C189(1.00); C421(1.07)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C84(0.94); C189(1.01)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C84(1.08); C189(1.04); C421(1.01)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C84(1.15); C189(0.95); C421(1.05)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C84(1.15); C189(1.01); C421(1.00)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C84(1.09); C189(0.94)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C84(1.03); C189(0.95); C421(1.06)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C84(0.89); C189(1.07); C421(0.94)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C84(1.25); C189(0.91)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C84(1.02); C189(1.00); C421(0.95)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C84(0.82); C189(0.89)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C84(1.15); C189(0.91); C421(1.11)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C84(1.11); C189(1.03); C421(0.94)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C84(0.87); C189(0.96); C421(1.07)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C84(1.00); C189(0.98)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C84(1.01); C189(1.03); C421(0.97)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C84(1.26); C189(1.01)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C84(1.04); C189(0.94); C421(1.06)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C84(1.09); C189(1.03); C421(1.00)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C84(0.84); C189(0.97)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C84(1.48); C189(0.97); C421(1.09)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C84(1.30); C189(1.00); C421(0.95)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C84(0.94); C189(0.96); C421(1.13)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C84(1.06); C189(1.00)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C84(0.94); C189(0.97); C421(1.01)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C84(1.13); C189(0.98)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C84(1.17); C189(0.95); C421(1.01)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C84(1.00); C189(0.94)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C84(1.00); C189(0.96)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C84(1.25); C189(0.91); C421(1.06)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C84(1.02); C189(1.00); C421(0.98)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C84(1.11); C189(0.98); C421(1.07)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C84(1.02); C189(0.97)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C84(1.06); C189(0.94); C421(0.94)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C84(1.04); C189(0.98)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C84(1.13); C189(1.01); C421(1.02)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C84(0.99); C189(1.15)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C84(1.06); C189(0.95); C421(1.11)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C84(1.04); C189(0.98); C421(0.96)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C84(1.09); C189(0.97); C421(1.01)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C84(0.94); C189(1.03); C421(1.12)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C84(1.04); C189(0.98)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C84(1.09); C189(0.92); C421(0.93)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C84(1.10); C189(1.02)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C84(1.06); C189(1.01); C421(1.04)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C84(0.96); C189(0.93)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C84(0.98); C189(0.96); C421(1.12)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C84(1.06); C189(0.93)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C84(1.16); C189(1.01)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C84(1.15); C189(1.04); C421(0.98)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 11.79  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C84(0.53)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C84(0.82)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C84(0.71); C189(1.06); C421(0.91)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C189(0.95); C421(1.06)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C84(1.12)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C189(0.99)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C84(0.91); C189(1.02)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C189(1.02); C421(1.02)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C84(1.42)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C189(1.01)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C84(0.98); C189(1.01)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C189(0.96); C421(0.98)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C84(1.10)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C84(0.88); C189(1.10)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C189(1.04)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C84(0.83); C189(0.95)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C189(1.01); C421(0.99)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C84(1.22)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C189(1.04)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C84(0.83); C189(0.98)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C189(0.87); C421(1.02)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C84(0.99)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C189(0.91)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C84(1.01); C189(0.94)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C84(1.08); C189(0.97); C421(0.93)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C189(1.00); C421(1.00)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C84(1.09)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C189(1.08)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C84(0.88); C189(1.17)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C189(0.95); C421(1.01)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C84(1.17)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C189(1.00)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C84(0.93); C189(0.93)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C189(0.99); C421(1.02)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C84(1.26)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C189(0.96)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C84(0.98); C189(1.09)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C189(1.03); C421(0.99)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C84(0.84); C189(0.94)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C84(1.13); C189(1.05); C421(1.04)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C84(1.17); C189(1.02); C421(0.97)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C189(0.99)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C84(1.11); C189(0.94); C421(1.10)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C84(1.07); C189(1.07)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C84(1.06); C189(0.91); C421(1.04)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C84(1.11); C189(1.05)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C84(1.18); C189(0.99); C421(1.00)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C84(0.98)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C189(0.89)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C84(1.14); C189(0.84)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C189(0.96); C421(1.00)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C84(0.93); C189(0.97)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C84(0.86); C189(0.96)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C84(1.09); C189(1.04); C421(1.03)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C84(1.19); C189(1.08); C421(0.96)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C84(0.86); C189(0.93); C421(0.95)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C84(1.04); C189(1.27)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C84(1.32); C189(1.01); C421(1.02)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C84(1.19); C189(1.02)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C84(1.10); C189(1.03); C421(0.88)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C84(0.97)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C84(0.80); C189(0.94)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C189(0.96); C421(1.05)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C189(0.90); C421(1.00)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C84(0.91); C189(0.95)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C84(1.09); C189(0.97); C421(1.00)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C84(1.15); C189(1.05); C421(0.91)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C84(1.10); C189(1.02); C421(1.01)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C84(1.17); C189(0.91)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C84(0.89); C189(0.92); C421(0.92)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C84(1.23); C189(1.05)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C84(1.07); C189(1.00); C421(1.05)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C84(0.92)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C84(1.01); C189(0.82)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C189(0.92)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C189(0.97); C421(1.01)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C84(0.95); C189(1.10)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C84(1.19); C189(1.00); C421(0.87)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C84(1.02); C189(0.97); C421(0.93)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C84(0.77); C189(1.02); C421(1.06)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C84(1.04); C189(1.23)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C84(1.18); C189(0.94); C421(0.94)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C84(1.07); C189(1.03)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C84(0.98); C189(1.04); C421(0.91)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C84(1.09); C189(1.08); C421(0.90)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C84(1.03)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C189(0.95)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C84(0.95); C189(1.00)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C189(1.05); C421(0.97)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C84(1.32); C189(0.84)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C84(0.99); C189(0.82); C421(1.01)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C84(1.15); C189(1.01); C421(0.95)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C84(0.88); C189(0.94); C421(1.05)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C84(1.15); C189(0.96)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C84(1.00); C189(1.00); C421(0.95)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C84(1.06); C189(0.98); C421(1.01)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C84(1.06); C189(1.04)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C84(1.07); C189(1.08); C421(0.94)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C84(1.07)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C189(0.90)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C189(0.98); C421(0.96)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C84(0.77); C189(0.98)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C84(1.02); C189(1.01); C421(0.96)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C84(1.27); C189(1.06); C421(0.97)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C84(0.59); C189(1.31); C421(0.84)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C84(0.84); C189(1.00); C421(1.04)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C84(1.09); C189(1.07)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C84(0.87); C189(1.04); C421(1.02)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C84(0.91); C189(0.93)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C84(1.05); C189(1.04); C421(0.92)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C84(1.00)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C189(0.91)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C84(0.92); C189(1.08)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C189(0.91); C421(1.08)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C84(0.92); C189(0.94)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C84(1.02); C189(1.07)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C84(0.83); C189(1.02); C421(0.90)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C84(1.03); C189(1.01); C421(0.92)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C84(0.90); C189(1.06); C421(1.04)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C84(0.96); C189(1.08)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C84(1.19); C189(0.95); C421(0.95)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C84(1.09); C189(1.38)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C84(0.98); C189(1.02); C421(0.98)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C84(0.96)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C189(0.94)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C84(0.86); C189(1.04)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C84(0.87); C189(1.20)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C189(1.28)  LDD1702  [3]
 LDCM0625  F8 Ramos C84(1.66)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C84(1.81)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C84(20.00)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C84(0.84)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C84(1.16)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C84(1.16)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C84(1.07)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C84(1.02)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C84(1.04)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C84(1.17)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C84(0.58)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C84(1.33)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C84(0.91)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C84(2.26)  LDD2201  [9]
 LDCM0468  Fragment33 HEK-293T C84(0.95); C189(0.97)  LDD1671  [8]
 LDCM0596  Fragment38 Ramos C84(0.77)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C84(0.91)  LDD2184  [9]
 LDCM0427  Fragment51 HEK-293T C189(0.91)  LDD1631  [8]
 LDCM0610  Fragment52 Ramos C84(1.53)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C84(1.89)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C84(1.13)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C84(1.14)  LDD2188  [9]
 LDCM0022  KB02 HEK-293T C84(0.68); C189(0.96); C421(1.04)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C84(1.04); C189(0.97); C421(1.00)  LDD1497  [8]
 LDCM0024  KB05 G361 C97(1.69); C202(8.01)  LDD3311  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C189(0.75)  LDD2109  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C189(0.70)  LDD2125  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C189(1.16)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C189(0.55)  LDD2140  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Histone acetyltransferase KAT7 (KAT7) MYST (SAS/MOZ) family O95251
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) STE Ser/Thr protein kinase family Q99683
Lymphokine-activated killer T-cell-originated protein kinase (PBK) STE Ser/Thr protein kinase family Q96KB5
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
GTP-binding protein GEM (GEM) RGK family P55040
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Protein ARK2N (ARK2N) . Q96B23
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Huntingtin (HTT) Huntingtin family P42858
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
TBC1 domain family member 1 (TBC1D1) . Q86TI0
Transcription factor
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine/serine-rich nuclear protein 1 (CSRNP1) AXUD1 family Q96S65
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) BZIP family Q68CJ9
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
ETS domain-containing transcription factor ERF (ERF) ETS family P50548
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein Eos (IKZF4) Ikaros C2H2-type zinc-finger protein family Q9H2S9
Zinc finger and BTB domain-containing protein 22 (ZBTB22) Krueppel C2H2-type zinc-finger protein family O15209
Zinc finger protein 23 (ZNF23) Krueppel C2H2-type zinc-finger protein family P17027
Zinc finger protein 639 (ZNF639) Krueppel C2H2-type zinc-finger protein family Q9UID6
Zinc finger protein 8 (ZNF8) Krueppel C2H2-type zinc-finger protein family P17098
Dr1-associated corepressor (DRAP1) NC2 alpha/DRAP1 family Q14919
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
Tumor protein 63 (TP63) P53 family Q9H3D4
Transcription factor Sp4 (SP4) Sp1 C2H2-type zinc-finger protein family Q02446
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
BEN domain-containing protein 3 (BEND3) . Q5T5X7
Class A basic helix-loop-helix protein 9 (BHLHA9) . Q7RTU4
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Homeobox protein MOX-1 (MEOX1) . P50221
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Mesoderm induction early response protein 2 (MIER2) . Q8N344
Transcription factor AP-4 (TFAP4) . Q01664
Other
Click To Hide/Show 56 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Breast cancer metastasis-suppressor 1 (BRMS1) BRMS1 family Q9HCU9
Breast cancer metastasis-suppressor 1-like protein (BRMS1L) BRMS1 family Q5PSV4
Caveolae-associated protein 2 (CAVIN2) CAVIN family O95810
Coilin (COIL) Coilin family P38432
Cyclin-H (CCNH) Cyclin family P51946
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Inhibitory synaptic factor 1 (INSYN1) INSYN1 family Q2T9L4
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Janus kinase and microtubule-interacting protein 1 (JAKMIP1) JAKMIP family Q96N16
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
KxDL motif-containing protein 1 (KXD1) KXD1 family Q9BQD3
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
Testis-specific Y-encoded-like protein 2 (TSPYL2) Nucleosome assembly protein (NAP) family Q9H2G4
Oxysterol-binding protein-related protein 3 (OSBPL3) OSBP family Q9H4L5
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Protein ripply3 (RIPPLY3) Ripply family P57055
Troponin I, slow skeletal muscle (TNNI1) Troponin I family P19237
Vasculin (GPBP1) Vasculin family Q86WP2
Gelsolin (GSN) Villin/gelsolin family P06396
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) ZCCHC12 family Q6PEW1
Angiogenic factor with G patch and FHA domains 1 (AGGF1) . Q8N302
Axin-2 (AXIN2) . Q9Y2T1
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Centrobin (CNTROB) . Q8N137
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Cytohesin-interacting protein (CYTIP) . O60759
Ecotropic viral integration site 5 protein homolog (EVI5) . O60447
Fibronectin type III domain-containing protein 8 (FNDC8) . Q8TC99
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
INO80 complex subunit E (INO80E) . Q8NBZ0
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Melanoma-associated antigen 6 (MAGEA6) . P43360
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Uncharacterized protein KIAA1958 (KIAA1958) . Q8N8K9
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1
WW domain-binding protein 11 (WBP11) . Q9Y2W2
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578