Details of the Target

General Information of Target

Target ID LDTP10189
Target Name Optineurin (OPTN)
Gene Name OPTN
Gene ID 10133
Synonyms
FIP2; GLC1E; HIP7; HYPL; NRP; Optineurin; E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; HIP-7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription factor IIIA-interacting protein; TFIIIA-IntP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIRRVLPHGMGRGLLTRRPGTRRGGFSLDWDGKVSEIKKKIKSILPGRSCDLLQDTSHLP
PEHSDVVIVGGGVLGLSVAYWLKKLESRRGAIRVLVVERDHTYSQASTGLSVGGICQQFS
LPENIQLSLFSASFLRNINEYLAVVDAPPLDLRFNPSGYLLLASEKDAAAMESNVKVQRQ
EGAKVSLMSPDQLRNKFPWINTEGVALASYGMEDEGWFDPWCLLQGLRRKVQSLGVLFCQ
GEVTRFVSSSQRMLTTDDKAVVLKRIHEVHVKMDRSLEYQPVECAIVINAAGAWSAQIAA
LAGVGEGPPGTLQGTKLPVEPRKRYVYVWHCPQGPGLETPLVADTSGAYFRREGLGSNYL
GGRSPTEQEEPDPANLEVDHDFFQDKVWPHLALRVPAFETLKVQSAWAGYYDYNTFDQNG
VVGPHPLVVNMYFATGFSGHGLQQAPGIGRAVAEMVLKGRFQTIDLSPFLFTRFYLGEKI
QENNII
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm, perinuclear region
Function
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.; (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response. During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1.
Uniprot ID
Q96CV9
Ensemble ID
ENST00000263036.9
HGNC ID
HGNC:17142

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A673 Deletion: p.R482_E483delinsK .
HEL SNV: p.S269R .
HEL9217 SNV: p.S269R .
KYSE150 SNV: p.R217T DBIA    Probe Info 
KYSE30 SNV: p.E288K DBIA    Probe Info 
MELJUSO SNV: p.E187Q DBIA    Probe Info 
ONS76 SNV: p.N169T .
SW403 SNV: p.M573L DBIA    Probe Info 
WM2664 Insertion: p.N549EfsTer16 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K106(10.00); K108(2.04); K213(7.73); K327(5.64)  LDD0277  [3]
ONAyne
 Probe Info  		K246(2.83); K333(5.26)  LDD0275  [3]
Probe 1
 Probe Info  		Y533(7.66)  LDD3495  [4]
DBIA
 Probe Info  		C334(1.75)  LDD3313  [5]
BTD
 Probe Info  		C555(2.29)  LDD1700  [6]
HHS-475
 Probe Info  		Y471(0.82)  LDD0264  [7]
Acrolein
 Probe Info  		N.A.  LDD0222  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C334(0.24)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C334(0.37)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C334(1.15)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C334(1.98)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C334(1.09)  LDD2103  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C334(0.62)  LDD2131  [6]
 LDCM0214  AC1 HEK-293T C239(0.89)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C239(0.88); C472(1.38)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C239(0.95)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C239(1.06); C555(1.03)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C239(1.12)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C239(0.93); C472(1.03)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C239(0.90)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C239(0.93); C472(1.48)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C239(0.92)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C239(1.05); C472(1.19)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C239(0.98); C555(1.05)  LDD1519  [12]
 LDCM0282  AC22 HEK-293T C239(1.13)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C239(1.01); C472(0.80)  LDD1522  [12]
 LDCM0285  AC25 HEK-293T C239(0.90)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C239(1.03); C472(1.09)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C239(1.02)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C239(1.00); C555(1.03)  LDD1527  [12]
 LDCM0290  AC3 HEK-293T C239(1.04)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C239(0.97)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C239(1.04); C472(0.83)  LDD1531  [12]
 LDCM0294  AC33 HEK-293T C239(0.88)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C239(0.95); C472(1.08)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C239(0.97)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C239(1.04); C555(1.07)  LDD1536  [12]
 LDCM0299  AC38 HEK-293T C239(1.06)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C239(1.09); C472(1.12)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C239(0.93); C555(1.03)  LDD1540  [12]
 LDCM0303  AC41 HEK-293T C239(0.76)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C239(0.92); C472(1.31)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C239(1.10)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C239(1.00); C555(0.93)  LDD1545  [12]
 LDCM0308  AC46 HEK-293T C239(1.05)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C239(1.09); C472(1.15)  LDD1548  [12]
 LDCM0311  AC49 HEK-293T C239(0.92)  LDD1550  [12]
 LDCM0313  AC50 HEK-293T C239(0.91); C472(1.11)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C239(0.92)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C239(1.02); C555(0.99)  LDD1554  [12]
 LDCM0317  AC54 HEK-293T C239(0.98)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C239(1.05); C472(0.96)  LDD1557  [12]
 LDCM0320  AC57 HEK-293T C239(0.87)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C239(0.98); C472(1.10)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C239(0.98)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C239(1.01)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C239(1.01); C555(0.99)  LDD1563  [12]
 LDCM0326  AC62 HEK-293T C239(0.95)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C239(1.00); C472(0.85)  LDD1566  [12]
 LDCM0334  AC7 HEK-293T C239(1.05); C472(0.86)  LDD1568  [12]
 LDCM0545  Acetamide MDA-MB-231 C334(0.27); C555(1.14)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C334(1.32)  LDD2113  [6]
 LDCM0356  AKOS034007680 HEK-293T C239(0.83)  LDD1570  [12]
 LDCM0156  Aniline NCI-H1299 14.54  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0368  CL10 HEK-293T C239(0.94)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C239(1.01); C472(1.05)  LDD1573  [12]
 LDCM0371  CL102 HEK-293T C239(1.02); C472(0.90)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C239(0.93)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C239(1.09); C472(1.14)  LDD1577  [12]
 LDCM0375  CL106 HEK-293T C239(0.99); C472(0.91)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C239(0.96)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C239(0.99); C472(1.05)  LDD1581  [12]
 LDCM0379  CL11 HEK-293T C239(0.88); C472(0.77)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C239(1.03); C472(0.74)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C239(1.03)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C239(1.01); C472(1.08)  LDD1586  [12]
 LDCM0384  CL114 HEK-293T C239(0.86); C472(0.85)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C239(0.88)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C239(1.08); C472(1.38)  LDD1590  [12]
 LDCM0388  CL118 HEK-293T C239(0.94); C472(0.97)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C239(0.94)  LDD1593  [12]
 LDCM0391  CL120 HEK-293T C239(0.91); C472(1.09)  LDD1595  [12]
 LDCM0393  CL122 HEK-293T C239(1.05); C472(1.06)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C239(0.97)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C239(0.87); C472(1.08)  LDD1599  [12]
 LDCM0397  CL126 HEK-293T C239(1.08); C472(1.19)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C239(1.02)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C239(1.13); C472(1.16)  LDD1603  [12]
 LDCM0401  CL14 HEK-293T C239(1.18); C472(1.11)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C239(1.04)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C239(0.95); C472(1.18)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C239(1.00)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C239(0.96); C472(1.24)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C239(1.16)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C239(1.14); C472(0.97)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C239(1.00); C555(1.02)  LDD1612  [12]
 LDCM0410  CL22 HEK-293T C239(1.08)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C239(0.86); C472(1.13)  LDD1615  [12]
 LDCM0414  CL26 HEK-293T C239(1.14); C472(0.85)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C239(1.03)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C239(0.88); C472(1.02)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C239(0.88)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C239(1.10)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C239(0.93); C472(1.41)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C239(0.94)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C239(0.95); C555(1.06)  LDD1625  [12]
 LDCM0423  CL34 HEK-293T C239(0.99)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C239(0.95); C472(0.87)  LDD1628  [12]
 LDCM0428  CL39 HEK-293T C239(0.94)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C239(0.91); C472(0.89)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C239(0.90); C472(1.16)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C239(0.82)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C239(0.95); C472(0.97)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C239(0.92)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C239(0.92); C555(1.06)  LDD1638  [12]
 LDCM0436  CL46 HEK-293T C239(0.97)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C239(0.86); C472(0.84)  LDD1641  [12]
 LDCM0440  CL5 HEK-293T C239(0.99)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C239(1.06); C472(0.99)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C239(0.96); C472(0.99)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C239(0.88)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C239(1.02); C472(0.96)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C239(1.11)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C239(0.91); C555(1.15)  LDD1650  [12]
 LDCM0449  CL58 HEK-293T C239(1.07)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C239(0.84); C472(0.95)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C239(0.83); C472(1.24)  LDD1654  [12]
 LDCM0454  CL62 HEK-293T C239(1.15); C472(0.92)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C239(1.03)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C239(0.80); C472(0.97)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C239(0.96)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C239(0.88); C472(1.25)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C239(0.99)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C239(0.85); C555(1.07)  LDD1663  [12]
 LDCM0462  CL7 HEK-293T C239(1.16)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C239(0.99)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C239(0.82); C472(0.89)  LDD1667  [12]
 LDCM0467  CL74 HEK-293T C239(0.98); C472(1.12)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C239(0.98); C472(1.00)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C239(0.89)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C239(0.99); C472(1.16)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C239(1.08)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C239(0.80); C555(0.89)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C239(0.85); C555(1.10)  LDD1677  [12]
 LDCM0476  CL82 HEK-293T C239(0.99)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C239(0.93); C472(0.87)  LDD1680  [12]
 LDCM0480  CL86 HEK-293T C239(1.10); C472(1.34)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C239(1.00)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C239(0.89); C472(1.04)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C239(1.06)  LDD1686  [12]
 LDCM0485  CL90 HEK-293T C239(0.58); C472(1.16)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C239(1.00)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C239(0.90); C555(1.03)  LDD1690  [12]
 LDCM0489  CL94 HEK-293T C239(0.95)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C239(0.80); C472(0.87)  LDD1693  [12]
 LDCM0493  CL98 HEK-293T C239(1.00); C472(0.91)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C239(1.01)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C239(1.06)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C239(1.10)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C239(1.01); C472(0.94)  LDD1631  [12]
 LDCM0116  HHS-0101 DM93 Y471(0.82)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y471(0.73)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y471(1.10)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y471(0.77)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y471(1.15)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C239(0.96)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C239(1.08)  LDD1497  [12]
 LDCM0024  KB05 Hs 936.T C334(1.75)  LDD3313  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C334(1.29)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C334(0.92)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C334(1.12)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C334(1.34)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C334(0.78)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C334(0.81)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C334(0.94)  LDD2098  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C334(1.12)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C334(0.22)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C334(1.01)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C334(0.28)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C334(0.47)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C334(0.97)  LDD2111  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C334(0.42)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C334(0.60)  LDD2116  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C334(3.32)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C334(0.97)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C334(0.86)  LDD2122  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C334(0.70)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C334(0.58)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C334(1.02)  LDD2126  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C334(0.99)  LDD2128  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C334(0.47)  LDD2134  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C334(1.18)  LDD2136  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C555(2.29)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C334(0.76)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C334(1.05)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C334(2.78)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C334(0.90)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C334(4.23)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C334(0.45)  LDD2148  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C334(1.92)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 39 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 7 (PSMC2) AAA ATPase family P35998
Alpha/beta hydrolase domain-containing protein 17C (ABHD17C) ABHD17 family Q6PCB6
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2) APS kinase family; Sulfate adenylyltransferase family O95340
Acyl-CoA synthetase short-chain family member 3, mitochondrial (ACSS3) ATP-dependent AMP-binding enzyme family Q9H6R3
Threonine--tRNA ligase 1, cytoplasmic (TARS1) Class-II aminoacyl-tRNA synthetase family P26639
Corrinoid adenosyltransferase MMAB (MMAB) Cob(I)alamin adenosyltransferase family Q96EY8
NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1) Complex I 51 kDa subunit family P49821
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (DUS3L) Dus family Q96G46
L-amino-acid oxidase (IL4I1) Flavin monoamine oxidase family Q96RQ9
Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2) GDA1/CD39 NTPase family Q9Y5L3
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1) Glycosyltransferase 29 family Q92185
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (MGAT4B) Glycosyltransferase 54 family Q9UQ53
Polyamine deacetylase HDAC10 (HDAC10) Histone deacetylase family Q969S8
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
L-lactate dehydrogenase A-like 6B (LDHAL6B) LDH family Q9BYZ2
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) Maf family O95671
NmrA-like family domain-containing protein 1 (NMRAL1) NmrA-type oxidoreductase family Q9HBL8
Ketimine reductase mu-crystallin (CRYM) Ornithine cyclodeaminase/mu-crystallin family Q14894
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Calpain-1 catalytic subunit (CAPN1) Peptidase C2 family P07384
Carboxypeptidase N catalytic chain (CPN1) Peptidase M14 family P15169
Thimet oligopeptidase (THOP1) Peptidase M3 family P52888
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) CAMK Ser/Thr protein kinase family Q9BUB5
Serine/threonine-protein kinase TBK1 (TBK1) Ser/Thr protein kinase family Q9UHD2
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
ADP-ribosylation factor-like protein 16 (ARL16) Arf family Q0P5N6
Ras-related protein Rab-10 (RAB10) Rab family P61026
Ras-related protein Rab-8A (RAB8A) Rab family P61006
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) Succinate/malate CoA ligase beta subunit family Q9P2R7
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
RING finger protein 112 (RNF112) GB1/RHD3 GTPase family Q9ULX5
Immunity-related GTPase family M protein (IRGM) IRG family A1A4Y4
Ubiquitin-conjugating enzyme E2 A (UBE2A) Ubiquitin-conjugating enzyme family P49459
E3 ubiquitin-protein ligase HACE1 (HACE1) . Q8IYU2
E3 ubiquitin-protein ligase PPP1R11 (PPP1R11) . O60927
E3 ubiquitin-protein ligase RNF216 (RNF216) . Q9NWF9
Sphingosine kinase 2 (SPHK2) . Q9NRA0
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A5 (ANXA5) Annexin family P08758
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Protein cornichon homolog 3 (CNIH3) Cornichon family Q8TBE1
Huntingtin (HTT) Huntingtin family P42858
Gamma-aminobutyric acid receptor subunit gamma-1 (GABRG1) Ligand-gated ion channel family Q8N1C3
Proton myo-inositol cotransporter (SLC2A13) Sugar transporter (TC 2.A.1.1) family Q96QE2
Peroxisomal membrane protein PEX16 (PEX16) Peroxin-16 family Q9Y5Y5
Protein S100-A1 (S100A1) S-100 family P23297
Zinc transporter ZIP1 (SLC39A1) ZIP transporter (TC 2.A.5) family Q9NY26
Optineurin (OPTN) . Q96CV9
Stromal interaction molecule 1 (STIM1) . Q13586
Syntenin-1 (SDCBP) . O00560
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 1 (SMAD1) Dwarfin/SMAD family Q15797
Interferon regulatory factor 8 (IRF8) IRF family Q02556
Telomere zinc finger-associated protein (ZBTB48) Krueppel C2H2-type zinc-finger protein family P10074
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 17 (ZNF17) Krueppel C2H2-type zinc-finger protein family P17021
Zinc finger protein 281 (ZNF281) Krueppel C2H2-type zinc-finger protein family Q9Y2X9
Zinc finger protein 329 (ZNF329) Krueppel C2H2-type zinc-finger protein family Q86UD4
Zinc finger protein 398 (ZNF398) Krueppel C2H2-type zinc-finger protein family Q8TD17
Zinc finger protein 419 (ZNF419) Krueppel C2H2-type zinc-finger protein family Q96HQ0
Zinc finger protein 597 (ZNF597) Krueppel C2H2-type zinc-finger protein family Q96LX8
Zinc finger protein 670 (ZNF670) Krueppel C2H2-type zinc-finger protein family Q9BS34
Zinc finger protein with KRAB and SCAN domains 1 (ZKSCAN1) Krueppel C2H2-type zinc-finger protein family P17029
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Achaete-scute homolog 4 (ASCL4) . Q6XD76
THAP domain-containing protein 6 (THAP6) . Q8TBB0
Zinc finger protein 426 (ZNF426) . Q9BUY5
Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76) . Q96EF9
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxytryptamine receptor 1E (HTR1E) G-protein coupled receptor 1 family P28566
P2Y purinoceptor 4 (P2RY4) G-protein coupled receptor 1 family P51582
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 3 member A2 (BTN3A2) BTN/MOG family P78410
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) MHC class II family P04440
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Red (IK) RED family Q13123
Other
Click To Hide/Show 51 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cofilin-1 (CFL1) Actin-binding proteins ADF family P23528
AP-3 complex subunit beta-1 (AP3B1) Adaptor complexes large subunit family O00203
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
Dickkopf-related protein 4 (DKK4) Dickkopf family Q9UBT3
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Histone H3-like centromeric protein A (CENPA) Histone H3 family P49450
Histone H3.2 (H3C15; H3C14; H3C13) Histone H3 family Q71DI3
Baculoviral IAP repeat-containing protein 5 (BIRC5) IAP family O15392
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
55 kDa erythrocyte membrane protein (MPP1) MAGUK family Q00013
Mitochondrial fission process protein 1 (MTFP1) MTFP1 family Q9UDX5
60S ribosome subunit biogenesis protein NIP7 homolog (NIP7) NIP7 family Q9Y221
Protein CIMAP1D (CIMAP1D) ODF3 family Q3SX64
. Paralemmin family Q8IXS6
Leupaxin (LPXN) Paxillin family O60711
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
SNW domain-containing protein 1 (SNW1) SNW family Q13573
tRNA (32-2'-O)-methyltransferase regulator THADA (THADA) THADA family Q6YHU6
Protein PAXX (PAXX) XRCC4-XLF family Q9BUH6
Protein zyg-11 homolog B (ZYG11B) Zyg-11 family Q9C0D3
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
Centrosome-associated protein CEP250 (CEP250) . Q9BV73
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
DAZ-associated protein 2 (DAZAP2) . Q15038
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Heat shock factor 2-binding protein (HSF2BP) . O75031
KH domain-containing RNA-binding protein QKI (QKI) . Q96PU8
Ligand of Numb protein X 2 (LNX2) . Q8N448
Methyl-CpG-binding protein 2 (MECP2) . P51608
Myeloma-overexpressed gene protein (MYEOV) . Q96EZ4
NudC domain-containing protein 2 (NUDCD2) . Q8WVJ2
Orofacial cleft 1 candidate gene 1 protein (OFCC1) . Q8IZS5
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
PRKCA-binding protein (PICK1) . Q9NRD5
Protein MGARP (MGARP) . Q8TDB4
Putative uncharacterized protein FLJ37218 . Q8N1Y9
Ras association domain-containing protein 2 (RASSF2) . P50749
RNA-binding protein 12 (RBM12) . Q9NTZ6
Sequestosome-1 (SQSTM1) . Q13501
Spermatogenesis-associated serine-rich protein 1 (SPATS1) . Q496A3
TBC1 domain family member 15 (TBC1D15) . Q8TC07
TBC1 domain family member 17 (TBC1D17) . Q9HA65
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Uncharacterized protein C17orf67 (C17orf67) . Q0P5P2
Uncharacterized protein C8orf48 (C8orf48) . Q96LL4
Uncharacterized protein KIAA0825 (KIAA0825) . Q8IV33
Vitamin K-dependent protein S (PROS1) . P07225
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402