Details of the Target

General Information of Target

Target ID LDTP10136
Target Name Serine/threonine-protein kinase Sgk3 (SGK3)
Gene Name SGK3
Gene ID 100533105
Synonyms
CISK; SGKL; Serine/threonine-protein kinase Sgk3; EC 2.7.11.1; Cytokine-independent survival kinase; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAESGSDFQQRRRRRRDPEEPEKTELSERELAVAVAVSQENDEENEERWVGPLPVEATL
AKKRKVLEFERVYLDNLPSASMYERSYMHRDVITHVVCTKTDFIITASHDGHVKFWKKIE
EGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQC
EWIYCPGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVS
SDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGS
DRKVRIFRFVTGKLMRVFDESLSMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVRLIN
IVFDETGHFVLYGTMLGIKVINVETNRCVRILGKQENIRVMQLALFQGIAKKHRAATTIE
MKASENPVLQNIQADPTIVCTSFKKNRFYMFTKREPEDTKSADSDRDVFNEKPSKEEVMA
ATQAEGPKRVSDSAIIHTSMGDIHTKLFPVECPKTVENFCVHSRNGYYNGHTFHRIIKGF
MIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTP
WLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSIINITVK
Target Bioclass
Enzyme
Family
Protein kinase superfamily, AGC Ser/Thr protein kinase family
Subcellular location
Cytoplasmic vesicle
Function
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
Uniprot ID
Q96BR1
Ensemble ID
ENST00000345714.8
HGNC ID
HGNC:10812
ChEMBL ID
CHEMBL6186

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.T317N .
CCK81 SNV: p.H278R .
COLO792 SNV: p.P73S .
HCC1395 SNV: p.A92V .
HCT15 SNV: p.P417L .
HT115 SNV: p.F187V; p.E310Ter .
KASUMI2 SNV: p.Y356C .
NCIH2291 SNV: p.A349P .
NCIH358 SNV: p.P382Q .
SKMEL2 SNV: p.R103S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y104(10.07)  LDD3495  [1]
AHL-Pu-1
 Probe Info  		C13(3.40)  LDD0168  [2]
HHS-475
 Probe Info  		Y104(0.13); Y58(0.80)  LDD0264  [3]
DBIA
 Probe Info  		C308(20.00)  LDD0080  [4]
AMP probe
 Probe Info  		N.A.  LDD0200  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C13(3.40)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C13(2.62)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C322(0.81); C308(0.94)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C13(1.12); C322(1.07); C308(1.07)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C322(1.06); C308(1.06)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C13(0.98); C322(0.82); C308(0.98)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C322(0.81); C308(1.05)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C322(1.08); C308(1.05)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C322(0.87); C308(0.95)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C13(1.17); C322(0.99); C308(0.96)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C322(1.12); C308(1.03)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C13(1.15); C322(0.94); C308(1.03)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C13(0.94); C322(0.74); C308(0.96)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C13(1.03); C322(0.82); C308(0.94)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C322(0.95); C308(1.06)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C322(1.04); C308(1.09)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C13(1.14); C322(0.96); C308(0.86)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C322(0.92); C308(0.97)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C13(1.17); C322(0.91); C308(1.00)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C322(1.21); C308(0.98)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C13(0.90); C322(0.86); C308(1.01)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C13(1.03); C322(1.09); C308(1.04)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C322(1.00); C308(1.00)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C322(1.20); C308(0.94)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C322(0.94); C308(1.04)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C13(0.96); C322(1.09); C308(0.98)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C322(0.99); C308(0.95)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C13(1.12); C322(1.05); C308(0.94)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C322(0.82); C308(1.10)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C13(1.09); C322(1.19); C308(1.07)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C13(1.19); C322(1.02); C308(1.01)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C322(0.85); C308(0.98)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C322(0.91); C308(0.98)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C13(0.92); C322(1.06); C308(1.09)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C13(1.20); C322(1.25); C308(1.08)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C322(0.91); C308(1.05)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C13(1.15); C322(0.95); C308(0.86)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C322(1.71); C308(1.15)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C13(1.04); C322(0.77); C308(1.01)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C13(1.16); C322(0.99); C308(1.04)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C322(1.01); C308(1.01)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C322(1.00); C308(1.08)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C13(1.02); C322(1.01); C308(0.88)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C322(0.96); C308(0.99)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C13(1.02); C322(1.00); C308(1.01)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C13(1.20); C322(1.01); C308(0.89)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C322(1.02); C308(1.01)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C13(1.08); C322(0.92); C308(1.02)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C13(1.10); C322(1.02); C308(1.07)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C322(1.00); C308(0.98)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C322(1.03); C308(0.99)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C13(1.10); C322(0.94); C308(0.90)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C322(0.82); C308(0.96)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C13(1.10); C322(1.29); C308(1.06)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C322(1.18); C308(1.04)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C322(0.87); C308(1.06)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C13(1.00); C322(0.95); C308(1.06)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C13(1.02); C322(0.98); C308(0.98)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C322(1.30); C308(0.94)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C322(0.94); C308(0.97)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C13(0.95); C322(1.02); C308(0.91)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C322(0.97); C308(1.02)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C13(1.02); C322(1.15); C308(0.96)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C13(1.09); C322(0.97); C308(0.98)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C322(0.76); C308(0.93)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C13(1.06); C322(1.11); C308(0.86)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C13(1.15); C322(0.94); C308(1.30)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C322(0.14); C308(2.87)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C308(0.99)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C13(1.02); C322(0.99); C308(1.01)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C322(0.99); C308(1.39)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C322(1.22); C308(0.94)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C308(0.97)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C13(1.07); C322(1.03); C308(1.05)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C322(1.20); C308(0.98)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C322(1.28); C308(1.02)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C308(1.13)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C13(0.95); C322(0.80); C308(1.02)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C322(1.07); C308(1.69)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C322(1.16); C308(1.74)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C322(1.04); C308(0.97)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C308(1.02)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C13(1.09); C322(0.74); C308(0.99)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C322(1.04); C308(1.25)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C322(1.22); C308(1.05)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C308(1.03)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C13(1.07); C322(1.06); C308(0.99)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C322(1.23); C308(0.99)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C322(1.24); C308(0.97)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C13(1.36); C322(1.19); C308(1.35)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C308(0.85)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C13(1.16); C322(0.90); C308(1.06)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C322(1.12); C308(1.04)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C322(0.86); C308(1.81)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C308(0.94)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C13(1.04); C322(0.92); C308(0.90)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C322(1.03); C308(1.08)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C322(1.13); C308(0.87)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C308(0.92)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C13(1.07); C322(0.92); C308(1.15)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C322(1.26); C308(1.04)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C322(1.36); C308(1.32)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C308(0.91)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C322(0.95); C308(1.69)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C13(1.16); C322(0.96); C308(0.96)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C322(0.91); C308(1.10)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C322(1.06); C308(1.05)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C13(0.97); C322(1.13); C308(1.14)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C13(1.09); C322(1.25); C308(1.56)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C322(1.15); C308(1.41)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C322(1.07); C308(1.32)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C13(1.30); C322(1.14); C308(1.19)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C13(1.02); C322(0.90); C308(1.19)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C322(1.12); C308(0.99)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C322(1.10); C308(0.93)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C308(1.05)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C322(0.88); C308(0.96)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C322(1.23); C308(1.05)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C13(1.03); C322(0.95); C308(1.21)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C322(0.84); C308(1.22)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C13(0.96); C322(0.97); C308(1.13)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C13(0.95); C322(1.19); C308(3.02)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C322(1.15); C308(1.44)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C322(1.00); C308(1.40)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C13(1.06); C322(1.04); C308(1.36)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C13(0.99); C322(0.83); C308(1.06)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C322(1.17); C308(1.57)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C308(1.01)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C308(0.92)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C322(0.80); C308(1.17)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C13(1.16); C322(1.02); C308(1.06)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C322(1.24); C308(1.07)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C13(1.12); C322(1.05); C308(1.15)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C13(1.00); C322(1.15); C308(1.98)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C322(1.14); C308(1.30)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C322(0.89); C308(1.40)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C13(0.83); C322(1.10); C308(1.31)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C13(0.99); C322(0.86); C308(0.91)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C322(0.82); C308(1.03)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C322(0.97); C308(1.11)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C308(0.90)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C322(0.69); C308(1.28)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C13(1.10); C322(0.88); C308(1.12)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C322(1.00); C308(1.00)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C13(0.97); C322(0.83); C308(1.39)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C13(1.01); C322(0.67); C308(1.45)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C322(0.83); C308(1.36)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C322(0.94); C308(1.37)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C13(1.21); C322(1.25); C308(1.10)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C13(1.00); C322(0.92); C308(1.29)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C13(1.01); C322(0.93); C308(0.93)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C322(1.04); C308(1.02)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C322(1.59); C308(0.98)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C308(1.01)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C322(1.03); C308(1.06)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C13(1.25); C322(0.90); C308(1.15)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C322(0.98); C308(1.05)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C13(1.02); C322(0.87); C308(1.32)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C13(1.05); C322(0.96); C308(1.53)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C322(0.91); C308(1.15)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C322(0.92); C308(1.23)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C322(1.20); C308(1.31)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C13(1.72); C322(1.15); C308(1.22)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C13(1.09); C322(0.93); C308(1.21)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C322(1.12); C308(0.96)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C308(0.86)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C322(0.72); C308(1.22)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C13(1.18); C322(0.84); C308(1.06)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C322(0.93); C308(1.00)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C13(0.92); C322(1.38); C308(3.56)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C13(0.89); C322(0.89); C308(1.03)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C13(0.92); C322(0.92); C308(1.10)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C322(0.94); C308(1.11)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C322(1.21); C308(1.31)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C13(0.88); C322(1.12); C308(1.41)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C13(0.93); C322(0.82); C308(1.01)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C322(0.99); C308(1.01)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C322(1.26); C308(1.02)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C308(0.91)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C322(1.01); C308(0.93)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C13(1.18); C322(1.18); C308(1.28)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C13(1.04); C322(1.04); C308(1.79)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C322(0.73); C308(1.54)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C13(0.93); C322(0.99); C308(1.49)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C13(1.02); C322(0.99); C308(1.43)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C322(0.81); C308(1.33)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C322(1.18); C308(2.64)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C13(0.81); C322(1.03); C308(1.20)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C13(1.04); C322(0.96); C308(1.12)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C322(1.04); C308(1.26)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C322(1.08); C308(1.05)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C322(1.11); C308(1.10)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C322(0.82); C308(1.11)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C322(0.98); C308(1.19)  LDD1631  [9]
 LDCM0116  HHS-0101 DM93 Y104(0.13); Y58(0.80)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y104(0.16); Y58(0.70)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y104(0.74); Y58(0.88)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y104(0.77); Y58(1.43)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y58(1.29)  LDD0268  [3]
 LDCM0022  KB02 HCT 116 C308(20.00)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C308(2.65)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C308(1.66)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Itchy homolog (ITCH) . Q96J02

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402