Details of the Target

General Information of Target

Target ID LDTP09973
Target Name Mediator of RNA polymerase II transcription subunit 12 (MED12)
Gene Name MED12
Gene ID 9968
Synonyms
ARC240; CAGH45; HOPA; KIAA0192; TNRC11; TRAP230; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPTEGSEVAIKIDFDFAPG
SFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHLAWLNQGKVLPQNMTTTHA
VAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLHYYLTSAIQLLRKDSIMENGT
LCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQEFGNQTLFTIFTCLGAPVQYFS
LKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLSTYNCQLLKASSKKCIPDPIAIASL
SFLTSVIIFSKSRV
Target Bioclass
Other
Family
Mediator complex subunit 12 family
Subcellular location
Nucleus
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Uniprot ID
Q93074
Ensemble ID
ENST00000374080.8
HGNC ID
HGNC:11957

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D SNV: p.E33K DBIA    Probe Info 
A2780 SNV: p.D23Y DBIA    Probe Info 
AU565 SNV: p.S1400F DBIA    Probe Info 
CAL33 SNV: p.E1020D DBIA    Probe Info 
EFO27 SNV: p.V781I .
HCC44 SNV: p.E1091K DBIA    Probe Info 
HCT116 SNV: p.G1807C .
HCT15 SNV: p.C1203G; p.R1465C .
HGC27 SNV: p.F1672C .
ICC3 Insertion: p.T805EfsTer3 DBIA    Probe Info 
J82 SNV: p.T115A .
JEKO1 SNV: p.E1781Ter .
JURKAT SNV: p.T1241I Compound 10    Probe Info 
KYSE180 SNV: p.H179L .
LN18 SNV: p.P1430S .
MCC13 SNV: p.M1375I; p.K1634Ter; p.T2171I .
MDAMB157 SNV: p.L457R .
NCIH1048 SNV: p.R1636H .
NCIH196 Insertion: p.D395EfsTer16 .
NCIH1993 SNV: p.D963Y .
NCIH358 SNV: p.Y1834C .
OCUG1 SNV: p.L36P DBIA    Probe Info 
P31FUJ SNV: p.P1746T .
REH SNV: p.A2124V .
RKO SNV: p.N1072S DBIA    Probe Info 
RL952 SNV: p.Q2081R .
SNGM SNV: p.R1319H DBIA    Probe Info 
SNU1 SNV: p.R1138Q DBIA    Probe Info 
SW1271 Substitution: p.W379F .
SW948 SNV: p.V2042I DBIA    Probe Info 
U937 Deletion: p.F1672Ter
SNV: p.I1671M		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C997(3.08)  LDD0169  [2]
DBIA
 Probe Info  		C481(62.63); C541(9.47); C444(15.81); C83(45.56)  LDD0209  [3]
Acrolein
 Probe Info  		C1325(0.00); C481(0.00)  LDD0222  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1651(0.00); C1287(0.00); C541(0.00); C364(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C982(0.00); C970(0.00); C481(0.00); C1488(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C83(0.00); C1287(0.00); C1488(0.00); C1188(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		C444(0.00); C997(0.00); C1301(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		C1651(0.00); C997(0.00); C1006(0.00)  LDD2224  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [7]
IPM
 Probe Info  		C83(0.00); C444(0.00)  LDD0147  [8]
TFBX
 Probe Info  		C481(0.00); C997(0.00); C1301(0.00); C1203(0.00)  LDD0148  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
AOyne
 Probe Info  		10.90  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C997(3.08)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C541(1.16); C83(1.08); C1523(0.86); C1006(0.94)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C541(1.01); C83(0.99); C1523(1.01); C1006(1.12)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C83(1.11); C1523(1.01); C1006(1.01); C1188(0.98)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C541(0.98); C83(1.12); C1523(1.14); C1006(0.70)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C541(1.09); C1523(1.07); C1006(1.16); C1188(0.99)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C541(1.19); C83(1.01); C1006(1.17); C1188(1.04)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C541(1.36); C83(1.11); C1523(1.01); C1006(0.97)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C541(0.98); C83(1.03); C1523(0.90); C1006(1.06)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C83(1.21); C1523(1.07); C1006(0.98); C1188(1.27)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C541(1.05); C83(1.05); C1523(0.94); C1006(1.06)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C541(1.05); C83(1.11); C1523(1.09); C1006(1.06)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C83(1.12); C1006(1.07); C1188(1.04); C1287(0.94)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C541(0.97); C1523(1.07); C1006(1.04); C1188(0.88)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C541(1.12); C83(0.96); C1006(0.99); C1188(1.08)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C541(1.01); C83(1.04); C1523(0.99); C1188(0.98)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C541(1.14); C83(1.22); C1523(0.97); C1006(0.93)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C541(0.94); C83(1.03); C1523(1.07); C1006(1.07)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C83(1.14); C1523(1.06); C1006(0.74); C1188(1.03)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C541(0.88); C83(1.01); C1523(1.07); C1006(0.82)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C83(1.05); C1006(0.91); C1188(0.98); C1287(0.93)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C83(1.06); C1523(0.80); C1006(1.02); C1188(1.06)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C541(1.13); C1523(1.09); C1006(1.16); C1188(1.26)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C541(0.99); C83(1.13); C1006(1.13); C1188(1.05)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C541(1.07); C83(0.94); C1523(1.01); C1188(0.86)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C541(1.04); C83(1.33); C1523(0.95); C1006(1.13)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C541(1.07); C83(1.15); C1523(0.95); C1006(1.08)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C83(1.12); C1523(1.03); C1006(1.15); C1188(0.99)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C541(0.98); C83(0.83); C1523(1.08); C1006(1.08)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C83(1.12); C1006(1.14); C1188(0.99); C1287(0.92)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C541(0.89); C1523(1.22); C1006(1.08); C1188(1.04)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C541(1.13); C83(1.14); C1006(1.08); C1188(1.11)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C541(0.87); C83(0.85); C1523(0.97); C1006(0.71)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C541(1.01); C83(1.14); C1523(0.94); C1188(0.83)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C541(1.03); C83(1.09); C1523(1.00); C1006(1.15)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C541(1.23); C83(1.14); C1523(0.93); C1006(1.09)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C83(1.19); C1523(0.96); C1006(0.98); C1188(1.07)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C541(1.03); C83(1.06); C1523(1.08); C1006(1.02)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C83(1.17); C1006(1.10); C1188(1.03); C1287(0.94)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C541(1.07); C1523(1.18); C1006(1.12); C1188(1.15)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C541(1.13); C83(1.14); C1006(1.07); C1188(1.02)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C541(1.03); C83(1.11); C1523(0.89); C1188(0.97)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C541(1.22); C83(1.18); C1523(1.00); C1006(1.06)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C83(1.08); C1006(1.39); C1188(0.93); C1287(1.01)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C541(1.00); C83(1.18); C1523(0.93); C1006(1.04)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C83(1.14); C1523(1.07); C1006(0.84); C1188(1.06)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C541(0.91); C83(1.02); C1523(1.12); C1006(0.89)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C83(1.15); C1006(1.05); C1188(1.02); C1287(1.05)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C541(0.97); C1523(1.12); C1006(1.06); C1188(1.13)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C541(1.14); C83(1.18); C1006(1.15); C1188(1.08)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C541(1.08); C83(1.13); C1523(0.88); C1188(0.83)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C541(0.91); C83(1.20); C1523(0.97); C1006(1.02)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C541(0.97); C83(1.06); C1523(0.91); C1006(1.05)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C83(1.08); C1523(0.93); C1006(0.84); C1188(1.00)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C541(0.89); C1523(1.06); C1006(0.99); C1188(1.24)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C541(0.95); C83(1.09); C1523(1.06); C1006(1.07)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C83(1.06); C1006(0.94); C1188(1.10); C1287(0.95)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C541(0.97); C1523(0.99); C1006(1.18); C1188(1.00)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C541(0.96); C83(1.08); C1006(1.01); C1188(0.96)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C541(1.14); C83(1.02); C1523(0.83); C1188(0.84)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C541(0.91); C83(1.03); C1006(1.02); C1188(1.06)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C541(1.03); C83(1.09); C1523(0.92); C1188(0.92)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C83(1.09); C1006(0.90); C1188(1.01); C1287(1.09)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C541(1.35); C83(1.06); C1523(0.98); C1006(0.90)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C541(1.10); C83(1.20); C1523(1.07); C1188(0.92)  LDD1514  [10]
 LDCM0108  Chloroacetamide HeLa C1325(0.00); C481(0.00)  LDD0222  [4]
 LDCM0632  CL-Sc Hep-G2 C997(20.00)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C541(0.97); C83(1.01); C1523(1.16); C1006(1.27)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C541(0.77); C1523(2.40); C1006(1.12); C1188(1.59)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C541(1.05); C83(1.00); C1523(0.88); C1006(0.92)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C541(1.10); C83(1.13); C1523(0.98); C1006(1.50)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C541(1.09); C83(1.07); C1523(0.81); C1188(1.03)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C541(1.24); C83(1.18); C1188(1.04); C1287(1.05)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C541(1.18); C83(1.17); C1523(0.96); C1006(1.03)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C541(0.99); C83(1.01); C1523(1.13); C1006(0.90)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C541(1.03); C83(1.04); C1523(0.83); C1188(0.94)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C541(1.12); C83(1.19); C1188(1.04); C1287(1.14)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C541(1.16); C83(1.19); C1523(1.08); C1006(0.93)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C541(1.12); C83(1.03); C1523(1.10); C1006(1.39)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C541(0.82); C83(1.11); C1006(1.02); C1188(1.12)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C541(1.08); C83(1.18); C1523(1.02); C1188(1.02)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C541(0.95); C83(1.17); C1188(1.11); C1287(1.10)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C541(1.14); C83(1.13); C1523(0.96); C1006(1.05)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C541(1.09); C83(1.02); C1523(0.95); C1006(1.07)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C541(1.07); C83(1.14); C1523(0.90); C1188(1.11)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C541(0.93); C83(1.19); C1188(1.04); C1287(1.07)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C541(1.21); C83(1.13); C1523(0.97); C1006(1.03)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C541(1.13); C83(0.95); C1523(0.93); C1006(1.14)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C541(1.42); C83(1.11); C1523(0.90); C1188(0.99)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C541(1.04); C83(1.12); C1188(1.10); C1287(1.30)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C541(0.93); C83(1.20); C1523(1.48); C1188(0.95)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C541(1.24); C83(1.10); C1523(0.96); C1006(1.11)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C541(1.03); C83(1.05); C1523(0.93); C1006(1.04)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C541(1.34); C83(1.08); C1523(0.84); C1188(0.98)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C541(0.88); C83(1.28); C1188(1.13); C1287(0.89)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C541(1.40); C83(1.39); C1523(1.02); C1006(1.04)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C541(0.97); C83(0.99); C1523(0.96); C1006(1.20)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C541(1.03); C83(0.94); C1523(0.74); C1188(0.97)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C541(0.84); C83(1.16); C1188(1.02); C1287(0.93)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C541(1.03); C83(1.15); C1523(0.95); C1006(0.88)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C541(1.05); C83(0.99); C1523(1.05); C1006(1.74)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C541(1.02); C83(1.12); C1523(0.89); C1188(0.98)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C541(1.01); C83(1.46); C1188(1.12); C1287(1.23)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C541(1.11); C83(1.09); C1523(1.04); C1006(1.14)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C541(1.04); C83(1.29); C1523(1.25); C1006(1.13)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C541(1.07); C83(0.99); C1523(1.23); C1006(1.03)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C83(1.07); C1523(1.46); C1006(0.78); C1188(1.04)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C541(1.04); C83(0.84); C1523(0.95); C1188(1.11)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C541(0.89); C83(1.08); C1523(1.89); C1006(0.95)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C83(1.18); C1006(0.97); C1188(1.23); C1287(1.31)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C541(0.99); C1523(2.25); C1006(1.04); C1188(1.37)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C541(1.06); C83(1.12); C1006(1.07); C1188(1.09)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C541(0.98); C83(1.27); C1523(1.70); C1188(1.03)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C541(0.99); C83(1.01); C1523(1.09); C1006(0.99)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C541(0.95); C83(0.93); C1523(1.00); C1188(1.07)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C541(1.08); C83(1.15); C1188(1.15); C1287(1.02)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C541(1.09); C83(1.10); C1523(1.05); C1006(0.98)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C541(1.12); C83(1.19); C1523(1.12); C1006(0.88)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C541(1.01); C83(1.36); C1188(1.17); C1287(1.08)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C541(1.20); C83(1.15); C1523(1.13); C1006(1.03)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C83(1.14); C1523(1.33); C1006(0.76); C1188(1.08)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C541(0.98); C83(1.05); C1523(1.68); C1006(0.88)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C83(1.37); C1006(1.40); C1188(1.17); C1287(1.80)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C541(1.06); C1523(1.78); C1006(0.98); C1188(1.32)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C541(1.34); C83(1.19); C1006(1.00); C1188(1.10)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C541(1.12); C83(1.24); C1523(1.63); C1188(0.83)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C541(1.03); C83(0.89); C1523(1.02); C1006(1.05)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C541(0.82); C83(1.11); C1188(1.01); C1287(1.36)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C541(0.90); C83(1.04); C1523(0.99); C1006(0.97)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C541(1.04); C83(0.97); C1523(1.04); C1006(0.93)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C541(1.16); C83(1.24); C1523(1.08); C1006(0.95)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C541(1.03); C83(1.17); C1523(1.00); C1006(1.00)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C83(0.98); C1523(1.47); C1006(0.96); C1188(1.03)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C541(1.01); C83(1.02); C1523(1.51); C1006(0.90)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C83(1.13); C1006(1.01); C1188(1.00); C1287(1.21)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C541(0.87); C1523(1.81); C1006(0.97); C1188(1.22)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C541(1.01); C83(1.35); C1006(0.96); C1188(1.09)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C541(1.10); C83(1.04); C1523(1.63); C1188(0.75)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C541(0.96); C83(0.96); C1523(0.83); C1006(1.07)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C541(0.98); C83(1.03); C1523(1.13); C1006(1.10)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C541(1.34); C83(1.01); C1523(0.97); C1188(1.06)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C541(1.29); C83(1.04); C1523(1.00); C1006(1.12)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C541(1.01); C83(1.20); C1523(1.12); C1006(1.18)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C541(1.01); C83(1.24); C1523(1.28); C1006(1.05)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C83(1.11); C1523(1.42); C1006(0.92); C1188(1.13)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C541(0.95); C83(0.88); C1523(1.61); C1006(1.29)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C83(1.16); C1006(1.15); C1188(1.17); C1287(1.45)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C541(0.99); C1523(1.90); C1006(1.03); C1188(1.22)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C541(1.28); C83(1.43); C1006(1.08); C1188(1.12)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C541(1.03); C83(1.05); C1523(1.18); C1006(1.03)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C541(0.92); C83(1.17); C1523(1.43); C1188(0.87)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C541(0.93); C83(1.03); C1523(0.95); C1006(0.81)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C541(1.24); C83(1.01); C1523(0.87); C1188(1.13)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C541(1.10); C83(1.03); C1188(1.03); C1287(0.97)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C541(1.18); C83(1.22); C1523(0.99); C1006(1.00)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C541(1.11); C83(1.12); C1523(1.10); C1006(1.08)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C541(1.00); C83(0.97); C1523(1.01); C1006(1.17)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C83(1.14); C1523(1.29); C1006(0.90); C1188(1.00)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C541(0.98); C83(1.15); C1523(1.56); C1006(0.91)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C83(1.20); C1006(1.16); C1188(1.15); C1287(1.14)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C83(1.00); C1523(1.23); C1006(0.95); C1188(1.15)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C541(0.90); C1523(1.76); C1006(1.00); C1188(0.94)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C541(1.18); C83(1.16); C1006(1.11); C1188(1.03)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C541(0.95); C83(1.19); C1523(1.40); C1188(0.78)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C541(0.97); C83(1.10); C1523(0.99); C1006(1.13)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C541(1.06); C83(0.99); C1523(0.82); C1188(1.00)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C541(1.24); C83(1.07); C1523(1.03); C1006(1.09)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C541(1.05); C83(1.10); C1523(1.05); C1006(0.99)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C541(0.98); C83(1.12); C1523(0.99); C1006(1.03)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C83(1.20); C1523(1.23); C1006(1.12); C1188(0.96)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C541(0.66); C83(0.82); C1523(1.68); C1006(1.44)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C541(0.99); C83(0.94); C1523(1.37); C1006(1.01)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C83(1.19); C1006(1.44); C1188(1.08); C1287(0.92)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C541(0.87); C1523(1.62); C1006(0.95); C1188(0.97)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C541(0.98); C83(1.06); C1006(1.00); C1188(1.07)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C541(0.91); C83(1.02); C1523(1.23); C1188(0.97)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C541(0.90); C83(0.97); C1523(1.00); C1006(0.95)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C541(0.98); C83(0.90); C1523(0.77); C1188(0.96)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C541(0.90); C83(1.14); C1188(0.99); C1287(0.90)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C541(0.96); C83(1.00); C1523(0.91); C1006(0.97)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C541(1.11); C83(1.13); C1523(0.94); C1006(1.09)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C83(1.01); C1006(0.97); C1188(1.15); C1287(1.01)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C541(0.83); C83(1.22); C1523(1.26); C1006(1.27)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C83(1.07); C1523(1.00); C1006(0.91); C1188(1.05)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C541(0.95); C83(0.81); C1523(1.19); C1006(0.98)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C83(1.06); C1006(1.09); C1188(1.13); C1287(1.08)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C541(1.04); C1523(1.70); C1006(0.97); C1188(1.27)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C541(0.91); C83(1.13); C1006(1.03); C1188(1.21)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C541(0.93); C83(1.10); C1523(1.07); C1188(1.01)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C541(0.99); C83(0.95); C1523(1.14); C1006(0.96)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C541(1.18); C83(0.91); C1523(0.89); C1188(1.09)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C541(0.84); C83(1.08); C1188(1.03); C1287(0.88)  LDD1697  [10]
 LDCM0634  CY-0357 Hep-G2 C1523(0.81)  LDD2228  [6]
 LDCM0495  E2913 HEK-293T C541(0.90); C83(0.99); C1188(0.99); C1287(1.12)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C541(1.14); C83(1.09); C1188(1.15); C1287(1.05)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C541(0.98); C83(0.90); C1523(0.87); C1188(0.98)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C541(0.94); C1523(0.88); C1287(0.91); C481(0.94)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C481(62.63); C541(9.47); C444(15.81); C83(45.56)  LDD0209  [3]
 LDCM0024  KB05 MEWO C1188(3.02)  LDD3319  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid beta precursor like protein 1 (APLP1) APP family P51693
Amyloid beta precursor like protein 2 (APLP2) APP family Q06481
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840