Details of the Target

General Information of Target

Target ID LDTP09816
Target Name TBC1 domain family member 5 (TBC1D5)
Gene Name TBC1D5
Gene ID 9779
Synonyms
KIAA0210; TBC1 domain family member 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFP
KSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSM
MYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSV
ISLFHAHEEATDKITERIKEEMSKDQPDYAMYSRISSSPTHSLYVFVRNFVCRIGEDAEL
FMSLYDPNKQTVISENYLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIV
RVGKMDLKDTGAKKCTQGLRRPFGVAVMDITDIIKGKAESDEEKQHFIPFHPVTAENDFL
HSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPG
DVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVV
YYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGT
TLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVF
SISTLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIM
MEHSQSDEYDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTY
LDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNL
MKSQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMN
EIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQVLERKYCVELLNSILEVLSYQD
AAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQ
TSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTN
FEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQN
KICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEV
EGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNR
MSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCAS
QVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQ
NLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMT
QFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQ
RFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIE
TMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHP
EDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVR
EMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQ
EEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAA
IPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTR
KKVNQFFKTMLASKSAEEGKQIPDSLSTDL
Target Bioclass
Transporter and channel
Subcellular location
Endosome membrane
Function
May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes.
Uniprot ID
Q92609
Ensemble ID
ENST00000253692.11
HGNC ID
HGNC:19166

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K442(5.00); K456(0.63)  LDD0277  [2]
DBIA
 Probe Info  		C96(1.87); C728(1.33)  LDD3310  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C192(0.00); C96(0.00); C706(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C192(0.00); C96(0.00); C706(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C192(0.00); C606(0.00); C96(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [6]
IPM
 Probe Info  		C676(0.00); C706(0.00)  LDD0147  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		11.50  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C706(1.21); C676(1.12); C96(1.03); C192(0.92)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C706(1.13); C676(0.98); C96(0.99); C192(0.95)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C676(0.90); C96(0.99); C192(1.02)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C706(0.99); C676(1.03); C96(1.02); C192(0.86)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C676(0.98); C96(0.50); C192(0.92); C606(1.15)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C706(0.88); C676(1.09); C96(0.84); C192(1.18)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C706(1.22); C676(1.05); C96(0.99); C192(0.89)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C706(1.02); C676(0.86); C96(0.92); C192(1.00)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C676(1.02); C96(0.87); C192(0.91)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C706(0.96); C676(0.78); C96(1.04); C192(1.00)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C706(0.84); C676(0.97); C96(0.97); C192(0.94)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C706(1.31); C676(1.22); C96(1.04); C192(0.98)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C676(0.88); C96(0.50); C192(0.98); C606(1.01)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C706(1.16); C676(1.19); C96(0.87); C192(1.09)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C706(0.94); C676(0.79); C96(0.75); C192(1.03)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C706(0.94); C676(1.16); C96(0.92); C192(1.03)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C706(1.03); C676(1.07); C96(0.95); C192(0.91)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C676(1.01); C96(1.01); C192(0.99)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C706(0.98); C676(0.93); C96(0.96); C192(0.93)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C706(1.14); C676(1.09); C96(0.96); C192(1.01)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C676(0.95); C96(1.05); C192(0.99)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C676(0.96); C96(0.53); C192(1.00); C606(1.02)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C706(0.89); C676(1.08); C96(0.89); C192(1.07)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C706(1.05); C676(1.02); C96(0.83); C192(1.05)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C706(0.99); C676(1.05); C96(1.17); C192(0.82)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C706(0.91); C676(0.96); C96(0.97); C192(0.98)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C676(1.01); C96(0.88); C192(0.93)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C706(1.18); C676(0.83); C96(1.03); C192(0.98)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C706(1.07); C676(1.09); C96(0.95); C192(0.93)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C676(1.00); C96(0.40); C192(1.00); C606(1.07)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C706(0.91); C676(0.97); C96(0.79); C192(1.21)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C706(1.00); C676(1.05); C96(0.96); C192(0.96)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C706(0.99); C676(1.05); C96(0.78); C192(1.13)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C706(1.21); C676(1.09); C96(1.08); C192(0.96)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C706(1.23); C676(0.80); C96(0.96); C192(0.87)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C676(0.93); C96(0.97); C192(0.99)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C706(0.96); C676(0.84); C96(1.00); C192(0.98)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C706(1.17); C676(1.04); C96(1.12); C192(0.88)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C676(1.05); C96(0.48); C192(0.99); C606(1.03)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C706(1.06); C676(1.12); C96(0.87); C192(1.02)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C706(1.00); C676(0.96); C96(0.81); C192(0.98)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C706(1.07); C676(0.80); C96(1.07); C192(0.96)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C706(1.11); C676(0.96); C96(1.02); C192(0.97)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C706(1.14); C676(0.92); C96(0.97); C192(0.94)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C676(0.87); C96(0.88); C192(0.96)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C706(0.91); C676(1.02); C96(1.03); C192(1.02)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C706(1.11); C676(0.98); C96(1.04); C192(1.02)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C676(1.05); C96(0.45); C192(0.92); C606(1.26)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C706(0.94); C676(1.08); C96(0.83); C192(1.07)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C706(1.04); C676(1.08); C96(0.81); C192(1.08)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C706(1.08); C676(0.90); C96(1.05); C192(0.97)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C706(0.99); C676(0.94); C96(1.01); C192(1.01)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C676(0.90); C96(0.98); C192(1.00)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C676(1.00); C96(0.45); C192(1.06); C606(1.08)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C706(1.09); C676(0.85); C96(1.04); C192(1.01)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C706(1.13); C676(1.03); C96(0.98); C192(0.98)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C676(0.93); C96(0.54); C192(0.95); C606(1.17)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C706(1.16); C676(1.00); C96(0.84); C192(1.06)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C706(1.00); C676(1.19); C96(0.78); C192(1.12)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C706(0.82); C676(0.93); C96(0.87); C192(0.99)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C706(1.19); C676(0.81); C96(0.76); C192(1.16)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C706(1.20); C676(1.08); C96(1.06); C192(1.04)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C706(1.05); C676(1.05); C96(1.04); C192(0.91)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C706(1.00); C676(0.90); C96(0.77); C192(1.09)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 13.90  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C192(2.48); C96(2.05)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C706(1.15); C676(0.74); C96(0.72); C192(0.94)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C676(1.17); C96(0.49); C192(0.93); C606(0.70)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C706(1.16); C676(0.85); C96(0.98); C192(1.09)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C706(0.93); C676(0.82); C96(0.76); C192(0.92)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C676(0.90); C96(0.81); C192(1.01)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C706(1.14); C676(1.09); C96(0.97); C192(1.06)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C706(1.10); C676(1.09); C96(1.02); C192(0.98)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C706(0.99); C676(0.93); C96(0.75); C192(0.83)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C676(0.98); C96(0.83); C192(1.00)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C706(1.07); C676(0.97); C96(1.05); C192(0.99)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C706(1.05); C676(0.77); C96(1.01); C192(0.97)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C706(1.06); C676(0.88); C96(0.77); C192(0.93)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C706(0.89); C676(1.20); C96(0.93); C192(1.08)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C676(1.08); C96(0.79); C192(1.11)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C706(1.04); C676(0.89); C96(1.06); C192(0.97)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C706(1.14); C676(0.79); C96(1.00); C192(1.13)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C706(1.20); C676(0.87); C96(0.70); C192(0.96)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C676(0.85); C96(0.71); C192(1.13)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C706(1.16); C676(1.07); C96(0.93); C192(1.17)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C706(1.16); C676(1.19); C96(1.01); C192(1.04)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C706(1.27); C676(0.90); C96(0.77); C192(0.85)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C676(1.08); C96(0.85); C192(0.90)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C706(0.92); C676(0.86); C96(0.97); C192(1.03)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C706(1.04); C676(0.78); C96(0.93); C192(1.14)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C706(1.14); C676(1.31); C96(0.95); C192(1.02)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C706(1.03); C676(0.88); C96(0.74); C192(0.87)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C676(1.03); C96(0.88); C192(1.07)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C706(0.99); C676(1.11); C96(0.94); C192(0.98)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C706(1.02); C676(1.17); C96(0.96); C192(0.94)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C706(1.23); C676(0.80); C96(0.68); C192(0.94)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C676(0.98); C96(0.86); C192(1.01)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C706(0.92); C676(0.94); C96(1.01); C192(1.04)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C706(1.14); C676(0.79); C96(0.97); C192(1.00)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C706(1.01); C676(1.02); C96(0.83); C192(0.96)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C676(1.07); C96(0.77); C192(1.01)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C706(1.03); C676(0.90); C96(0.93); C192(1.05)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C706(1.08); C676(0.90); C96(1.02); C192(1.00)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C706(1.06); C676(1.11); C96(1.00); C192(1.03)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C706(0.89); C676(0.90); C96(1.19); C192(0.97)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C676(1.10); C96(0.98); C192(1.04)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C676(0.99); C96(0.87); C192(0.94)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C706(0.95); C676(1.10); C96(1.21); C192(1.00)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C706(1.02); C676(1.03); C96(1.09); C192(1.02)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C676(1.11); C96(0.53); C192(1.04); C606(0.69)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C706(0.81); C676(1.14); C96(0.96); C192(1.20)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C706(0.87); C676(0.87); C96(0.97); C192(1.10)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C706(1.14); C676(0.76); C96(0.82); C192(0.98)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C676(0.98); C96(0.84); C192(1.07)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C706(1.19); C676(1.10); C96(1.08); C192(1.10)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C706(0.99); C676(0.91); C96(1.01); C192(1.00)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C706(1.06); C676(0.91); C96(1.06); C192(0.96)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C706(0.88); C676(0.77); C96(1.07); C192(1.03)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C706(1.21); C676(1.02); C96(1.05); C192(1.02)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C676(1.10); C96(1.08); C192(1.09)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C706(0.86); C676(0.83); C96(1.07); C192(0.98)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C706(1.12); C676(0.89); C96(0.92); C192(0.99)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C676(0.90); C96(0.48); C192(1.11); C606(0.61)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C706(1.09); C676(0.91); C96(0.98); C192(1.13)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C706(0.92); C676(1.56); C96(0.90); C192(1.07)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C706(0.91); C676(0.86); C96(0.79); C192(1.06)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C706(1.06); C676(1.17); C96(1.00); C192(1.08)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C706(1.06); C676(0.82); C96(1.03); C192(0.99)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C706(1.16); C676(1.24); C96(1.06); C192(1.02)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C706(0.94); C676(1.13); C96(1.03); C192(1.13)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C706(1.17); C676(1.03); C96(1.11); C192(1.00)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C676(1.17); C96(1.16); C192(1.09)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C706(0.89); C676(0.86); C96(1.15); C192(0.92)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C706(1.21); C676(1.02); C96(1.13); C192(0.96)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C676(1.14); C96(0.53); C192(0.91); C606(0.63)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C706(1.01); C676(0.93); C96(1.01); C192(1.33)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C706(0.94); C676(0.74); C96(0.97); C192(1.11)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C706(1.33); C676(0.82); C96(0.77); C192(0.96)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C706(1.04); C676(1.19); C96(1.15); C192(1.11)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C676(0.89); C96(0.80); C192(1.03)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C706(1.07); C676(0.79); C96(1.06); C192(0.91)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C706(1.07); C676(0.94); C96(1.08); C192(0.87)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C706(0.91); C676(0.99); C96(1.07); C192(1.02)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C676(1.16); C96(0.97); C192(0.99)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C706(0.87); C676(1.14); C96(1.09); C192(0.98)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C706(1.55); C676(1.28); C96(1.11); C192(0.95)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C676(0.91); C96(0.41); C192(0.84); C606(0.62)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C706(1.03); C676(1.11); C96(0.87); C192(1.09)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C706(0.84); C676(0.75); C96(1.11); C192(0.99)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C706(0.94); C676(0.82); C96(0.82); C192(1.08)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C706(0.91); C676(0.75); C96(0.85); C192(0.94)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C676(0.87); C96(0.84); C192(1.02)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C706(1.03); C676(1.00); C96(0.98); C192(0.97)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C706(1.00); C676(0.81); C96(0.96); C192(1.11)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C706(1.04); C676(1.08); C96(1.06); C192(0.87)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C706(1.13); C676(1.09); C96(0.98); C192(1.02)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C676(1.01); C96(1.01); C192(1.02)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C706(1.04); C676(1.16); C96(1.11); C192(0.91)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C706(1.05); C676(1.18); C96(1.00); C192(1.05)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C676(1.01); C96(0.99); C192(1.09)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C676(1.08); C96(0.52); C192(1.03); C606(0.71)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C706(1.13); C676(1.17); C96(0.98); C192(1.08)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C706(0.90); C676(0.95); C96(0.96); C192(1.20)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C706(0.96); C676(0.82); C96(0.72); C192(1.03)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C676(0.87); C96(0.80); C192(1.02)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C706(1.14); C676(0.81); C96(1.02); C192(1.04)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C706(1.00); C676(0.94); C96(0.99); C192(0.99)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C706(1.11); C676(1.35); C96(1.05); C192(0.96)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C676(0.94); C96(1.05); C192(0.99)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C706(0.85); C676(1.11); C96(0.97); C192(1.16)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C706(0.98); C676(0.91); C96(1.06); C192(0.95)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C706(1.17); C676(1.12); C96(0.99); C192(0.92)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C676(1.09); C96(0.58); C192(1.01); C606(0.72)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C706(0.96); C676(1.10); C96(1.02); C192(1.03)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C706(0.97); C676(1.19); C96(0.91); C192(1.10)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C706(1.12); C676(0.72); C96(0.78); C192(1.06)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C676(0.82); C96(0.89); C192(1.05)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C706(1.09); C676(1.22); C96(1.06); C192(0.97)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C706(1.09); C676(0.76); C96(1.09); C192(1.19)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C706(0.96); C676(1.10); C96(1.12); C192(0.95)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C706(1.20); C676(1.26); C96(1.15); C192(1.01)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C706(1.23); C676(0.84); C96(0.96); C192(1.08)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C676(0.96); C96(1.04); C192(1.06)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C706(1.02); C676(1.08); C96(1.10); C192(0.95)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C706(1.06); C676(1.06); C96(1.05); C192(0.94)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C676(1.12); C96(0.47); C192(0.55); C606(0.65)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C706(0.66); C676(0.90); C96(0.81); C192(1.04)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C706(1.11); C676(0.63); C96(0.81); C192(1.12)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C706(1.06); C676(0.85); C96(0.77); C192(0.87)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C676(0.87); C96(0.82); C192(0.92)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C706(1.01); C676(1.07); C96(0.98); C192(1.09)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C706(1.14); C676(0.85); C96(1.02); C192(1.00)  LDD1698  [10]
 LDCM0625  F8 Ramos C96(0.87); C192(0.42)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C96(0.67); C192(2.20)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C96(0.60); C192(0.72)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C96(1.18); C192(1.56)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C96(0.99); C192(0.63)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C96(1.76); C192(2.93)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C96(1.33)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C96(0.85); C192(0.68)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C96(0.85); C192(0.72)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C96(0.60); C192(0.65)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C96(1.06); C192(0.45)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C96(0.85); C192(0.72)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C96(0.85); C192(1.01)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C96(0.58); C192(1.66)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C706(0.93); C676(1.02); C96(0.94); C192(0.92)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C96(1.07); C192(0.53)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C96(1.08); C192(1.00)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C676(0.93); C96(0.85); C192(0.94)  LDD1631  [10]
 LDCM0610  Fragment52 Ramos C96(1.61); C192(0.29)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C96(0.75); C192(0.76)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C96(1.29); C192(1.21)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C96(1.29)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C706(0.95); C676(1.10); C192(1.07); C606(1.03)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C706(1.03); C676(1.04); C192(1.08); C606(1.01)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C96(1.87); C728(1.33)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acidic mammalian chitinase (CHIA) Glycosyl hydrolase 18 family Q9BZP6
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1
Huntingtin (HTT) Huntingtin family P42858
Vacuolar protein sorting-associated protein 29 (VPS29) VPS29 family Q9UBQ0
Vacuolar protein sorting-associated protein 35 (VPS35) VPS35 family Q96QK1
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 25 (ZBTB25) . P24278
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Ataxin-1 (ATXN1) ATXN1 family P54253
F-box/LRR-repeat protein 7 (FBXL7) FBXL7 family Q9UJT9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578