Details of the Target

General Information of Target

Target ID LDTP09812
Target Name Septin-8 (SEPTIN8)
Gene Name SEPTIN8
Gene ID 23176
Synonyms
KIAA0202; SEPT8; Septin-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHA
NNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAM
LLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALN
YGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKL
VEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGK
MNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGK
DISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVF
SRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKV
KVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGT
QPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEA
NLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQ
DHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELG
QRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVV
RAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPH
QNGECYPNEKNSVNMDLD
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
Subcellular location
Cytoplasm
Function
Filament-forming cytoskeletal GTPase. May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles.; [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.
Uniprot ID
Q92599
Ensemble ID
ENST00000296873.11
HGNC ID
HGNC:16511

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.Q409R .
IGR1 Substitution: p.P319L DBIA    Probe Info 
MCC13 SNV: p.D176N .
MOLT4 SNV: p.A104V; p.A126V IA-alkyne    Probe Info 
NALM6 SNV: p.R375W .
SW480 SNV: p.W478Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y258(10.86)  LDD0259  [1]
STPyne
 Probe Info  		K193(8.33); K387(1.10); K423(4.18)  LDD0277  [2]
Probe 1
 Probe Info  		Y88(26.04); Y326(24.95)  LDD3495  [3]
DBIA
 Probe Info  		C49(3.29)  LDD3312  [4]
BTD
 Probe Info  		C49(0.88)  LDD2101  [5]
AHL-Pu-1
 Probe Info  		C271(3.03)  LDD0168  [6]
HHS-465
 Probe Info  		Y300(10.00)  LDD2237  [7]
5E-2FA
 Probe Info  		H414(0.00); H24(0.00)  LDD2235  [8]
m-APA
 Probe Info  		H414(0.00); H24(0.00); H76(0.00)  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C80(0.00); C271(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C303(0.00); C271(0.00); C80(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C80(0.00); C49(0.00); C271(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		C271(0.00); C80(0.00)  LDD2226  [10]
IPM
 Probe Info  		N.A.  LDD2156  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
AOyne
 Probe Info  		14.70  LDD0443  [13]
NAIA_5
 Probe Info  		C271(0.00); C153(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C271(3.03)  LDD0168  [6]
 LDCM0214  AC1 HEK-293T C271(1.05); C153(1.02); C80(0.96)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C271(0.97); C153(1.34); C49(0.91); C80(1.09)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C271(1.04); C153(0.78); C49(1.34); C80(0.95)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C271(1.02); C153(1.02); C80(0.98); C303(1.21)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C271(1.14); C153(0.82); C80(0.97); C303(1.18)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C271(0.97); C153(1.00); C80(1.03); C303(1.08)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C271(1.08); C153(1.61); C80(0.95)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C271(1.04); C153(1.43); C49(0.84); C80(0.97)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C271(0.99); C153(0.83); C49(1.06); C80(0.85)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C271(0.95); C153(1.23); C49(1.07); C80(1.10)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C271(0.97); C153(1.14); C80(0.91); C303(1.26)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C271(1.03); C153(0.87); C80(0.96); C303(0.82)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C271(0.96); C153(0.97); C80(1.04); C303(1.09)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C271(0.99); C153(1.01); C80(1.01); C303(1.24)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C271(0.96); C153(1.49); C80(0.95)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C271(1.08); C153(1.22); C80(0.90)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C271(1.01); C153(1.01); C49(0.90); C80(1.04)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C271(1.05); C153(0.88); C49(0.95); C80(0.79)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C271(1.08); C153(1.14); C80(1.11); C303(0.97)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C271(0.92); C153(0.86); C80(0.99); C303(0.88)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C271(1.09); C153(1.08); C49(1.65); C80(0.81)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C271(1.05); C153(0.77); C80(1.04); C303(1.10)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C271(1.06); C153(1.11); C80(0.99); C303(1.09)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C271(1.03); C153(1.18); C80(0.94)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C271(1.01); C153(1.33); C80(1.02)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C271(0.96); C153(1.23); C49(0.96); C80(1.00)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C271(1.09); C153(0.65); C49(1.41); C80(1.02)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C271(0.98); C153(1.12); C80(1.08); C303(0.93)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C271(0.97); C153(0.89); C80(1.01); C303(0.94)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C271(0.99); C153(1.02); C80(1.07); C303(1.20)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C271(0.93); C153(1.24); C80(1.04); C303(1.15)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C271(1.01); C153(1.25); C80(0.98); C303(1.44)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C271(1.04); C153(1.30); C80(0.95)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C271(1.04); C153(0.99); C80(1.05)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C271(0.95); C153(1.05); C49(1.01); C80(0.98)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C271(1.02); C153(0.77); C49(0.93); C80(1.13)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C271(0.95); C153(1.13); C80(0.99); C303(1.15)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C271(1.09); C153(0.98); C80(1.01); C303(0.77)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C271(0.92); C153(0.91); C80(1.01); C303(1.38)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C271(1.00); C153(0.98); C80(0.98); C303(1.12)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C271(0.97); C153(1.68); C80(1.01)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C271(1.06); C153(1.56); C80(1.14)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C271(0.94); C153(0.86); C80(1.03); C303(0.73)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C271(0.92); C153(0.98); C49(0.99); C80(1.09)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C271(1.00); C153(0.99); C49(1.79); C80(0.89)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C271(1.09); C153(0.94); C80(0.90); C303(1.18)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C271(0.98); C153(0.75); C80(1.04); C303(1.00)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C271(0.99); C153(0.80); C80(0.99); C303(1.07)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C271(0.98); C153(0.95); C80(1.05); C303(1.13)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C271(0.98); C153(1.23); C80(0.87)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C271(1.14); C153(1.16); C80(0.94)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C271(1.04); C153(1.22); C49(1.02); C80(1.01)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C271(1.10); C153(1.13); C49(0.97); C80(0.89)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C271(1.05); C153(0.99); C80(0.97); C303(1.33)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C271(1.10); C153(1.13); C80(1.11); C303(1.08)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C271(1.08); C153(0.95); C80(1.01); C303(1.02)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C271(1.01); C153(0.74); C80(1.00); C303(0.99)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C271(1.00); C153(1.05); C80(1.00); C303(1.21)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C271(1.02); C153(1.65); C80(0.88)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C271(1.00); C153(0.92); C80(1.04); C303(1.26)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C271(1.04); C153(0.83); C80(0.82)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C271(0.98); C153(0.85); C80(0.93); C303(0.80)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C271(1.14); C153(0.89); C80(0.91)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C271(1.01); C153(0.91); C80(0.85)  LDD1514  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C271(1.18)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C271(2.38); C153(0.89); C80(0.94)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C271(2.73); C153(0.49); C80(1.00); C303(0.34)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C271(1.22); C49(1.08); C80(1.01)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C271(1.13); C153(1.00); C80(0.84)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C271(1.52); C80(1.00)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C271(1.11); C153(0.77); C80(0.98); C303(1.37)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C271(1.17); C49(0.94); C80(0.94)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C271(1.17); C153(0.88); C80(0.95)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C271(1.23); C80(1.06)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C271(1.05); C153(0.78); C80(0.90); C303(1.14)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C271(1.38); C49(0.89); C80(1.09)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C271(1.40); C153(1.31); C80(0.86)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C271(1.59); C153(0.85); C80(1.17); C303(0.34)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C271(1.77); C80(1.05)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C271(1.38); C153(0.78); C80(0.96); C303(1.14)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C271(1.35); C49(0.95); C80(1.14)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C271(1.01); C153(1.16); C80(0.99)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C271(1.71); C80(1.02)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C271(1.26); C153(0.80); C80(1.03); C303(1.20)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C271(1.21); C49(1.07); C80(0.99)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C271(1.16); C153(1.00); C80(0.95)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C271(1.10); C80(0.99)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C271(1.05); C153(0.83); C80(1.01); C303(1.31)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C271(1.16); C153(0.99); C80(0.94)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C271(1.01); C49(1.14); C80(1.03)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C271(1.11); C153(1.09); C80(0.87)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C271(1.19); C80(1.05)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C271(4.26); C153(0.72); C80(0.89); C303(1.13)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C271(1.28); C49(1.03); C80(0.94)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C271(1.12); C153(1.38); C80(0.77)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C271(2.65); C80(0.90)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C271(1.18); C153(1.15); C80(0.93); C303(1.55)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C271(1.07); C49(1.10); C80(0.99)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C271(2.49); C153(0.81); C80(0.82)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C271(2.19); C80(1.02)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C271(1.64); C153(0.64); C80(0.92); C303(1.22)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C271(1.10); C49(1.21); C80(1.21)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C271(1.97); C153(0.83); C80(1.02)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C271(1.02); C153(0.77); C49(1.07); C80(1.08)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C271(1.07); C153(0.60); C49(0.98); C80(1.06)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C271(1.32); C80(1.16)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C271(1.01); C153(0.80); C80(1.06); C303(0.55)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C271(3.27); C153(0.56); C80(0.91); C303(0.35)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C271(1.47); C153(0.64); C80(1.35); C303(0.40)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C271(0.96); C153(0.86); C80(1.30); C303(0.37)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C271(1.01); C153(0.69); C80(0.86)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C271(1.35); C153(0.93); C80(0.88)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C271(1.14); C80(1.01)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C271(1.11); C153(0.91); C80(0.96); C303(1.06)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C271(1.35); C49(0.89); C80(0.98)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C271(1.10); C153(0.63); C80(0.91)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C271(1.39); C153(0.66); C80(0.97); C303(1.02)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C271(0.98); C153(0.84); C49(1.06); C80(1.02)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C271(1.37); C153(0.68); C49(1.00); C80(0.92)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C271(1.07); C153(0.80); C80(1.20); C303(0.48)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C271(4.02); C153(0.50); C80(0.79); C303(0.28)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C271(1.28); C153(0.61); C80(1.15); C303(0.36)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C271(1.04); C153(0.77); C80(1.15); C303(0.35)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C271(1.14); C153(0.90); C80(0.84)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C271(1.20); C153(0.91); C80(0.94)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C271(3.63); C153(0.64); C80(0.97); C303(1.05)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C271(1.32); C49(0.99); C80(1.00)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C271(1.20); C49(1.01); C80(1.10)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C271(2.14); C153(1.25); C80(1.09)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C271(1.13); C153(0.87); C49(0.96); C80(1.05)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C271(1.11); C153(0.64); C49(0.84); C80(0.81)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C271(1.11); C153(0.79); C80(1.02); C303(0.50)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C271(3.88); C153(0.57); C80(1.00); C303(0.34)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C271(1.35); C153(0.82); C80(1.04); C303(0.32)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C271(1.12); C153(0.78); C80(1.13); C303(0.31)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C271(0.96); C153(0.97); C80(0.86)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C271(1.17); C153(0.68); C80(0.84)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C271(1.06); C153(0.78); C80(1.02)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C271(1.41); C80(1.02)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C271(1.53); C49(0.84); C80(1.06)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C271(3.28); C153(1.00); C80(0.97)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C271(2.94); C153(0.54); C49(0.99); C80(1.09)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C271(1.09); C153(0.71); C49(1.08); C80(1.13)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C271(1.38); C153(0.85); C80(1.10); C303(0.43)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C271(4.94); C153(0.52); C80(0.88); C303(0.43)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C271(1.27); C153(0.76); C80(1.14); C303(0.38)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C271(1.44); C153(0.82); C80(1.09); C303(0.40)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C271(1.63); C153(0.96); C49(0.80); C80(0.97)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C271(1.24); C153(0.85); C80(1.01)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C271(1.07); C153(0.92); C80(0.95)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C271(1.39); C80(0.91)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C271(1.15); C153(1.12); C80(0.96); C303(1.24)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C271(1.25); C49(0.95); C80(0.99)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C271(1.12); C153(1.08); C80(1.05)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C271(1.35); C153(0.70); C49(1.22); C80(0.99)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C271(1.03); C153(0.83); C49(0.98); C80(0.99)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C271(1.64); C153(0.71); C80(0.99); C303(0.47)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C271(2.96); C153(0.55); C80(0.91); C303(0.49)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C271(1.17); C153(0.68); C49(0.87); C80(0.84)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C271(0.99); C153(0.55); C80(1.08); C303(0.38)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C271(1.06); C153(0.75); C80(1.10); C303(0.36)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C271(0.93); C153(0.93); C80(0.89)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C271(1.28); C153(0.78); C80(0.98)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C271(1.17); C80(0.94)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C271(1.19); C49(1.04); C80(1.08)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C271(2.86); C153(0.69); C80(1.09)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C271(1.03); C153(0.97); C49(1.02); C80(1.09)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C271(1.13); C153(0.74); C49(0.93); C80(1.02)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C271(2.44); C153(0.65); C80(1.03); C303(0.42)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C271(1.07); C153(0.91); C80(1.08); C303(0.55)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C271(1.08); C153(0.68); C80(1.04); C303(0.44)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C271(1.07); C153(0.71); C80(1.02); C303(0.47)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C271(1.09); C153(0.82); C80(1.05); C303(0.41)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C271(1.32); C153(0.88); C80(0.84)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C271(1.10); C153(1.51); C80(0.70)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C271(1.28); C80(1.00)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C271(1.60); C153(1.04); C80(0.95); C303(2.04)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C271(1.13); C49(0.95); C80(0.89)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C271(1.16); C153(1.34); C80(0.92)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C271(1.34); C153(0.53); C80(1.00); C303(0.40)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C271(4.58); C153(0.68); C49(0.32); C80(0.95)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C271(1.38); C153(0.61); C49(1.20); C80(0.87)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C271(1.60); C153(0.87); C80(0.93); C303(0.62)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C271(1.72); C153(0.58); C80(0.95); C303(0.54)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C271(1.44); C153(0.91); C80(1.31); C303(0.46)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C271(1.98); C153(0.69); C80(1.01); C303(0.37)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C271(1.43); C153(0.77); C80(0.70)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C271(1.63); C153(1.35); C80(1.08)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C271(1.74); C80(0.96)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C271(2.40); C153(1.42); C80(0.94); C303(1.32)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C271(3.17); C153(1.11); C80(1.06); C303(1.26)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C271(2.11); C153(0.65); C80(1.03); C303(1.37)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C271(1.21); C80(1.18)  LDD1631  [14]
 LDCM0022  KB02 HEK-293T C80(1.03); C271(0.79)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C80(1.04); C271(0.98)  LDD1497  [14]
 LDCM0024  KB05 HMCB C49(3.29)  LDD3312  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C49(0.88)  LDD2101  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C271(1.08)  LDD2109  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C49(0.31)  LDD2115  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Septin-5 (SEPTIN5) Septin GTPase family Q99719
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Protein S100-B (S100B) S-100 family P04271

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402