Details of the Target

General Information of Target

Target ID LDTP09500
Target Name Histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L)
Gene Name DOT1L
Gene ID 84444
Synonyms
KIAA1814; KMT4; Histone-lysine N-methyltransferase, H3 lysine-79 specific; EC 2.1.1.360; DOT1-like protein; Histone H3-K79 methyltransferase; H3-K79-HMTase; Lysine N-methyltransferase 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGP
EGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTA
NPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQK
EEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLL
KARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGY
ELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIV
LRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQL
AGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARST
PSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGA
EPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPL
PEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHG
QDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEI
TAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARI
ERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSP
LQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGG
GLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLK
GEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLS
GPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSS
VPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, DOT1 family
Subcellular location
Nucleus
Function Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
TTD ID
T87686
Uniprot ID
Q8TEK3
DrugMap ID
TTSZ8T1
Ensemble ID
ENST00000398665.8
HGNC ID
HGNC:24948
ChEMBL ID
CHEMBL1795117

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K4(1.39)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
AHL-Pu-1
 Probe Info  		C1075(2.32)  LDD0169  [3]
DBIA
 Probe Info  		C696(25.71)  LDD0209  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		12.60  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C1075(2.32)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C1075(0.95); C696(0.99); C536(1.12); C45(1.08)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C1075(0.93); C696(1.01); C536(1.11); C750(0.92)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C696(0.98); C536(1.17); C45(0.99)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C1075(1.03); C696(0.95); C536(1.30)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C1075(0.90); C696(1.03); C536(1.08); C750(1.04)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C1075(0.97); C696(1.05); C1397(1.07); C750(0.77)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C1075(0.93); C696(1.10); C536(1.11); C45(0.89)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C1075(1.00); C696(1.07); C536(0.99); C750(1.10)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C696(1.23); C536(1.16); C45(0.96)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C1075(1.05); C696(1.04); C536(1.22); C750(0.99)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C1075(1.02); C696(1.05); C536(1.15)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C1075(1.04); C696(1.00); C750(0.99)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C1075(0.92); C696(0.89); C536(1.08); C750(1.10)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C1075(1.01); C696(0.92); C1397(0.89); C750(0.77)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C1075(0.89); C536(1.05); C1397(1.23); C750(1.12)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C1075(0.94); C696(1.05); C536(1.15); C45(0.91)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C1075(0.93); C696(1.03); C536(1.01); C750(0.99)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C696(1.01); C536(1.08); C45(0.87)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C1075(0.95); C696(1.12); C536(1.10)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C1075(0.96); C696(0.92); C750(0.92)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C696(1.08); C536(1.01); C45(0.98)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C1075(0.98); C696(0.99); C536(1.07); C750(1.05)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C1075(0.93); C696(0.97); C1397(0.96); C750(1.01)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C1075(1.05); C536(0.82); C1397(1.18); C750(1.04)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C1075(0.93); C696(1.28); C536(1.19); C45(0.99)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C1075(1.02); C696(1.01); C536(1.11); C750(1.13)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C696(1.06); C536(1.13); C45(0.95)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C1075(1.16); C696(0.90); C536(1.17)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C1075(1.01); C696(0.86); C750(0.98)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C1075(0.95); C696(0.92); C536(1.13); C750(1.09)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C1075(1.04); C696(1.02); C1397(0.82); C750(1.00)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C1075(1.06); C696(0.84); C536(1.10)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C1075(0.99); C536(0.88); C1397(0.92); C750(0.97)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C1075(0.92); C696(1.00); C536(1.27); C45(1.25)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C1075(1.01); C696(1.09); C536(1.22); C750(1.06)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C696(1.03); C536(1.16); C45(0.91)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C1075(1.02); C696(1.00); C536(1.17)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C1075(0.98); C696(0.97); C750(0.99)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C1075(0.88); C696(1.01); C536(1.16); C750(0.97)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C1075(1.13); C696(1.04); C1397(1.06); C750(0.92)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C1075(0.98); C536(1.05); C1397(1.02); C750(0.93)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C1075(0.83); C696(1.16); C536(1.45); C45(1.04)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C1075(0.95); C696(0.92); C750(0.86)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C1075(0.98); C696(1.01); C536(1.22); C750(0.91)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C696(1.05); C536(1.22); C45(0.93)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C1075(0.87); C696(0.94); C536(1.16)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C1075(0.93); C696(0.96); C750(1.01)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C1075(0.85); C696(1.07); C536(1.17); C750(1.04)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C1075(0.92); C696(0.97); C1397(1.06); C750(0.82)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C1075(0.91); C536(0.92); C1397(1.00); C750(0.98)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C1075(0.97); C696(1.01); C536(1.19); C45(1.02)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C1075(1.01); C696(1.05); C536(1.05); C750(0.98)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C696(1.06); C536(1.08); C45(1.01)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C1075(0.98); C696(0.99); C536(1.04); C750(1.09)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C1075(0.97); C696(1.06); C536(1.16)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C1075(1.03); C696(0.95); C750(0.97)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C1075(0.95); C696(1.03); C536(0.95); C750(1.41)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C1075(1.06); C696(0.95); C1397(1.15); C750(0.93)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C1075(0.97); C536(1.08); C1397(1.03); C750(1.06)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C1075(0.99); C696(0.93); C1397(0.83); C750(0.85)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C1075(1.08); C536(0.86); C1397(1.29); C750(0.87)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C1075(0.97); C696(0.93); C750(1.05)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C1075(0.87); C696(1.04); C536(1.19); C45(1.07)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C1075(0.93); C536(0.97); C1397(1.06); C750(0.90)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C1075(0.75); C536(1.25); C45(1.24)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C1075(1.11); C696(1.31); C536(1.16); C750(0.89)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C696(0.93); C536(1.06); C604(1.07); C1397(0.96)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C1075(0.96); C536(1.12); C45(1.05)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C696(1.22); C536(1.19); C604(1.22)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C1075(0.94); C536(1.26); C1397(1.00)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C696(0.94); C536(1.11); C604(0.67); C1397(0.91)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C1075(0.90); C536(1.03); C45(1.06)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C696(1.00); C536(0.84); C604(1.05)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C1075(0.93); C536(1.16); C1397(0.90)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C696(0.93); C536(1.07); C604(1.15); C1397(0.97)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C1075(0.94); C536(1.08); C45(1.06)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C1075(1.08); C696(1.00); C1397(0.97); C750(0.89)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C696(1.16); C536(1.16); C604(1.11)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C1075(0.91); C536(1.66); C1397(0.95)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C696(0.93); C536(0.86); C604(1.06); C1397(1.03)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C1075(0.96); C536(1.17); C45(1.08)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C696(1.01); C536(1.09); C604(1.09)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C1075(1.01); C536(1.34); C1397(1.08)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C696(0.93); C536(0.91); C604(0.95); C1397(0.99)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C1075(1.27); C536(1.26); C45(1.24)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C696(1.16); C536(1.10); C604(1.19)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C1075(1.01); C536(1.38); C1397(1.13)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C1075(1.19); C536(0.91); C1397(1.30); C750(0.92)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C696(0.98); C536(1.06); C604(1.03); C1397(1.16)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C1075(0.78); C536(1.22); C45(1.23)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C696(1.16); C536(1.34); C604(1.33)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C1075(0.79); C536(1.65); C1397(0.88)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C696(1.02); C536(1.01); C604(1.12); C1397(0.88)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C1075(0.73); C536(1.15); C45(1.20)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C696(1.01); C536(1.07); C604(1.05)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C1075(1.04); C536(1.29); C1397(0.85)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C696(0.96); C536(0.92); C604(1.00); C1397(1.09)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C1075(0.92); C536(1.09); C45(1.29)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C696(1.12); C536(1.15); C604(0.86)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C1075(0.95); C536(1.19); C1397(1.06)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C696(0.95); C536(0.83); C604(1.10); C1397(1.13)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C1075(1.17); C696(1.13); C536(1.21); C45(1.24)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C1075(1.03); C696(1.12); C536(1.01); C750(1.05)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C696(1.04); C536(1.25); C45(0.88)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C696(1.01); C536(1.16); C604(1.05)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C1075(1.19); C696(0.89); C536(1.12)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C1075(0.99); C696(1.12); C750(0.74)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C1075(1.16); C696(1.01); C536(1.16); C750(1.16)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C1075(1.10); C696(0.92); C1397(0.92); C750(1.07)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C1075(1.05); C536(0.97); C1397(1.37); C750(0.96)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C1075(0.93); C536(1.12); C45(0.97)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C696(0.97); C536(1.10); C604(0.86)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C1075(1.08); C536(1.22); C1397(0.99)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C696(0.97); C536(1.05); C604(0.92); C1397(0.93)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C1075(0.99); C696(1.07); C536(1.57); C45(1.11)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C1075(1.10); C536(1.48); C1397(1.05)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C1075(1.00); C696(1.00); C536(1.23); C750(0.90)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C696(1.14); C536(1.09); C45(0.96)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C1075(0.89); C696(1.01); C536(1.14)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C1075(0.87); C696(0.93); C750(0.71)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C1075(1.02); C696(1.05); C536(1.15); C750(0.96)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C1075(1.15); C696(0.92); C1397(1.16); C750(0.76)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C1075(1.17); C536(0.95); C1397(1.04); C750(0.66)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C1075(0.91); C536(1.04); C45(1.29)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C1075(1.01); C536(1.06); C1397(1.09)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C696(1.13); C536(0.86); C604(1.19); C1397(0.99)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C696(1.04); C536(0.92); C604(1.01); C1397(0.99)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C1075(1.00); C696(0.97); C536(1.16); C45(1.05)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C1075(1.06); C696(1.02); C536(1.05); C750(0.83)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C696(1.06); C536(0.99); C45(1.04)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C1075(1.01); C696(0.91); C536(1.09)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C1075(1.09); C696(0.93); C750(0.80)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C1075(1.04); C696(1.20); C536(1.00); C750(1.14)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C1075(1.40); C696(0.92); C1397(1.24); C750(0.85)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C1075(1.21); C536(1.11); C1397(1.05); C750(0.92)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C1075(1.17); C536(1.10); C45(1.36)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C1075(1.13); C696(0.85); C536(1.07); C45(1.05)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C696(0.85); C536(1.22); C604(1.15)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C696(0.95); C536(0.72); C604(0.93); C1397(1.09)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C1075(0.93); C696(1.17); C536(1.32); C45(1.32)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C1075(0.87); C696(1.11); C536(1.13); C750(0.98)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C696(1.07); C536(0.98); C45(1.05)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C1075(1.50); C696(1.03); C536(1.17)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C1075(1.16); C696(1.13); C750(1.06)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C1075(0.92); C696(0.93); C536(0.43); C750(1.00)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C1075(1.05); C696(0.93); C1397(1.12); C750(1.01)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C1075(1.18); C696(1.21); C536(1.02); C750(0.93)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C1075(1.14); C536(1.12); C1397(0.91); C750(0.81)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C1075(0.69); C536(0.96); C45(1.19)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C696(0.93); C536(1.26); C604(1.11)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C1075(0.98); C536(1.22); C1397(0.97)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C696(0.94); C536(0.97); C604(1.09); C1397(1.05)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C1075(0.97); C696(1.22); C536(1.18); C45(0.95)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C1075(1.06); C696(1.08); C536(0.97); C750(0.98)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C696(1.20); C536(1.08); C45(0.89)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C1075(0.94); C696(1.03); C536(1.21)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C1075(0.97); C696(1.03); C750(0.82)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C696(1.11); C536(1.04); C45(0.93)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C1075(1.13); C696(1.13); C536(1.04); C750(1.08)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C1075(1.15); C696(0.90); C1397(0.97); C750(0.90)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C1075(1.14); C536(1.16); C1397(1.51); C750(0.80)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C1075(0.91); C536(1.07); C45(1.08)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C696(1.01); C536(1.25); C604(1.19)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C696(0.97); C536(1.09); C604(1.13); C1397(1.01)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C1075(1.01); C696(1.12); C536(1.76); C45(0.88)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C1075(0.99); C696(1.03); C536(1.08); C750(0.94)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C696(1.10); C536(1.22); C45(0.88)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C1075(0.77); C696(1.21); C536(2.21)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C1075(1.14); C696(0.99); C536(1.35)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C1075(0.97); C696(1.01); C750(0.85)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C1075(1.00); C696(1.10); C536(1.03); C750(1.15)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C1075(1.14); C696(1.06); C1397(0.97); C750(0.95)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C1075(1.11); C536(0.93); C1397(1.08); C750(0.94)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C1075(0.79); C536(1.10); C45(1.19)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C696(1.08); C536(1.09); C604(1.34)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C1075(0.94); C536(1.25); C1397(0.90)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C696(0.96); C536(0.94); C604(0.96); C1397(0.96)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C1075(0.94); C696(1.04); C536(1.09); C45(1.04)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C1075(1.08); C696(0.99); C750(0.90)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C1075(0.85); C696(1.14); C536(1.29); C750(1.08)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C696(0.98); C536(1.11); C45(0.85)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C1075(1.08); C696(0.98); C536(1.01)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C1075(0.94); C696(1.06); C750(0.79)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C1075(1.04); C696(0.98); C536(1.09); C750(1.23)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C1075(1.07); C696(1.09); C1397(0.98); C750(0.69)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C1075(1.07); C536(1.16); C1397(0.91); C750(0.72)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C1075(0.79); C536(1.02); C45(1.09)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C696(0.96); C536(1.05); C604(1.22)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C1075(1.02); C536(1.10); C1397(0.89)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C1075(1.12); C536(0.87); C1397(1.07)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C1075(0.95); C536(1.24); C1397(0.97)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C696(1.05); C536(1.15); C604(1.13)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C1075(1.02); C750(0.84); C696(0.99)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C696(25.71)  LDD0209  [4]
 LDCM0024  KB05 OCI-Ly3 C1075(1.74)  LDD3372  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein AF-9 (MLLT3) . P42568
Protein ENL (MLLT1) . Q03111

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Epz-5676 Small molecular drug D0C6GK
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bromo-deaza-sah Small molecular drug D0L0DC
Epz-004777 Small molecular drug D09ENZ
Sgc0946 Small molecular drug D0S9SJ

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840