Details of the Target

General Information of Target

Target ID LDTP09492
Target Name Rhomboid-related protein 4 (RHBDD1)
Gene Name RHBDD1
Gene ID 84236
Synonyms
RHBDL4; Rhomboid-related protein 4; RRP4; EC 3.4.21.105; Rhomboid domain-containing protein 1; Rhomboid-like protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRRSRGINTGLILLLSQIFHVGINNIPPVTLATLALNIWFFLNPQKPLYSSCLSVEKCY
QQKDWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAYVITAFSVLTGVVYL
LLQFAVAEFMDEPDFKRSCAVGFSGVLFALKVLNNHYCPGGFVNILGFPVPNRFACWVEL
VAIHLFSPGTSFAGHLAGILVGLMYTQGPLKKIMEACAGGFSSSVGYPGRQYYFNSSGSS
GYQDYYPHGRPDHYEEAPRNYDTYTAGLSEEEQLERALQASLWDRGNTRNSPPPYGFHLS
PEEMRRQRLHRFDSQ
Target Bioclass
Enzyme
Family
Peptidase S54 family
Subcellular location
Endoplasmic reticulum membrane
Function
Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia.
Uniprot ID
Q8TEB9
Ensemble ID
ENST00000341329.7
HGNC ID
HGNC:23081

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO679 SNV: p.A33T .
HCT15 SNV: p.S281N .
HT115 SNV: p.E179K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C158(0.93)  LDD1125  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]
TFBX
 Probe Info  		C217(0.00); C59(0.00)  LDD0027  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C217(1.04); C139(0.96)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C217(1.01); C139(0.94)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C217(1.15); C139(0.89)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C217(1.01); C139(0.97)  LDD1510  [4]
 LDCM0246  AC128 PaTu 8988t C158(0.93)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C158(1.09)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C158(0.79)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C158(0.98)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C158(1.14)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C158(1.04)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C158(0.88)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C158(1.14)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C158(0.91)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C158(0.76)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C158(0.96)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C158(0.98)  LDD1137  [1]
 LDCM0259  AC14 HEK-293T C217(1.08); C139(0.94)  LDD1512  [4]
 LDCM0260  AC140 PaTu 8988t C158(1.30)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C158(0.86)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C158(0.86)  LDD1141  [1]
 LDCM0270  AC15 HEK-293T C217(1.06); C139(0.90)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C217(0.96); C139(1.00)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C217(1.07); C139(1.03)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C217(1.03); C139(0.88)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C217(0.97); C139(1.00)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C217(1.05); C139(0.93)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C217(1.01); C158(0.72); C139(1.02)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C217(1.04); C139(0.85)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C217(0.93); C139(0.87)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C217(0.94); C139(0.81)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C217(1.05); C139(0.91)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C217(0.97); C139(0.82)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C217(1.05); C139(1.01)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C217(0.97); C139(0.99)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C217(1.03); C158(0.85); C139(0.97)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C217(1.08); C139(0.91)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C217(1.09); C139(1.07)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C217(1.07); C139(0.98)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C217(0.99); C139(0.97)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C217(1.07); C139(1.05)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C217(1.02); C139(0.99)  LDD1534  [4]
 LDCM0296  AC35 PaTu 8988t C158(1.12)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C158(1.08)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C158(1.11)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C158(1.24)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C158(1.17)  LDD1179  [1]
 LDCM0301  AC4 HEK-293T C217(0.96); C139(1.05)  LDD1540  [4]
 LDCM0302  AC40 PaTu 8988t C158(1.37)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C158(0.93)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C158(0.95)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C158(1.36)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C158(1.11)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C158(1.34)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C158(0.94)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C158(0.81)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C158(0.91)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C158(1.13)  LDD1190  [1]
 LDCM0312  AC5 HEK-293T C217(1.05); C158(0.78); C139(1.00)  LDD1551  [4]
 LDCM0313  AC50 PaTu 8988t C158(1.11)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C158(1.20)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C158(1.03)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C158(0.95)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C158(1.34)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C158(1.08)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C158(1.30)  LDD1198  [1]
 LDCM0320  AC57 HEK-293T C217(1.03); C139(0.95)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C217(1.03); C139(1.10)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C217(1.15); C139(0.98)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C217(1.14); C139(1.05)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C217(0.98); C139(0.94)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C217(1.07); C158(1.01); C139(1.01)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C217(1.05); C139(1.06)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C217(1.02); C139(1.04)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C217(0.98); C139(0.91)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C217(0.86); C139(1.02)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C217(1.14); C139(0.97)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C217(1.00); C158(0.67); C139(0.97)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C217(0.95); C139(0.93)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C217(1.05); C139(0.93)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C217(0.96); C139(1.22)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C217(1.05); C139(1.11)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C217(1.06); C139(1.18)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C217(1.04); C139(1.00)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C217(1.24); C139(1.13)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C217(0.97); C139(0.93)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C217(1.12); C139(1.01)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C217(0.95); C139(1.17)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C217(1.09); C139(1.01)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C217(1.00); C139(1.01)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C217(1.07); C139(0.97)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C217(1.14); C139(1.24)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C217(1.11); C139(1.33)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C217(1.09); C139(1.18)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C217(0.99); C139(1.16)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C217(1.01); C139(0.83)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C217(1.01); C139(1.06)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C217(1.14); C139(1.45)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C217(0.99); C139(0.82)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C217(1.13); C139(0.87)  LDD1590  [4]
 LDCM0387  CL117 PaTu 8988t C158(1.04)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C158(0.95)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C158(1.37)  LDD1268  [1]
 LDCM0390  CL12 HEK-293T C217(1.30); C139(1.20)  LDD1594  [4]
 LDCM0391  CL120 PaTu 8988t C158(1.47)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C158(0.85)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C158(0.87)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C158(0.99)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C158(1.07)  LDD1274  [1]
 LDCM0396  CL125 HEK-293T C217(1.01); C139(1.06)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C217(1.07); C139(1.10)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C217(0.99); C139(1.06)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C217(1.14); C139(1.01)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C217(0.97); C139(1.15)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C217(1.00); C139(0.90)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C217(1.00); C139(1.32)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C217(1.19); C139(1.06)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C217(0.99); C139(1.08)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C217(1.02); C139(1.09)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C217(1.14); C139(0.98)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C217(1.10); C139(1.03)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C217(1.09); C139(1.04)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C217(1.31); C158(0.97); C139(1.27)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C217(1.18); C139(1.03)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C217(1.06); C139(1.07)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C217(1.15); C139(1.10)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C217(0.97); C139(1.37)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C217(0.97); C139(0.97)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C217(1.02); C139(0.93)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C217(1.17); C139(0.96)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C217(1.15); C139(0.86)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C217(1.04); C139(1.20)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C217(0.96); C139(1.19)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C217(0.98); C139(0.99)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C217(1.06); C139(1.00)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C217(0.86); C158(2.78); C139(1.40)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C217(1.23); C139(1.21)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C217(1.11); C139(0.83)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C217(0.97); C139(1.01)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C217(1.11); C139(1.28)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C217(1.00); C139(1.01)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C217(1.23); C139(1.35)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C217(1.05); C139(0.85)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C217(1.09); C139(1.05)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C217(1.02); C139(1.21)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C217(1.06); C139(0.99)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C217(0.99); C139(1.02)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C217(0.90); C158(1.69); C139(1.01)  LDD1639  [4]
 LDCM0436  CL46 PaTu 8988t C158(0.59)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C158(0.70)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C158(0.64)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C158(0.85)  LDD1318  [1]
 LDCM0440  CL5 HEK-293T C217(1.08); C139(0.99)  LDD1644  [4]
 LDCM0441  CL50 PaTu 8988t C158(0.68)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C158(1.25)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C158(0.87)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C158(0.96)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C158(0.79)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C158(0.99)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C158(0.34)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C158(1.23)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C158(1.35)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C158(1.09)  LDD1329  [1]
 LDCM0451  CL6 HEK-293T C217(1.15); C139(1.30)  LDD1654  [4]
 LDCM0452  CL60 PaTu 8988t C158(0.92)  LDD1331  [1]
 LDCM0453  CL61 HEK-293T C217(0.98); C139(1.32)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C217(1.08); C139(0.97)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C217(0.95); C139(0.91)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C217(1.29); C139(1.43)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C217(1.01); C139(0.88)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C217(0.94); C139(1.02)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C217(1.10); C139(1.05)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C217(1.18); C139(1.06)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C217(1.13); C158(1.03); C139(1.08)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C217(1.19); C139(1.11)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C217(1.21); C139(1.00)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C217(1.08); C139(0.97)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C217(0.98); C139(1.02)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C217(1.00); C139(1.11)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C217(0.98); C139(0.95)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C217(1.09); C139(0.86)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C217(1.17); C139(1.18)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C217(0.97); C139(0.93)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C217(1.23); C139(1.06)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C217(1.04); C139(1.69)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C217(0.97); C139(1.04)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C217(0.98); C158(0.98); C139(0.96)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C217(1.15); C139(0.98)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C217(1.24); C139(1.14)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C217(1.22); C139(1.45)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C217(1.11); C139(1.54)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C217(1.00); C139(1.15)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C217(1.03); C139(1.22)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C217(1.11); C139(1.06)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C217(1.04); C139(0.94)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C217(1.16); C158(1.22); C139(1.18)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C217(0.86); C139(1.57)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C217(1.19); C139(1.10)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C217(1.29); C139(1.18)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C217(1.08); C158(1.08); C139(1.46)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C217(1.02); C139(0.96)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C217(1.13); C139(1.43)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C217(1.37); C139(1.45)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C217(1.18); C139(1.44)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C217(1.03); C139(1.28)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C217(0.97); C139(0.98)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C217(1.09); C139(0.98)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C217(0.97); C139(1.07)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C217(0.89); C139(1.04)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C217(1.01); C139(1.01)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C217(0.91); C139(1.12)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C217(0.87); C139(0.62)  LDD1502  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q7L5N7
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 3-beta-HSD family Q15738
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 66 member 2 (SLC66A2) . Q8N2U9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycophorin-C (GYPC) Glycophorin-C family P04921
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Cell growth regulator with RING finger domain protein 1 (CGRRF1) . Q99675
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
Transmembrane protein 42 (TMEM42) . Q69YG0

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402