Details of the Target

General Information of Target

Target ID LDTP09451
Target Name Serine/threonine-protein kinase 35 (STK35)
Gene Name STK35
Gene ID 140901
Synonyms
CLIK1; PDIK1; STK35L1; Serine/threonine-protein kinase 35; EC 2.7.11.1; CLP-36-interacting kinase 1; CLIK-1; PDLIM1-interacting kinase 1; Serine/threonine-protein kinase 35 L1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARA
ATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGA
RAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEA
PGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPEN
VELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGER
ILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRD
LKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDF
YMAPEVWEGHYTAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEAL
LENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQVTCAA
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family
Subcellular location
Nucleus
Uniprot ID
Q8TDR2
Ensemble ID
ENST00000381482.8
HGNC ID
HGNC:16254
ChEMBL ID
CHEMBL5651

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C267(0.83); C532(1.12)  LDD0533  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C267(0.83); C532(1.12)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C267(0.99); C532(1.08)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C267(0.97); C532(0.97)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C267(0.85); C532(1.04)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C267(0.83); C532(0.95)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C267(1.17); C532(1.11)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C267(0.80); C532(1.32)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C267(1.01); C532(1.08)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C267(0.89); C532(1.14)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C267(0.78); C532(0.92)  LDD0542  [2]
 LDCM0227  AC110 HCT 116 C267(0.99); C532(1.09)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C267(0.70); C532(1.24)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C267(0.79); C532(1.25)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C267(1.14)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C267(0.94)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C267(1.01)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C267(1.00)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C267(1.00)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C267(0.98)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C267(1.12)  LDD0553  [2]
 LDCM0238  AC120 HCT 116 C267(1.05)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C267(0.88)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C267(1.05)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C267(0.90)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C267(0.84)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C267(1.03)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C267(1.01)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C267(0.90)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C532(0.81)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C532(0.94)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C532(1.03)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C532(0.90)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C532(1.26)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C532(1.06)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C532(1.04)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C532(1.02)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C532(1.03)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C532(0.93)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C532(0.91)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C532(1.21)  LDD0575  [2]
 LDCM0260  AC140 HCT 116 C532(1.09)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C532(1.13)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C532(1.15)  LDD0579  [2]
 LDCM0285  AC25 HCT 116 C267(0.96)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C267(0.80)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C267(0.87)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C267(0.96)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C267(0.85)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C267(0.86)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C267(0.86)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C267(0.78)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C267(0.84)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C267(0.87)  LDD0612  [2]
 LDCM0308  AC46 HCT 116 C267(0.91)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C267(0.98)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C267(1.03)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C267(0.98)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C267(0.94)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C267(0.94)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C267(0.98)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C267(1.03)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C267(0.95)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C267(1.14)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C267(1.08)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C267(0.84)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C267(0.81)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C267(0.77)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C267(0.89)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C267(1.18)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C267(0.81)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C267(0.74)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C267(0.88)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C267(1.11)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C267(1.07)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C267(0.79)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C267(0.96)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C267(0.74)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C267(0.83)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C267(0.84)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C267(0.96)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C267(0.74)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C267(0.86)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C267(0.87)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C267(0.87)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C267(0.82)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C267(0.80)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C267(0.80)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C267(0.78)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C267(0.70)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C267(1.02)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C267(0.67); C532(1.13)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C267(1.01); C532(1.02)  LDD0683  [2]
 LDCM0367  CL1 HCT 116 C267(0.66)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C267(1.33)  LDD0685  [2]
 LDCM0379  CL11 HCT 116 C267(1.20)  LDD0696  [2]
 LDCM0382  CL112 HCT 116 C267(0.95)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C267(0.74)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C267(0.71)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C267(0.87)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C267(0.98)  LDD0703  [2]
 LDCM0390  CL12 HCT 116 C267(1.21)  LDD0707  [2]
 LDCM0392  CL121 HCT 116 C267(0.98)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C267(0.93)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C267(0.99)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C267(1.02)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C267(0.98)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C267(0.91)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C267(0.85)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C267(0.77)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C267(0.83)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C267(1.39)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C267(1.20)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C532(1.35)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C532(0.80); C267(1.03)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C532(0.96); C267(1.12)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C532(1.02); C267(1.08)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C267(0.78)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C532(0.95); C267(1.30)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C532(0.88); C267(1.06)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C267(0.86); C532(0.89)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C532(1.07); C267(1.07)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C267(1.11); C532(1.34)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C267(1.05); C532(1.04)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C267(1.14); C532(1.23)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C267(1.00); C532(1.28)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C267(0.99); C532(1.26)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C267(1.05); C532(1.14)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C267(0.82)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C267(1.36); C532(1.20)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C267(1.06)  LDD0737  [2]
 LDCM0429  CL4 HCT 116 C267(0.79)  LDD0746  [2]
 LDCM0436  CL46 HCT 116 C532(1.07)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C532(1.02)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C532(0.99)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C532(0.86)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C267(0.73)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C532(1.03)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C532(1.06)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C532(1.07)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C532(0.88)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C532(0.97)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C532(0.98)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C532(0.89)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C532(1.00)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C532(0.98)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C532(1.02)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C267(1.10)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C532(0.99)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C532(0.53)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C532(1.56)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C532(1.05)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C532(1.00)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C532(1.05)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C532(1.21)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C532(1.24)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C532(0.74)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C532(0.99)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C267(0.86)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C532(1.17)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C532(1.10)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C532(1.03)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C532(0.74)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C532(0.87)  LDD0784  [2]
 LDCM0473  CL8 HCT 116 C267(1.12)  LDD0790  [2]
 LDCM0484  CL9 HCT 116 C267(1.15)  LDD0801  [2]
 LDCM0468  Fragment33 HCT 116 C532(1.02)  LDD0785  [2]
 LDCM0022  KB02 42-MG-BA C388(0.99)  LDD2244  [4]
 LDCM0023  KB03 MDA-MB-231 C388(1.10)  LDD1701  [5]
 LDCM0024  KB05 COLO792 C388(2.66)  LDD3310  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxysterol-binding protein-related protein 3 (OSBPL3) OSBP family Q9H4L5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761