Details of the Target

General Information of Target

Target ID LDTP09117
Target Name Cyclin-Y (CCNY)
Gene Name CCNY
Gene ID 219771
Synonyms
C10orf9; CBCP1; CFP1; Cyclin-Y; Cyc-Y; Cyclin box protein 1; Cyclin fold protein 1; cyclin-X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPS
DHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTI
KCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFS
AAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQI
LKDITVEDMNELERQFLELLQFNINVPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAH
KLEAISRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS
Target Bioclass
Other
Family
Cyclin family, Cyclin Y subfamily
Subcellular location
Nucleus; Cell membrane
Function
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.
Uniprot ID
Q8ND76
Ensemble ID
ENST00000265375.13
HGNC ID
HGNC:23354
ChEMBL ID
CHEMBL3885550

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1187 SNV: p.G2W .
HEC1 SNV: p.E56K .
HEC1B SNV: p.E56K .
HT115 SNV: p.R176W .
NALM6 SNV: p.Y172D .
SBC5 SNV: p.A272V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K301(8.90); K312(6.92)  LDD0277  [2]
DBIA
 Probe Info  		C39(2.22)  LDD3365  [3]
AHL-Pu-1
 Probe Info  		C238(2.05)  LDD0171  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_5
 Probe Info  		C39(0.00); C309(0.00)  LDD2224  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
AOyne
 Probe Info  		14.70  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C238(2.05)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C208(0.98); C122(1.01)  LDD1507  [10]
 LDCM0215  AC10 PaTu 8988t C208(0.85)  LDD1094  [11]
 LDCM0226  AC11 PaTu 8988t C208(0.94)  LDD1105  [11]
 LDCM0230  AC113 HEK-293T C101(0.86)  LDD0828  [11]
 LDCM0231  AC114 HEK-293T C101(0.93)  LDD0829  [11]
 LDCM0232  AC115 HEK-293T C101(1.19)  LDD0830  [11]
 LDCM0233  AC116 HEK-293T C101(0.99)  LDD0831  [11]
 LDCM0234  AC117 HEK-293T C101(0.88)  LDD0832  [11]
 LDCM0235  AC118 HEK-293T C101(0.98)  LDD0833  [11]
 LDCM0236  AC119 HEK-293T C101(0.90)  LDD0834  [11]
 LDCM0237  AC12 PaTu 8988t C208(1.10)  LDD1116  [11]
 LDCM0238  AC120 HEK-293T C101(1.09)  LDD0836  [11]
 LDCM0239  AC121 HEK-293T C101(1.03)  LDD0837  [11]
 LDCM0240  AC122 HEK-293T C101(0.75)  LDD0838  [11]
 LDCM0241  AC123 HEK-293T C101(0.68)  LDD0839  [11]
 LDCM0242  AC124 HEK-293T C101(0.78)  LDD0840  [11]
 LDCM0243  AC125 HEK-293T C101(0.83)  LDD0841  [11]
 LDCM0244  AC126 HEK-293T C101(0.77)  LDD0842  [11]
 LDCM0245  AC127 HEK-293T C101(0.77)  LDD0843  [11]
 LDCM0259  AC14 PaTu 8988t C208(0.97)  LDD1138  [11]
 LDCM0270  AC15 PaTu 8988t C208(0.81)  LDD1149  [11]
 LDCM0276  AC17 PaTu 8988t C208(1.26)  LDD1155  [11]
 LDCM0277  AC18 PaTu 8988t C208(0.92)  LDD1156  [11]
 LDCM0278  AC19 PaTu 8988t C208(1.17)  LDD1157  [11]
 LDCM0279  AC2 HEK-293T C208(0.95); C122(0.94)  LDD1518  [10]
 LDCM0280  AC20 PaTu 8988t C208(1.12)  LDD1159  [11]
 LDCM0281  AC21 PaTu 8988t C208(1.00)  LDD1160  [11]
 LDCM0282  AC22 PaTu 8988t C208(1.26)  LDD1161  [11]
 LDCM0283  AC23 PaTu 8988t C208(1.08)  LDD1162  [11]
 LDCM0284  AC24 PaTu 8988t C208(1.32)  LDD1163  [11]
 LDCM0285  AC25 PaTu 8988t C208(1.22)  LDD1164  [11]
 LDCM0286  AC26 PaTu 8988t C208(1.90)  LDD1165  [11]
 LDCM0287  AC27 PaTu 8988t C208(1.23)  LDD1166  [11]
 LDCM0288  AC28 PaTu 8988t C208(1.26)  LDD1167  [11]
 LDCM0289  AC29 PaTu 8988t C208(1.31)  LDD1168  [11]
 LDCM0290  AC3 HEK-293T C208(1.06); C122(0.96)  LDD1529  [10]
 LDCM0291  AC30 PaTu 8988t C208(1.34)  LDD1170  [11]
 LDCM0292  AC31 PaTu 8988t C208(1.16)  LDD1171  [11]
 LDCM0293  AC32 PaTu 8988t C208(1.61)  LDD1172  [11]
 LDCM0294  AC33 PaTu 8988t C208(1.32)  LDD1173  [11]
 LDCM0295  AC34 PaTu 8988t C208(1.53)  LDD1174  [11]
 LDCM0296  AC35 PaTu 8988t C208(0.98)  LDD1175  [11]
 LDCM0297  AC36 PaTu 8988t C208(0.98)  LDD1176  [11]
 LDCM0298  AC37 PaTu 8988t C208(0.87)  LDD1177  [11]
 LDCM0299  AC38 PaTu 8988t C208(0.94)  LDD1178  [11]
 LDCM0300  AC39 PaTu 8988t C208(1.10)  LDD1179  [11]
 LDCM0301  AC4 HEK-293T C208(1.00); C122(0.93)  LDD1540  [10]
 LDCM0302  AC40 PaTu 8988t C208(0.95)  LDD1181  [11]
 LDCM0303  AC41 PaTu 8988t C208(0.83)  LDD1182  [11]
 LDCM0304  AC42 PaTu 8988t C208(0.86)  LDD1183  [11]
 LDCM0305  AC43 PaTu 8988t C208(0.92)  LDD1184  [11]
 LDCM0306  AC44 PaTu 8988t C208(0.93)  LDD1185  [11]
 LDCM0307  AC45 PaTu 8988t C208(0.90)  LDD1186  [11]
 LDCM0308  AC46 PaTu 8988t C208(0.85)  LDD1187  [11]
 LDCM0309  AC47 PaTu 8988t C208(1.00)  LDD1188  [11]
 LDCM0310  AC48 PaTu 8988t C208(0.82)  LDD1189  [11]
 LDCM0311  AC49 PaTu 8988t C208(0.84)  LDD1190  [11]
 LDCM0312  AC5 HEK-293T C208(0.90); C122(0.95)  LDD1551  [10]
 LDCM0313  AC50 PaTu 8988t C208(0.92)  LDD1192  [11]
 LDCM0314  AC51 PaTu 8988t C208(0.93)  LDD1193  [11]
 LDCM0315  AC52 PaTu 8988t C208(0.96)  LDD1194  [11]
 LDCM0316  AC53 PaTu 8988t C208(0.98)  LDD1195  [11]
 LDCM0317  AC54 PaTu 8988t C208(1.07)  LDD1196  [11]
 LDCM0318  AC55 PaTu 8988t C208(0.94)  LDD1197  [11]
 LDCM0319  AC56 PaTu 8988t C208(1.01)  LDD1198  [11]
 LDCM0320  AC57 HEK-293T C208(1.10); C122(1.01)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C208(1.05); C122(1.01)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C208(1.12); C122(0.99)  LDD1561  [10]
 LDCM0323  AC6 PaTu 8988t C208(0.90)  LDD1202  [11]
 LDCM0324  AC60 HEK-293T C208(1.01); C122(1.00)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C208(1.00); C122(1.07)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C208(0.97); C122(1.01)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C208(1.08); C122(0.97)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C208(0.97); C122(1.00)  LDD1567  [10]
 LDCM0334  AC7 PaTu 8988t C208(1.01)  LDD1213  [11]
 LDCM0345  AC8 PaTu 8988t C208(0.81)  LDD1224  [11]
 LDCM0349  AC83 HEK-293T C101(1.00)  LDD0947  [11]
 LDCM0350  AC84 HEK-293T C101(0.92)  LDD0948  [11]
 LDCM0351  AC85 HEK-293T C101(1.16)  LDD0949  [11]
 LDCM0352  AC86 HEK-293T C101(1.28)  LDD0950  [11]
 LDCM0353  AC87 HEK-293T C101(0.94)  LDD0951  [11]
 LDCM0354  AC88 HEK-293T C101(0.97)  LDD0952  [11]
 LDCM0355  AC89 HEK-293T C101(0.93)  LDD0953  [11]
 LDCM0357  AC90 HEK-293T C101(0.85)  LDD0955  [11]
 LDCM0358  AC91 HEK-293T C101(0.78)  LDD0956  [11]
 LDCM0359  AC92 HEK-293T C101(0.89)  LDD0957  [11]
 LDCM0360  AC93 HEK-293T C101(0.94)  LDD0958  [11]
 LDCM0361  AC94 HEK-293T C101(1.07)  LDD0959  [11]
 LDCM0362  AC95 HEK-293T C101(0.97)  LDD0960  [11]
 LDCM0363  AC96 HEK-293T C101(1.11)  LDD0961  [11]
 LDCM0364  AC97 HEK-293T C101(0.73)  LDD0962  [11]
 LDCM0248  AKOS034007472 PaTu 8988t C208(0.99)  LDD1127  [11]
 LDCM0356  AKOS034007680 PaTu 8988t C208(1.06)  LDD1235  [11]
 LDCM0275  AKOS034007705 PaTu 8988t C208(0.96)  LDD1154  [11]
 LDCM0632  CL-Sc Hep-G2 C309(0.29)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C208(1.12); C122(0.99)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C208(1.84); C122(1.15)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C208(1.02); C122(0.89); C101(1.13)  LDD1573  [10]
 LDCM0370  CL101 PaTu 8988t C208(1.03)  LDD1249  [11]
 LDCM0371  CL102 PaTu 8988t C208(0.93)  LDD1250  [11]
 LDCM0372  CL103 PaTu 8988t C208(1.19)  LDD1251  [11]
 LDCM0373  CL104 PaTu 8988t C208(1.02)  LDD1252  [11]
 LDCM0374  CL105 PaTu 8988t C208(1.09)  LDD1253  [11]
 LDCM0375  CL106 PaTu 8988t C208(1.12)  LDD1254  [11]
 LDCM0376  CL107 PaTu 8988t C208(0.88)  LDD1255  [11]
 LDCM0377  CL108 PaTu 8988t C208(0.86)  LDD1256  [11]
 LDCM0378  CL109 PaTu 8988t C208(1.37)  LDD1257  [11]
 LDCM0379  CL11 HEK-293T C208(1.87); C122(1.14)  LDD1583  [10]
 LDCM0380  CL110 PaTu 8988t C208(1.00)  LDD1259  [11]
 LDCM0381  CL111 PaTu 8988t C208(1.18)  LDD1260  [11]
 LDCM0382  CL112 PaTu 8988t C208(1.06)  LDD1261  [11]
 LDCM0383  CL113 PaTu 8988t C208(1.28)  LDD1262  [11]
 LDCM0384  CL114 PaTu 8988t C208(1.24)  LDD1263  [11]
 LDCM0385  CL115 PaTu 8988t C208(1.12)  LDD1264  [11]
 LDCM0386  CL116 PaTu 8988t C208(1.39)  LDD1265  [11]
 LDCM0387  CL117 PaTu 8988t C208(1.05)  LDD1266  [11]
 LDCM0388  CL118 PaTu 8988t C208(0.87)  LDD1267  [11]
 LDCM0389  CL119 PaTu 8988t C208(0.82)  LDD1268  [11]
 LDCM0390  CL12 HEK-293T C208(1.57); C122(0.94)  LDD1594  [10]
 LDCM0391  CL120 PaTu 8988t C208(0.76)  LDD1270  [11]
 LDCM0392  CL121 PaTu 8988t C208(1.11)  LDD1271  [11]
 LDCM0393  CL122 PaTu 8988t C208(1.00)  LDD1272  [11]
 LDCM0394  CL123 PaTu 8988t C208(1.05)  LDD1273  [11]
 LDCM0395  CL124 PaTu 8988t C208(0.97)  LDD1274  [11]
 LDCM0396  CL125 HEK-293T C208(1.09); C122(1.12)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C208(1.08); C122(0.93)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C208(1.02); C122(0.99); C39(0.75)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C208(1.14); C122(1.00); C101(1.39)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C208(1.13); C122(0.98)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C208(1.20); C122(1.06)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C208(1.18); C122(1.16); C39(1.22)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C101(0.86)  LDD1001  [11]
 LDCM0404  CL17 HEK-293T C101(0.96)  LDD1002  [11]
 LDCM0405  CL18 HEK-293T C101(0.74)  LDD1003  [11]
 LDCM0406  CL19 HEK-293T C101(0.94)  LDD1004  [11]
 LDCM0407  CL2 HEK-293T C208(1.08); C122(1.00)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C101(0.77)  LDD1006  [11]
 LDCM0409  CL21 HEK-293T C101(0.84)  LDD1007  [11]
 LDCM0410  CL22 HEK-293T C101(0.76)  LDD1008  [11]
 LDCM0411  CL23 HEK-293T C101(0.56)  LDD1009  [11]
 LDCM0412  CL24 HEK-293T C101(0.74)  LDD1010  [11]
 LDCM0413  CL25 HEK-293T C101(0.92)  LDD1011  [11]
 LDCM0414  CL26 HEK-293T C101(1.04)  LDD1012  [11]
 LDCM0415  CL27 HEK-293T C101(0.93)  LDD1013  [11]
 LDCM0416  CL28 HEK-293T C101(0.86)  LDD1014  [11]
 LDCM0417  CL29 HEK-293T C101(0.73)  LDD1015  [11]
 LDCM0418  CL3 HEK-293T C208(1.22); C122(0.99); C39(0.98)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C101(0.69)  LDD1017  [11]
 LDCM0420  CL31 HEK-293T C101(0.90)  LDD1018  [11]
 LDCM0421  CL32 HEK-293T C101(1.36)  LDD1019  [11]
 LDCM0422  CL33 HEK-293T C101(1.16)  LDD1020  [11]
 LDCM0423  CL34 HEK-293T C101(1.13)  LDD1021  [11]
 LDCM0424  CL35 HEK-293T C101(1.11)  LDD1022  [11]
 LDCM0425  CL36 HEK-293T C101(1.03)  LDD1023  [11]
 LDCM0426  CL37 HEK-293T C101(1.32)  LDD1024  [11]
 LDCM0428  CL39 HEK-293T C101(0.79)  LDD1026  [11]
 LDCM0429  CL4 HEK-293T C208(1.25); C122(1.03); C101(1.20)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C101(1.44)  LDD1028  [11]
 LDCM0431  CL41 HEK-293T C101(0.96)  LDD1029  [11]
 LDCM0432  CL42 HEK-293T C101(1.13)  LDD1030  [11]
 LDCM0433  CL43 HEK-293T C101(0.90)  LDD1031  [11]
 LDCM0434  CL44 HEK-293T C101(1.03)  LDD1032  [11]
 LDCM0435  CL45 HEK-293T C101(0.91)  LDD1033  [11]
 LDCM0436  CL46 PaTu 8988t C208(0.91)  LDD1315  [11]
 LDCM0437  CL47 PaTu 8988t C208(1.39)  LDD1316  [11]
 LDCM0438  CL48 PaTu 8988t C208(1.14)  LDD1317  [11]
 LDCM0439  CL49 PaTu 8988t C208(0.90)  LDD1318  [11]
 LDCM0440  CL5 HEK-293T C208(1.29); C122(0.99)  LDD1644  [10]
 LDCM0441  CL50 PaTu 8988t C208(0.86)  LDD1320  [11]
 LDCM0442  CL51 PaTu 8988t C208(0.88)  LDD1321  [11]
 LDCM0443  CL52 PaTu 8988t C208(1.01)  LDD1322  [11]
 LDCM0444  CL53 PaTu 8988t C208(0.76)  LDD1323  [11]
 LDCM0445  CL54 PaTu 8988t C208(0.83)  LDD1324  [11]
 LDCM0446  CL55 PaTu 8988t C208(1.01)  LDD1325  [11]
 LDCM0447  CL56 PaTu 8988t C208(1.22)  LDD1326  [11]
 LDCM0448  CL57 PaTu 8988t C208(1.21)  LDD1327  [11]
 LDCM0449  CL58 PaTu 8988t C208(0.95)  LDD1328  [11]
 LDCM0450  CL59 PaTu 8988t C208(0.95)  LDD1329  [11]
 LDCM0451  CL6 HEK-293T C208(1.31); C122(0.96)  LDD1654  [10]
 LDCM0452  CL60 PaTu 8988t C208(1.21)  LDD1331  [11]
 LDCM0453  CL61 HEK-293T C208(1.03); C122(1.02)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C208(1.00); C122(1.04)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C208(0.91); C122(0.93); C39(1.03)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C208(1.07); C122(0.98); C101(1.13)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C208(0.96); C122(0.95)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C208(1.03); C122(0.86)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C208(1.04); C122(0.92)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C208(1.10); C122(0.94)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C208(1.17); C122(0.97)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C208(1.36); C122(1.07)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C208(1.19); C122(1.10)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C208(1.39); C122(1.13)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C208(1.21); C122(0.91)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C208(1.04); C122(0.87)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C208(0.93); C122(1.01)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C208(1.04); C122(0.98); C101(1.01)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C208(1.07); C122(1.01)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C208(1.12); C122(0.99)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C208(1.03); C122(1.03)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C208(2.36); C122(1.90)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C208(0.99); C122(0.98)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C208(1.22); C122(1.02)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C208(1.23); C122(1.01)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C208(1.37); C122(1.12)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C208(1.36); C122(0.99)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C208(1.03); C122(0.98)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C208(1.30); C122(0.94)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C208(1.13); C122(0.95); C39(0.58)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C208(1.02); C122(0.98); C101(1.55)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C208(1.17); C122(1.01)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C208(1.33); C122(1.09)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C208(2.01); C122(1.13)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C208(1.16); C122(0.95)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C208(1.14); C122(0.98)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C208(1.47); C122(1.04)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C208(1.04); C122(1.02)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C208(1.52); C122(1.18)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C208(1.26); C122(1.01)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C208(1.07); C122(1.03)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C208(1.01); C122(1.06)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C208(0.94); C122(0.94); C39(0.97)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C208(0.97); C122(0.85); C39(0.97)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C208(0.98); C122(0.95); C39(1.09)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C101(1.18)  LDD1025  [11]
 LDCM0022  KB02 HEK-293T C238(0.87); C208(0.88)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C238(1.11); C208(0.97)  LDD1497  [10]
 LDCM0024  KB05 OVCAR-3 C39(2.22)  LDD3365  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-1 (CUL1) Cullin family Q13616
Cyclin-dependent kinase 14 (CDK14) CMGC Ser/Thr protein kinase family O94921
Cyclin-dependent kinase 16 (CDK16) CMGC Ser/Thr protein kinase family Q00536

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.