Details of the Target
General Information of Target
Target ID | LDTP08907 | |||||
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Target Name | E3 ubiquitin-protein ligase RNF10 (RNF10) | |||||
Gene Name | RNF10 | |||||
Gene ID | 9921 | |||||
Synonyms |
KIAA0262; RIE2; E3 ubiquitin-protein ligase RNF10; EC 2.3.2.27; RING finger protein 10 |
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3D Structure | ||||||
Sequence |
MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGS
KRYNRKRELSYPKNESFNNQSRRSSSQKSKTFNKMPPQRGGGSSKLFSSSFNGGRRDEVA EAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQTGHFEGSGHGSWGKRNKWGHKPFNKEL FLQANCQFVVSEDQDYTAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRC GHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESHQYVVGDTITMQLMKRE KGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLLASKEQVLHRVVLEEKVALEQQLAEEK HTPESCFIEAAIQELKTREEALSGLAGSRREVTGVVAALEQLVLMAPLAKESVFQPRKGV LEYLSAFDEETTEVCSLDTPSRPLALPLVEEEEAVSEPEPEGLPEACDDLELADDNLKEG TICTESSQQEPITKSGFTRLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLERSPEK ISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPVVSKETLEMFSDDIEKR KRQRQKKAREERRRERRIEIEENKKQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGPTS TEGHGALSISPLSRSPGSHADFLLTPLSPTASQGSPSFCVGSLEEDSPFPSFAQMLRVGK AKADVWPKTAPKKDENSLVPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPA TSDPLSEEKGGKKRKKQKQKLLFSTSVVHTK |
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Target Bioclass |
Enzyme
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Family |
RNF10 family
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Subcellular location |
Cytoplasm
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Function |
E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3, promoting their degradation by the proteasome. Also promotes ubiquitination of 40S ribosomal proteins in response to ribosome stalling during translation elongation. The action of RNF10 in iRQC is counteracted by USP10. May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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NAIA_5 Probe Info |
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C366(20.00) | LDD2227 | [1] | |
IA-alkyne Probe Info |
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C505(2.50) | LDD0371 | [2] | |
DBIA Probe Info |
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C483(19.88) | LDD0209 | [3] | |
ATP probe Probe Info |
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N.A. | LDD0199 | [4] | |
NAIA_4 Probe Info |
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N.A. | LDD2226 | [1] | |
IPM Probe Info |
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C483(0.00); C366(0.00) | LDD2156 | [5] | |
VSF Probe Info |
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N.A. | LDD0007 | [6] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0025 | 4SU-RNA | HEK-293T | C505(2.50) | LDD0371 | [2] |
LDCM0026 | 4SU-RNA+native RNA | HEK-293T | C505(2.82) | LDD0372 | [2] |
LDCM0214 | AC1 | HEK-293T | C366(0.95) | LDD1507 | [7] |
LDCM0215 | AC10 | HEK-293T | C366(0.92) | LDD1508 | [7] |
LDCM0226 | AC11 | HEK-293T | C366(1.08) | LDD1509 | [7] |
LDCM0237 | AC12 | HEK-293T | C366(0.93); C483(0.97) | LDD1510 | [7] |
LDCM0259 | AC14 | HEK-293T | C366(0.89) | LDD1512 | [7] |
LDCM0270 | AC15 | HEK-293T | C366(0.93) | LDD1513 | [7] |
LDCM0276 | AC17 | HEK-293T | C366(0.84) | LDD1515 | [7] |
LDCM0277 | AC18 | HEK-293T | C366(0.91) | LDD1516 | [7] |
LDCM0278 | AC19 | HEK-293T | C366(0.98) | LDD1517 | [7] |
LDCM0279 | AC2 | HEK-293T | C366(0.97) | LDD1518 | [7] |
LDCM0280 | AC20 | HEK-293T | C366(0.91); C483(0.98) | LDD1519 | [7] |
LDCM0281 | AC21 | HEK-293T | C366(1.00) | LDD1520 | [7] |
LDCM0282 | AC22 | HEK-293T | C366(0.85) | LDD1521 | [7] |
LDCM0283 | AC23 | HEK-293T | C366(0.94) | LDD1522 | [7] |
LDCM0284 | AC24 | HEK-293T | C366(1.03) | LDD1523 | [7] |
LDCM0285 | AC25 | HEK-293T | C366(0.76) | LDD1524 | [7] |
LDCM0286 | AC26 | HEK-293T | C366(0.97) | LDD1525 | [7] |
LDCM0287 | AC27 | HEK-293T | C366(1.08) | LDD1526 | [7] |
LDCM0288 | AC28 | HEK-293T | C366(1.10); C483(1.07) | LDD1527 | [7] |
LDCM0289 | AC29 | HEK-293T | C366(0.94) | LDD1528 | [7] |
LDCM0290 | AC3 | HEK-293T | C366(0.99) | LDD1529 | [7] |
LDCM0291 | AC30 | HEK-293T | C366(0.90) | LDD1530 | [7] |
LDCM0292 | AC31 | HEK-293T | C366(1.03) | LDD1531 | [7] |
LDCM0293 | AC32 | HEK-293T | C366(1.03) | LDD1532 | [7] |
LDCM0294 | AC33 | HEK-293T | C366(0.99) | LDD1533 | [7] |
LDCM0295 | AC34 | HEK-293T | C366(0.96) | LDD1534 | [7] |
LDCM0296 | AC35 | HEK-293T | C366(1.08) | LDD1535 | [7] |
LDCM0297 | AC36 | HEK-293T | C366(1.04); C483(0.96) | LDD1536 | [7] |
LDCM0298 | AC37 | HEK-293T | C366(0.86) | LDD1537 | [7] |
LDCM0299 | AC38 | HEK-293T | C366(0.89) | LDD1538 | [7] |
LDCM0300 | AC39 | HEK-293T | C366(0.99) | LDD1539 | [7] |
LDCM0301 | AC4 | HEK-293T | C366(0.87); C483(1.07) | LDD1540 | [7] |
LDCM0302 | AC40 | HEK-293T | C366(1.08) | LDD1541 | [7] |
LDCM0303 | AC41 | HEK-293T | C366(0.67) | LDD1542 | [7] |
LDCM0304 | AC42 | HEK-293T | C366(0.93) | LDD1543 | [7] |
LDCM0305 | AC43 | HEK-293T | C366(1.12) | LDD1544 | [7] |
LDCM0306 | AC44 | HEK-293T | C366(1.17); C483(0.83) | LDD1545 | [7] |
LDCM0307 | AC45 | HEK-293T | C366(0.97) | LDD1546 | [7] |
LDCM0308 | AC46 | HEK-293T | C366(0.95) | LDD1547 | [7] |
LDCM0309 | AC47 | HEK-293T | C366(1.03) | LDD1548 | [7] |
LDCM0310 | AC48 | HEK-293T | C366(1.17) | LDD1549 | [7] |
LDCM0311 | AC49 | HEK-293T | C366(0.92) | LDD1550 | [7] |
LDCM0312 | AC5 | HEK-293T | C366(0.90) | LDD1551 | [7] |
LDCM0313 | AC50 | HEK-293T | C366(0.85) | LDD1552 | [7] |
LDCM0314 | AC51 | HEK-293T | C366(1.04) | LDD1553 | [7] |
LDCM0315 | AC52 | HEK-293T | C366(0.96); C483(1.16) | LDD1554 | [7] |
LDCM0316 | AC53 | HEK-293T | C366(0.95) | LDD1555 | [7] |
LDCM0317 | AC54 | HEK-293T | C366(0.80) | LDD1556 | [7] |
LDCM0318 | AC55 | HEK-293T | C366(0.99) | LDD1557 | [7] |
LDCM0319 | AC56 | HEK-293T | C366(1.03) | LDD1558 | [7] |
LDCM0320 | AC57 | HEK-293T | C366(0.75) | LDD1559 | [7] |
LDCM0321 | AC58 | HEK-293T | C366(0.99) | LDD1560 | [7] |
LDCM0322 | AC59 | HEK-293T | C366(0.94) | LDD1561 | [7] |
LDCM0323 | AC6 | HEK-293T | C366(0.88) | LDD1562 | [7] |
LDCM0324 | AC60 | HEK-293T | C366(1.07); C483(1.00) | LDD1563 | [7] |
LDCM0325 | AC61 | HEK-293T | C366(0.95) | LDD1564 | [7] |
LDCM0326 | AC62 | HEK-293T | C366(0.92) | LDD1565 | [7] |
LDCM0327 | AC63 | HEK-293T | C366(0.94) | LDD1566 | [7] |
LDCM0328 | AC64 | HEK-293T | C366(1.05) | LDD1567 | [7] |
LDCM0334 | AC7 | HEK-293T | C366(1.08) | LDD1568 | [7] |
LDCM0345 | AC8 | HEK-293T | C366(1.05) | LDD1569 | [7] |
LDCM0248 | AKOS034007472 | HEK-293T | C366(0.99) | LDD1511 | [7] |
LDCM0356 | AKOS034007680 | HEK-293T | C366(1.13) | LDD1570 | [7] |
LDCM0275 | AKOS034007705 | HEK-293T | C366(1.00) | LDD1514 | [7] |
LDCM0632 | CL-Sc | Hep-G2 | C366(20.00) | LDD2227 | [1] |
LDCM0367 | CL1 | HEK-293T | C366(1.00) | LDD1571 | [7] |
LDCM0368 | CL10 | HEK-293T | C366(0.98) | LDD1572 | [7] |
LDCM0369 | CL100 | HEK-293T | C366(1.18) | LDD1573 | [7] |
LDCM0370 | CL101 | HEK-293T | C366(0.90) | LDD1574 | [7] |
LDCM0371 | CL102 | HEK-293T | C366(0.92); C483(0.85) | LDD1575 | [7] |
LDCM0372 | CL103 | HEK-293T | C366(0.91) | LDD1576 | [7] |
LDCM0373 | CL104 | HEK-293T | C366(0.92) | LDD1577 | [7] |
LDCM0374 | CL105 | HEK-293T | C366(1.03) | LDD1578 | [7] |
LDCM0375 | CL106 | HEK-293T | C366(1.03); C483(1.08) | LDD1579 | [7] |
LDCM0376 | CL107 | HEK-293T | C366(1.10) | LDD1580 | [7] |
LDCM0377 | CL108 | HEK-293T | C366(0.89) | LDD1581 | [7] |
LDCM0378 | CL109 | HEK-293T | C366(0.94) | LDD1582 | [7] |
LDCM0379 | CL11 | HEK-293T | C366(1.10) | LDD1583 | [7] |
LDCM0380 | CL110 | HEK-293T | C366(0.96); C483(0.89) | LDD1584 | [7] |
LDCM0381 | CL111 | HEK-293T | C366(0.97) | LDD1585 | [7] |
LDCM0382 | CL112 | HEK-293T | C366(0.88) | LDD1586 | [7] |
LDCM0383 | CL113 | HEK-293T | C366(0.90) | LDD1587 | [7] |
LDCM0384 | CL114 | HEK-293T | C366(1.14); C483(0.98) | LDD1588 | [7] |
LDCM0385 | CL115 | HEK-293T | C366(1.21) | LDD1589 | [7] |
LDCM0386 | CL116 | HEK-293T | C366(0.95) | LDD1590 | [7] |
LDCM0387 | CL117 | HEK-293T | C366(1.07) | LDD1591 | [7] |
LDCM0388 | CL118 | HEK-293T | C366(0.95); C483(1.17) | LDD1592 | [7] |
LDCM0389 | CL119 | HEK-293T | C366(1.19) | LDD1593 | [7] |
LDCM0390 | CL12 | HEK-293T | C366(0.96) | LDD1594 | [7] |
LDCM0391 | CL120 | HEK-293T | C366(1.10) | LDD1595 | [7] |
LDCM0392 | CL121 | HEK-293T | C366(1.05) | LDD1596 | [7] |
LDCM0393 | CL122 | HEK-293T | C366(0.89); C483(1.09) | LDD1597 | [7] |
LDCM0394 | CL123 | HEK-293T | C366(1.04) | LDD1598 | [7] |
LDCM0395 | CL124 | HEK-293T | C366(1.32) | LDD1599 | [7] |
LDCM0396 | CL125 | HEK-293T | C366(1.02) | LDD1600 | [7] |
LDCM0397 | CL126 | HEK-293T | C366(0.92); C483(0.87) | LDD1601 | [7] |
LDCM0398 | CL127 | HEK-293T | C366(0.98) | LDD1602 | [7] |
LDCM0399 | CL128 | HEK-293T | C366(1.20) | LDD1603 | [7] |
LDCM0400 | CL13 | HEK-293T | C366(0.91) | LDD1604 | [7] |
LDCM0401 | CL14 | HEK-293T | C366(1.02); C483(0.80) | LDD1605 | [7] |
LDCM0402 | CL15 | HEK-293T | C366(0.80) | LDD1606 | [7] |
LDCM0403 | CL16 | HEK-293T | C366(1.16) | LDD1607 | [7] |
LDCM0404 | CL17 | HEK-293T | C366(0.73) | LDD1608 | [7] |
LDCM0405 | CL18 | HEK-293T | C366(0.92) | LDD1609 | [7] |
LDCM0406 | CL19 | HEK-293T | C366(1.09) | LDD1610 | [7] |
LDCM0407 | CL2 | HEK-293T | C366(0.95); C483(0.87) | LDD1611 | [7] |
LDCM0408 | CL20 | HEK-293T | C366(0.92); C483(0.98) | LDD1612 | [7] |
LDCM0409 | CL21 | HEK-293T | C366(1.08) | LDD1613 | [7] |
LDCM0410 | CL22 | HEK-293T | C366(0.88) | LDD1614 | [7] |
LDCM0411 | CL23 | HEK-293T | C366(1.04) | LDD1615 | [7] |
LDCM0412 | CL24 | HEK-293T | C366(0.99) | LDD1616 | [7] |
LDCM0413 | CL25 | HEK-293T | C366(1.16) | LDD1617 | [7] |
LDCM0414 | CL26 | HEK-293T | C366(0.94); C483(0.76) | LDD1618 | [7] |
LDCM0415 | CL27 | HEK-293T | C366(1.14) | LDD1619 | [7] |
LDCM0416 | CL28 | HEK-293T | C366(0.82) | LDD1620 | [7] |
LDCM0417 | CL29 | HEK-293T | C366(0.93) | LDD1621 | [7] |
LDCM0418 | CL3 | HEK-293T | C366(0.94) | LDD1622 | [7] |
LDCM0419 | CL30 | HEK-293T | C366(0.86) | LDD1623 | [7] |
LDCM0420 | CL31 | HEK-293T | C366(1.04) | LDD1624 | [7] |
LDCM0421 | CL32 | HEK-293T | C366(0.91); C483(1.16) | LDD1625 | [7] |
LDCM0422 | CL33 | HEK-293T | C366(1.01) | LDD1626 | [7] |
LDCM0423 | CL34 | HEK-293T | C366(0.92) | LDD1627 | [7] |
LDCM0424 | CL35 | HEK-293T | C366(0.94) | LDD1628 | [7] |
LDCM0425 | CL36 | HEK-293T | C366(1.07) | LDD1629 | [7] |
LDCM0426 | CL37 | HEK-293T | C366(1.05) | LDD1630 | [7] |
LDCM0428 | CL39 | HEK-293T | C366(1.05) | LDD1632 | [7] |
LDCM0429 | CL4 | HEK-293T | C366(1.06) | LDD1633 | [7] |
LDCM0430 | CL40 | HEK-293T | C366(1.21) | LDD1634 | [7] |
LDCM0431 | CL41 | HEK-293T | C366(0.90) | LDD1635 | [7] |
LDCM0432 | CL42 | HEK-293T | C366(0.91) | LDD1636 | [7] |
LDCM0433 | CL43 | HEK-293T | C366(1.16) | LDD1637 | [7] |
LDCM0434 | CL44 | HEK-293T | C366(1.09); C483(0.99) | LDD1638 | [7] |
LDCM0435 | CL45 | HEK-293T | C366(1.10) | LDD1639 | [7] |
LDCM0436 | CL46 | HEK-293T | C366(0.90) | LDD1640 | [7] |
LDCM0437 | CL47 | HEK-293T | C366(1.01) | LDD1641 | [7] |
LDCM0438 | CL48 | HEK-293T | C366(0.98) | LDD1642 | [7] |
LDCM0439 | CL49 | HEK-293T | C366(1.25) | LDD1643 | [7] |
LDCM0440 | CL5 | HEK-293T | C366(0.91) | LDD1644 | [7] |
LDCM0441 | CL50 | HEK-293T | C366(0.97); C483(1.24) | LDD1645 | [7] |
LDCM0443 | CL52 | HEK-293T | C366(1.25) | LDD1646 | [7] |
LDCM0444 | CL53 | HEK-293T | C366(0.95) | LDD1647 | [7] |
LDCM0445 | CL54 | HEK-293T | C366(1.33) | LDD1648 | [7] |
LDCM0446 | CL55 | HEK-293T | C366(1.14) | LDD1649 | [7] |
LDCM0447 | CL56 | HEK-293T | C366(1.01); C483(1.04) | LDD1650 | [7] |
LDCM0448 | CL57 | HEK-293T | C366(1.06) | LDD1651 | [7] |
LDCM0449 | CL58 | HEK-293T | C366(0.99) | LDD1652 | [7] |
LDCM0450 | CL59 | HEK-293T | C366(0.97) | LDD1653 | [7] |
LDCM0451 | CL6 | HEK-293T | C366(1.09) | LDD1654 | [7] |
LDCM0452 | CL60 | HEK-293T | C366(1.04) | LDD1655 | [7] |
LDCM0453 | CL61 | HEK-293T | C366(0.89) | LDD1656 | [7] |
LDCM0454 | CL62 | HEK-293T | C366(1.03); C483(0.88) | LDD1657 | [7] |
LDCM0455 | CL63 | HEK-293T | C366(1.18) | LDD1658 | [7] |
LDCM0456 | CL64 | HEK-293T | C366(1.14) | LDD1659 | [7] |
LDCM0457 | CL65 | HEK-293T | C366(0.95) | LDD1660 | [7] |
LDCM0458 | CL66 | HEK-293T | C366(1.03) | LDD1661 | [7] |
LDCM0459 | CL67 | HEK-293T | C366(0.96) | LDD1662 | [7] |
LDCM0460 | CL68 | HEK-293T | C366(0.94); C483(1.14) | LDD1663 | [7] |
LDCM0461 | CL69 | HEK-293T | C366(1.02) | LDD1664 | [7] |
LDCM0462 | CL7 | HEK-293T | C366(1.23) | LDD1665 | [7] |
LDCM0463 | CL70 | HEK-293T | C366(0.90) | LDD1666 | [7] |
LDCM0464 | CL71 | HEK-293T | C366(1.04) | LDD1667 | [7] |
LDCM0465 | CL72 | HEK-293T | C366(0.97) | LDD1668 | [7] |
LDCM0466 | CL73 | HEK-293T | C366(0.90) | LDD1669 | [7] |
LDCM0467 | CL74 | HEK-293T | C366(0.98); C483(0.85) | LDD1670 | [7] |
LDCM0469 | CL76 | HEK-293T | C366(1.02) | LDD1672 | [7] |
LDCM0470 | CL77 | HEK-293T | C366(0.81) | LDD1673 | [7] |
LDCM0471 | CL78 | HEK-293T | C366(0.88) | LDD1674 | [7] |
LDCM0472 | CL79 | HEK-293T | C366(1.01) | LDD1675 | [7] |
LDCM0473 | CL8 | HEK-293T | C366(0.95); C483(0.94) | LDD1676 | [7] |
LDCM0474 | CL80 | HEK-293T | C366(1.06); C483(0.91) | LDD1677 | [7] |
LDCM0475 | CL81 | HEK-293T | C366(1.04) | LDD1678 | [7] |
LDCM0476 | CL82 | HEK-293T | C366(0.94) | LDD1679 | [7] |
LDCM0477 | CL83 | HEK-293T | C366(0.97) | LDD1680 | [7] |
LDCM0478 | CL84 | HEK-293T | C366(0.89) | LDD1681 | [7] |
LDCM0479 | CL85 | HEK-293T | C366(0.92) | LDD1682 | [7] |
LDCM0480 | CL86 | HEK-293T | C366(0.82); C483(1.14) | LDD1683 | [7] |
LDCM0481 | CL87 | HEK-293T | C366(0.79) | LDD1684 | [7] |
LDCM0482 | CL88 | HEK-293T | C366(1.10) | LDD1685 | [7] |
LDCM0483 | CL89 | HEK-293T | C366(0.73) | LDD1686 | [7] |
LDCM0484 | CL9 | HEK-293T | C366(1.07) | LDD1687 | [7] |
LDCM0485 | CL90 | HEK-293T | C366(1.34) | LDD1688 | [7] |
LDCM0486 | CL91 | HEK-293T | C366(1.25) | LDD1689 | [7] |
LDCM0487 | CL92 | HEK-293T | C366(0.97); C483(1.14) | LDD1690 | [7] |
LDCM0488 | CL93 | HEK-293T | C366(0.97) | LDD1691 | [7] |
LDCM0489 | CL94 | HEK-293T | C366(1.07) | LDD1692 | [7] |
LDCM0490 | CL95 | HEK-293T | C366(1.01) | LDD1693 | [7] |
LDCM0491 | CL96 | HEK-293T | C366(0.85) | LDD1694 | [7] |
LDCM0492 | CL97 | HEK-293T | C366(1.07) | LDD1695 | [7] |
LDCM0493 | CL98 | HEK-293T | C366(0.91); C483(1.04) | LDD1696 | [7] |
LDCM0494 | CL99 | HEK-293T | C366(0.86) | LDD1697 | [7] |
LDCM0495 | E2913 | HEK-293T | C366(0.89) | LDD1698 | [7] |
LDCM0468 | Fragment33 | HEK-293T | C366(1.00) | LDD1671 | [7] |
LDCM0427 | Fragment51 | HEK-293T | C366(0.92); C483(1.00) | LDD1631 | [7] |
LDCM0023 | KB03 | Jurkat | C483(19.88) | LDD0209 | [3] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Transporter and channel
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
Huntingtin-interacting protein 1 (HIP1) | SLA2 family | O00291 | |||
Alpha-synuclein (SNCA) | Synuclein family | P37840 | |||
Wolframin (WFS1) | . | O76024 |
Other
References