Details of the Target

General Information of Target

Target ID LDTP08693
Target Name Inactive histone-lysine N-methyltransferase 2E (KMT2E)
Gene Name KMT2E
Gene ID 55904
Synonyms
MLL5; Inactive histone-lysine N-methyltransferase 2E; Inactive lysine N-methyltransferase 2E; Myeloid/lymphoid or mixed-lineage leukemia protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP
YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR
CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK
RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK
CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA
QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG
KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE
IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN
INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN
QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ
ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH
IGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPAL
NKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYS
PHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQ
ERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTH
TDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEI
KRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPV
SDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSV
NSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDN
LIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCA
SSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ
VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE
LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQW
DSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH
CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY
PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ
QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ
TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP
PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALH
HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP
NSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
Subcellular location
Cytoplasm; Chromosome; Nucleus, nucleoplasm
Function
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry. Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition. During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells.; [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.
Uniprot ID
Q8IZD2
Ensemble ID
ENST00000311117.8
HGNC ID
HGNC:18541
ChEMBL ID
CHEMBL4523393

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S861N .
DU145 Deletion: p.K873NfsTer8 .
HCT15 SNV: p.N736K .
HEC1B SNV: p.P1019H .
HG3 SNV: p.L471V .
HT115 SNV: p.R576I .
HUH28 SNV: p.S50Ter .
KMRC20 SNV: p.E827G .
MM1S SNV: p.C453R .
SNGM SNV: p.S522N .
SW1990 SNV: p.Q1092Ter .
SW948 SNV: p.D10G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C839(3.02)  LDD0080  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C411(0.83)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C411(1.14); C815(1.04)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C411(1.01)  LDD1509  [3]
 LDCM0230  AC113 PaTu 8988t C411(0.64)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C411(1.27)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C411(0.94)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C411(0.95)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C411(0.81)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C411(1.29)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C411(1.49)  LDD1115  [1]
 LDCM0237  AC12 HEK-293T C411(0.98)  LDD1510  [3]
 LDCM0238  AC120 PaTu 8988t C411(1.28)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C411(1.15)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C411(0.97)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C411(0.87)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C411(1.28)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C411(0.89)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C411(1.00)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C411(1.50)  LDD1124  [1]
 LDCM0259  AC14 HEK-293T C411(0.99)  LDD1512  [3]
 LDCM0263  AC143 HCT 116 C411(0.88)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C411(1.22)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C411(1.21)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C411(1.30)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C411(1.25)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C411(1.10)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C411(1.08)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C411(0.95)  LDD1513  [3]
 LDCM0271  AC150 HCT 116 C411(0.92)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C411(1.21)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C411(1.26)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C411(1.39)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C411(1.47)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C411(1.81)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C411(1.41)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C411(1.35)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C411(0.76)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C411(1.36)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C411(0.80)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C411(0.77)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C411(0.84)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C411(0.86)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C411(0.85)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C411(0.77)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C411(1.04)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C411(0.95)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C411(1.00); C815(1.06)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C411(1.06)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C411(0.92)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C411(0.98)  LDD1528  [3]
 LDCM0290  AC3 HCT 116 C411(0.70)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C411(1.01)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C411(0.90)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C411(1.15)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C411(1.01)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C411(1.11); C815(0.92)  LDD1534  [3]
 LDCM0296  AC35 HCT 116 C411(0.58)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C411(0.73)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C411(0.78)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C411(1.13)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C411(1.49)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C411(0.89)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C411(1.44)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C411(1.26)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C411(0.82)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C411(0.88)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C411(1.06)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C411(1.07)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C411(0.91)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C411(0.99)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C411(0.91)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C411(0.98)  LDD1550  [3]
 LDCM0312  AC5 HCT 116 C411(0.79)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C411(0.94); C815(0.87)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C411(0.95)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C411(0.90)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C411(0.92)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C411(1.07)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C411(1.07)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C411(0.86)  LDD1558  [3]
 LDCM0320  AC57 HCT 116 C411(2.02)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C411(2.14)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C411(3.03)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C411(0.98)  LDD1562  [3]
 LDCM0324  AC60 HCT 116 C411(2.45)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C411(1.30)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C411(20.00)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C411(2.02)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C411(2.51)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C411(2.50)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C411(1.83)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C411(2.96)  LDD0648  [1]
 LDCM0334  AC7 HEK-293T C411(0.99)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C411(0.84)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C411(1.16)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C411(0.99)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C411(1.03)  LDD1514  [3]
 LDCM0367  CL1 HCT 116 C411(1.00)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C411(0.80)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C411(0.70)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C411(1.05)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C411(1.00); C815(1.34); C1441(1.11)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C411(1.10)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C411(1.16)  LDD1577  [3]
 LDCM0374  CL105 HCT 116 C411(0.66)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C411(0.85)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C411(0.71)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C411(0.89)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C411(0.85)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C411(0.85)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C411(0.80)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C411(0.76)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C411(0.98)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C411(0.90)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C411(0.96); C815(0.98); C1441(0.91)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C411(0.95)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C411(1.01)  LDD1590  [3]
 LDCM0387  CL117 HCT 116 C411(1.04)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C411(1.02)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C411(0.89)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C411(0.84)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C411(1.80)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C411(1.03)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C411(0.97); C815(1.18); C1441(0.80)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C411(0.98)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C411(1.00)  LDD1599  [3]
 LDCM0396  CL125 HCT 116 C411(1.39)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C411(2.02)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C411(1.68)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C411(1.32)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C411(1.09)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C411(1.25)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C411(1.06)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C411(1.08)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C411(1.10)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C411(1.03); C815(0.90)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C411(1.05)  LDD1610  [3]
 LDCM0407  CL2 HCT 116 C411(0.83)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C411(1.04)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C411(1.24)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C411(1.14)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C411(1.10)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C411(0.92)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C411(0.95)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C411(0.98); C815(1.05); C1441(1.02)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C411(1.00)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C411(1.24)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C411(0.95)  LDD1621  [3]
 LDCM0418  CL3 HCT 116 C411(0.83)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C411(0.96); C815(0.76)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C411(1.07)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C411(1.12)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C411(1.02)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C411(1.03)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C411(1.13)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C411(0.90)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C411(0.99)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C411(1.01)  LDD1632  [3]
 LDCM0429  CL4 HCT 116 C411(0.76)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C411(1.03)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C411(0.95)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C411(1.11); C815(0.79)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C411(1.20)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C411(0.99)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C411(0.98)  LDD1639  [3]
 LDCM0436  CL46 PaTu 8988t C411(1.58)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C411(1.08)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C411(0.93)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C411(1.44)  LDD1318  [1]
 LDCM0440  CL5 HCT 116 C411(1.08)  LDD0757  [1]
 LDCM0441  CL50 PaTu 8988t C411(1.30)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C411(1.55)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C411(0.78)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C411(1.16)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C411(1.19)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C411(0.99)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C411(0.22)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C411(1.37)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C411(2.00)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C411(2.30)  LDD1329  [1]
 LDCM0451  CL6 HCT 116 C411(0.75)  LDD0768  [1]
 LDCM0452  CL60 PaTu 8988t C411(1.32)  LDD1331  [1]
 LDCM0453  CL61 HEK-293T C411(1.03)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C411(1.06); C815(0.80); C1441(0.76)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C411(1.04)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C411(1.15)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C411(0.97)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C411(1.00); C815(1.23)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C411(1.06)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C411(1.11)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C411(1.19)  LDD1664  [3]
 LDCM0462  CL7 HCT 116 C411(1.40)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C411(1.05)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C411(1.07)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C411(1.51)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C411(1.08)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C411(0.97); C815(1.22); C1441(1.19)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C411(1.10)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C411(1.06)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C411(1.05); C815(0.82)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C411(0.97)  LDD1675  [3]
 LDCM0473  CL8 HCT 116 C411(1.07)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C411(1.03)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C411(1.02)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C411(1.15)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C411(1.34)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C411(0.89)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C411(1.04)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C411(0.98); C815(0.91); C1441(1.41)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C411(0.95)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C411(1.00)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C411(0.98)  LDD1686  [3]
 LDCM0484  CL9 HCT 116 C411(0.94)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C411(1.27); C815(1.20)  LDD1688  [3]
 LDCM0486  CL91 HCT 116 C411(1.06)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C411(0.74)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C411(0.76)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C411(0.90)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C411(0.83)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C411(0.73)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C411(1.05)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C411(0.73)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C411(0.71)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C411(1.04)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C411(1.01)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C411(1.05); C815(0.79); C1441(0.69)  LDD1631  [3]
 LDCM0022  KB02 HCT 116 C839(3.02)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C839(2.07)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C839(2.27)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Natural cytotoxicity triggering receptor 2 (NCR2) Natural cytotoxicity receptor (NCR) family O95944

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402