Details of the Target

General Information of Target

Target ID LDTP08600
Target Name Polyhomeotic-like protein 2 (PHC2)
Gene Name PHC2
Gene ID 1912
Synonyms
EDR2; PH2; Polyhomeotic-like protein 2; hPH2; Early development regulatory protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENELPVPHTSSSACATSSTSGASSSSGCNNSSSGGSGRPTGPQISVYSGIPDRQTVQVI
QQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQLQSLAAVQQASLVSNRQG
STSGSNVSAQAPAQSSSINLAASPAAAQLLNRAQSVNSAAASGIAQQAVLLGNTSSPALT
ASQAQMYLRAQMLIFTPTATVATVQPELGTGSPARPPTPAQVQNLTLRTQQTPAAAASGP
TPTQPVLPSLALKPTPGGSQPLPTPAQSRNTAQASPAGAKPGIADSVMEPHKKGDGNSSV
PGSMEGRAGLSRTVPAVAAHPLIAPAYAQLQPHQLLPQPSSKHLQPQFVIQQQPQPQQQQ
PPPQQSRPVLQAEPHPQLASVSPSVALQPSSEAHAMPLGPVTPALPLQCPTANLHKPGGS
QQCHPPTPDTGPQNGHPEGVPHTPQRRFQHTSAVILQLQPASPPQQCVPDDWKEVAPGEK
SVPETRSGPSPHQQAIVTAMPGGLPVPTSPNIQPSPAHETGQGIVHALTDLSSPGMTSGN
GNSASSIAGTAPQNGENKPPQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKK
YAQGFLPEKLPQQDHTTTTDSEMEEPYLQESKEEGAPLKLKCELCGRVDFAYKFKRSKRF
CSMACAKRYNVGCTKRVGLFHSDRSKLQKAGAATHNRRRASKASLPPLTKDTKKQPTGTV
PLSVTAALQLTHSQEDSSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLELPDMHMRDLV
GMGHHFLPSEPTKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNI
KLGPALKIYARISMLKDS
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Uniprot ID
Q8IXK0
Ensemble ID
ENST00000257118.5
HGNC ID
HGNC:3183

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K598(6.25); K667(10.00); K675(10.00); K847(9.40)  LDD0277  [2]
BTD
 Probe Info  		C673(0.46)  LDD2099  [3]
DBIA
 Probe Info  		C673(4.22)  LDD0209  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C809(0.00); C673(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		C809(0.00); C673(0.00)  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C673(0.00); C740(0.00)  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C809(0.87)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C673(0.54)  LDD2117  [3]
 LDCM0214  AC1 HEK-293T C740(0.90); C673(1.07); C665(1.04)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C740(1.02); C809(1.00); C673(0.90); C665(1.03)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C740(1.13); C809(1.01); C673(1.02); C665(0.99)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C740(1.10); C809(0.92); C673(0.98); C665(1.08)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C740(1.10); C809(0.97); C673(1.00); C665(1.08)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C740(0.99); C809(0.95); C673(1.01); C665(1.11)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C740(1.03); C673(1.05); C665(1.09)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C740(1.12); C809(0.88); C673(0.98); C665(0.98)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C740(1.02); C809(0.92); C673(1.55); C665(0.83)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C740(0.93); C809(0.99); C673(0.94); C665(0.94)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C740(0.87); C809(0.94); C673(0.99); C665(0.98)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C740(0.99); C809(0.98); C673(0.98); C665(1.00)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C740(1.05); C809(1.00); C673(0.99); C665(1.02)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C740(1.08); C809(0.92); C673(0.95); C665(1.11)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C740(0.85); C809(1.01); C673(0.92); C467(0.96)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C740(1.14); C673(1.06); C665(1.02)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C740(1.07); C809(0.97); C673(1.00); C665(1.04)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C740(1.05); C809(0.99); C673(1.02); C665(0.94)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C740(0.88); C809(0.93); C673(1.00); C665(0.98)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C740(1.10); C809(1.03); C673(0.99); C665(1.08)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C740(0.89); C809(0.85); C673(0.99); C665(0.97)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C740(0.90); C809(1.01); C673(1.03); C665(1.08)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C740(1.00); C809(1.01); C673(0.99); C665(1.06)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C740(0.84); C809(1.02); C673(0.97); C467(1.11)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C740(1.09); C673(1.08); C665(0.93)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C740(0.98); C809(1.00); C673(0.94); C665(1.03)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C740(1.12); C809(0.89); C673(1.00); C665(1.09)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C740(0.94); C809(0.93); C673(0.90); C665(1.05)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C740(0.96); C809(1.13); C673(0.88); C665(1.11)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C740(1.03); C809(0.97); C673(0.96); C665(1.00)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C740(1.11); C809(0.93); C673(0.97); C665(1.08)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C740(0.85); C809(0.99); C673(0.91); C665(0.91)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C740(1.04); C809(1.00); C673(0.97); C467(1.14)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C740(0.86); C673(1.02); C665(1.12)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C740(1.02); C809(0.90); C673(1.02); C665(1.06)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C740(1.08); C809(1.02); C673(0.98); C665(0.99)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C740(0.96); C809(0.99); C673(0.98); C665(1.03)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C740(1.25); C809(1.06); C673(0.95); C665(1.07)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C740(1.07); C809(1.00); C673(0.94); C665(0.96)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C740(1.07); C809(0.95); C673(1.01); C665(0.99)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C740(0.86); C809(1.13); C673(1.01); C467(1.10)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C740(1.06); C673(1.08); C665(1.01)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C740(1.04); C809(1.08); C673(0.93); C665(1.02)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C740(1.05); C809(0.95); C673(0.95); C665(0.93)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C740(0.90); C809(0.97); C673(0.96); C665(1.00)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C740(1.01); C809(1.00); C673(0.96); C665(1.03)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C740(1.21); C809(1.25); C673(0.91); C665(1.06)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C740(0.95); C809(1.00); C673(0.99); C665(0.98)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C740(1.03); C809(0.86); C673(1.01); C665(1.02)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C740(0.94); C809(0.93); C673(0.95); C467(1.10)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C740(1.00); C673(1.07); C665(1.04)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C740(1.00); C809(0.99); C673(1.00); C665(1.00)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C740(0.94); C809(1.00); C673(0.98); C665(0.95)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C740(0.90); C809(1.00); C673(0.95); C665(1.00)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C740(0.92); C809(0.94); C673(0.91); C665(1.01)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C740(1.01); C809(1.09); C673(0.91); C665(1.04)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C740(0.98); C809(0.95); C673(0.96); C665(1.03)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C740(0.95); C809(0.96); C673(0.98); C665(1.03)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C740(0.90); C809(0.98); C673(1.09); C467(1.39)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C740(1.03); C809(0.88); C673(1.01); C665(1.16)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C740(1.01); C809(0.96); C673(1.04); C467(1.24)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C740(1.12); C809(1.16); C673(0.89); C665(1.05)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C740(0.89); C673(1.13); C665(0.97)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C740(1.06); C809(0.96); C673(0.95); C467(1.01)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 13.12  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C740(0.90); C809(0.87); C673(0.97); C665(0.99)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C740(1.25); C809(0.87); C673(1.12); C665(1.10)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C740(0.70); C809(1.04); C673(0.97); C665(1.02)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C740(1.10); C809(0.91); C673(0.90); C665(1.03)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C740(1.10); C809(0.86); C673(1.08); C665(1.01)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C740(1.54); C809(0.99); C673(1.10); C665(1.01)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C740(0.97); C809(1.14); C673(1.01); C665(1.01)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C740(0.93); C809(0.92); C673(0.99); C665(0.92)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C740(0.89); C809(0.97); C673(0.99); C665(1.00)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C740(0.83); C809(0.88); C673(1.02); C665(1.00)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C740(1.30); C809(0.96); C673(1.05); C665(1.06)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C740(1.12); C809(0.84); C673(0.95); C665(0.97)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C740(1.23); C809(1.09); C673(1.05); C665(1.06)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C740(1.25); C809(0.91); C673(0.91); C665(0.92)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C740(1.13); C809(0.87); C673(1.01); C665(0.95)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C740(0.79); C809(1.04); C673(1.05); C665(1.04)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C740(1.03); C809(0.94); C673(1.00); C665(1.05)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C740(1.01); C809(0.83); C673(0.95); C665(0.97)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C740(0.99); C809(1.01); C673(1.03); C665(0.98)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C740(1.07); C809(1.15); C673(1.02); C665(1.05)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C740(0.97); C809(1.04); C673(0.97); C665(1.09)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C740(1.21); C809(0.96); C673(0.99); C665(0.98)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C740(0.77); C809(1.03); C673(1.04); C665(1.02)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C740(0.85); C809(0.89); C673(0.90); C467(0.53)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C740(0.77); C809(1.03); C673(1.04); C665(0.92)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C740(1.07); C809(0.88); C673(0.92); C665(1.01)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C740(1.01); C809(0.91); C673(1.04); C665(0.97)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C740(1.32); C809(0.99); C673(0.96); C665(0.91)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C740(1.15); C809(0.98); C673(0.96); C665(0.97)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C740(0.99); C809(0.96); C673(0.92); C665(1.08)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C740(1.21); C809(0.89); C673(0.97); C665(1.07)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C740(1.18); C809(1.04); C673(0.99); C665(0.94)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C740(1.00); C809(0.92); C673(0.97); C665(1.01)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C740(1.03); C809(0.91); C673(1.07); C665(0.92)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C740(1.10); C809(1.02); C673(0.99); C665(1.11)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C740(1.25); C809(0.92); C673(1.03); C665(0.96)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C740(0.86); C809(1.30); C673(0.98); C665(1.10)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C740(1.13); C673(1.17); C665(0.99)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C740(1.23); C809(0.97); C673(1.01); C665(0.98)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C740(1.53); C809(0.91); C673(0.99); C665(1.04)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C740(1.16); C809(1.07); C673(1.03); C665(1.01)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C740(1.10); C809(0.98); C673(1.04); C665(1.10)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C740(1.06); C809(0.99); C673(1.00); C665(1.12)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C740(1.41); C809(1.05); C673(1.06); C665(1.16)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C740(1.36); C809(0.97); C673(1.07); C665(1.00)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C740(1.04); C809(1.19); C673(0.96); C467(0.51)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C740(0.96); C809(0.83); C673(0.97); C665(0.88)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C740(1.24); C809(0.94); C673(0.94); C665(1.05)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C740(1.07); C809(0.97); C673(1.05); C665(0.97)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C740(0.96); C809(1.21); C673(1.01); C665(1.13)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C740(1.19); C673(1.14); C665(0.98)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C740(0.98); C809(0.94); C673(0.97); C665(0.97)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C740(1.16); C809(0.83); C673(1.00); C665(1.09)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C740(1.33); C809(0.89); C673(1.14); C665(0.99)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C740(1.07); C809(0.95); C673(1.00); C665(1.02)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C740(1.15); C809(0.84); C673(1.00); C665(0.88)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C740(1.31); C809(1.11); C673(1.08); C665(1.07)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C740(1.44); C809(1.13); C673(1.15); C665(1.05)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C740(0.98); C809(0.90); C673(0.87); C467(0.49)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C740(0.88); C809(0.96); C673(0.93); C665(0.95)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C740(1.03); C809(0.89); C673(1.01); C665(1.04)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C740(1.01); C809(0.96); C673(0.94); C665(0.90)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C740(0.88); C809(1.02); C673(1.05); C665(1.15)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C740(0.99); C673(1.18); C665(1.07)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C740(1.07); C809(0.88); C673(1.03); C665(1.01)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C740(1.80); C809(0.98); C673(1.06); C665(0.99)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C740(1.12); C809(0.96); C673(1.15); C665(1.04)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C740(1.01); C809(0.93); C673(1.09); C665(1.09)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C740(1.51); C809(0.97); C673(1.08); C665(1.05)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C740(0.97); C809(0.99); C673(1.13); C665(0.98)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C740(0.86); C809(0.98); C673(0.99); C467(0.55)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C740(0.94); C809(0.91); C673(0.96); C665(1.00)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C740(1.43); C673(1.17); C665(1.03)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C740(1.00); C809(0.94); C673(1.09); C665(1.07)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C740(0.95); C809(0.88); C673(1.07); C665(1.02)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C740(1.47); C673(1.00); C665(1.00)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C740(1.15); C809(0.82); C673(0.98); C665(0.99)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C740(1.60); C809(0.90); C673(1.07); C665(1.02)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C740(1.24); C809(1.01); C673(1.01); C665(0.97)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C740(1.14); C809(0.97); C673(1.09); C665(0.99)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C740(1.80); C809(1.01); C673(1.01); C665(1.13)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C740(1.19); C809(0.93); C673(1.10); C665(1.01)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C740(1.18); C809(0.89); C673(0.95); C665(0.92)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C740(0.85); C809(0.94); C673(0.89); C467(0.51)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C740(0.87); C809(0.87); C673(0.85); C665(1.04)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C740(0.89); C809(0.95); C673(0.97); C665(0.96)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C740(1.03); C809(1.08); C673(0.97); C665(1.00)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C740(0.90); C809(1.16); C673(1.02); C665(1.02)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C740(1.03); C673(1.10); C665(1.06)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C740(1.24); C809(0.83); C673(0.98); C665(1.08)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C740(1.42); C809(0.95); C673(1.02); C665(1.05)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C740(1.34); C809(1.06); C673(0.96); C665(1.01)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C740(1.26); C809(1.08); C673(0.94); C665(1.08)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C740(1.28); C809(0.91); C673(1.01); C665(0.99)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C740(1.27); C809(0.99); C673(1.04); C665(1.07)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C740(1.33); C809(0.96); C673(1.04); C665(1.01)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C740(0.92); C809(1.04); C673(0.96); C467(0.53)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C740(0.98); C809(0.90); C673(0.88); C665(0.92)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C740(1.08); C809(0.98); C673(0.98); C665(1.09)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C740(0.91); C809(1.00); C673(0.98); C665(1.00)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C740(0.95); C673(1.15); C665(1.00)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C740(1.25); C809(0.89); C673(0.95); C665(1.11)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C740(1.37); C809(0.91); C673(0.98); C665(0.99)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C740(0.94); C809(0.88); C673(1.03); C665(0.75)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C740(1.19); C809(1.08); C673(1.01); C665(0.98)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C740(1.27); C809(1.12); C673(0.92); C665(1.03)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C740(1.25); C809(1.02); C673(1.01); C665(1.01)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C740(1.11); C809(0.84); C673(0.97); C665(1.01)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C740(1.04); C809(0.94); C673(0.97); C467(0.60)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C740(0.98); C809(0.99); C673(0.79); C665(0.97)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C740(1.32); C809(1.03); C673(0.92); C665(1.06)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C740(0.75); C809(1.08); C673(1.00); C665(1.01)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C740(1.02); C809(0.85); C673(0.96); C665(0.97)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C740(0.94); C673(0.98); C665(0.91)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C740(1.04); C809(1.03); C673(1.02); C665(1.18)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C740(1.34); C809(0.78); C673(0.95); C665(0.86)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C740(1.24); C809(0.96); C673(0.95); C665(0.96)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C740(0.95); C809(1.00); C673(0.93); C665(0.90)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C740(1.27); C809(0.90); C673(0.90); C665(1.05)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C740(1.28); C809(1.06); C673(0.95); C665(1.02)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C740(1.08); C809(0.80); C673(1.08); C665(0.77)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C740(0.92); C809(0.86); C673(1.21); C467(1.15)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C740(0.87); C809(0.87); C673(0.95); C665(0.88)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C740(1.11); C809(0.87); C673(1.07); C665(1.07)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C740(0.96); C809(1.03); C673(0.97); C665(0.88)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C740(1.00); C809(1.02); C673(1.04); C665(1.04)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C673(1.38)  LDD1702  [3]
 LDCM0625  F8 Ramos C809(1.10)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C809(0.97)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C809(0.17)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C809(1.14)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C809(0.97)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C809(1.25)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C809(1.48)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C809(1.04)  LDD2195  [15]
 LDCM0578  Fragment27 Ramos C809(0.86)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C809(0.56)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C809(1.11)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C809(0.86)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C809(0.82)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C740(0.97); C809(0.97); C673(0.99); C665(1.03)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C809(0.77)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C809(0.87)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C740(1.25); C809(0.93); C673(0.93); C665(1.04)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C809(0.98)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C809(0.98)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C809(0.96)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C809(1.47)  LDD2188  [15]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C673(0.90); C740(0.94); C665(1.03); C809(1.05)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C673(4.22)  LDD0209  [4]
 LDCM0024  KB05 G361 C88(3.94)  LDD3311  [16]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C673(0.46)  LDD2099  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C673(0.67)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C673(0.61)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C809(4.64)  LDD2114  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C673(0.81); C642(0.72)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C673(0.54)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C673(0.84)  LDD2127  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C673(0.61)  LDD2134  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C673(0.78)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C673(0.79)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C673(0.39)  LDD2140  [3]
 LDCM0131  RA190 MM1.R C740(1.93)  LDD0304  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) Archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family P62875
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Developmentally-regulated GTP-binding protein 1 (DRG1) OBG GTPase family Q9Y295
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
Polycomb complex protein BMI-1 (BMI1) . P35226
Polycomb group RING finger protein 2 (PCGF2) . P35227
Polycomb group RING finger protein 3 (PCGF3) . Q3KNV8
Polycomb group RING finger protein 5 (PCGF5) . Q86SE9
RWD domain-containing protein 2B (RWDD2B) . P57060
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Transcription factor Sp1 (SP1) Sp1 C2H2-type zinc-finger protein family P08047
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Other
Click To Hide/Show 28 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Bystin (BYSL) Bystin family Q13895
Protein FAM124A (FAM124A) FAM124 family Q86V42
Protein FAM13C (FAM13C) FAM13 family Q8NE31
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM74A1 (FAM74A1) FAM74 family Q5RGS3
Protein FAM74A4/A6 (FAM74A4; FAM74A6) FAM74 family Q5TZK3
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Speriolin-like protein (SPATC1L) Speriolin family Q9H0A9
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Chromobox protein homolog 8 (CBX8) . Q9HC52
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Kelch repeat and BTB domain-containing protein 7 (KBTBD7) . Q8WVZ9
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) . Q96JM7
Melanoma-associated antigen B6 (MAGEB6) . Q8N7X4
Microspherule protein 1 (MCRS1) . Q96EZ8
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
Rhombotin-1 (LMO1) . P25800
Rhombotin-2 (LMO2) . P25791
Scm-like with four MBT domains protein 1 (SFMBT1) . Q9UHJ3
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.