Details of the Target

General Information of Target

Target ID LDTP08511
Target Name Palmitoyltransferase ZDHHC21 (ZDHHC21)
Gene Name ZDHHC21
Gene ID 340481
Synonyms
Palmitoyltransferase ZDHHC21; EC 2.3.1.225; DHHC domain-containing cysteine-rich protein 21; DHHC-21; Zinc finger DHHC domain-containing protein 21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLRIHFVVDPHGWCCMGLIVFVWLYNIVLIPKIVLFPHYEEGHIPGILIIIFYGISIFC
LVALVRASITDPGRLPENPKIPHGEREFWELCNKCNLMRPKRSHHCSRCGHCVRRMDHHC
PWINNCVGEDNHWLFLQLCFYTELLTCYALMFSFCHYYYFLPLKKRNLDLFVFRHELAIM
RLAAFMGITMLVGITGLFYTQLIGIITDTTSIEKMSNCCEDISRPRKPWQQTFSEVFGTR
WKILWFIPFRQRQPLRVPYHFANHV
Target Bioclass
Enzyme
Family
DHHC palmitoyltransferase family
Subcellular location
Golgi apparatus membrane
Function
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor. Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK.
Uniprot ID
Q8IVQ6
Ensemble ID
ENST00000380916.9
HGNC ID
HGNC:20750

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C92(1.13)  LDD3312  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C92(0.58)  LDD1093  [3]
 LDCM0215  AC10 PaTu 8988t C92(0.92)  LDD1094  [3]
 LDCM0216  AC100 PaTu 8988t C218(1.39); C219(1.39)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C218(0.95); C219(0.95)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C218(1.24); C219(1.24)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C218(1.76); C219(1.76)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C218(0.99); C219(0.99)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C218(1.43); C219(1.43)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C218(1.16); C219(1.16)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C218(1.39); C219(1.39)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C218(1.11); C219(1.11)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C218(1.25); C219(1.25)  LDD1104  [3]
 LDCM0226  AC11 PaTu 8988t C92(0.90)  LDD1105  [3]
 LDCM0227  AC110 PaTu 8988t C218(1.41); C219(1.41)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C218(1.36); C219(1.36)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C218(1.71); C219(1.71)  LDD1108  [3]
 LDCM0230  AC113 PaTu 8988t C218(0.85); C219(0.85)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C218(0.62); C219(0.62)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C218(0.84); C219(0.84)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C218(0.87); C219(0.87)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C218(0.52); C219(0.52)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C218(0.80); C219(0.80)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C218(0.98); C219(0.98)  LDD1115  [3]
 LDCM0237  AC12 PaTu 8988t C92(0.79)  LDD1116  [3]
 LDCM0238  AC120 PaTu 8988t C218(0.66); C219(0.66)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C218(0.73); C219(0.73)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C218(0.74); C219(0.74)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C218(0.82); C219(0.82)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C218(0.61); C219(0.61)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C218(0.84); C219(0.84)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C218(0.62); C219(0.62)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C218(0.79); C219(0.79)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C218(1.75); C219(1.75)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C218(1.35); C219(1.35)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C218(1.27); C219(1.27)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C218(1.08); C219(1.08)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C218(1.04); C219(1.04)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C218(1.24); C219(1.24)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C218(1.28); C219(1.28)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C218(1.37); C219(1.37)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C218(1.79); C219(1.79)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C218(1.47); C219(1.47)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C218(1.34); C219(1.34)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C218(1.50); C219(1.50)  LDD1137  [3]
 LDCM0259  AC14 PaTu 8988t C92(1.07)  LDD1138  [3]
 LDCM0260  AC140 PaTu 8988t C218(1.48); C219(1.48)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C218(1.08); C219(1.08)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C218(1.42); C219(1.42)  LDD1141  [3]
 LDCM0270  AC15 PaTu 8988t C92(1.04)  LDD1149  [3]
 LDCM0279  AC2 PaTu 8988t C92(0.69)  LDD1158  [3]
 LDCM0290  AC3 PaTu 8988t C92(0.66)  LDD1169  [3]
 LDCM0296  AC35 PaTu 8988t C92(0.80)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C92(0.72)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C92(0.69)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C92(0.74)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C92(0.65)  LDD1179  [3]
 LDCM0301  AC4 PaTu 8988t C92(0.80)  LDD1180  [3]
 LDCM0302  AC40 PaTu 8988t C92(0.62)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C92(0.69)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C92(0.77)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C92(0.74)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C92(0.56)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C92(0.65)  LDD1186  [3]
 LDCM0308  AC46 PaTu 8988t C92(0.71)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C92(0.71)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C92(0.64)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C92(0.53)  LDD1190  [3]
 LDCM0312  AC5 PaTu 8988t C92(0.63)  LDD1191  [3]
 LDCM0313  AC50 PaTu 8988t C92(0.52)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C92(0.13)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C92(0.61)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C92(0.51)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C92(0.52)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C92(0.70)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C92(0.48)  LDD1198  [3]
 LDCM0323  AC6 PaTu 8988t C92(0.94)  LDD1202  [3]
 LDCM0334  AC7 PaTu 8988t C92(0.94)  LDD1213  [3]
 LDCM0345  AC8 PaTu 8988t C92(1.17)  LDD1224  [3]
 LDCM0365  AC98 PaTu 8988t C218(1.43); C219(1.43)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C218(1.06); C219(1.06)  LDD1245  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C92(1.09)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C92(0.90)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C92(0.91)  LDD1154  [3]
 LDCM0367  CL1 PaTu 8988t C92(1.24)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C92(0.88)  LDD1247  [3]
 LDCM0369  CL100 PaTu 8988t C92(0.70)  LDD1248  [3]
 LDCM0370  CL101 PaTu 8988t C92(0.84)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C92(0.94)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C92(0.87)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C92(0.96)  LDD1252  [3]
 LDCM0379  CL11 PaTu 8988t C92(1.24)  LDD1258  [3]
 LDCM0387  CL117 PaTu 8988t C92(0.67)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C92(0.83)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C92(0.78)  LDD1268  [3]
 LDCM0390  CL12 PaTu 8988t C92(0.99)  LDD1269  [3]
 LDCM0391  CL120 PaTu 8988t C92(0.76)  LDD1270  [3]
 LDCM0392  CL121 PaTu 8988t C92(0.75)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C92(0.66)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C92(0.60)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C92(0.59)  LDD1274  [3]
 LDCM0400  CL13 PaTu 8988t C92(1.04)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C92(0.88)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C92(1.06)  LDD1281  [3]
 LDCM0407  CL2 PaTu 8988t C92(1.12)  LDD1286  [3]
 LDCM0418  CL3 PaTu 8988t C92(0.98)  LDD1297  [3]
 LDCM0420  CL31 PaTu 8988t C218(1.24); C219(1.24)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C218(1.55); C219(1.55)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C218(1.58); C219(1.58)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C218(1.44); C219(1.44)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C218(1.30); C219(1.30)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C218(2.82); C219(2.82)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C218(1.31); C219(1.31)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C218(1.34); C219(1.34)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C92(1.05)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C218(1.39); C219(1.39)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C218(1.23); C219(1.23)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C218(1.38); C219(1.38)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C218(1.47); C219(1.47)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C218(1.20); C219(1.20)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C218(1.94); C219(1.94)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C92(0.99)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C92(0.79)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C92(0.78)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C92(0.88)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C92(1.03)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C92(0.79)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C92(0.89)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C92(0.85)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C92(0.72)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C92(0.74)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C92(0.77)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C92(0.38)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C92(0.58)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C92(0.78)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C92(0.66)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C92(1.08)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C92(0.64)  LDD1331  [3]
 LDCM0462  CL7 PaTu 8988t C92(1.06)  LDD1341  [3]
 LDCM0469  CL76 PaTu 8988t C92(0.91)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C92(0.76)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C92(0.65)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C92(0.63)  LDD1351  [3]
 LDCM0473  CL8 PaTu 8988t C92(0.94)  LDD1352  [3]
 LDCM0474  CL80 PaTu 8988t C92(0.54)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C92(0.61)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C92(0.64)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C92(0.60)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C92(0.74)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C92(0.65)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C92(0.56)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C92(0.62)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C92(0.55)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C92(0.68)  LDD1362  [3]
 LDCM0484  CL9 PaTu 8988t C92(0.95)  LDD1363  [3]
 LDCM0485  CL90 PaTu 8988t C92(0.51)  LDD1364  [3]
 LDCM0486  CL91 PaTu 8988t C92(0.76)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C92(0.67)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C92(0.72)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C92(0.66)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C92(0.55)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C92(0.70)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C92(0.74)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C92(0.66)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C92(0.68)  LDD1373  [3]
 LDCM0427  Fragment51 PaTu 8988t C218(1.45); C219(1.45)  LDD1306  [3]
 LDCM0022  KB02 22RV1 C92(1.34)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C92(1.37)  LDD2660  [1]
 LDCM0024  KB05 HMCB C92(1.13)  LDD3312  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Ribonuclease kappa (RNASEK) RNase K family Q6P5S7
Tripartite motif-containing protein 59 (TRIM59) TRIM/RBCC family Q8IWR1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Protein kish-B (TMEM167B) KISH family Q9NRX6
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Chondrolectin (CHODL) . Q9H9P2

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.