Details of the Target

General Information of Target

Target ID LDTP08210
Target Name Probable RNA-binding protein 23 (RBM23)
Gene Name RBM23
Gene ID 55147
Synonyms
RNPC4; Probable RNA-binding protein 23; CAPER beta; CAPERbeta; RNA-binding motif protein 23; RNA-binding region-containing protein 4; Splicing factor SF2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASDDFDIVIEAMLEAPYKKEEDEQQRKEVKKDYPSNTTSSTSNSGNETSGSSTIGETSK
KKRSRSHNKSRDRKRSRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRR
EDRVHYRSPPLATGYRYGHSKSPHFREKSPVREPVDNLSPEERDARTVFCMQLAARIRPR
DLEDFFSAVGKVRDVRIISDRNSRRSKGIAYVEFCEIQSVPLAIGLTGQRLLGVPIIVQA
SQAEKNRLAAMANNLQKGNGGPMRLYVGSLHFNITEDMLRGIFEPFGKIDNIVLMKDSDT
GRSKGYGFITFSDSECARRALEQLNGFELAGRPMRVGHVTERLDGGTDITFPDGDQELDL
GSAGGRFQLMAKLAEGAGIQLPSTAAAAAAAAAQAAALQLNGAVPLGALNPAALTALSPA
LNLASQCFQLSSLFTPQTM
Target Bioclass
Other
Family
Splicing factor SR family
Subcellular location
Nucleus
Function
RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor. Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity.
Uniprot ID
Q86U06
Ensemble ID
ENST00000346528.9
HGNC ID
HGNC:20155

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.A416V .
HCT116 SNV: p.M334I .
Ishikawa (Heraklio) 02 ER SNV: p.T133N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		Y266(6.77)  LDD2237  [1]
Acrolein
 Probe Info  		N.A.  LDD0221  [2]
DBIA
 Probe Info  		C316(1.06)  LDD0532  [3]
1c-yne
 Probe Info  		N.A.  LDD0228  [4]
Crotonaldehyde
 Probe Info  		C170(0.00); H338(0.00)  LDD0219  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C215(1.02)  LDD1507  [5]
 LDCM0215  AC10 HCT 116 C316(1.06)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C316(0.88)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C316(0.82)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C316(0.77)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C316(0.93)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C316(0.96)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C316(1.12)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C316(0.83)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C316(0.86)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C316(0.94)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C316(0.85)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C316(0.70)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C316(0.92)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C316(0.65)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C316(0.72)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C316(0.91)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C316(0.88)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C316(0.96)  LDD0562  [3]
 LDCM0259  AC14 HCT 116 C316(0.88)  LDD0576  [3]
 LDCM0263  AC143 HEK-293T C316(1.41)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C316(1.07)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C316(1.05)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C316(1.39)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C316(1.13)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C316(1.27)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C316(0.93)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C316(0.95)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C316(1.37)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C316(1.30)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C316(0.98)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C316(1.31)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C316(1.12)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C316(1.15)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C316(1.31)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C316(1.10)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C215(1.07)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C215(0.94)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C215(0.94)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C215(0.93)  LDD1519  [5]
 LDCM0284  AC24 HEK-293T C215(0.96)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C215(1.01)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C215(0.96)  LDD1525  [5]
 LDCM0288  AC28 HEK-293T C215(0.78)  LDD1527  [5]
 LDCM0293  AC32 HEK-293T C215(0.89)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C215(1.04)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C215(0.93)  LDD1534  [5]
 LDCM0297  AC36 HEK-293T C215(1.17)  LDD1536  [5]
 LDCM0301  AC4 HEK-293T C215(1.07)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C215(0.99)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C215(1.10)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C215(1.09)  LDD1543  [5]
 LDCM0306  AC44 HEK-293T C215(1.06)  LDD1545  [5]
 LDCM0310  AC48 HEK-293T C215(0.94)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C215(0.96)  LDD1550  [5]
 LDCM0313  AC50 HEK-293T C215(0.97)  LDD1552  [5]
 LDCM0315  AC52 HEK-293T C215(1.05)  LDD1554  [5]
 LDCM0319  AC56 HEK-293T C215(0.88)  LDD1558  [5]
 LDCM0320  AC57 HCT 116 C316(1.18)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C316(0.98)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C316(1.12)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C316(1.07)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C316(0.86)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C316(1.11)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C316(1.07)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C316(1.08)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C316(0.90)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C316(1.00)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C316(0.87)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C316(1.19)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C316(1.11)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C316(0.94)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C316(0.88)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C316(0.91)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C316(1.06)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C316(0.98)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C316(1.02)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C316(1.05)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C316(0.85)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C316(0.90)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C316(0.94)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C316(1.06)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C316(1.18)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C316(0.96)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C316(1.07)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C316(1.06)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C316(1.03)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C316(0.99)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C316(0.97)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C316(1.00)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C316(0.98)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C316(0.99)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C316(1.12)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C316(1.04)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C316(0.95)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C316(1.06)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C316(1.01)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C316(1.01)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C316(0.91)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C316(1.02)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C316(0.88)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C316(0.89)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C316(0.98)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C316(0.84)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C316(0.92)  LDD0592  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C316(1.30)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C316(1.18)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C215(0.91)  LDD1573  [5]
 LDCM0370  CL101 HCT 116 C316(0.86)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C316(1.00)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C316(1.25)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C316(0.95)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C215(0.95)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C215(0.95)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C215(1.00)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C215(0.95)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C215(0.93)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C316(1.02)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C215(0.91)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C215(0.85)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C215(0.93)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C215(1.21)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C215(1.04)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C215(0.87)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C215(0.95)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C215(1.03)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C215(1.05)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C215(1.16)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C316(1.56)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C215(1.05)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C215(0.93)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C215(1.02)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C215(1.06)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C215(1.00)  LDD1599  [5]
 LDCM0396  CL125 HCT 116 C316(1.15)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C316(1.02)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C316(0.94)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C316(0.91)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C316(1.19)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C316(1.16)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C316(1.16)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C316(0.91)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C316(0.94)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C316(0.73)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C316(0.96)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C316(1.09)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C316(1.14)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C316(1.01)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C316(0.99)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C316(1.17)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C316(1.02)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C316(1.05)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C316(1.07)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C316(0.86)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C316(1.00)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C316(1.28)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C316(1.01)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C316(1.07)  LDD1017  [3]
 LDCM0421  CL32 HEK-293T C215(0.96)  LDD1625  [5]
 LDCM0425  CL36 HEK-293T C215(0.90)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C215(0.85)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C215(1.24)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C316(1.22)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C215(1.10)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C215(0.95)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C215(0.88)  LDD1636  [5]
 LDCM0434  CL44 HEK-293T C215(0.89)  LDD1638  [5]
 LDCM0436  CL46 HCT 116 C316(0.99)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C316(0.79)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C316(1.01)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C316(1.04)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C316(1.13)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C316(1.02)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C316(0.93)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C316(1.00)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C316(0.94)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C316(0.93)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C316(0.96)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C316(0.90)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C316(1.14)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C316(1.01)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C316(0.96)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C316(1.15)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C316(1.07)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C316(1.13)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C316(1.21)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C316(1.23)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C316(1.35)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C316(1.26)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C316(1.45)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C316(1.42)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C316(1.24)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C316(1.11)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C316(1.33)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C316(1.09)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C316(1.24)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C316(1.59)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C316(1.50)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C316(1.23)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C316(0.98)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C316(1.35)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C316(0.96)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C316(1.26)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C316(0.65)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C316(1.12)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C316(1.20)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C316(1.12)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C316(1.33)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C316(0.85)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C316(1.33)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C316(1.27)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C316(1.24)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C316(1.20)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C316(1.35)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C316(0.81)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C316(1.18)  LDD1083  [3]
 LDCM0487  CL92 HEK-293T C215(0.84)  LDD1690  [5]
 LDCM0491  CL96 HEK-293T C215(1.05)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C215(1.06)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C215(1.04)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C215(1.10)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C215(1.40)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C316(1.63)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C215(1.13)  LDD1631  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0022  KB02 HEK-293T C215(1.00)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C215(1.01)  LDD1497  [5]
 LDCM0024  KB05 RVH421 C316(1.40)  LDD3320  [6]
 LDCM0109  NEM HeLa N.A.  LDD0225  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3

References

1 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840