Details of the Target

General Information of Target

Target ID LDTP08182
Target Name Trafficking protein particle complex subunit 6B (TRAPPC6B)
Gene Name TRAPPC6B
Gene ID 122553
Synonyms
Trafficking protein particle complex subunit 6B; TRAPP complex subunit 6B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MADEALFLLLHNEMVSGVYKSAEQGEVENGRCITKLENMGFRVGQGLIERFTKDTARFKD
ELDIMKFICKDFWTTVFKKQIDNLRTNHQGIYVLQDNKFRLLTQMSAGKQYLEHASKYLA
FTCGLIRGGLSNLGIKSIVTAEVSSMPACKFQVMIQKL
Target Bioclass
Other
Family
TRAPP small subunits family, BET3 subfamily
Subcellular location
Golgi apparatus, cis-Golgi network
Function
Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable).
Uniprot ID
Q86SZ2
Ensemble ID
ENST00000330149.10
HGNC ID
HGNC:23066

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IPC298 SNV: p.F51S .
SNU1 SNV: p.Q110L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C95(5.12)  LDD3312  [1]
BTD
 Probe Info  		C149(0.67)  LDD2091  [2]
IPM
 Probe Info  		C149(2.09)  LDD1701  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C123(0.00); C149(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C149(0.00); C123(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C149(0.00); C123(0.00)  LDD0037  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
NAIA_5
 Probe Info  		C69(0.00); C32(0.00); C149(0.00); C123(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C123(0.99)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C149(1.00)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C149(1.00); C123(1.07)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C149(0.95); C123(0.99)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C149(0.97); C123(0.97)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C149(0.96); C123(0.95)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C149(0.97); C123(0.94)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C149(1.00)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C149(0.93); C123(0.96)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C123(1.08)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C149(0.98); C123(0.91)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C149(1.03); C123(0.95)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C149(0.87); C123(0.87)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C149(0.92); C123(1.11)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C149(0.96); C123(0.94)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C149(1.02); C123(0.93)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C149(0.98)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C149(1.07); C123(1.00)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C149(1.00); C123(0.93)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C149(1.01); C123(0.96)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C123(0.99)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C149(0.96); C123(0.90)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C149(1.02); C123(1.02)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C149(1.00); C123(1.05)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C149(1.03); C123(0.97)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C149(0.90)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C149(1.04); C123(1.04)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C149(0.93); C123(1.03)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C149(1.04); C123(0.92)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C149(0.88); C123(1.03)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C149(0.95); C123(0.99)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C123(1.09)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C149(0.99); C123(1.01)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C149(1.07); C123(0.94)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C149(1.03)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C149(1.01); C123(1.05)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C149(0.97); C123(1.07)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C149(1.02); C123(1.09)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C149(1.04); C123(1.14)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C149(1.03); C123(1.11)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C149(0.89); C123(1.16)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C149(0.94); C123(0.93)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C123(1.22)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C149(1.02)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C149(1.01); C123(1.00)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C149(0.89); C123(1.03)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C149(1.03); C123(0.91)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C149(0.96); C123(0.94)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C149(1.04); C123(1.08)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C149(1.00); C123(1.03)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C123(0.91)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C123(0.88)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C123(0.98)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C149(0.97); C123(1.07)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C123(0.80)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C123(1.37)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C123(0.89)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C123(0.98)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C123(1.00)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C123(1.18)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C123(0.89)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C123(1.09)  LDD0929  [6]
 LDCM0334  AC7 HEK-293T C149(1.06); C123(1.01)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C149(1.01); C123(1.01)  LDD1569  [7]
 LDCM0349  AC83 HEK-293T C123(1.04)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C123(1.35)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C123(1.18)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C123(1.19)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C123(1.21)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C123(1.35)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C123(1.45)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C123(1.35)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C123(1.21)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C123(1.24)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C123(1.28)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C123(1.21)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C123(1.35)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C123(1.25)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C123(2.29)  LDD0962  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C32(1.03)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C149(1.15); C123(1.00)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C149(1.01); C123(1.00)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C149(1.01); C123(0.97)  LDD1514  [7]
 LDCM0498  BS-3668 MDA-MB-231 C149(0.67)  LDD2091  [2]
 LDCM0367  CL1 HEK-293T C149(1.28); C123(0.81)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C149(1.38); C123(0.96)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C123(1.32)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C149(1.11); C123(0.95)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C149(1.60); C123(1.14)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C149(0.88)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C149(0.93); C123(1.15)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C149(1.09); C123(0.97)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C149(1.21); C123(1.07)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C149(0.84)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C149(1.04); C123(0.86)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C149(1.11); C123(0.90)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C149(1.28); C123(1.13)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C149(1.49); C123(1.07)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C149(0.92)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C149(1.05); C123(0.81)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C149(1.05); C123(1.02)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C149(1.54); C123(1.07)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C149(0.81)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C149(0.90); C123(0.98)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C149(1.03); C123(0.95)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C149(1.37); C123(0.96)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C149(0.90)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C149(1.07); C123(1.09)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C149(0.98); C123(0.95)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C149(1.05); C123(1.00)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C149(1.39); C123(1.07)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C149(1.15)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C149(1.12); C123(0.95)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C123(0.79)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C123(0.80)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C123(0.82)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C123(0.81)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C149(1.04); C123(0.92)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C149(1.21); C123(1.02)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C149(1.55)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C149(0.95); C123(0.83)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C149(1.46); C123(0.83)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C149(1.04)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C149(1.03); C123(1.18)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C149(1.21); C123(0.96)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C149(1.05); C123(1.05)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C149(1.50); C123(0.99)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C149(1.02); C123(1.08)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C149(1.25); C123(1.15)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C149(1.19); C123(1.18)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C149(1.27); C123(1.05)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C149(1.08); C123(0.96)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C149(0.82)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C149(0.97); C123(1.10)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C149(0.92); C123(1.12)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C149(0.95)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C149(1.01)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C123(1.64)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C123(1.27)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C123(0.72)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C123(1.26)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C123(1.04)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C123(0.99)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C123(1.43)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C123(1.41)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C149(1.11); C123(0.93)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C123(1.46)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C123(2.02)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C123(1.97)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C123(1.93)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C123(1.29)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C123(1.35)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C149(1.08); C123(1.01)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C149(1.17); C123(1.02)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C149(1.06); C123(1.15)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C149(1.16); C123(0.97)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C149(1.04); C123(0.84)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C149(1.54); C123(1.37)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C149(1.13); C123(0.98)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C149(1.32); C123(1.01)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C149(1.66)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C149(1.07); C123(1.09)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C149(0.95); C123(1.08)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C149(1.40); C123(0.97)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C149(1.03); C123(1.09)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C149(1.15); C123(1.13)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C149(1.32)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C149(1.09); C123(1.03)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C123(1.56)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C123(1.51)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C123(1.98)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C123(1.01)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C123(1.28)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C123(1.04)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C123(0.93)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C123(1.01)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C123(0.98)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C149(1.10); C123(1.15)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C123(1.03)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C123(1.08)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C123(1.11)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C123(1.02)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C123(1.93)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C149(1.02); C123(1.07)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C149(1.24); C123(0.99)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C149(1.01)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C149(1.09); C123(1.16)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C149(1.75); C123(1.50)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C149(0.99); C123(1.16)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C149(1.13); C123(0.99)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C149(1.00); C123(1.03)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C149(1.10); C123(1.19)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C149(1.18); C123(1.10)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C149(1.17); C123(0.95)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C149(1.14); C123(1.15)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C149(1.00)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C149(0.91); C123(1.06)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C149(1.06); C123(1.10)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C149(1.22); C123(1.02)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C149(1.94)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C123(1.04)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C123(1.09)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C123(1.25)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C123(1.43)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C123(1.70)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C123(1.38)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C123(1.22)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C123(1.05)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C123(1.01)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C149(0.94)  LDD1698  [7]
 LDCM0625  F8 Ramos C123(0.64); C149(1.73); C32(4.11)  LDD2187  [8]
 LDCM0572  Fragment10 Ramos C123(0.44); C149(0.88); C32(1.37)  LDD2189  [8]
 LDCM0573  Fragment11 Ramos C123(0.19); C149(0.31); C32(1.40)  LDD2190  [8]
 LDCM0574  Fragment12 Ramos C123(0.59); C149(0.97); C32(1.08)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C123(0.62); C149(1.01); C32(0.70)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C123(1.07); C149(1.24); C32(0.37)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C123(0.55); C149(0.77); C32(0.38)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C123(0.79); C149(1.09)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C123(0.85); C149(0.55)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C123(0.73); C149(0.97); C32(0.48)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C123(1.18); C149(0.76); C32(0.59)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C123(0.50); C149(0.99); C32(1.07)  LDD2199  [8]
 LDCM0589  Fragment31 Ramos C123(0.92); C149(1.19); C32(0.80)  LDD2200  [8]
 LDCM0590  Fragment32 Ramos C123(0.35); C149(0.60); C32(1.01)  LDD2201  [8]
 LDCM0468  Fragment33 HEK-293T C123(1.49)  LDD1066  [6]
 LDCM0596  Fragment38 Ramos C123(0.48); C149(0.81); C32(0.98)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C123(0.86); C149(1.56); C32(0.46)  LDD2184  [8]
 LDCM0427  Fragment51 HEK-293T C123(1.25)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C123(0.49); C149(1.17); C32(0.89)  LDD2204  [8]
 LDCM0614  Fragment56 Ramos C123(0.56); C149(1.03); C32(0.91)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C123(0.68); C149(1.21); C32(0.46)  LDD2186  [8]
 LDCM0571  Fragment9 Ramos C123(0.65); C149(1.05); C32(0.41)  LDD2188  [8]
 LDCM0022  KB02 HEK-293T C149(0.87)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C149(0.91)  LDD1497  [7]
 LDCM0024  KB05 HMCB C95(5.12)  LDD3312  [1]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C149(1.05)  LDD2126  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C32(1.04)  LDD2136  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Trafficking protein particle complex subunit 3 (TRAPPC3) TRAPP small subunits family O43617

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-palmitoyl-l-cysteine . DB08342

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578