Details of the Target

General Information of Target

Target ID LDTP08144
Target Name Transcription initiation factor TFIID subunit 8 (TAF8)
Gene Name TAF8
Gene ID 129685
Synonyms
TAFII43; TBN; Transcription initiation factor TFIID subunit 8; Protein taube nuss; TBP-associated factor 43 kDa; TBP-associated factor 8; Transcription initiation factor TFIID 43 kDa subunit; TAFII-43; TAFII43; hTAFII43
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADAAATAGAGGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVET
LTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVIT
APPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAA
SQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEMQQMEET
DSSEQDEQTDTENLALHISMEDSGAEKENTSVLQQNPSLSGSRNGEENIIDNPYLRPVKK
PKIRRKKSLS
Target Bioclass
Other
Family
TAF8 family
Subcellular location
Nucleus
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF8 is involved in forming the TFIID-B module, together with TAF5. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.
Uniprot ID
Q7Z7C8
Ensemble ID
ENST00000372977.8
HGNC ID
HGNC:17300

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT1080 SNV: p.E63Q .
HUPT4 SNV: p.T251I DBIA    Probe Info 
JURKAT SNV: p.R304H .
MOLT4 SNV: p.D171H IA-alkyne    Probe Info 
SUPT1 SNV: p.A226V .
TGBC52TKB SNV: p.G11S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K77(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C80(2.94)  LDD3310  [2]
BTD
 Probe Info  		C80(1.04)  LDD2137  [3]
HHS-475
 Probe Info  		Y172(0.51)  LDD0264  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
HHS-465
 Probe Info  		Y172(0.00); Y29(0.00)  LDD2240  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C80(1.03)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C80(1.01)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C80(0.94)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C80(0.98)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C80(1.04)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C80(1.04)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C80(1.01)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C80(0.98)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C80(0.84)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C80(1.00)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C80(1.00)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C80(0.95)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C80(1.05)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C80(1.04)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C80(1.07)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C80(1.03)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C80(1.01)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C80(1.04)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C80(0.98)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C80(0.94)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C80(0.99)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C80(1.03)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C80(1.01)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C80(1.05)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C80(1.09)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C80(0.99)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C80(1.00)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C80(1.00)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C80(1.03)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C80(1.04)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C80(1.02)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C80(1.07)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C80(0.98)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C80(0.96)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C80(0.99)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C80(1.01)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C80(0.96)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C80(0.94)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C80(1.05)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C80(1.01)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C80(1.05)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C80(0.95)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C80(1.03)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C80(0.99)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C80(0.98)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C80(0.96)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C80(0.98)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C80(1.05)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C80(0.99)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C80(1.04)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C80(0.96)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C80(0.96)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C80(0.94)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C80(1.00)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C80(0.99)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C80(0.97)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C80(1.00)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C80(1.01)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C80(0.97)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C80(1.07)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C80(1.03)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C80(1.02)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C80(1.03)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C80(1.01)  LDD1514  [11]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C80(0.94)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C80(1.34)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C80(0.98)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C80(0.96)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C80(1.07)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C80(0.99)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C80(0.98)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C80(0.93)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C80(0.96)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C80(0.95)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C80(0.95)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C80(0.98)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C80(1.02)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C80(1.12)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C80(1.01)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C80(1.00)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C80(0.99)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C80(1.11)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C80(1.00)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C80(0.98)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C80(0.97)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C80(0.96)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C80(0.96)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C80(0.95)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C80(0.97)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C80(0.95)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C80(1.01)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C80(1.08)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C80(0.98)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C80(0.91)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C80(0.93)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C80(0.90)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C80(0.95)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C80(0.89)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C80(1.01)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C80(0.98)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C80(1.02)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C80(1.02)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C80(0.98)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C80(0.93)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C80(1.00)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C80(0.98)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C80(0.98)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C80(1.00)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C80(0.96)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C80(1.05)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C80(0.88)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C80(1.05)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C80(0.94)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C80(0.96)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C80(0.99)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C80(1.01)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C80(1.00)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C80(0.95)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C80(0.91)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C80(1.19)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C80(0.97)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C80(1.06)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C80(1.06)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C80(0.94)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C80(1.03)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C80(1.00)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C80(1.00)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C80(1.07)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C80(0.99)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C80(1.02)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C80(1.04)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C80(0.99)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C80(1.04)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C80(1.04)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C80(1.11)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C80(0.84)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C80(0.93)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C80(0.97)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C80(1.01)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C80(1.08)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C80(1.03)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C80(0.97)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C80(0.95)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C80(0.97)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C80(0.99)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C80(0.98)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C80(1.06)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C80(1.03)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C80(0.88)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C80(1.07)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C80(0.98)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C80(1.00)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C80(1.00)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C80(1.06)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C80(0.97)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C80(0.90)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C80(0.92)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C80(0.97)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C80(1.06)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C80(0.97)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C80(0.99)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C80(0.91)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C80(1.01)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C80(0.98)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C80(0.97)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C80(0.94)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C80(0.98)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C80(1.51)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C80(0.93)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C80(0.89)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C80(1.03)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C80(1.03)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C80(1.01)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C80(0.80)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C80(0.94)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C80(0.86)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C80(0.94)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C80(0.89)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C80(0.91)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C80(1.25)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C80(0.90)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C80(0.96)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C80(1.01)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C80(1.00)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C80(1.29)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C80(0.92)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C80(0.96)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C80(1.00)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C80(1.01)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C80(1.00)  LDD1698  [11]
 LDCM0625  F8 Ramos C80(1.93)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C80(1.59)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C80(3.27)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C80(2.14)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C80(1.07)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C80(1.94)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C80(3.99)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C80(0.71)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C80(3.17)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C80(1.04)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C80(0.60)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C80(1.30)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C80(1.08)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C80(2.28)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C80(0.94)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C80(1.30)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C80(2.29)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C80(1.04)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C80(1.07)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C80(1.15)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C80(2.09)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C80(4.98)  LDD2188  [12]
 LDCM0116  HHS-0101 DM93 Y172(0.51)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y172(0.33)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y172(0.45)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y172(0.66)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y172(0.66)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C80(0.99)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C80(0.97)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C80(2.94)  LDD3310  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C80(1.04)  LDD2137  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C80(1.16)  LDD2146  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine--tRNA ligase, cytoplasmic (SARS1) Class-II aminoacyl-tRNA synthetase family P49591
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) Classic translation factor GTPase family P41091
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Transcription initiation factor TFIID subunit 10 (TAF10) TAF10 family Q12962

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578