Details of the Target

General Information of Target

Target ID LDTP08067
Target Name COMM domain-containing protein 6 (COMMD6)
Gene Name COMMD6
Gene ID 170622
Synonyms
COMM domain-containing protein 6
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKC
FEMTIPQFQNFYRQFKEIAAVIETV
Target Bioclass
Other
Subcellular location
Nucleus
Function May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.
Uniprot ID
Q7Z4G1
Ensemble ID
ENST00000355801.4
HGNC ID
HGNC:24015

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.Q67VfsTer16 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K39(3.62)  LDD2217  [1]
BTD
 Probe Info  		C35(0.94)  LDD2109  [2]
DBIA
 Probe Info  		C60(0.74)  LDD0613  [3]
ATP probe
 Probe Info  		K57(0.00); K59(0.00)  LDD0199  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
m-APA
 Probe Info  		N.A.  LDD0404  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		C35(0.00); C60(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C35(0.96)  LDD2117  [2]
 LDCM0025  4SU-RNA HEK-293T C35(2.45)  LDD0371  [14]
 LDCM0214  AC1 PaTu 8988t C60(0.60)  LDD1093  [3]
 LDCM0215  AC10 PaTu 8988t C60(0.77)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C60(0.82)  LDD1105  [3]
 LDCM0230  AC113 PaTu 8988t C60(1.24)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C60(1.08)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C60(1.36)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C60(1.01)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C60(1.11)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C60(0.84)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C60(1.11)  LDD1115  [3]
 LDCM0237  AC12 PaTu 8988t C60(0.58)  LDD1116  [3]
 LDCM0238  AC120 PaTu 8988t C60(1.31)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C60(1.16)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C60(1.22)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C60(1.17)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C60(0.90)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C60(0.98)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C60(1.24)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C60(0.98)  LDD1124  [3]
 LDCM0259  AC14 PaTu 8988t C60(0.92)  LDD1138  [3]
 LDCM0263  AC143 PaTu 8988t C60(1.27)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C60(1.43)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C60(1.07)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C60(0.94)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C60(1.13)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C60(0.92)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C60(1.13)  LDD1148  [3]
 LDCM0270  AC15 PaTu 8988t C60(0.61)  LDD1149  [3]
 LDCM0271  AC150 PaTu 8988t C60(1.29)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C60(0.93)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C60(1.28)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C60(0.95)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C60(1.28)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C60(1.25)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C60(1.06)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C60(0.94)  LDD2169  [3]
 LDCM0279  AC2 PaTu 8988t C60(0.85)  LDD1158  [3]
 LDCM0281  AC21 HEK-293T C35(0.92)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C35(0.99)  LDD1521  [15]
 LDCM0284  AC24 HEK-293T C35(1.04)  LDD1523  [15]
 LDCM0289  AC29 HEK-293T C35(0.99)  LDD1528  [15]
 LDCM0290  AC3 PaTu 8988t C60(0.71)  LDD1169  [3]
 LDCM0291  AC30 HEK-293T C35(1.05)  LDD1530  [15]
 LDCM0293  AC32 HEK-293T C35(1.00)  LDD1532  [15]
 LDCM0296  AC35 HCT 116 C60(0.74)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C60(0.92)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C60(0.77)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C60(1.06)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C60(1.09)  LDD0617  [3]
 LDCM0301  AC4 PaTu 8988t C60(0.64)  LDD1180  [3]
 LDCM0302  AC40 HCT 116 C60(1.00)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C60(0.63)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C60(1.14)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C60(0.92)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C60(0.85)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C60(1.09)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C35(1.08)  LDD1547  [15]
 LDCM0310  AC48 HEK-293T C35(1.07)  LDD1549  [15]
 LDCM0312  AC5 PaTu 8988t C60(0.77)  LDD1191  [3]
 LDCM0316  AC53 HEK-293T C35(1.04)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C35(1.03)  LDD1556  [15]
 LDCM0319  AC56 HEK-293T C35(1.01)  LDD1558  [15]
 LDCM0323  AC6 PaTu 8988t C60(0.81)  LDD1202  [3]
 LDCM0325  AC61 HEK-293T C35(0.94)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C35(0.92)  LDD1565  [15]
 LDCM0328  AC64 HEK-293T C35(0.88)  LDD1567  [15]
 LDCM0334  AC7 PaTu 8988t C60(0.82)  LDD1213  [3]
 LDCM0345  AC8 PaTu 8988t C60(0.81)  LDD1224  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C60(0.76)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C60(0.76)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C60(0.74)  LDD1154  [3]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [12]
 LDCM0632  CL-Sc Hep-G2 C35(20.00)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C60(1.14)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C60(1.01)  LDD0685  [3]
 LDCM0369  CL100 PaTu 8988t C60(1.28)  LDD1248  [3]
 LDCM0370  CL101 PaTu 8988t C60(0.79)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C60(0.74)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C60(0.56)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C60(0.85)  LDD1252  [3]
 LDCM0379  CL11 HCT 116 C60(0.82)  LDD0696  [3]
 LDCM0387  CL117 HCT 116 C60(0.90)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C60(0.89)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C60(0.89)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C60(1.22)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C60(0.83)  LDD0708  [3]
 LDCM0400  CL13 HCT 116 C60(1.00)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C60(1.20)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C60(0.91)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C60(0.56)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C60(0.56)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C60(0.73)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C60(0.57)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C60(0.93)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C60(1.08)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C60(0.92)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C60(0.43)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C60(0.78)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C60(1.04)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C60(1.04)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C60(1.09)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C60(0.89)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C60(0.59)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C60(0.61)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C60(1.13)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C60(0.84)  LDD0736  [3]
 LDCM0422  CL33 HEK-293T C35(1.42)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C35(1.31)  LDD1627  [15]
 LDCM0425  CL36 HEK-293T C35(1.68)  LDD1629  [15]
 LDCM0429  CL4 HCT 116 C60(0.93)  LDD0746  [3]
 LDCM0435  CL45 HEK-293T C35(1.39)  LDD1639  [15]
 LDCM0436  CL46 HCT 116 C60(1.34)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C60(1.36)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C60(1.11)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C60(1.27)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C60(0.91)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C60(1.43)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C60(1.40)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C60(1.61)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C60(1.02)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C60(1.45)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C60(1.32)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C60(1.35)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C60(1.54)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C60(1.08)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C60(1.19)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C60(0.85)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C60(1.04)  LDD0769  [3]
 LDCM0453  CL61 PaTu 8988t C60(0.98)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C60(0.84)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C60(1.21)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C60(1.32)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C60(1.06)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C60(1.09)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C60(1.20)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C60(1.07)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C60(1.07)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C60(0.99)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C60(1.19)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C60(1.08)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C60(0.98)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C60(0.88)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C60(1.10)  LDD1346  [3]
 LDCM0473  CL8 HCT 116 C60(0.99)  LDD0790  [3]
 LDCM0475  CL81 HEK-293T C35(1.28)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C35(1.24)  LDD1679  [15]
 LDCM0478  CL84 HEK-293T C35(1.50)  LDD1681  [15]
 LDCM0484  CL9 HCT 116 C60(0.89)  LDD0801  [3]
 LDCM0486  CL91 PaTu 8988t C60(0.78)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C60(0.61)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C60(0.87)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C60(0.92)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C60(0.61)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C60(0.87)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C60(1.16)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C60(0.66)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C60(0.94)  LDD1373  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C35(1.16)  LDD1702  [2]
 LDCM0625  F8 Ramos C35(1.51)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C35(1.28)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C35(0.64)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C35(0.93)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C35(1.08)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C35(0.58)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C35(0.71)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C35(0.99)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C35(0.58)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C35(0.96)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C35(0.60)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C35(1.14)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C35(0.93)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C35(0.95)  LDD2201  [16]
 LDCM0468  Fragment33 PaTu 8988t C60(1.16)  LDD1347  [3]
 LDCM0596  Fragment38 Ramos C35(1.21)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C35(1.11)  LDD2184  [16]
 LDCM0610  Fragment52 Ramos C35(1.36)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C35(1.38)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C35(0.86)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C35(0.81)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C35(0.94)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C35(1.04)  LDD1497  [15]
 LDCM0024  KB05 UACC257 C35(2.42)  LDD3325  [17]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C35(0.94)  LDD2109  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C35(0.78)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C35(0.91)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C35(1.17)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C35(1.20)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C35(0.99)  LDD2137  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C35(1.63)  LDD2144  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C35(0.27)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C35(0.43)  LDD2207  [18]
 LDCM0131  RA190 MM1.R C35(1.16)  LDD0304  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 22 (CCDC22) CCDC22 family O60826
Coiled-coil domain-containing protein 93 (CCDC93) CCDC93 family Q567U6
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock 70 kDa protein 6 (HSPA6) Heat shock protein 70 family P17066
COMM domain-containing protein 1 (COMMD1) . Q8N668
COMM domain-containing protein 9 (COMMD9) . Q9P000

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.