Details of the Target

General Information of Target

Target ID LDTP07943
Target Name Volume-regulated anion channel subunit LRRC8D (LRRC8D)
Gene Name LRRC8D
Gene ID 55144
Synonyms
LRRC5; Volume-regulated anion channel subunit LRRC8D; Leucine-rich repeat-containing protein 5; Leucine-rich repeat-containing protein 8D; HsLRRC8D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS
PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF
ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS
NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST
SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED
SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY
MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL
HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS
GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR
CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT
KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL
QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES
LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL
NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL
EVKEALNQDINIPFANGI
Target Bioclass
Transporter and channel
Family
LRRC8 family
Subcellular location
Cell membrane
Function
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. LRRC8A and LRRC8D are required for the uptake of the drug cisplatin. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion. VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Mediates the import of the antibiotic blasticidin-S into the cell.
Uniprot ID
Q7L1W4
Ensemble ID
ENST00000337338.9
HGNC ID
HGNC:16992

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K290(5.16)  LDD0277  [2]
DBIA
 Probe Info  		C820(3.55)  LDD3310  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		C218(0.00); C786(0.00)  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C218(1.05)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C218(1.09)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C218(1.15)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C733(1.08); C218(1.07)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C733(0.85); C218(1.02)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C733(0.94); C218(1.07)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C218(1.13)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C218(1.07)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C218(1.11)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C218(0.92)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C733(0.80); C218(0.99)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C733(0.84); C218(0.98)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C733(0.77); C218(0.89)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C733(1.18); C218(0.95)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C218(0.95)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C218(1.03)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C218(1.20)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C218(1.09)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C733(0.96); C218(1.06)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C733(0.76); C218(0.92)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C218(1.06)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C733(0.55); C218(0.99)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C733(0.86); C218(1.05)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C218(0.89)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C218(1.00)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C218(1.22)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C218(1.12)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C733(1.16); C218(1.03)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C733(0.81); C218(1.02)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C733(0.89); C218(0.99)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C733(0.95); C218(0.90)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C733(0.83); C218(1.09)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C218(0.91)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C218(1.18)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C218(1.11)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C218(1.23)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C733(0.81); C218(1.04)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C733(0.97); C218(0.93)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C733(0.68); C218(1.02)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C733(0.90); C218(1.09)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C218(1.04)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C218(1.18)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C733(0.71); C218(0.80)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C218(1.07)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C218(1.03)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C733(0.93); C218(0.96)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C733(0.95); C218(0.99)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C733(1.24); C218(1.05)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C733(0.92); C218(1.06)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C218(1.05)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C218(1.10)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C218(0.97)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C218(1.17)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C733(0.94); C218(1.10)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C733(0.81); C218(0.98)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C733(0.67); C218(0.93)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C733(0.65); C218(0.97)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C733(0.93); C218(1.05)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C218(1.21)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C733(0.93); C218(0.95)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C218(0.93)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C733(0.78); C218(0.90)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C218(1.13)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C218(0.98)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C218(0.96)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C733(1.03); C218(0.92)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C218(0.89)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C218(0.94)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C218(0.95)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C733(0.96); C218(0.85)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C218(0.97)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C218(0.94)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C218(0.95)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C733(0.85); C218(0.93)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C218(1.02)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C218(1.02)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C733(1.03); C218(1.22)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C218(1.05)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C733(0.94); C218(0.98)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C218(0.90)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C218(0.94)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C218(1.01)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C733(0.78); C218(1.03)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C218(1.01)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C218(1.03)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C218(0.96)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C733(0.90); C218(0.88)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C218(1.09)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C218(0.91)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C218(1.02)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C218(1.07)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C733(0.67); C218(0.95)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C218(1.12)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C218(1.00)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C218(0.99)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C733(0.93); C218(1.01)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C218(0.89)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C218(1.02)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C218(1.04)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C733(0.81); C218(0.93)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C218(0.95)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C218(0.94)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C218(1.14)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C218(1.20)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C218(0.97)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C733(0.80); C218(1.12)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C733(0.91); C218(0.96)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C733(0.76); C218(1.07)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C733(1.17); C218(1.03)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C218(1.11)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C218(0.95)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C218(1.01)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C733(1.04); C218(1.00)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C218(0.96)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C218(1.19)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C733(1.00); C218(0.90)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C218(1.20)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C218(1.13)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C733(0.79); C218(0.99)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C733(0.63); C218(0.83)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C733(0.98); C218(1.07)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C733(1.10); C218(1.00)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C218(0.90)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C218(0.90)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C733(1.01); C218(0.81)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C218(0.85)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C218(1.07)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C218(1.16)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C218(1.04)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C218(1.00)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C733(0.86); C218(1.07)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C733(0.69); C218(1.09)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C733(0.76); C218(1.09)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C733(0.92); C218(0.96)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C218(1.03)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C218(1.01)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C218(1.06)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C218(0.99)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C218(0.94)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C218(1.13)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C218(1.12)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C218(1.04)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C733(0.90); C218(1.01)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C733(0.93); C218(1.18)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C733(0.90); C218(1.13)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C733(0.90); C218(1.09)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C218(1.06)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C218(1.01)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C218(1.05)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C218(1.05)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C733(0.77); C218(0.84)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C218(0.87)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C218(1.21)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C218(1.22)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C218(1.15)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C733(0.89); C218(0.97)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C733(0.81); C218(1.07)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C218(1.18)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C733(0.74); C218(1.09)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C733(1.11); C218(1.22)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C218(0.96)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C218(0.90)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C218(1.06)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C218(1.03)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C218(1.12)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C218(1.06)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C218(1.23)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C733(0.92); C218(1.09)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C733(0.86); C218(1.00)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C733(0.85); C218(1.05)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C733(0.86); C218(1.18)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C733(1.09); C218(1.02)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C218(0.93)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C218(1.11)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C218(1.15)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C733(0.88); C218(1.10)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C218(1.02)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C218(1.00)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C733(0.65); C218(0.94)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C218(0.99)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C218(1.04)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C733(0.69); C218(0.87)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C733(0.83); C218(0.86)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C733(1.01); C218(1.03)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C733(0.67); C218(0.97)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C218(0.97)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C218(0.96)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C218(1.07)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C733(0.95); C218(1.02)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C733(1.00); C218(0.85)  LDD1698  [9]
 LDCM0625  F8 Ramos C218(1.12)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C218(1.54)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C218(10.90)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C218(1.27)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C218(0.94)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C218(0.53)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C218(1.11)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C218(0.85)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C218(0.84)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C218(0.78)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C218(1.20)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C218(1.03)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C218(0.90)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C218(0.95)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C733(0.78); C218(0.92)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C218(1.27)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C218(1.07)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C218(1.07)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C218(1.04)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C218(1.51)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C218(1.35)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C218(1.74)  LDD2188  [10]
 LDCM0022  KB02 HEK-293T C218(1.01); C203(0.90)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C218(1.11); C203(1.14)  LDD1497  [9]
 LDCM0024  KB05 COLO792 C820(3.55)  LDD3310  [3]
 LDCM0109  NEM HeLa N.A.  LDD0232  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Volume-regulated anion channel subunit LRRC8A (LRRC8A) LRRC8 family Q8IWT6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578