Details of the Target

General Information of Target

Target ID LDTP07911
Target Name Fibrillin-3 (FBN3)
Gene Name FBN3
Gene ID 84467
Synonyms
KIAA1776; Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLEGLYLARGPLARLLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVC
GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC
SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER
DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNI
HTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLF
GGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLF
PGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCL
NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQA
TPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTM
CVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLG
GLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPA
KDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGK
DCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVC
RNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA
AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGL
MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESL
EFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALD
AQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPL
LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSC
HAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDEC
EENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGS
FVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH
DLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDNGQCLN
APGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGG
GNCTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRG
DSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVI
LEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSGICGPGT
CYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI
GQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQ
IGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG
GACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGT
CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFEL
TADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC
LFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCC
CSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVC
VNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGL
MMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHA
RGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCD
EGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCP
LPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA
TTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL
CVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLV
SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCG
SASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGY
FRAGQGHCVSGLGFSPGPQDTPDKEELLSSEACYECKINGLSPRDRPRRSAHRDHQVNLA
TLDSEALLTLGLNLSHLGRAERILELRPALEGLEGRIRYVIVRGNEQGFFRMHHLRGVSS
LQLGRRRPGPGTYRLEVVSHMAGPWGVQPEGQPGPWGQALRLKVQLQLL
Target Bioclass
Other
Family
Fibrillin family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
[Fibrillin-3]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support.
Uniprot ID
Q75N90
Ensemble ID
ENST00000270509.6
HGNC ID
HGNC:18794

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C500(1.35)  LDD0637  [1]
TFBX
 Probe Info  		N.A.  LDD0027  [2]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0320  AC57 HCT 116 C500(1.35)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C500(1.28)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C500(1.19)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C500(1.12)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C500(1.34)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C500(1.20)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C500(1.13)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C500(1.53)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C500(1.29)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C500(0.95)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C500(1.04)  LDD0648  [1]
 LDCM0349  AC83 HCT 116 C500(1.26)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C500(1.26)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C500(1.37)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C500(1.27)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C500(1.14)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C500(1.04)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C500(1.07)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C500(1.39)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C500(1.11)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C500(1.10)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C500(1.14)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C500(1.72)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C500(1.07)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C500(1.45)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C500(1.61)  LDD0681  [1]
 LDCM0396  CL125 HCT 116 C500(1.23)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C500(1.22)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C500(0.90)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C500(1.14)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C500(1.02)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C500(1.06)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C500(1.28)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C500(1.22)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C500(1.04)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C500(1.08)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C500(1.18)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C500(1.45)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C500(1.34)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C500(1.34)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C500(1.21)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C500(1.28)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C500(1.58)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C500(1.38)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C500(1.29)  LDD0736  [1]
 LDCM0421  CL32 HCT 116 C500(0.50)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C500(0.49)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C500(0.58)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C500(0.68)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C500(0.62)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C500(0.58)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C500(0.54)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C500(0.48)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C500(0.71)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C500(0.34)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C500(0.49)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C500(0.44)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C500(0.71)  LDD0752  [1]
 LDCM0436  CL46 HCT 116 C500(0.98)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C500(1.08)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C500(1.09)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C500(0.99)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C500(1.09)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C500(1.19)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C500(1.07)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C500(1.31)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C500(1.21)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C500(1.36)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C500(1.07)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C500(1.24)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C500(1.22)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C500(1.29)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C500(1.34)  LDD0769  [1]
 LDCM0427  Fragment51 HCT 116 C500(0.50)  LDD0744  [1]
 LDCM0022  KB02 A-375 C1124(1.66); C1526(1.35)  LDD2255  [3]
 LDCM0023  KB03 A-375 C1124(3.07)  LDD2672  [3]
 LDCM0024  KB05 NCI-H1299 C1526(3.02)  LDD3343  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840