Details of the Target

General Information of Target

Target ID LDTP07780
Target Name E3 ubiquitin-protein ligase RNF19B (RNF19B)
Gene Name RNF19B
Gene ID 127544
Synonyms
IBRDC3; NKLAM; E3 ubiquitin-protein ligase RNF19B; EC 2.3.2.31; IBR domain-containing protein 3; Natural killer lytic-associated molecule; RING finger protein 19B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP
LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
TVLKPEGGEARV
Target Bioclass
Enzyme
Family
RBR family, RNF19 subfamily
Subcellular location
Cytoplasmic granule membrane
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death.
Uniprot ID
Q6ZMZ0
Ensemble ID
ENST00000235150.5
HGNC ID
HGNC:26886

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C290(5.00)  LDD0209  [1]
IA-alkyne
 Probe Info  		C290(1.15)  LDD2182  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
YN-1
 Probe Info  		N.A.  LDD0447  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C290(1.15)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C290(1.07); C137(1.08)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C290(1.21); C137(1.01)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C290(1.13); C695(1.15)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C290(1.13)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C290(1.20)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C290(1.18)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C290(1.07); C137(0.97)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C290(1.45); C137(1.30)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C290(0.90); C137(0.91)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C290(1.08); C695(1.14)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C290(1.14)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C290(1.08)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C290(1.00)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C290(0.90)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C290(1.17)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C290(1.11); C137(1.00)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C290(1.18); C137(1.00)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C290(1.08); C695(1.09)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C290(1.04)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C290(1.16); C137(0.96)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C290(1.06)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C290(1.06)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C290(1.04)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C290(1.12)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C290(1.07); C137(1.01)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C290(1.20); C137(1.06)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C290(1.14); C695(0.94)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C290(1.04)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C290(1.04)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C290(1.13)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C290(1.05); C695(1.35)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C290(1.12)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C290(1.24)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C290(1.10); C137(1.00)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C290(1.22); C137(1.08)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C290(1.13); C695(1.17)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C290(1.08)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C290(1.07)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C290(1.17)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C290(1.09)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C290(1.29)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C290(1.12)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C290(1.23); C137(1.01)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C290(1.09); C137(1.09)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C290(1.10); C695(1.17)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C290(1.02)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C290(1.09)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C290(1.22)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C290(1.14)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C290(1.11)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C290(0.96); C137(1.05)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C290(1.06); C137(0.97)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C290(0.98)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C290(1.09); C695(0.92)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C290(1.00)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C290(1.13)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C290(1.07)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C290(1.01)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C290(1.03)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C290(1.00)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C290(1.02)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C290(1.10)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C290(1.10)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C290(1.05)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C290(1.47)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C290(1.01)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C290(0.95)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C290(1.10)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C290(1.08); C137(0.94)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C290(1.06)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C290(0.97)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C290(1.13)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C290(1.14); C137(0.88)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C290(0.95)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C290(1.15)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C290(1.59)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C290(1.23)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C290(1.07); C137(0.94)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C290(0.96)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C290(0.98)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C290(1.04)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C290(1.15); C137(0.99)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C290(0.94)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C290(1.00)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C290(1.07)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C290(1.12); C137(0.92)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C290(1.39)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C290(1.07)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C290(1.11)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C290(1.14)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C290(1.13); C137(1.16)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C290(1.05)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C290(0.92)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C290(0.93)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C290(1.00); C137(0.96)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C290(1.01)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C290(1.00)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C290(1.02)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C290(1.23); C137(1.07)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C290(1.05)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C290(1.30)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C290(1.25); C137(0.96)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C290(1.41); C137(1.09)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C290(1.04)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C290(1.22); C695(1.23)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C290(1.45)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C290(1.41)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C290(1.71)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C290(1.40)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C290(1.05)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C290(1.11)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C290(1.18); C137(0.93)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C290(1.10)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C290(1.28)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C290(1.16); C137(1.06)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C290(1.14); C137(0.95)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C290(1.38); C137(1.10)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C290(1.26); C695(1.06)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C290(1.75)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C290(1.47)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C290(1.73)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C290(1.52)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C290(1.13)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C290(1.14); C137(1.07)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C290(1.02)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C290(1.08)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C290(1.18)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C290(1.05); C137(0.98)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C290(1.17); C137(1.09)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C290(1.18); C695(1.23)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C290(1.43)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C290(1.31)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C290(1.71)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C290(1.42)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C290(1.04)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C290(1.23)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C290(1.04)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C290(1.14)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C290(1.36)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C290(1.37); C137(1.05)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C290(1.27); C137(1.12)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C290(1.37); C695(1.03)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C290(1.43)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C290(1.41)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C290(1.83)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C290(1.19); C137(1.16)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C290(1.49)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C290(0.93)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C290(1.02)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C290(1.21); C137(0.94)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C290(0.98)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C290(1.23)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C290(1.18); C137(1.07)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C290(1.28); C137(1.08)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C290(1.08); C695(0.94)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C290(1.29)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C290(1.18); C137(0.97)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C290(1.45)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C290(1.59)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C290(1.47)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C290(0.93)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C290(1.09)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C290(1.07)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C290(1.27)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C290(1.21); C137(0.92)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C290(1.36); C137(1.11)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C290(1.44); C695(0.85)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C290(1.28); C695(1.28)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C290(1.42)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C290(1.32)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C290(1.53)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C290(1.31)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C290(0.89)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C290(1.03)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C290(1.04); C137(1.07)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C290(0.98)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C290(1.16)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C290(1.31)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C290(1.35); C137(1.39)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C290(1.26); C137(1.07)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C290(1.08); C695(0.90)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C290(1.27)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C290(1.19)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C290(1.35)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C290(1.19)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C290(0.90)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C290(0.99)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C290(1.02); C137(1.06)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C290(1.30); C137(1.00)  LDD1698  [5]
 LDCM0625  F8 Ramos C290(0.96)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C290(0.84)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C290(1.80)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C290(0.67)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C290(1.52)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C290(0.72)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C290(0.67)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C290(0.69)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C290(1.02)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C290(1.11)  LDD2197  [2]
 LDCM0588  Fragment30 Ramos C290(0.98)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C290(1.09)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C290(0.96)  LDD2201  [2]
 LDCM0468  Fragment33 HEK-293T C290(1.16); C137(0.91)  LDD1671  [5]
 LDCM0596  Fragment38 Ramos C290(0.57)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C290(0.83)  LDD2184  [2]
 LDCM0427  Fragment51 HEK-293T C290(1.32)  LDD1631  [5]
 LDCM0610  Fragment52 Ramos C290(3.07)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C290(0.68)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C290(0.96)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C290(0.71)  LDD2188  [2]
 LDCM0022  KB02 HEK-293T C290(0.81); C333(0.83)  LDD1492  [5]
 LDCM0023  KB03 Jurkat C290(5.00)  LDD0209  [1]
 LDCM0024  KB05 SK-MEL-28 C695(1.49)  LDD3427  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mesoderm-specific transcript homolog protein (MEST) AB hydrolase superfamily Q5EB52
Antigen peptide transporter 1 (TAP1) ABCB family Q03518
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) Isoprenylcysteine carboxyl methyltransferase family O60725
Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH) Dihydroorotate dehydrogenase family Q02127
Farnesyl pyrophosphate synthase (FDPS) FPP/GGPP synthase family P14324
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) Ubiquitin-conjugating enzyme family P68036
Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) Ubiquitin-conjugating enzyme family O14933
Uridine-cytidine kinase-like 1 (UCKL1) Uridine kinase family Q9NWZ5
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
B-lymphocyte antigen CD20 (MS4A1) MS4A family P11836
Magnesium transporter NIPA4 (NIPAL4) NIPA family Q0D2K0
Transmembrane protein 208 (TMEM208) TMEM208 family Q9BTX3
Transmembrane protein 100 (TMEM100) . Q9NV29
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
Selenoprotein K (SELENOK) Selenoprotein K family Q9Y6D0
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Asialoglycoprotein receptor 1 (ASGR1) . P07306
C-type lectin domain family 1 member A (CLEC1A) . Q8NC01

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840