Details of the Target

General Information of Target

Target ID LDTP07741
Target Name Myosin phosphatase Rho-interacting protein (MPRIP)
Gene Name MPRIP
Gene ID 23164
Synonyms
KIAA0864; MRIP; RHOIP3; Myosin phosphatase Rho-interacting protein; M-RIP; Rho-interacting protein 3; RIP3; p116Rip
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD
NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC
ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS
SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG
LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR
SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS
ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD
SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK
HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS
KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD
ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH
LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL
QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR
EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA
LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY
ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS
RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQ
VSWDT
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Function
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
Uniprot ID
Q6WCQ1
Ensemble ID
ENST00000341712.8
HGNC ID
HGNC:30321

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.83  LDD0402  [1]
STPyne
 Probe Info  		K390(6.96); K405(5.32); K909(9.92)  LDD0277  [2]
Probe 1
 Probe Info  		Y915(12.38)  LDD3495  [3]
DBIA
 Probe Info  		C831(1.23); C724(1.54)  LDD3311  [4]
BTD
 Probe Info  		C957(1.24)  LDD2109  [5]
AHL-Pu-1
 Probe Info  		C508(2.73)  LDD0168  [6]
HHS-475
 Probe Info  		Y450(0.66)  LDD0264  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_4
 Probe Info  		C724(0.00); C831(0.00); C957(0.00)  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		C724(0.00); C831(0.00); C957(0.00)  LDD0147  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		C120(0.00); C957(0.00); C503(0.00); H779(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		C508(0.00); C957(0.00); C503(0.00); C724(0.00)  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
HHS-465
 Probe Info  		N.A.  LDD2240  [17]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C508(2.73)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C508(2.21); C503(2.29)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C724(0.95); C503(1.11); C508(1.20)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C957(0.94); C831(0.96); C503(1.20)  LDD1508  [19]
 LDCM0237  AC12 HEK-293T C724(0.99); C120(1.02); C831(0.94); C503(1.03)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C957(1.03); C724(1.05); C831(1.05); C503(1.02)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C957(0.97)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C724(1.07); C503(1.08); C508(1.06)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C957(1.00); C831(0.97); C503(1.30)  LDD1516  [19]
 LDCM0279  AC2 HEK-293T C957(0.97); C831(0.88); C503(1.23)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C724(1.07); C120(1.10); C831(1.05); C503(0.99)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C724(0.94); C831(1.03); C503(1.09)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C957(1.04); C724(1.03); C831(1.02); C503(1.03)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C957(0.93)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C957(0.99); C724(1.14); C503(1.13); C508(1.17)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C724(0.90); C503(1.13); C508(1.23)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C957(1.01); C831(0.97); C503(1.15)  LDD1525  [19]
 LDCM0288  AC28 HEK-293T C724(0.99); C120(1.09); C831(0.91); C503(1.16)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C724(0.97); C831(1.01); C503(1.15)  LDD1528  [19]
 LDCM0291  AC30 HEK-293T C957(1.06); C724(1.05); C831(1.07); C503(0.96)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C957(1.01)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C957(1.04); C724(1.11); C503(0.98); C508(1.04)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C724(1.02); C503(1.06); C508(1.19)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C957(0.95); C831(0.98); C503(1.19)  LDD1534  [19]
 LDCM0297  AC36 HEK-293T C724(1.30); C120(1.19); C831(0.98); C503(1.07)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C724(0.95); C831(1.13); C503(1.08)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C957(1.05); C724(0.95); C831(1.07); C503(0.85)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C957(0.92)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C724(1.09); C120(1.04); C831(0.91); C503(1.21)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C957(0.99); C724(1.19); C503(1.05); C508(1.06)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C724(0.96); C503(1.15); C508(1.15)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C957(1.01); C831(1.00); C503(1.44)  LDD1543  [19]
 LDCM0306  AC44 HEK-293T C724(1.15); C120(1.11); C831(0.96); C503(1.14)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C724(1.13); C831(1.24); C503(1.20)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C957(1.06); C724(1.01); C831(1.01); C503(0.94)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C957(0.92)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C957(0.99); C724(1.08); C503(1.11); C508(1.02)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C724(1.06); C503(1.11); C508(1.21)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C724(1.00); C831(1.01); C503(1.13)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C957(0.92); C831(1.00); C503(1.38)  LDD1552  [19]
 LDCM0315  AC52 HEK-293T C724(1.16); C120(1.14); C831(1.00); C503(1.12)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C724(0.96); C831(1.08); C503(1.15)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C957(0.99); C724(0.97); C831(1.00); C503(1.08)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C957(0.89)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C957(1.00); C724(1.11); C503(1.06); C508(1.12)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C724(1.19); C503(1.26); C508(1.11)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C957(0.97); C831(1.01); C503(1.38)  LDD1560  [19]
 LDCM0323  AC6 HEK-293T C957(1.02); C724(1.01); C831(0.96); C503(1.11)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C724(1.07); C120(1.02); C831(0.90); C503(1.12)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C724(0.97); C831(1.09); C503(1.17)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C957(1.02); C724(1.01); C831(1.00); C503(1.02)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C957(0.97)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C957(1.02); C724(1.13); C503(1.24); C508(1.49)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C957(0.85)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C957(1.06); C724(1.32); C503(1.15); C508(1.23)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C724(1.03); C831(1.19); C503(1.17)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C724(1.03); C503(1.20); C508(1.14)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C957(1.03); C724(0.97); C503(1.00); C508(1.18)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C120(0.00); H633(0.00); H481(0.00)  LDD0222  [15]
 LDCM0367  CL1 HEK-293T C503(1.15)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C957(0.93); C724(1.12); C831(1.21); C503(0.75)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C957(1.04); C120(1.04); C503(1.12); C508(1.11)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C503(1.12)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C957(0.92); C724(0.96); C503(0.92)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C957(0.98); C503(0.97)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C957(1.00); C120(1.04); C503(1.00); C508(1.10)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C503(1.09)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C957(0.91); C724(0.79); C503(0.96)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C957(0.95); C503(0.88)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C957(1.04); C120(1.08); C503(1.05); C508(1.16)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C503(1.10)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C957(0.89)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C957(0.86); C724(0.81); C503(0.89)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C957(0.90); C503(0.90)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C957(1.08); C120(0.97); C503(0.92); C508(1.06)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C503(1.01)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C957(0.86); C724(0.90); C503(0.99)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C957(0.94); C503(1.00)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C957(1.04); C120(1.23); C503(1.11); C508(1.08)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C503(1.14)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C957(1.07); C724(1.07); C503(1.16)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C957(0.93); C503(1.03)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C957(0.74); C724(1.12); C503(1.05); C508(0.93)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C957(1.05); C120(1.14); C503(1.04); C508(1.10)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C503(1.07)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C957(0.90); C724(1.00); C503(1.12)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C957(0.87); C503(1.07)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C957(1.04); C120(1.04); C503(1.06); C508(1.09)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C503(1.27)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C957(0.97); C724(0.93); C503(1.09)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C957(1.02); C503(1.27)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C957(1.05); C120(1.07); C503(1.48); C508(1.29)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C503(0.96)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C957(0.87); C724(0.96); C503(1.08)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C957(0.88); C503(0.89)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C957(1.09); C120(1.16); C503(0.95); C508(1.11)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C724(1.13); C503(0.79); C508(0.87)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C957(0.91); C831(1.06); C503(1.25)  LDD1609  [19]
 LDCM0407  CL2 HEK-293T C957(0.92); C724(1.01); C503(0.96)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C724(1.23); C120(1.23); C831(1.00); C503(0.78)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C724(1.11); C831(1.03); C503(1.08)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C957(1.05); C724(0.98); C831(1.27); C503(0.80)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C957(1.08)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C957(0.70); C724(1.29); C503(0.90); C508(0.86)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C503(0.85)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C957(0.83); C724(1.06); C503(0.89)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C957(0.99); C503(0.93)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C957(0.99); C120(1.07); C503(0.86); C508(1.03)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C724(1.11); C503(0.88); C508(1.03)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C957(0.91); C503(0.73)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C957(1.05); C831(1.08); C503(1.20)  LDD1623  [19]
 LDCM0421  CL32 HEK-293T C724(1.13); C120(1.17); C831(1.08); C503(0.95)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C724(1.06); C831(0.87); C503(0.94)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C957(1.12); C724(0.95); C831(1.09); C503(0.79)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C957(1.07)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C957(0.63); C724(1.04); C503(0.88); C508(0.80)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C503(0.94)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C957(0.96); C503(0.89)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C957(1.08); C120(1.14); C503(0.90); C508(1.01)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C957(1.07); C120(1.19); C503(0.86); C508(0.86)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C724(1.03); C503(1.05); C508(1.00)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C957(0.97); C831(0.90); C503(1.17)  LDD1636  [19]
 LDCM0434  CL44 HEK-293T C724(1.09); C120(1.02); C831(0.87); C503(0.98)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C724(1.01); C831(1.10); C503(1.04)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C957(1.15); C724(1.19); C831(1.07); C503(0.95)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C957(1.20)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C957(0.71); C724(1.14); C503(0.97); C508(0.90)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C503(0.96)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C724(1.14); C503(0.91); C508(0.85)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C957(0.88); C724(1.06); C503(0.87)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C957(1.15); C120(1.11); C503(0.96); C508(1.27)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C724(1.22); C503(1.05); C508(1.08)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C957(0.84); C831(0.97); C503(1.08)  LDD1648  [19]
 LDCM0447  CL56 HEK-293T C724(1.04); C120(1.03); C831(0.98); C503(0.92)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C724(1.19); C831(1.01); C503(1.00)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C957(1.14); C724(1.03); C831(1.21); C503(0.75)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C957(1.03)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C957(1.02); C831(0.94); C503(1.16)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C957(0.66); C724(1.07); C503(0.89); C508(0.95)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C503(1.10)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C957(0.90); C724(0.97); C503(0.93)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C957(0.95); C503(0.89)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C957(1.01); C120(1.07); C503(0.90); C508(0.98)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C724(1.11); C503(0.96); C508(1.13)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C957(1.03); C831(1.04); C503(1.15)  LDD1661  [19]
 LDCM0460  CL68 HEK-293T C724(1.10); C120(1.09); C831(1.05); C503(0.94)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C724(1.02); C831(1.06); C503(1.11)  LDD1664  [19]
 LDCM0463  CL70 HEK-293T C957(1.17); C724(0.98); C831(1.32); C503(0.87)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C957(0.98)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C957(0.72); C724(1.16); C503(0.84); C508(0.90)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C503(1.23)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C957(0.99); C724(1.07); C503(0.98)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C957(1.03); C120(1.04); C503(0.95); C508(0.98)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C724(0.82); C503(1.00); C508(1.14)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C957(0.98); C831(0.99); C503(1.29)  LDD1674  [19]
 LDCM0473  CL8 HEK-293T C724(1.19); C120(0.93); C831(0.84); C503(0.91)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C724(1.38); C120(1.04); C831(0.92); C503(0.77)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C724(1.00); C831(1.10); C503(1.08)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C957(1.19); C724(0.99); C831(1.19); C503(0.98)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C957(0.98)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C957(0.77); C724(0.88); C503(0.99); C508(0.90)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C503(1.20)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C957(0.86); C724(0.97); C503(1.17)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C957(0.97); C503(1.08)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C957(1.03); C120(1.13); C503(1.16); C508(0.94)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C724(1.13); C503(1.16); C508(1.28)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C724(1.00); C831(1.19); C503(1.03)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C957(0.86); C831(0.83); C503(0.96)  LDD1688  [19]
 LDCM0487  CL92 HEK-293T C724(1.08); C120(1.13); C831(0.92); C503(0.92)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C724(1.08); C831(1.04); C503(1.11)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C957(1.10); C724(1.00); C831(1.18); C503(0.88)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C957(0.80)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C957(1.03); C724(1.35); C503(1.17); C508(1.16)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C503(1.05)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C957(0.93); C724(0.98); C503(0.93)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C957(0.99); C503(1.09)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C957(0.94); C503(0.81)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C503(1.11); C508(1.06); C831(0.75)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C957(0.94); C503(1.00)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C957(0.91); C724(1.16); C503(0.96)  LDD1631  [19]
 LDCM0116  HHS-0101 DM93 Y450(0.66)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y450(0.62)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y450(0.74)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y450(0.67)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y450(0.74)  LDD0268  [7]
 LDCM0107  IAA HeLa C120(0.00); H630(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C724(0.96); C831(0.98); C508(1.04); C503(0.93)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C724(1.05); C831(1.05); C508(0.98); C503(1.02)  LDD1497  [19]
 LDCM0024  KB05 G361 C831(1.23); C724(1.54)  LDD3311  [4]
 LDCM0109  NEM HeLa H836(0.00); H630(0.00)  LDD0223  [15]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C957(1.24)  LDD2109  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C957(1.80)  LDD2124  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C957(1.01)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C957(2.38)  LDD2137  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402