Details of the Target

General Information of Target

Target ID LDTP07725
Target Name ADAMTS-like protein 4 (ADAMTSL4)
Gene Name ADAMTSL4
Gene ID 54507
Synonyms
TSRC1; ADAMTS-like protein 4; ADAMTSL-4; Thrombospondin repeat-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC
GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG
RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR
SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV
APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD
PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP
IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL
NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD
DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW
AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS
SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP
LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG
TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL
RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP
CTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDM
RACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPP
ALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPC
NSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCAHVLERSPQDPS
Target Bioclass
Enzyme
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.
Uniprot ID
Q6UY14
Ensemble ID
ENST00000271643.9
HGNC ID
HGNC:19706

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.D1031N .
COLO678 SNV: p.E753G .
JURKAT SNV: p.Q821Ter .
KNS81FD Substitution: p.P828L .
LNCaP clone FGC SNV: p.C926Y .
LU65 SNV: p.H324R .
MDAMB231 SNV: p.Q1032K .
MELJUSO SNV: p.C705Ter .
MEWO SNV: p.M838I .
MOLT4 SNV: p.Q211K .
SNGM SNV: p.L95I .
WM2664 Insertion: p.P303SfsTer29 .
YSCCC SNV: p.E607Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C474(0.68); C484(0.54)  LDD1093  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C474(0.68); C484(0.54)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C477(0.85); C474(1.21); C484(1.19)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C477(0.92); C474(0.86); C484(0.98)  LDD1105  [1]
 LDCM0230  AC113 PaTu 8988t C474(0.65); C484(0.65)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C474(1.16); C484(1.16)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C474(0.78); C484(0.78)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C474(0.75); C484(0.75)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C474(1.00); C484(1.00)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C474(0.89); C484(0.89)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C474(0.71); C484(0.71)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C477(0.85); C474(1.11); C484(0.92)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C474(0.81); C484(0.81)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C474(0.67); C484(0.67)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C474(0.98); C484(0.98)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C474(0.79); C484(0.79)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C474(0.62); C484(0.62)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C474(1.01); C484(1.01)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C474(0.75); C484(0.75)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C474(0.83); C484(0.83)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C477(1.15); C474(1.15); C484(1.15)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C477(0.77); C474(0.77); C484(0.77)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C477(0.76); C474(0.76); C484(0.76)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C477(1.07); C474(1.07); C484(1.07)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C477(1.15); C474(1.15); C484(1.15)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C477(1.29); C474(1.29); C484(1.29)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C477(0.79); C474(0.79); C484(0.79)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C477(1.08); C474(1.08); C484(1.08)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C477(0.93); C474(0.93); C484(0.93)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C477(1.03); C474(1.03); C484(1.03)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C477(0.86); C474(0.86); C484(0.86)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C477(1.24); C474(1.24); C484(1.24)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C477(0.82); C474(1.01); C484(0.98)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C477(0.90); C474(0.90); C484(0.90)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C477(1.31); C474(1.31); C484(1.31)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C477(1.32); C474(1.32); C484(1.32)  LDD1141  [1]
 LDCM0270  AC15 PaTu 8988t C477(0.88); C474(1.17); C484(1.07)  LDD1149  [1]
 LDCM0276  AC17 PaTu 8988t C477(0.87); C474(0.92); C484(0.92)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C477(0.74); C474(1.10); C484(0.93)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C477(0.76); C474(1.11); C484(0.85)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C474(0.81); C484(0.54)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C477(0.74); C474(1.00); C484(1.20)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C477(0.92); C474(1.04); C484(0.89)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C477(0.77); C474(0.92); C484(0.99)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C477(0.80); C474(0.98); C484(0.99)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C477(0.74); C474(1.16); C484(1.04)  LDD1163  [1]
 LDCM0285  AC25 PaTu 8988t C474(0.81); C484(0.81)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C474(0.67); C484(0.67)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C474(0.93); C484(0.93)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C474(0.86); C484(0.86)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C474(0.85); C484(0.85)  LDD1168  [1]
 LDCM0290  AC3 PaTu 8988t C474(0.78); C484(0.53)  LDD1169  [1]
 LDCM0291  AC30 PaTu 8988t C474(0.88); C484(0.88)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C474(0.73); C484(0.73)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C474(0.88); C484(0.88)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C474(0.89); C484(0.89)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C474(0.95); C484(0.95)  LDD1174  [1]
 LDCM0296  AC35 PaTu 8988t C484(1.06)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C484(1.31)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C484(0.82)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C484(0.95)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C484(1.06)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C474(0.74); C484(0.56)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C484(1.11)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C484(1.14)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C484(0.99)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C484(1.11)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C484(0.82)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C484(1.23)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C477(1.15); C474(1.07); C484(1.07)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C477(0.73); C474(0.78); C484(0.78)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C477(0.99); C474(1.03); C484(1.03)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C477(0.98); C474(0.92); C484(0.92)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C474(0.64); C484(0.51)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C477(0.69); C474(0.80); C484(0.80)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C477(0.29); C474(0.25); C484(0.25)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C477(0.79); C474(0.92); C484(0.92)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C477(1.11); C474(1.03); C484(1.03)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C477(0.76); C474(0.74); C484(0.74)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C477(1.01); C474(1.14); C484(1.14)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C477(0.87); C474(0.95); C484(0.95)  LDD1198  [1]
 LDCM0320  AC57 PaTu 8988t C477(1.07); C484(1.07)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C477(0.96); C484(0.96)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C477(0.91); C484(0.91)  LDD1201  [1]
 LDCM0323  AC6 PaTu 8988t C477(0.89); C474(1.05); C484(1.00)  LDD1202  [1]
 LDCM0324  AC60 PaTu 8988t C477(0.98); C484(0.98)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C477(2.28); C484(2.28)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C477(1.27); C484(1.27)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C477(1.13); C484(1.13)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C477(1.18); C484(1.18)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C477(0.94); C484(0.94)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C477(1.04); C484(1.04)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C477(1.26); C484(1.26)  LDD1210  [1]
 LDCM0332  AC68 PaTu 8988t C474(0.81); C484(0.81)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C474(0.78); C484(0.78)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C477(0.80); C474(1.72); C484(1.20)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C474(0.73); C484(0.73)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C474(0.79); C484(0.79)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C474(0.79); C484(0.79)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C474(0.79); C484(0.79)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C474(0.47); C484(0.47)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C474(0.93); C484(0.93)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C474(0.85); C484(0.85)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C474(0.77); C484(0.77)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C474(0.70); C484(0.70)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C474(0.77); C484(0.77)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C477(1.06); C474(1.50); C484(1.20)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C474(0.56); C484(0.56)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C474(0.85); C484(0.85)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C474(0.67); C484(0.67)  LDD1227  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C477(1.10); C474(1.21); C484(1.22)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C477(0.81); C474(1.24); C484(1.05)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C477(0.79); C474(1.28); C484(1.03)  LDD1154  [1]
 LDCM0367  CL1 PaTu 8988t C477(1.27); C474(1.04); C484(1.01)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C477(1.33); C474(1.39); C484(1.41)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C474(0.63); C484(0.44)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C477(1.00); C474(1.56); C484(1.11)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C477(1.16); C474(1.41); C484(1.16)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C477(1.03); C474(1.23); C484(1.44)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C477(0.89); C474(0.97); C484(1.03)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C477(0.89); C474(1.17); C484(1.11)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C477(0.73); C474(1.07); C484(1.01)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C477(0.58); C474(0.97); C484(0.76)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C477(0.79); C474(1.05); C484(1.00)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C477(0.73); C474(1.17); C484(1.05)  LDD1257  [1]
 LDCM0379  CL11 PaTu 8988t C477(0.95); C474(1.06); C484(0.86)  LDD1258  [1]
 LDCM0380  CL110 PaTu 8988t C477(0.84); C474(1.16); C484(1.17)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C477(0.69); C474(0.89); C484(0.85)  LDD1260  [1]
 LDCM0382  CL112 PaTu 8988t C474(0.92); C484(0.92)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C474(0.93); C484(0.93)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C474(1.09); C484(1.09)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C474(0.83); C484(0.83)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C474(1.14); C484(1.14)  LDD1265  [1]
 LDCM0387  CL117 PaTu 8988t C484(1.28)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C484(1.05)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C484(0.99)  LDD1268  [1]
 LDCM0390  CL12 PaTu 8988t C477(1.14); C474(1.08); C484(1.02)  LDD1269  [1]
 LDCM0391  CL120 PaTu 8988t C484(1.37)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C477(1.15); C474(1.13); C484(1.13)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C477(1.08); C474(1.00); C484(1.00)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C477(2.37); C474(1.72); C484(1.72)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C477(0.90); C474(0.81); C484(0.81)  LDD1274  [1]
 LDCM0396  CL125 PaTu 8988t C477(1.27); C484(1.27)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C477(0.99); C484(0.99)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C477(1.14); C484(1.14)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C477(1.04); C484(1.04)  LDD1278  [1]
 LDCM0400  CL13 PaTu 8988t C477(0.86); C474(0.96); C484(0.93)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C477(0.93); C474(1.06); C484(0.86)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C477(3.40); C474(2.33); C484(2.16)  LDD1281  [1]
 LDCM0403  CL16 PaTu 8988t C474(1.43); C484(1.43)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C474(1.88); C484(1.88)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C474(0.86); C484(0.86)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C474(1.05); C484(1.05)  LDD1285  [1]
 LDCM0407  CL2 PaTu 8988t C477(1.67); C474(1.30); C484(1.27)  LDD1286  [1]
 LDCM0408  CL20 PaTu 8988t C474(0.96); C484(0.96)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C474(1.15); C484(1.15)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C474(1.19); C484(1.19)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C474(1.30); C484(1.30)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C474(1.27); C484(1.27)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C474(1.81); C484(1.81)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C474(1.16); C484(1.16)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C474(1.55); C484(1.55)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C474(1.71); C484(1.71)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C474(1.57); C484(1.57)  LDD1296  [1]
 LDCM0418  CL3 PaTu 8988t C477(1.56); C474(1.39); C484(1.32)  LDD1297  [1]
 LDCM0419  CL30 PaTu 8988t C474(1.50); C484(1.50)  LDD1298  [1]
 LDCM0420  CL31 PaTu 8988t C477(1.00); C474(0.94); C484(0.94)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C477(0.93); C474(0.87); C484(0.87)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C477(0.84); C474(1.12); C484(1.12)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C477(0.81); C474(1.06); C484(1.06)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C477(1.17); C474(1.09); C484(1.09)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C477(0.99); C474(0.81); C484(0.81)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C477(0.90); C474(0.95); C484(0.95)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C477(0.87); C474(0.92); C484(0.92)  LDD1307  [1]
 LDCM0429  CL4 PaTu 8988t C477(1.42); C474(1.25); C484(1.37)  LDD1308  [1]
 LDCM0430  CL40 PaTu 8988t C477(0.74); C474(0.82); C484(0.82)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C477(0.83); C474(0.85); C484(0.85)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C477(0.62); C474(0.76); C484(0.76)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C477(0.46); C474(0.90); C484(0.90)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C477(0.82); C474(0.93); C484(0.93)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C477(1.45); C474(1.13); C484(1.13)  LDD1314  [1]
 LDCM0436  CL46 PaTu 8988t C474(1.10); C484(1.03)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C474(0.82); C484(0.72)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C474(0.82); C484(0.83)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C474(0.92); C484(1.25)  LDD1318  [1]
 LDCM0440  CL5 PaTu 8988t C477(0.74); C474(0.87); C484(0.82)  LDD1319  [1]
 LDCM0441  CL50 PaTu 8988t C474(1.00); C484(0.86)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C474(0.72); C484(0.85)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C474(0.83); C484(1.15)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C474(0.77); C484(0.77)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C474(1.18); C484(0.97)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C474(0.80); C484(1.06)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C474(0.40); C484(0.29)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C474(0.68); C484(0.99)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C474(0.72); C484(1.17)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C474(0.66); C484(0.95)  LDD1329  [1]
 LDCM0451  CL6 PaTu 8988t C477(1.67); C474(1.38); C484(1.37)  LDD1330  [1]
 LDCM0452  CL60 PaTu 8988t C474(0.71); C484(0.93)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C477(0.68); C474(1.16); C484(1.16)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C477(0.65); C474(1.35); C484(1.35)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C477(0.90); C474(1.39); C484(1.39)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C477(0.47); C474(1.17); C484(1.17)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C477(0.54); C474(1.06); C484(1.06)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C477(0.55); C474(1.09); C484(1.09)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C477(0.91); C474(1.56); C484(1.56)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C477(1.00); C474(1.63); C484(1.63)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C477(1.03); C474(1.22); C484(1.22)  LDD1340  [1]
 LDCM0462  CL7 PaTu 8988t C477(1.06); C474(0.97); C484(0.95)  LDD1341  [1]
 LDCM0463  CL70 PaTu 8988t C477(0.93); C474(1.78); C484(1.78)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C477(0.57); C474(1.52); C484(1.52)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C477(0.54); C474(0.96); C484(0.96)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C477(1.01); C474(2.18); C484(2.18)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C477(0.56); C474(1.36); C484(1.36)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C474(1.24); C484(1.11)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C474(0.78); C484(0.68)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C474(1.08); C484(1.19)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C474(0.69); C484(0.80)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C477(1.33); C474(1.17); C484(1.22)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C474(0.75); C484(1.05)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C474(1.00); C484(0.88)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C474(1.21); C484(1.01)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C474(0.94); C484(0.88)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C474(0.73); C484(0.81)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C474(1.69); C484(1.28)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C474(1.04); C484(0.89)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C474(1.09); C484(0.95)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C474(0.76); C484(0.89)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C474(0.73); C484(1.07)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C477(1.25); C474(1.24); C484(1.25)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C474(1.01); C484(0.97)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C474(0.68); C484(0.45)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C474(0.72); C484(0.49)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C474(0.60); C484(0.40)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C474(0.63); C484(0.46)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C474(0.66); C484(0.63)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C474(0.94); C484(0.58)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C474(0.75); C484(0.49)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C474(0.77); C484(0.52)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C474(0.69); C484(0.46)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C477(0.66); C474(1.29); C484(1.29)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C477(0.94); C474(0.90); C484(0.90)  LDD1306  [1]
 LDCM0022  KB02 J82 C762(1.89)  LDD2402  [2]
 LDCM0023  KB03 HT-1376 C762(1.52)  LDD2787  [2]
 LDCM0024  KB05 HT-1376 C762(1.72)  LDD3204  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 46 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Alkaline phosphatase, placental type (ALPP) Alkaline phosphatase family P05187
Glycine amidinotransferase, mitochondrial (GATM) Amidinotransferase family P50440
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Cytochrome P450 2S1 (CYP2S1) Cytochrome P450 family Q96SQ9
DNA polymerase delta catalytic subunit (POLD1) DNA polymerase type-B family P28340
Fumarylacetoacetase (FAH) FAH family P16930
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) FKBP-type PPIase family P68106
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Glutathione S-transferase P (GSTP1) Pi family P09211
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) Helicase family P19447
Inositol hexakisphosphate kinase 1 (IP6K1) Inositol phosphokinase (IPK) family Q92551
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (QPRT) NadC/ModD family Q15274
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Cathepsin B (CTSB) Peptidase C1 family P07858
Caspase-6 (CASP6) Peptidase C14A family P55212
Ubiquitin carboxyl-terminal hydrolase 21 (USP21) Peptidase C19 family Q9UK80
Hepatocyte growth factor (HGF) Peptidase S1 family P14210
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
Serine/threonine-protein kinase Nek8 (NEK8) NEK Ser/Thr protein kinase family Q86SG6
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) Protein-tyrosine phosphatase family Q8WUK0
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
Ras-related protein Rab-2B (RAB2B) Rab family Q8WUD1
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Rho-related GTP-binding protein RhoJ (RHOJ) Rho family Q9H4E5
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
DNA topoisomerase 3-beta-1 (TOP3B) Type IA topoisomerase family O95985
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) UDP-N-acetylglucosamine 2-epimerase family; ROK (NagC/XylR) family Q9Y223
Ataxin-3 (ATXN3) . P54252
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
F-box only protein 17 (FBXO17) . Q96EF6
Germ cell-less protein-like 2 (GMCL2) . Q8NEA9
Josephin-1 (JOSD1) . Q15040
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
RING finger and CHY zinc finger domain-containing protein 1 (RCHY1) . Q96PM5
Transporter and channel
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Transmembrane protein 150A (TMEM150A) DRAM/TMEM150 family Q86TG1
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) Ligand-gated ion channel family P43681
Solute carrier family 23 member 1 (SLC23A1) Nucleobase:cation symporter-2 (NCS2) family Q9UHI7
Phospholipid scramblase 4 (PLSCR4) Phospholipid scramblase family Q9NRQ2
Na(+)/citrate cotransporter (SLC13A5) SLC13A/DASS transporter family Q86YT5
Alpha-crystallin B chain (CRYAB) Small heat shock protein (HSP20) family P02511
Sodium- and chloride-dependent transporter XTRP3 (SLC6A20) Sodium:neurotransmitter symporter (SNF) family Q9NP91
Slit homolog 1 protein (SLIT1) . O75093
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Protein c-Fos (FOS) BZIP family P01100
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Nuclear receptor subfamily 4 group A member 3 (NR4A3) Nuclear hormone receptor family Q92570
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
POU domain, class 4, transcription factor 2 (POU4F2) POU transcription factor family Q12837
SWI/SNF complex subunit SMARCC1 (SMARCC1) SMARCC family Q92922
Endothelial transcription factor GATA-2 (GATA2) . P23769
Homeobox protein VENTX (VENTX) . O95231
THAP domain-containing protein 6 (THAP6) . Q8TBB0
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuromedin-U receptor 2 (NMUR2) G-protein coupled receptor 1 family Q9GZQ4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4) LRFN family Q6PJG9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transforming growth factor beta-1 proprotein (TGFB1) TGF-beta family P01137
Other
Click To Hide/Show 99 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L6 (APOL6) Apolipoprotein L family Q9BWW8
Active regulator of SIRT1 (RPS19BP1) AROS family Q86WX3
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
Chordin (CHRD) Chordin family Q9H2X0
Copine-7 (CPNE7) Copine family Q9UBL6
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Cystatin-SA (CST2) Cystatin family P09228
Mammalian ependymin-related protein 1 (EPDR1) Ependymin family Q9UM22
Eukaryotic translation initiation factor 4E type 2 (EIF4E2) Eukaryotic initiation factor 4E family O60573
Protein FAM124B (FAM124B) FAM124 family Q9H5Z6
F-box/WD repeat-containing protein 5 (FBXW5) FBXW5 family Q969U6
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GNG13) G protein gamma family Q9P2W3
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Gastric inhibitory polypeptide (GIP) Glucagon family P09681
Putative golgin subfamily A member 8D (GOLGA8DP) GOLGA8 family Q0D2H9
Protein DGCR6L (DGCR6L) Gonadal family Q9BY27
Progranulin (GRN) Granulin family P28799
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Insulin (INS) Insulin family P01308
Integrin beta-2 (ITGB2) Integrin beta chain family P05107
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-5 (KRTAP1-5) KRTAP type 1 family Q9BYS1
Keratin-associated protein 10-11 (KRTAP10-11) KRTAP type 10 family P60412
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 19-2 (KRTAP19-2) KRTAP type 19 family Q3LHN2
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 4-4 (KRTAP4-4) KRTAP type 4 family Q9BYR3
Keratin-associated protein 5-2 (KRTAP5-2) KRTAP type 5 family Q701N4
Keratin-associated protein 5-3 (KRTAP5-3) KRTAP type 5 family Q6L8H2
Keratin-associated protein 5-4 (KRTAP5-4) KRTAP type 5 family Q6L8H1
Keratin-associated protein 5-6 (KRTAP5-6) KRTAP type 5 family Q6L8G9
Keratin-associated protein 5-7 (KRTAP5-7) KRTAP type 5 family Q6L8G8
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Keratin-associated protein 9-4 (KRTAP9-4) KRTAP type 9 family Q9BYQ2
Late cornified envelope protein 1A (LCE1A) LCE family Q5T7P2
Late cornified envelope protein 1B (LCE1B) LCE family Q5T7P3
Late cornified envelope protein 1C (LCE1C) LCE family Q5T751
Late cornified envelope protein 1F (LCE1F) LCE family Q5T754
Late cornified envelope protein 2A (LCE2A) LCE family Q5TA79
Late cornified envelope protein 2B (LCE2B) LCE family O14633
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Late cornified envelope protein 2D (LCE2D) LCE family Q5TA82
Late cornified envelope protein 3A (LCE3A) LCE family Q5TA76
Late cornified envelope protein 3C (LCE3C) LCE family Q5T5A8
Late cornified envelope protein 3D (LCE3D) LCE family Q9BYE3
Late cornified envelope protein 3E (LCE3E) LCE family Q5T5B0
Late cornified envelope protein 4A (LCE4A) LCE family Q5TA78
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Protein NATD1 (NATD1) NATD1 family Q8N6N6
Neurotrophin-4 (NTF4) NGF-beta family P34130
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) SHFL family Q9NUL5
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Protein sprouty homolog 1 (SPRY1) Sprouty family O43609
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Gelsolin (GSN) Villin/gelsolin family P06396
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Brorin (VWC2) . Q2TAL6
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
C-type lectin domain family 18 member A (CLEC18A) . A5D8T8
Calcium homeostasis endoplasmic reticulum protein (CHERP) . Q8IWX8
Chromobox protein homolog 3 (CBX3) . Q13185
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2) . Q9Y6H1
Down syndrome critical region protein 8 (DSCR8) . Q96T75
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
FMR1-interacting protein NUFIP2 (NUFIP2) . Q7Z417
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Keratin-associated protein 21-2 (KRTAP21-2) . Q3LI59
LIM domain transcription factor LMO4 (LMO4) . P61968
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Noelin-3 (OLFM3) . Q96PB7
Nuclear protein AMMECR1 (AMMECR1) . Q9Y4X0
Placental protein 13-like (LGALS14) . Q8TCE9
PTB-containing, cubilin and LRP1-interacting protein (PID1) . Q7Z2X4
R3H domain-containing protein 2 (R3HDM2) . Q9Y2K5
Ral guanine nucleotide dissociation stimulator-like 2 (RGL2) . O15211
Rhombotin-1 (LMO1) . P25800
Rhombotin-2 (LMO2) . P25791
RING finger protein 11 (RNF11) . Q9Y3C5
Serine protease inhibitor Kazal-type 2 (SPINK2) . P20155
Spermatogenesis-associated protein 8 (SPATA8) . Q6RVD6
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Sushi domain-containing protein 6 (SUSD6) . Q92537
Tether containing UBX domain for GLUT4 (ASPSCR1) . Q9BZE9
Vasorin (VASN) . Q6EMK4

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840