Details of the Target

General Information of Target

Target ID LDTP07416
Target Name rRNA methyltransferase 1, mitochondrial (MRM1)
Gene Name MRM1
Gene ID 79922
Synonyms
rRNA methyltransferase 1, mitochondrial; EC 2.1.1.-; 16S rRNA; guanosine(1145)-2'-O)-methyltransferase; 16S rRNA [Gm1145] 2'-O-methyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLSTVRGATWGRLVTRHFSHAARHGERPGGEELSRLLLDDLVPTSRLELLFGMTPCLL
ALQAARRSVARLLLQAGKAGLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVC
MEVSPLRPRPWREAGEASPGDDPQQLWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRN
SCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGCPSTEDPQSSEIPI
MSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTILPRRQLPPGLESLNVSVAAGILL
HSICSQRKGFPTEGERRQLLQDPQEPSARSEGLSMAQHPGLSSGPEKERQNEG
Target Bioclass
Enzyme
Family
Class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase TrmH family
Subcellular location
Mitochondrion
Function
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Uniprot ID
Q6IN84
Ensemble ID
ENST00000611231.2
HGNC ID
HGNC:26202

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 Substitution: p.V149P .
COLO679 SNV: p.V171E DBIA    Probe Info 
HEC1 SNV: p.Q217H .
HEP3B217 Substitution: p.V149P DBIA    Probe Info 
HT Substitution: p.V149P .
IPC298 SNV: p.P186S DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.A222V .
MDAMB436 Substitution: p.V149P .
MFE296 SNV: p.M110L .
MOLM13 Substitution: p.V149P .
NCIH1155 SNV: p.P285L .
NCIH1993 Substitution: p.V149P .
REH SNV: p.A295V .
SKNMC Insertion: p.V149PfsTer43 .
SW948 SNV: p.K106T .
TF1 Substitution: p.V149P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K173(10.00)  LDD0277  [1]
BTD
 Probe Info  		C182(0.52)  LDD2127  [2]
DBIA
 Probe Info  		C182(61.53)  LDD0209  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		C58(0.00); C182(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C182(1.00)  LDD1507  [11]
 LDCM0215  AC10 HCT 116 C182(1.03)  LDD0532  [12]
 LDCM0226  AC11 HCT 116 C182(0.96)  LDD0543  [12]
 LDCM0237  AC12 HCT 116 C182(1.00)  LDD0554  [12]
 LDCM0259  AC14 HCT 116 C182(0.96)  LDD0576  [12]
 LDCM0270  AC15 HCT 116 C182(0.96)  LDD0587  [12]
 LDCM0276  AC17 HEK-293T C182(1.08)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C182(0.98)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C182(1.07)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C182(1.01)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C182(1.14)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C182(1.05)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C182(1.07)  LDD1521  [11]
 LDCM0284  AC24 HEK-293T C182(1.05)  LDD1523  [11]
 LDCM0285  AC25 HCT 116 C182(1.03)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C182(1.03)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C182(0.86)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C182(0.97)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C182(0.85)  LDD0606  [12]
 LDCM0290  AC3 HEK-293T C182(0.90)  LDD1529  [11]
 LDCM0291  AC30 HCT 116 C182(0.83)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C182(0.97)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C182(0.97)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C182(0.90)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C182(0.79)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C182(0.98)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C182(0.95)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C182(1.02)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C182(0.96)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C182(1.06)  LDD0617  [12]
 LDCM0301  AC4 HEK-293T C182(0.89)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C182(0.99)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C182(1.00)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C182(1.08)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C182(0.99)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C182(1.06)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C182(0.98)  LDD0624  [12]
 LDCM0308  AC46 HEK-293T C182(1.16)  LDD1547  [11]
 LDCM0310  AC48 HEK-293T C182(1.18)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C182(1.19)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C182(1.07)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C182(1.09)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C182(0.94)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C182(1.02)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C182(1.18)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C182(1.18)  LDD1556  [11]
 LDCM0319  AC56 HEK-293T C182(1.14)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C182(1.05)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C182(1.01)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C182(1.07)  LDD1561  [11]
 LDCM0323  AC6 HCT 116 C182(0.94)  LDD0640  [12]
 LDCM0324  AC60 HEK-293T C182(1.08)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C182(1.04)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C182(1.05)  LDD1565  [11]
 LDCM0328  AC64 HEK-293T C182(0.97)  LDD1567  [11]
 LDCM0332  AC68 HCT 116 C182(0.81)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C182(0.86)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C182(0.97)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C182(0.87)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C182(0.80)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C182(0.84)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C182(0.98)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C182(0.80)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C182(0.86)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C182(0.92)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C182(0.93)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C182(0.99)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C182(0.86)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C182(0.93)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C182(0.89)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C182(0.85)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C182(0.83)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C182(1.07)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C182(0.99)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C182(1.05)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C182(0.98)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C182(0.93)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C182(1.02)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C182(0.98)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C182(1.11)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C182(1.18)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C182(1.04)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C182(0.87)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C182(1.16)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C182(1.19)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C182(1.15)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C182(1.12)  LDD0681  [12]
 LDCM0248  AKOS034007472 HCT 116 C182(0.97)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C182(1.06)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C182(0.92)  LDD0592  [12]
 LDCM0367  CL1 HEK-293T C182(1.20)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C182(1.15)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C182(1.03)  LDD1573  [11]
 LDCM0370  CL101 HCT 116 C182(0.91)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C182(1.00)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C182(1.05)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C182(0.86)  LDD0690  [12]
 LDCM0374  CL105 HEK-293T C182(1.17)  LDD1578  [11]
 LDCM0377  CL108 HEK-293T C182(1.04)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C182(0.96)  LDD1582  [11]
 LDCM0382  CL112 HCT 116 C182(0.89)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C182(0.92)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C182(0.83)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C182(0.98)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C182(1.07)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C182(0.93)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C182(1.08)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C182(1.09)  LDD0706  [12]
 LDCM0390  CL12 HEK-293T C182(1.02)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C182(0.96)  LDD0708  [12]
 LDCM0392  CL121 HEK-293T C182(1.08)  LDD1596  [11]
 LDCM0395  CL124 HEK-293T C182(1.11)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C182(1.13)  LDD1600  [11]
 LDCM0399  CL128 HEK-293T C182(0.98)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C182(1.06)  LDD1604  [11]
 LDCM0403  CL16 HEK-293T C182(1.14)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C182(1.26)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C182(1.01)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C182(0.93)  LDD1610  [11]
 LDCM0408  CL20 HEK-293T C182(1.26)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C182(1.24)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C182(1.09)  LDD1614  [11]
 LDCM0412  CL24 HEK-293T C182(1.06)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C182(0.94)  LDD1617  [11]
 LDCM0416  CL28 HEK-293T C182(1.09)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C182(0.95)  LDD1621  [11]
 LDCM0419  CL30 HEK-293T C182(1.05)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C182(0.99)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C182(1.36)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C182(1.25)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C182(1.17)  LDD1627  [11]
 LDCM0425  CL36 HEK-293T C182(1.09)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C182(0.99)  LDD1630  [11]
 LDCM0429  CL4 HEK-293T C182(0.90)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C182(0.91)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C182(1.50)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C182(1.05)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C182(1.18)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C182(1.02)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C182(1.08)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C182(1.27)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C182(0.97)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C182(1.12)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C182(1.21)  LDD0756  [12]
 LDCM0440  CL5 HEK-293T C182(1.10)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C182(1.10)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C182(1.26)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C182(1.22)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C182(0.87)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C182(1.03)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C182(0.85)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C182(0.80)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C182(0.99)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C182(1.09)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C182(1.01)  LDD0767  [12]
 LDCM0451  CL6 HEK-293T C182(1.11)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C182(1.27)  LDD0769  [12]
 LDCM0453  CL61 HEK-293T C182(1.01)  LDD1656  [11]
 LDCM0456  CL64 HEK-293T C182(1.11)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C182(1.19)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C182(1.13)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C182(0.94)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C182(1.22)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C182(1.23)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C182(0.86)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C182(1.16)  LDD1666  [11]
 LDCM0465  CL72 HEK-293T C182(1.01)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C182(1.01)  LDD1669  [11]
 LDCM0469  CL76 HEK-293T C182(0.95)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C182(1.01)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C182(1.10)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C182(1.18)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C182(1.02)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C182(1.25)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C182(1.19)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C182(1.15)  LDD1679  [11]
 LDCM0478  CL84 HEK-293T C182(1.08)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C182(1.01)  LDD1682  [11]
 LDCM0482  CL88 HEK-293T C182(1.04)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C182(1.19)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C182(1.11)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C182(1.15)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C182(1.06)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C182(1.18)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C182(1.15)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C182(1.16)  LDD1692  [11]
 LDCM0491  CL96 HEK-293T C182(1.12)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C182(0.98)  LDD1695  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C182(1.10)  LDD1702  [2]
 LDCM0022  KB02 HEK-293T C182(1.03)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C182(61.53)  LDD0209  [3]
 LDCM0024  KB05 RVH421 C111(1.23)  LDD3320  [13]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C182(0.52)  LDD2127  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Inactive ribonuclease-like protein 10 (RNASE10) Pancreatic ribonuclease family Q5GAN6
Caspase-6 (CASP6) Peptidase C14A family P55212
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) VKOR family Q8N0U8
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein cornichon homolog 1 (CNIH1) Cornichon family O95406
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Statherin (STATH) Histatin/statherin family P02808
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Aquaporin-2 (AQP2) MIP/aquaporin (TC 1.A.8) family P41181
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Adiponectin (ADIPOQ) . Q15848
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 3 (CMTM3) Chemokine-like factor family Q96MX0
C-C motif chemokine 4 (CCL4) Intercrine beta (chemokine CC) family P13236
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
Protein MAL2 (MAL2) MAL family Q969L2
LRP chaperone MESD (MESD) MESD family Q14696
Nurim (NRM) Nurim family Q8IXM6
NXPE family member 3 (NXPE3) NXPE family Q969Y0
Selenoprotein K (SELENOK) Selenoprotein K family Q9Y6D0
Spexin (SPX) Spexin family Q9BT56
Synaptotagmin-3 (SYT3) Synaptotagmin family Q9BQG1
Syntaxin-7 (STX7) Syntaxin family O15400
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Gelsolin (GSN) Villin/gelsolin family P06396
Alpha-tocopherol transfer protein (TTPA) . P49638
CGG triplet repeat-binding protein 1 (CGGBP1) . Q9UFW8
DnaJ homolog subfamily C member 30, mitochondrial (DNAJC30) . Q96LL9
Killer cell lectin-like receptor subfamily G member 1 (KLRG1) . Q96E93
Transmembrane protein 42 (TMEM42) . Q69YG0
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840