Details of the Target

General Information of Target

Target ID LDTP07316
Target Name Protein fantom (RPGRIP1L)
Gene Name RPGRIP1L
Gene ID 23322
Synonyms
FTM; KIAA1005; NPHP8; Protein fantom; Nephrocystin-8; RPGR-interacting protein 1-like protein; RPGRIP1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE
NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH
ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF
QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE
NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR
ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE
NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL
VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL
VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL
QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL
ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ
YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK
GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS
STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD
HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT
DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP
RPKPRQRLTPVDKKVSFVDIMPHQSDETSPPPEDRKEISPEVEHIPEIEINMLTVPHVPK
VSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSA
SDSDDCIIPGPISKNIKQSLALSPGLGCSSAISAHCNFRLPGSSDFPASASQVDGITGAC
HHTQPSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVY
YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHV
DLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA
Target Bioclass
Other
Family
RPGRIP1 family
Subcellular location
Cytoplasm
Function
Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2.
Uniprot ID
Q68CZ1
Ensemble ID
ENST00000262135.9
HGNC ID
HGNC:29168

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Q684R .
CAL51 Deletion: p.N131TfsTer3 .
DU145 SNV: p.H1017R .
HUH7 SNV: p.D73E .
IGR1 SNV: p.D1285E .
MFE319 SNV: p.H120Y; p.N349D .
MOLT4 Deletion: p.S707AfsTer10 .
OSRC2 SNV: p.V663G .
RL952 Deletion: p.S952CfsTer2 .
SNU1 SNV: p.T1034A .
SW480 SNV: p.Q138Ter .
TE4 SNV: p.Q116L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C798(0.75); C799(0.75)  LDD0533  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C798(0.75); C799(0.75)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C798(0.82); C799(0.82)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C798(0.79); C799(0.79)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C798(0.85); C799(0.85)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C798(0.68); C799(0.68)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C798(1.08); C799(1.08)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C798(1.07); C799(1.07)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C798(0.75); C799(0.75)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C798(1.04); C799(1.04)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C798(0.68); C799(0.68)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C798(0.77); C799(0.77)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C798(0.95); C799(0.95)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C798(0.84); C799(0.84)  LDD0546  [1]
 LDCM0270  AC15 HEK-293T C798(1.13)  LDD1513  [4]
 LDCM0283  AC23 HEK-293T C798(0.97)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C173(0.90)  LDD1523  [4]
 LDCM0292  AC31 HEK-293T C798(1.00)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C173(1.09)  LDD1532  [4]
 LDCM0300  AC39 HEK-293T C798(1.23)  LDD1539  [4]
 LDCM0302  AC40 HEK-293T C173(1.03)  LDD1541  [4]
 LDCM0309  AC47 HEK-293T C798(1.05)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C173(0.90)  LDD1549  [4]
 LDCM0318  AC55 HEK-293T C798(1.15)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C173(1.05)  LDD1558  [4]
 LDCM0327  AC63 HEK-293T C798(1.21)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C173(1.22)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C798(1.08)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C173(0.85)  LDD1569  [4]
 LDCM0365  AC98 HCT 116 C798(1.29); C799(1.29)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C798(0.93); C799(0.93)  LDD0683  [1]
 LDCM0275  AKOS034007705 HEK-293T C173(0.99)  LDD1514  [4]
 LDCM0372  CL103 HEK-293T C798(1.00)  LDD1576  [4]
 LDCM0376  CL107 HEK-293T C798(1.07)  LDD1580  [4]
 LDCM0379  CL11 HEK-293T C798(1.18)  LDD1583  [4]
 LDCM0381  CL111 HEK-293T C798(0.91)  LDD1585  [4]
 LDCM0385  CL115 HEK-293T C798(0.98)  LDD1589  [4]
 LDCM0389  CL119 HEK-293T C798(1.04)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C173(1.11)  LDD1594  [4]
 LDCM0394  CL123 HEK-293T C798(0.92)  LDD1598  [4]
 LDCM0398  CL127 HEK-293T C798(1.00)  LDD1602  [4]
 LDCM0402  CL15 HEK-293T C798(1.06)  LDD1606  [4]
 LDCM0403  CL16 HCT 116 C798(1.41); C799(1.41)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C798(1.44); C799(1.44)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C798(1.68); C799(1.68)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C798(1.44); C799(1.44)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C798(1.62); C799(1.62)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C798(1.61); C799(1.61)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C798(1.87); C799(1.87)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C798(1.46); C799(1.46)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C798(1.40); C799(1.40)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C798(1.43); C799(1.43)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C798(1.23); C799(1.23)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C798(1.55); C799(1.55)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C798(1.35); C799(1.35)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C798(1.52); C799(1.52)  LDD0734  [1]
 LDCM0418  CL3 HEK-293T C798(1.09)  LDD1622  [4]
 LDCM0419  CL30 HCT 116 C798(1.41); C799(1.41)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C798(1.02); C799(1.02)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C798(1.28); C799(1.28)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C798(0.95); C799(0.95)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C798(0.98); C799(0.98)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C798(1.35); C799(1.35)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C798(1.04); C799(1.04)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C798(1.61); C799(1.61)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C798(1.30); C799(1.30)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C798(1.20); C799(1.20)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C798(1.32); C799(1.32)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C798(1.43); C799(1.43)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C798(1.26); C799(1.26)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C798(1.20); C799(1.20)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C798(1.19); C799(1.19)  LDD0752  [1]
 LDCM0437  CL47 HEK-293T C798(1.17)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C173(0.93)  LDD1642  [4]
 LDCM0450  CL59 HEK-293T C798(1.17)  LDD1653  [4]
 LDCM0452  CL60 HEK-293T C173(0.97)  LDD1655  [4]
 LDCM0453  CL61 HCT 116 C798(1.04); C799(1.04)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C798(1.01); C799(1.01)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C798(1.08); C799(1.08)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C798(1.30); C799(1.30)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C798(1.24); C799(1.24)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C798(1.22); C799(1.22)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C798(1.25); C799(1.25)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C798(1.33); C799(1.33)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C798(1.07); C799(1.07)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C798(1.34); C799(1.34)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C798(1.00); C799(1.00)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C798(1.18); C799(1.18)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C798(1.04); C799(1.04)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C798(1.27); C799(1.27)  LDD0784  [1]
 LDCM0477  CL83 HEK-293T C798(1.15)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C173(0.94)  LDD1681  [4]
 LDCM0481  CL87 HEK-293T C798(1.10)  LDD1684  [4]
 LDCM0490  CL95 HEK-293T C798(0.86)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C173(0.79)  LDD1694  [4]
 LDCM0494  CL99 HEK-293T C798(1.09)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C798(1.21)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C798(1.14); C799(1.14)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C798(1.58); C799(1.58)  LDD0744  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nephrocystin-4 (NPHP4) NPHP4 family O75161

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402