Details of the Target

General Information of Target

Target ID LDTP07181
Target Name Mitogen-activated protein kinase kinase kinase 21 (MAP3K21)
Gene Name MAP3K21
Gene ID 84451
Synonyms
KIAA1804; MLK4; Mitogen-activated protein kinase kinase kinase 21; EC 2.7.11.25; Mitogen-activated protein kinase kinase kinase MLK4; Mixed lineage kinase 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLR
RGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVA
FERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRH
PNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNW
AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT
KMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK
LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDD
WKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELN
ILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSS
SSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQM
KDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPK
QIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTE
SALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSL
PSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCP
TAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPT
PTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAY
PQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRS
KTSRPSIYELEKEFLS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Function Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
TTD ID
T92334
Uniprot ID
Q5TCX8
DrugMap ID
TTSW9YL
Ensemble ID
ENST00000366622.1
HGNC ID
HGNC:29798
ChEMBL ID
CHEMBL3627584

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.A722V .
ABC1 SNV: p.S413F .
COLO792 SNV: p.G653R .
GB1 SNV: p.T783I .
HCT15 SNV: p.Y330H .
HT115 SNV: p.E314K .
IGR1 SNV: p.P840S .
KYM1 SNV: p.A218T .
MEWO SNV: p.G653R .
NCIH1155 SNV: p.A305T .
NCIH358 SNV: p.A164P .
RH30 SNV: p.N268S .
SUPT1 SNV: p.P194L .
SW480 SNV: p.K497N .
TOV21G SNV: p.P113T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C281(3.56)  LDD3411  [1]
AHL-Pu-1
 Probe Info  		C369(3.52)  LDD0172  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C369(3.52)  LDD0172  [2]
 LDCM0214  AC1 HEK-293T C190(0.92); C369(0.97)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C100(1.29)  LDD0813  [8]
 LDCM0226  AC11 HEK-293T C100(1.07)  LDD0824  [8]
 LDCM0237  AC12 HEK-293T C100(1.19)  LDD0835  [8]
 LDCM0259  AC14 HEK-293T C100(1.15)  LDD0857  [8]
 LDCM0270  AC15 HEK-293T C100(1.00)  LDD0868  [8]
 LDCM0276  AC17 HEK-293T C190(1.14); C369(0.97)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C190(1.72); C369(0.98)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C190(0.84); C369(1.07); C281(1.14)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C190(0.96); C369(0.93)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C100(0.97); C190(0.93); C369(0.91)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C190(1.05); C591(0.93)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C100(1.04); C190(0.96); C369(1.00)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C100(1.09); C190(0.90); C369(1.06)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C100(0.98); C190(1.21); C369(0.86); C591(1.01)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C190(0.85); C369(0.95)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C190(1.12); C369(1.02)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C190(1.02); C369(1.05); C281(0.99)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C100(1.01); C190(0.94); C369(1.09)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C190(0.97); C591(1.09)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C190(0.95); C369(1.02); C281(1.00)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C100(1.05); C190(0.89); C369(0.92)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C100(0.97); C190(0.98); C369(1.04)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C100(0.93); C190(1.11); C369(0.87); C591(0.91)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C190(0.96); C369(1.01)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C190(1.05); C369(0.99)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C100(1.19)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C100(0.97)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C100(1.18)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C100(1.15)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C100(1.00)  LDD0898  [8]
 LDCM0301  AC4 HEK-293T C100(0.97); C190(0.80); C369(1.12)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C100(1.10)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C100(1.26)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C100(1.11)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C100(1.24)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C100(1.09)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C100(0.99)  LDD0905  [8]
 LDCM0308  AC46 HEK-293T C281(0.89)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C281(1.10)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C281(0.58)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C281(0.65)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C190(0.98); C591(0.87)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C281(1.02)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C281(0.49)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C281(0.47)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C281(0.90)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C281(0.63)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C281(0.78)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C281(0.92)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C281(1.07)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C281(1.18)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C281(0.94)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C100(1.03)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C281(0.39)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C281(0.61)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C281(1.02)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C281(0.67)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C281(0.84)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C281(0.72)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C281(1.12)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C281(1.17)  LDD0929  [8]
 LDCM0334  AC7 HEK-293T C100(1.57)  LDD0932  [8]
 LDCM0345  AC8 HEK-293T C100(1.28)  LDD0943  [8]
 LDCM0248  AKOS034007472 HEK-293T C100(0.94)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C100(1.27)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C100(1.23)  LDD0873  [8]
 LDCM0367  CL1 HEK-293T C100(0.76)  LDD0965  [8]
 LDCM0368  CL10 HEK-293T C100(1.56)  LDD0966  [8]
 LDCM0370  CL101 HEK-293T C100(2.19)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C100(1.33)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C100(1.78)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C100(1.57)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C100(0.94); C190(1.06); C369(1.18)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C197(1.01)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C190(1.12); C369(0.94); C281(0.64)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C100(1.12); C190(1.12); C369(0.91)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C100(1.33)  LDD0977  [8]
 LDCM0380  CL110 HEK-293T C197(1.06)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C190(1.03); C369(1.10); C281(0.79)  LDD1585  [7]
 LDCM0383  CL113 HEK-293T C100(1.25); C190(0.96); C369(0.86)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C197(1.06)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C190(1.03); C369(1.02); C281(0.85)  LDD1589  [7]
 LDCM0387  CL117 HEK-293T C100(1.10)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C100(1.09)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C100(1.03)  LDD0987  [8]
 LDCM0390  CL12 HEK-293T C100(0.75)  LDD0988  [8]
 LDCM0391  CL120 HEK-293T C100(1.08)  LDD0989  [8]
 LDCM0392  CL121 HEK-293T C281(0.74)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C281(0.87)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C281(1.01)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C281(0.56)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C281(1.15)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C281(1.01)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C281(1.13)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C281(1.19)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C100(1.15)  LDD0998  [8]
 LDCM0401  CL14 HEK-293T C100(1.21)  LDD0999  [8]
 LDCM0402  CL15 HEK-293T C100(1.43)  LDD1000  [8]
 LDCM0403  CL16 HEK-293T C281(1.24)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C281(1.14)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C281(0.79)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C281(0.98)  LDD1004  [8]
 LDCM0407  CL2 HEK-293T C100(1.03)  LDD1005  [8]
 LDCM0408  CL20 HEK-293T C281(0.91)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C281(0.96)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C281(0.74)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C281(0.91)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C281(1.08)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C281(1.05)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C281(1.04)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C281(1.12)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C281(1.23)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C281(1.42)  LDD1015  [8]
 LDCM0418  CL3 HEK-293T C100(0.81)  LDD1016  [8]
 LDCM0419  CL30 HEK-293T C281(0.81)  LDD1017  [8]
 LDCM0420  CL31 HEK-293T C100(0.95)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C100(1.10)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C100(1.17)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C100(1.11)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C100(0.95)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C100(0.89)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C100(0.88)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C100(0.94)  LDD1026  [8]
 LDCM0429  CL4 HEK-293T C100(1.18)  LDD1027  [8]
 LDCM0430  CL40 HEK-293T C100(1.13)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C100(0.86)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C100(1.05)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C100(1.13)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C100(1.36)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C100(0.73)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C281(0.59)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C281(0.89)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C281(0.70)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C281(0.89)  LDD1037  [8]
 LDCM0440  CL5 HEK-293T C100(0.85)  LDD1038  [8]
 LDCM0441  CL50 HEK-293T C281(0.50)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C281(0.59)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C281(1.36)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C281(1.37)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C281(0.68)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C281(0.79)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C281(0.80)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C281(0.77)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C281(0.62)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C281(0.53)  LDD1048  [8]
 LDCM0451  CL6 HEK-293T C100(0.91)  LDD1049  [8]
 LDCM0452  CL60 HEK-293T C281(0.42)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C100(1.20); C190(1.00); C369(0.91)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C197(0.91)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C190(1.14); C369(1.13); C281(0.96)  LDD1658  [7]
 LDCM0457  CL65 HEK-293T C190(0.92); C369(0.96)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C190(1.12); C369(0.88)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C190(0.95); C369(0.91); C281(0.92)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C100(1.25); C190(0.93); C369(0.83)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C190(0.85); C591(0.89)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C100(1.55)  LDD1060  [8]
 LDCM0463  CL70 HEK-293T C100(1.51); C190(1.16); C369(0.85)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C100(1.37); C190(0.93); C369(0.96)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C100(1.26); C190(0.93); C369(0.78); C591(1.00)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C100(0.99); C190(1.15); C369(1.17)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C197(1.50)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C281(0.96)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C281(0.78)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C281(0.97)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C281(0.60)  LDD1070  [8]
 LDCM0473  CL8 HEK-293T C100(0.89)  LDD1071  [8]
 LDCM0474  CL80 HEK-293T C281(0.87)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C281(0.98)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C281(1.19)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C281(1.46)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C281(0.94)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C281(1.01)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C281(0.68)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C281(0.77)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C281(0.90)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C281(0.82)  LDD1081  [8]
 LDCM0484  CL9 HEK-293T C100(1.04)  LDD1082  [8]
 LDCM0485  CL90 HEK-293T C281(0.95)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C190(1.00); C369(0.86); C281(0.99)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C100(1.07); C190(0.92); C369(0.94)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C190(1.05); C591(1.01)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C100(1.12); C190(0.81); C369(0.96)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C100(0.86); C190(1.09); C369(1.28)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C100(1.09); C190(1.14); C369(0.78); C591(1.03)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C100(1.25); C190(0.97); C369(0.97)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C197(1.00)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C190(1.15); C369(1.08); C281(1.08)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C190(1.05); C369(1.19); C281(0.84)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C190(1.13); C369(1.01); C281(0.88)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C100(0.87)  LDD1025  [8]
 LDCM0022  KB02 HEK-293T C190(1.03); C644(0.97)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C190(0.97); C644(0.98)  LDD1497  [7]
 LDCM0024  KB05 RPMI-8226 C281(3.56)  LDD3411  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) Ser/Thr protein kinase family O15111
Mitogen-activated protein kinase kinase kinase 10 (MAP3K10) STE Ser/Thr protein kinase family Q02779

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.