Details of the Target

General Information of Target

Target ID LDTP07175
Target Name Ribonuclease H2 subunit B (RNASEH2B)
Gene Name RNASEH2B
Gene ID 79621
Synonyms
DLEU8; Ribonuclease H2 subunit B; RNase H2 subunit B; Aicardi-Goutieres syndrome 2 protein; AGS2; Deleted in lymphocytic leukemia 8; Ribonuclease HI subunit B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQL
FEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDN
VFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKT
NNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSAS
LPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSKMTAAQKALAKVDKSGMKSIDTF
FGVKNKKKIGKV
Target Bioclass
Enzyme
Family
RNase H2 subunit B family
Subcellular location
Nucleus
Function
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Uniprot ID
Q5TBB1
Ensemble ID
ENST00000336617.8
HGNC ID
HGNC:25671

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.L127S .
LNCaP clone FGC Insertion: p.N305KfsTer2 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y262(10.57)  LDD0260  [2]
STPyne
 Probe Info  		K130(20.00)  LDD2218  [3]
HHS-475
 Probe Info  		Y262(0.57); Y23(0.85)  LDD0264  [4]
HHS-465
 Probe Info  		Y23(9.96)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0225  [6]
DBIA
 Probe Info  		C125(1.69)  LDD0861  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C125(0.00); C56(0.00); C44(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
ENE
 Probe Info  		N.A.  LDD0006  [11]
PPMS
 Probe Info  		N.A.  LDD0008  [11]
VSF
 Probe Info  		N.A.  LDD0007  [11]
AOyne
 Probe Info  		8.70  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C125(0.81)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C56(0.91)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C125(0.93); C56(0.82)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C125(0.94)  LDD1510  [15]
 LDCM0263  AC143 HEK-293T C125(1.69)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C125(2.07)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C125(1.56)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C125(1.45)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C125(1.94)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C125(1.56)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C125(1.23)  LDD0867  [7]
 LDCM0270  AC15 HEK-293T C125(0.90)  LDD1513  [15]
 LDCM0271  AC150 HEK-293T C125(1.56)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C125(1.44)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C125(1.22)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C125(1.84)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C125(1.70)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C125(1.56)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C125(1.68)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C125(2.44)  LDD2165  [7]
 LDCM0276  AC17 HEK-293T C125(1.30)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C125(1.14)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C125(1.12)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C56(0.90)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C125(1.50)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C125(0.98)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C125(1.18)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C125(1.40)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C125(1.19)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C125(1.16)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C125(1.34)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C125(1.28)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C125(1.02)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C125(1.16)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C125(0.88); C56(1.09)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C125(1.22)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C125(1.04)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C125(1.16)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C125(1.17)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C125(0.99)  LDD0893  [7]
 LDCM0296  AC35 HEK-293T C125(0.86); C56(0.84)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C125(0.97)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C125(1.03)  LDD1537  [15]
 LDCM0300  AC39 HEK-293T C125(0.96)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C125(1.03)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C125(1.05)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C125(0.90)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C56(1.11)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C125(0.93); C56(1.01)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C125(1.09)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C125(1.08)  LDD1546  [15]
 LDCM0308  AC46 PaTu 8988t C125(0.84)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C125(0.70)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C125(0.60)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C125(0.36)  LDD1190  [7]
 LDCM0312  AC5 HEK-293T C125(1.04)  LDD1551  [15]
 LDCM0313  AC50 PaTu 8988t C125(0.32)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C125(0.49)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C125(0.52)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C125(0.23)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C125(0.18)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C125(0.59)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C125(0.45)  LDD1198  [7]
 LDCM0320  AC57 HEK-293T C125(0.83)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C56(1.01)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C125(0.97); C56(0.87)  LDD1561  [15]
 LDCM0324  AC60 HEK-293T C125(1.07)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C125(0.94)  LDD1564  [15]
 LDCM0327  AC63 HEK-293T C125(1.03)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C125(1.13)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C125(1.00)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C125(1.01)  LDD1569  [15]
 LDCM0349  AC83 HEK-293T C125(0.95)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C125(1.47)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C125(1.17)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C125(1.07)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C125(1.31)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C125(1.34)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C125(1.45)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C125(1.45)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C125(1.21)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C125(1.15)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C125(1.31)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C125(1.74)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C125(1.39)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C125(1.67)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C125(2.04)  LDD0962  [7]
 LDCM0248  AKOS034007472 HEK-293T C125(1.00)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C125(0.87)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C125(0.98)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 13.49  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C7(1.08)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C125(0.95)  LDD1571  [15]
 LDCM0369  CL100 HEK-293T C125(1.21)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C125(0.95)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C125(1.06)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C125(0.84); C56(1.03)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C125(1.12)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C125(1.21)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C125(1.19)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C125(0.94)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C125(1.07)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C125(0.92)  LDD0976  [7]
 LDCM0379  CL11 HEK-293T C125(1.05)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C125(1.12)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C125(0.98)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C125(1.11)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C125(1.06)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C125(1.51)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C125(1.34)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C125(1.24)  LDD0984  [7]
 LDCM0387  CL117 HEK-293T C125(0.84)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C125(1.01)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C125(0.95); C56(1.09)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C125(0.74)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C125(1.14)  LDD1595  [15]
 LDCM0392  CL121 PaTu 8988t C125(0.86)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C125(0.57)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C125(0.40)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C125(0.46)  LDD1274  [7]
 LDCM0396  CL125 HEK-293T C125(1.21)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C125(0.97)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C125(0.99); C56(1.21)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C125(1.05)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C125(0.79)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C125(1.06)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C125(0.80); C56(1.09)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C125(1.01)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C125(0.72)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C56(0.85)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C125(0.87); C56(0.97)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C125(1.04)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C125(0.88)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C125(0.85)  LDD1613  [15]
 LDCM0411  CL23 HEK-293T C125(0.90)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C125(0.89)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C125(0.76)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C125(1.01)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C125(0.88); C56(1.13)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C125(1.13)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C125(0.90)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C125(0.91); C56(1.21)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C56(0.93)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C125(0.67); C56(0.84)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C125(0.90)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C125(0.86)  LDD1626  [15]
 LDCM0424  CL35 HEK-293T C125(0.88)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C125(0.91)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C125(1.03)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C125(0.83); C56(1.04)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C125(0.87)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C125(0.91)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C125(0.81)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C56(1.14)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C125(0.79); C56(0.77)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C125(0.92)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C125(0.91)  LDD1639  [15]
 LDCM0437  CL47 HEK-293T C125(0.81)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C125(0.86)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C125(0.97)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C125(0.88)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C125(1.02)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C125(0.92)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C125(0.80)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C56(0.93)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C125(0.83); C56(1.28)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C125(0.99)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C125(0.84)  LDD1651  [15]
 LDCM0450  CL59 HEK-293T C125(0.81)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C56(0.91)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C125(0.81)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C125(0.81)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C125(1.49)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C125(1.27)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C125(1.03)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C125(1.21)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C125(1.25)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C125(1.36)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C125(1.33)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C125(1.13)  LDD1059  [7]
 LDCM0462  CL7 HEK-293T C125(0.86); C56(1.20)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C125(1.25)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C125(1.00)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C125(0.99)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C125(1.57)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C125(2.27)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C125(0.73)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C125(0.71)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C125(0.81)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C125(0.75)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C125(0.81)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C125(0.81)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C125(0.83)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C125(0.94)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C125(1.67)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C125(0.95)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C125(0.82)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C125(0.52)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C125(0.78)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C125(0.91)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C125(0.85)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C125(1.07)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C125(1.10)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C125(0.84); C56(0.84)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C125(0.97)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C125(0.87)  LDD1691  [15]
 LDCM0490  CL95 HEK-293T C125(0.79)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C125(1.07)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C125(0.91)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C125(1.00)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C125(0.93); C56(1.15)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C125(0.87); C56(1.28)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C125(1.88)  LDD1066  [7]
 LDCM0427  Fragment51 HEK-293T C125(1.02)  LDD1631  [15]
 LDCM0116  HHS-0101 DM93 Y262(0.57); Y23(0.85)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y23(0.82)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y23(0.87)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y23(0.87); Y262(1.19)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y23(0.98); Y262(1.79)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C125(0.80)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C125(0.73)  LDD1497  [15]
 LDCM0024  KB05 HEK-293T C125(1.12)  LDD1502  [15]
 LDCM0109  NEM HeLa N.A.  LDD0225  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C7(1.00)  LDD2206  [16]
 LDCM0628  OTUB2-COV-1 HEK-293T C7(0.64)  LDD2207  [16]

References

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6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041264
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.