Details of the Target

General Information of Target

Target ID LDTP06946
Target Name Outer dense fiber protein 2 (ODF2)
Gene Name ODF2
Gene ID 4957
Synonyms
Outer dense fiber protein 2; Cenexin; Outer dense fiber of sperm tails protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSASSSGGSPRFPSCGKNGVTSLTQKKVLRAPCGAPSVTVTKSHKRGMKGDTVNVRRSVR
VKTKVPWMPPGKSSARPVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKM
NRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLR
HNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQ
MTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEA
DSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAEN
SRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYA
EQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLE
EKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYE
GMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLP
DILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENK
QLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIE
DARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLK
DRLEQSESTNRSMQNYVQFLKSSYANVFGDGPYSTFLTSSPIRSRSPPA
Target Bioclass
Other
Family
ODF2 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.
Uniprot ID
Q5BJF6
Ensemble ID
ENST00000372791.8
HGNC ID
HGNC:8114

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C118(2.68)  LDD0168  [1]
DBIA
 Probe Info  		C136(2.93)  LDD0080  [2]
N1
 Probe Info  		N.A.  LDD0245  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C118(2.68)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C80(3.58); C327(2.44)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C136(1.07)  LDD1507  [8]
 LDCM0226  AC11 HEK-293T C136(1.13)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C136(0.88)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C136(0.89); C243(1.11)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C136(1.01); C88(0.99)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C136(1.01)  LDD1515  [8]
 LDCM0278  AC19 HEK-293T C136(1.41)  LDD1517  [8]
 LDCM0280  AC20 HEK-293T C136(1.02)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C136(0.71); C243(1.20)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C136(0.81); C243(0.90)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C136(0.97); C88(1.27)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C136(0.90)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C136(1.08)  LDD1524  [8]
 LDCM0287  AC27 HEK-293T C136(1.04)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C136(1.09)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C136(0.92); C243(1.21)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C136(1.22)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C136(1.35); C243(0.93)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C136(0.79); C88(1.04)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C136(0.93)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C136(0.98)  LDD1533  [8]
 LDCM0296  AC35 HEK-293T C136(1.09)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C136(0.92)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C136(0.70); C243(1.00)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C136(1.19); C243(0.99)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C136(1.04); C88(0.84)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C136(1.08)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C136(0.91)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C136(1.11)  LDD1542  [8]
 LDCM0305  AC43 HEK-293T C136(1.16)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C136(0.98)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C136(0.98); C243(1.19)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C136(0.96); C243(0.95)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C136(1.15); C88(1.52)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C136(0.94)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C136(1.15)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C136(0.86); C243(0.97)  LDD1551  [8]
 LDCM0314  AC51 HEK-293T C136(1.07)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C136(1.05)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C136(0.72); C243(0.96)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C136(1.05); C243(1.00)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C136(0.89); C88(1.28)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C136(0.93)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C136(1.11)  LDD1559  [8]
 LDCM0322  AC59 HEK-293T C136(1.11)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C136(1.13); C243(0.92)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C136(1.23)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C136(0.93); C243(0.99)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C136(1.00); C243(0.86)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C136(1.18); C88(1.46)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C136(0.96)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C136(0.81); C88(1.18)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C136(0.98)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C136(0.74); C243(1.10)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C136(1.04)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C136(1.09)  LDD1514  [8]
 LDCM0632  CL-Sc Hep-G2 C136(1.10); C279(0.56)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C136(1.07); C327(1.01)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C136(0.75); C243(0.98)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C136(1.18)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C136(1.30); C327(1.00)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C136(0.35); C243(1.16)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C136(1.10)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C136(1.08)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C136(1.25); C327(1.03)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C136(0.71); C243(0.97)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C136(0.95)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C136(0.97)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C136(1.24); C327(0.99)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C136(1.30); C88(0.95)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C136(0.77); C243(1.13)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C136(1.07)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C136(1.16)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C136(1.23); C327(1.06)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C136(0.89); C243(1.21)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C136(1.12)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C136(1.06)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C136(1.36); C327(0.96)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C136(0.70); C243(1.16)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C136(0.88)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C136(0.85)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C136(1.08)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C136(1.15); C327(1.00)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C136(0.78); C243(0.99)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C136(0.93)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C136(1.13)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C136(1.93); C327(1.07)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C136(0.77); C243(1.14)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C136(1.34)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C136(1.36)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C136(1.36); C327(0.96)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C136(0.64); C243(0.81)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C136(0.93)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C136(0.97)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C136(0.99)  LDD1608  [8]
 LDCM0406  CL19 HEK-293T C136(0.98)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C136(1.00); C243(1.30)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C136(0.77)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C136(1.00); C243(0.88)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C136(0.69); C243(1.14)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C136(1.14); C88(1.15)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C136(0.81)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C136(1.60); C327(0.98)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C136(1.10); C243(1.09)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C136(0.86)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C136(0.90)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C136(1.03)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C136(0.90)  LDD1622  [8]
 LDCM0420  CL31 HEK-293T C136(0.91)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C136(0.66)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C136(0.77); C243(0.78)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C136(0.70); C243(0.98)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C136(1.38); C88(1.12)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C136(0.64)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C136(1.28); C327(1.05)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C136(0.87)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C136(1.07)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C136(0.93)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C136(1.01)  LDD1635  [8]
 LDCM0433  CL43 HEK-293T C136(0.82)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C136(0.80)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C136(1.20); C243(0.98)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C136(0.71); C243(0.99)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C136(1.53); C88(1.50)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C136(0.78)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C136(1.81); C327(1.00)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C136(1.01)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C136(0.85); C243(1.26)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C136(0.90)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C136(1.01)  LDD1647  [8]
 LDCM0446  CL55 HEK-293T C136(1.01)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C136(0.72)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C136(1.76); C243(0.81)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C136(0.89); C243(0.94)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C136(1.62); C88(1.18)  LDD1653  [8]
 LDCM0452  CL60 HEK-293T C136(0.80)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C136(1.91); C327(0.99)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C136(1.11); C243(1.01)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C136(0.94)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C136(0.91)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C136(0.89)  LDD1660  [8]
 LDCM0459  CL67 HEK-293T C136(0.93)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C136(0.74)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C136(0.89); C243(1.03)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C136(1.00)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C136(0.88); C243(0.99)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C136(1.31); C88(1.42)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C136(0.81)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C136(1.88); C327(0.98)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C136(1.21); C243(1.08)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C136(0.96)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C136(1.04)  LDD1673  [8]
 LDCM0472  CL79 HEK-293T C136(0.99)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C136(0.97)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C136(0.75)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C136(1.12); C243(0.93)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C136(0.82); C243(1.00)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C136(1.18); C88(1.01)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C136(0.85)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C136(2.29); C327(1.00)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C136(1.56); C243(1.20)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C136(1.30)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C136(1.49)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C136(0.92)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C136(0.79); C243(1.00)  LDD1687  [8]
 LDCM0486  CL91 HEK-293T C136(1.07)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C136(1.02)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C136(0.91); C243(1.07)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C136(1.00); C243(1.01)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C136(1.34); C88(1.65)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C136(0.90)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C136(0.78); C327(1.07)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C136(1.11); C243(1.06)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C136(1.27)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C136(0.92)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C136(1.07)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C136(0.77); C243(0.93)  LDD1631  [8]
 LDCM0022  KB02 HCT 116 C136(2.93)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C136(2.49)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C136(2.92)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inhibitor of growth protein 5 (ING5) ING family Q8WYH8
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
SNW domain-containing protein 1 (SNW1) SNW family Q13573
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402