Details of the Target

General Information of Target

Target ID LDTP06727
Target Name Autophagy-related protein 2 homolog A (ATG2A)
Gene Name ATG2A
Gene ID 23130
Synonyms
KIAA0404; Autophagy-related protein 2 homolog A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVN
EVLESMESPLELVEGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQPRRGPAPGAADSQS
WASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH
SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELP
AQEEPPEPPLQIGSCSGYMELMVKLKQNEAFPGPKLEVAGQLGSLHLLLTPRQLQQLQEL
LSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLD
NTDLFFSMAGLTSSVASALSELSLSDVDLASSVRSDMASRRLSAQAHPAGKMAPNPLLDT
MRPDSLLKMTLGGVTLTLLQTSAPSSGPPDLATHFFTEFDATKDGPFGSRDFHHLRPRFQ
RACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYTEIL
TFPGTLGSQASARPCAHLRHTQILRRVPKSRPRRSVACHCHSELALDLANFQADVELGAL
DRLAALLRLATVPAEPPAGLLTEPLPAMEQQTVFRLSAPRATLRLRFPIADLRPEPDPWA
GQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSK
ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSK
RTMYETEEMVIPGDPEEMRTFQSRTLALSRCSLEVILPSVHIFLPSKEVYESIYNRINND
LLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAH
FFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVL
DMEHGTLFSVSQYCGQPGLGYFCLEAEKATLYHRAAVDDYPLPSHLDLPSFAPPAQLAPT
IYPSEEGVTERGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMAL
PEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFT
LSSNIIMDTSTFLLRFILDDSALYLSDKCEVETLDLRRDYVCVLDVDLLELVIKTWKGST
EGKLSQPLFELRCSNNVVHVHSCADSCALLVNLLQYVMSTGDLHPPPRPPSPTEIAGQKL
SESPASLPSCPPVETALINQRDLADALLDTERSLRELAQPSGGHLPQASPISVYLFPGER
SGAPPPSPPVGGPAGSLGSCSEEKEDEREEEGDGDTLDSDEFCILDAPGLGIPPRDGEPV
VTQLHPGPIVVRDGYFSRPIGSTDLLRAPAHFPVPSTRVVLREVSLVWHLYGGRDFGPHP
GHRARTGLSGPRSSPSRCSGPNRPQNSWRTQGGSGRQHHVLMEIQLSKVSFQHEVYPAEP
ATGPAAPSQELEERPLSRQVFIVQELEVRDRLASSQINKFLYLHTSERMPRRAHSNMLTI
KALHVAPTTNLGGPECCLRVSLMPLRLNVDQDALFFLKDFFTSLVAGINPVVPGETSAEA
RPETRAQPSSPLEGQAEGVETTGSQEAPGGGHSPSPPDQQPIYFREFRFTSEVPIWLDYH
GKHVTMDQVGTFAGLLIGLAQLNCSELKLKRLCCRHGLLGVDKVLGYALNEWLQDIRKNQ
LPGLLGGVGPMHSVVQLFQGFRDLLWLPIEQYRKDGRLMRGLQRGAASFGSSTASAALEL
SNRLVQAIQATAETVYDILSPAAPVSRSLQDKRSARRLRRGQQPADLREGVAKAYDTVRE
GILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQIV
PDAHKDHALKWRSDSAQD
Target Bioclass
Transporter and channel
Family
ATG2 family
Subcellular location
Preautophagosomal structure membrane
Function
Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell.
Uniprot ID
Q2TAZ0
Ensemble ID
ENST00000377264.8
HGNC ID
HGNC:29028

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P910T .
HCT116 Deletion: p.P1246HfsTer92 .
HCT15 SNV: p.K1598N .
HEC1 SNV: p.G965S .
HEC1B SNV: p.G965S .
HT29 SNV: p.Q210H .
JHH7 SNV: p.R1665T .
JURKAT Deletion: p.G1888AfsTer2
SNV: p.R1780W		 .
LOXIMVI SNV: p.P855L .
MCC13 SNV: p.P1306S
Substitution: p.P416L;p.L451F		 .
MEC1 SNV: p.A614T .
MOLT4 Insertion: p.S1474QfsTer74
SNV: p.E500Ter;p.R1551Ter;p.Q1591R		 .
PF382 SNV: p.A1928T .
SW948 SNV: p.P1245S .
TOV21G SNV: p.G1649V .
UMUC3 SNV: p.G231E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1832(6.81); K1880(8.81); K725(1.58)  LDD0277  [1]
m-APA
 Probe Info  		14.04  LDD0403  [2]
DBIA
 Probe Info  		C201(1.30)  LDD3423  [3]
BTD
 Probe Info  		C941(3.61)  LDD2096  [4]
IA-alkyne
 Probe Info  		C11(9.05)  LDD1703  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
VSF
 Probe Info  		N.A.  LDD0007  [7]
AOyne
 Probe Info  		13.30  LDD0443  [9]
NAIA_5
 Probe Info  		C1458(0.00); C1870(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1169(1.03); C1270(1.13); C11(1.05); C767(1.28)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C1169(1.03); C1270(1.01); C11(0.89); C1704(1.06)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C1169(0.98); C1270(0.80); C1458(1.20); C1340(0.85)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C1169(0.94); C1458(1.02); C1577(0.96)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C1169(0.99); C1270(1.26); C1870(1.13); C11(1.04)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C1169(1.07); C1270(1.44); C1340(0.97)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C1169(1.04); C1270(0.97); C11(1.06); C767(1.02)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C1169(0.97); C1270(0.91); C11(0.98); C1704(0.95)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C1169(1.16); C1270(0.93); C1458(1.39); C1340(1.06)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C1169(0.91); C1270(1.07); C11(1.00); C1704(1.05)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C1169(1.05); C1458(1.11); C1577(1.05)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C1169(1.01); C1270(1.06); C1340(1.11); C1577(0.76)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C1169(1.06); C1270(1.00); C1870(1.15); C11(1.01)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C1169(1.08); C1270(1.08); C1340(1.08)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C1169(0.95); C1340(1.05)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C1169(1.10); C1270(1.35); C11(1.09); C767(1.16)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C1169(1.00); C1270(0.86); C11(0.89); C1704(1.30)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C1169(1.05); C1270(1.19); C1458(1.09); C1340(0.90)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C1169(1.03); C1458(1.11); C1577(0.78)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C1169(1.10); C1270(1.04); C1340(0.87); C1577(0.79)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C1169(0.84); C1270(0.95); C1458(1.09); C1340(0.96)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C1169(1.11); C1270(1.20); C1870(1.13); C11(1.11)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C1169(0.78); C1270(0.73); C1340(0.91)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C1169(0.95); C1340(1.02)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C1169(1.07); C1270(1.09); C11(1.09); C767(1.10)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C1169(1.03); C1270(0.81); C11(0.99); C1704(1.06)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C1169(1.04); C1270(1.00); C1458(1.23); C1340(0.93)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C1169(1.01); C1458(1.10); C1577(0.86)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C1169(1.06); C1270(0.97); C1340(0.94); C1577(1.19)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C1169(0.92); C1270(0.95); C1870(0.90); C11(1.06)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C1169(1.27); C1270(1.16); C1340(0.89)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C1169(0.93); C1458(1.06); C1577(1.04)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C1169(0.86); C1340(0.89)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C1169(0.91); C1270(1.10); C11(1.04); C767(1.21)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C1169(0.94); C1270(1.00); C11(1.01); C1704(1.15)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C1169(0.85); C1270(0.88); C1458(1.16); C1340(0.97)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C1169(1.07); C1458(1.13); C1577(1.06)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C1169(1.06); C1270(1.14); C1340(1.05); C1577(0.83)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C1169(0.82); C1270(1.07); C1870(0.64); C11(1.00)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C1169(1.14); C1270(0.96); C1340(0.99)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C1169(0.84); C1340(1.03)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C1169(1.00); C1270(0.95); C11(1.08); C767(1.11)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C1169(0.97); C1270(0.96); C1340(0.96); C1577(0.77)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C1169(0.89); C1270(0.87); C11(0.90); C1704(1.05)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C1169(1.08); C1270(0.91); C1458(1.11); C1340(0.91)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C1169(0.95); C1458(1.17); C1577(0.81)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C1169(0.98); C1270(0.90); C1340(1.09); C1577(0.78)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C1169(1.05); C1270(1.34); C1870(1.03); C11(1.04)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C1169(1.07); C1270(0.93); C1340(0.86)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C1169(0.89); C1340(0.98)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C1169(1.07); C1270(1.11); C11(1.13); C767(1.28)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C1169(0.97); C1270(1.35); C11(1.00); C1704(1.25)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C1169(0.97); C1270(0.70); C1458(1.06); C1340(0.76)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C1169(1.02); C1270(0.89); C1870(0.90); C11(1.12)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C1169(0.97); C1458(1.07); C1577(0.98)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C1169(1.00); C1270(1.24); C1340(1.11); C1577(1.00)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C1169(1.03); C1270(1.22); C1870(1.28); C11(1.11)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C1169(0.93); C1270(1.30); C1340(0.80)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C1169(0.89); C1340(1.12)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C1169(0.84); C1270(0.67); C1340(0.81)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C1169(0.92); C1340(0.94)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C1169(1.09); C1270(1.30); C1340(0.97); C1577(0.80)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C1169(1.05); C1270(1.12); C11(1.08); C767(1.19)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C1169(0.96); C1340(0.94)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 14.04  LDD0403  [2]
 LDCM0632  CL-Sc Hep-G2 C1870(8.80); C11(0.74); C1458(0.55)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C1169(1.03); C1270(0.63)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C1169(3.26); C1270(0.71); C1870(1.85); C11(1.72)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C1169(0.93); C11(1.15); C1577(0.80)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C1169(0.98); C1270(1.11)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C1169(1.20); C1270(0.77); C1458(1.10); C11(1.20)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C1169(0.98); C1270(1.17); C11(1.08)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C1169(0.86); C11(1.04); C1577(1.04)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C1169(1.24); C1270(0.78)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C1169(1.07); C1270(0.90); C1458(1.04); C11(1.09)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C1169(1.05); C1270(1.00); C11(0.96)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C1169(1.06); C11(0.99); C1577(0.91)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C1169(1.18); C1270(0.76)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C1169(1.62); C1270(0.88); C1340(1.32)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C1169(1.26); C1270(1.44); C1458(1.12); C11(1.09)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C1169(0.98); C1270(0.99); C11(1.33)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C1169(0.91); C11(1.06); C1577(0.95)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C1169(1.14); C1270(0.77)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C1169(1.19); C1270(1.34); C1458(1.07); C11(1.21)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C1169(0.99); C1270(1.25); C11(1.11)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C1169(0.94); C11(1.14); C1577(1.12)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C1169(1.13); C1270(0.90)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C1169(1.04); C1270(1.29); C1458(1.25); C11(1.16)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C1169(1.04); C1270(1.11); C11(0.95)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C1169(1.49); C1340(1.03)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C1169(0.89); C11(1.13); C1577(0.96)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C1169(1.12); C1270(0.82)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C1169(1.03); C1270(1.20); C1458(1.21); C11(0.99)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C1169(1.25); C1270(0.92); C11(1.35)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C1169(1.03); C11(1.24); C1577(0.83)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C1169(0.85); C1270(0.95)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C1169(1.04); C1270(0.91); C1458(0.97); C11(1.10)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C1169(0.94); C1270(1.21); C11(1.16)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C1169(1.01); C11(1.17); C1577(1.10)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C1169(1.12); C1270(0.81)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C1169(1.09); C1270(1.02); C1458(1.02); C11(0.78)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C1169(1.27); C1270(1.04); C11(1.35)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C1169(0.98); C11(0.96); C1577(0.85)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C1169(1.19); C1270(1.25); C11(1.37); C767(1.15)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C1169(1.16); C1270(0.99); C11(0.92); C1704(1.00)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C1169(2.12); C1270(1.00); C1458(1.23); C1340(0.96)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C1169(1.07); C1270(1.13); C1458(0.99); C11(0.92)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C1169(1.53); C1458(0.99); C1577(1.12)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C1169(3.14); C1270(0.85); C1340(1.96); C1577(0.76)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C1169(2.46); C1270(1.21); C1870(1.41); C11(1.07)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C1169(1.51); C1270(1.01); C1340(1.02)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C1169(1.53); C1340(1.00)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C1169(1.25); C1270(0.58)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C1169(1.02); C1270(1.13); C1458(1.00); C11(0.77)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C1169(1.05); C1270(1.00); C11(1.06)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C1169(0.95); C11(1.40); C1577(0.85)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C1169(1.29); C1270(1.07); C11(1.04); C767(0.97)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C1169(1.05); C1270(1.25); C11(1.24)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C1169(1.09); C1270(0.84); C11(0.88); C1704(1.01)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C1169(1.63); C1270(0.95); C1458(1.05); C1340(1.11)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C1169(1.26); C1458(1.12); C1577(1.14)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C1169(2.36); C1270(0.98); C1340(1.10); C1577(0.76)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C1169(3.63); C1270(1.31); C1870(0.77); C11(1.55)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C1169(2.17); C1270(0.77); C1340(1.08)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C1169(1.48); C1340(0.92)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C1169(0.96); C1270(1.09)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C1169(0.94); C1270(0.96); C11(1.15)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C1169(1.21); C11(1.17); C1577(0.89)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C1169(0.95); C11(1.01); C1577(1.03)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C1169(1.23); C1270(1.10); C11(1.27); C767(0.92)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C1169(1.10); C1270(0.88); C11(0.86); C1704(1.13)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C1169(1.22); C1270(0.94); C1458(1.09); C1340(1.02)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C1169(1.51); C1458(1.02); C1577(0.99)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C1169(2.35); C1270(0.81); C1340(1.07); C1577(0.69)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C1169(2.16); C1270(0.92); C1870(1.11); C11(1.09)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C1169(1.34); C1270(1.00); C1340(1.06)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C1169(1.49); C1340(1.11)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C1169(1.00); C1270(0.89)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C1169(1.02); C1270(1.00); C11(0.96); C767(1.14)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C1169(1.19); C1270(0.66); C1458(1.08); C11(1.33)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C1169(1.00); C11(1.08); C1577(1.18)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C1169(1.36); C1270(1.39); C11(1.20); C767(0.96)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C1169(1.12); C1270(0.92); C11(1.24); C1704(1.05)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C1169(1.63); C1270(1.07); C1458(1.12); C1340(0.94)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C1169(1.36); C1458(1.12); C1577(1.09)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C1169(2.12); C1270(0.95); C1340(1.12); C1577(0.88)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C1169(2.78); C1270(0.90); C1870(0.93); C11(1.34)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C1169(1.78); C1270(0.90); C1340(1.21)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C1169(1.09); C1270(1.10); C11(1.09); C1704(1.09)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C1169(1.53); C1340(1.25)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C1169(0.82); C1270(0.84)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C1169(0.98); C1270(0.85); C1458(1.05); C11(0.85)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C1169(0.93); C1270(1.11); C11(1.01)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C1169(1.21); C11(1.48); C1577(0.86)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C1169(1.12); C1270(1.47); C11(0.95); C767(0.93)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C1169(1.09); C1270(1.54); C11(0.96); C1704(0.97)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C1169(1.45); C1270(1.12); C1458(1.07); C1340(0.93)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C1169(1.47); C1458(1.04); C1577(1.09)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C1169(1.97); C1270(0.97); C1340(1.22); C1577(0.89)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C1169(1.44); C1270(0.87); C1458(0.96); C1340(0.90)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C1169(2.31); C1270(1.03); C1870(0.87); C11(1.07)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C1169(1.70); C1270(0.80); C1340(1.31)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C1169(1.30); C1340(0.90)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C1169(0.98); C1270(0.50)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C1169(1.04); C1270(1.27); C1458(1.01); C11(0.95)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C1169(0.94); C11(1.08); C1577(0.97)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C1169(1.04); C1270(1.61); C11(1.38); C767(1.12)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C1169(1.07); C1270(0.95); C11(0.90); C1704(0.95)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C1169(1.14); C1270(0.99); C1458(1.11); C1340(0.85)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C1169(1.52); C1458(1.06); C1577(0.95)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C1169(1.28); C1458(1.09); C1577(0.93)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C1169(1.95); C1270(0.91); C1340(1.78); C1577(0.92)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C1169(2.18); C1270(1.15); C1870(1.32); C11(1.04)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C1169(1.27); C1270(0.94); C1340(0.99)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C1169(1.31); C1340(0.91)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C1169(0.73); C1270(0.54)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C1169(1.00); C1270(1.21); C1458(1.00); C11(1.47)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C1169(1.03); C1270(1.13); C11(1.13)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C1169(0.75); C11(1.06); C1577(1.10)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C1169(1.08); C1270(1.42); C11(1.07); C767(1.24)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C1169(2.11); C1270(0.92); C1340(1.30); C1577(0.92)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C1169(1.15); C1270(1.07); C11(1.38); C1704(1.20)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C1169(1.03); C1270(1.25); C1458(0.97); C1340(0.90)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C1169(1.16); C1458(1.02); C1577(1.15)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C1169(1.91); C1270(0.87); C1340(0.91); C1577(0.71)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C1169(1.42); C1270(0.94); C1870(1.16); C11(1.17)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C1169(1.11); C1270(0.89); C1340(1.22)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C1169(1.18); C1340(0.99)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C1169(1.11); C1270(0.79)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C1169(1.07); C1270(1.13); C1458(1.07); C11(1.14)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C1169(0.84); C1270(0.86); C11(1.17)  LDD1697  [10]
 LDCM0634  CY-0357 Hep-G2 C1458(0.85)  LDD2228  [6]
 LDCM0495  E2913 HEK-293T C1169(1.05); C1270(1.06); C11(1.05)  LDD1698  [10]
 LDCM0625  F8 Ramos C1458(1.30); C1870(0.71)  LDD2187  [11]
 LDCM0573  Fragment11 Ramos C1870(0.26)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C1458(0.53); C1870(2.02)  LDD2191  [11]
 LDCM0576  Fragment14 Ramos C1870(4.47)  LDD2193  [11]
 LDCM0580  Fragment21 Ramos C1870(1.51)  LDD2195  [11]
 LDCM0586  Fragment28 Ramos C1458(0.48)  LDD2198  [11]
 LDCM0589  Fragment31 Ramos C1458(0.70)  LDD2200  [11]
 LDCM0468  Fragment33 HEK-293T C1169(1.05); C1270(1.34); C11(1.10)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C1870(7.13)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C1458(1.83); C1870(1.47)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C1169(1.02); C1270(1.34); C1458(1.06); C11(0.97)  LDD1631  [10]
 LDCM0614  Fragment56 Ramos C1870(0.63)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C1458(1.60)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C1870(1.07)  LDD2188  [11]
 LDCM0022  KB02 T cell C11(9.05)  LDD1703  [5]
 LDCM0023  KB03 Ramos C1458(2.34); C1870(1.33)  LDD2183  [11]
 LDCM0024  KB05 SK-ES1 C201(1.30)  LDD3423  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C941(3.61)  LDD2096  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C941(0.40)  LDD2126  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1577(2.01)  LDD2146  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein (GABARAP) ATG8 family O95166
Autophagy-related protein 9A (ATG9A) ATG9 family Q7Z3C6
Mitochondrial import receptor subunit TOM40 homolog (TOMM40) Tom40 family O96008
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
WD repeat domain phosphoinositide-interacting protein 4 (WDR45) WD repeat PROPPIN family Q9Y484

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578