Details of the Target

General Information of Target

Target ID LDTP06668
Target Name Cytoplasmic polyadenylation element-binding protein 4 (CPEB4)
Gene Name CPEB4
Gene ID 80315
Synonyms
KIAA1673; Cytoplasmic polyadenylation element-binding protein 4; CPE-BP4; CPE-binding protein 4; hCPEB-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAW
LFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQG
DNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSS
TIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQ
HHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWS
PGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSW
MEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINA
RTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLP
PDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDG
KLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIM
DRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPY
VLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDR
PRHISFRWN
Target Bioclass
Other
Family
RRM CPEB family
Subcellular location
Cytoplasm
Function
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation. Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes. In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory.
Uniprot ID
Q17RY0
Ensemble ID
ENST00000265085.10
HGNC ID
HGNC:21747

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.R674VfsTer41 .
CAL148 SNV: p.Q146Ter .
CAL51 SNV: p.F210S .
HEC1 SNV: p.E650D .
HT115 SNV: p.E136K .
IGROV1 Insertion: p.K678EfsTer9 .
KP4 SNV: p.R350L .
KYM1 SNV: p.Q102H .
RL952 SNV: p.R727H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C545(1.15)  LDD0812  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C545(1.15)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C545(1.06)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C545(1.05)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C545(1.09)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C545(0.94)  LDD1512  [2]
 LDCM0263  AC143 HEK-293T C545(1.32)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C545(1.30)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C545(1.29)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C545(1.14)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C545(2.36)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C545(1.29)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C545(1.11)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C545(0.89)  LDD1513  [2]
 LDCM0271  AC150 HEK-293T C545(0.94)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C545(1.10)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C545(1.52)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C545(1.58)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C545(0.83)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C545(1.46)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C545(1.69)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C545(1.53)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C545(0.96)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C545(0.88)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C545(0.90)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C545(1.05)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C545(0.98)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C545(0.95)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C545(1.02)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C545(0.89)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C545(1.08)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C545(0.84)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C545(0.94)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C545(1.00)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C545(1.00)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C545(0.90)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C545(1.23)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C545(0.90)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C545(0.98)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C545(1.03)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C545(0.88)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C545(0.97)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C545(0.99)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C545(1.10)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C545(0.99)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C545(0.91)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C545(1.04)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C545(1.17)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C545(1.09)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C545(1.05)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C545(0.99)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C545(0.99)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C545(1.14)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C545(1.00)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C545(0.96)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C545(1.08)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C545(1.10)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C545(1.01)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C545(1.39)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C545(1.00)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C545(1.09)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C545(1.04)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C545(0.97)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C545(0.98)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C545(1.03)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C545(1.04)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C545(0.95)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C545(0.96)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C545(1.05)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C545(0.89)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C545(0.94)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C545(0.88)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C545(0.90)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C545(0.95)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C545(1.07)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C545(0.98)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C545(1.05)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C545(1.10)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C545(0.93)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C545(1.04)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C545(0.82)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C545(0.83)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C545(1.04)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C545(0.98)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C545(1.12)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C545(1.07)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C545(0.93)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C545(0.84)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C545(1.09)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C545(1.12)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C545(0.92)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C545(0.86)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C545(1.13)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C545(1.19)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C545(1.10)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C545(1.00)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C545(1.00)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C545(1.09)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C545(1.21)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C545(0.86)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C545(0.94)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C545(1.08)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C545(1.32)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C545(1.05)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C545(1.00)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C545(0.92)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C545(1.12)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C545(0.94)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C545(0.88)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C545(0.93)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C545(1.10)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C545(0.96)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C545(0.95)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C545(0.95)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C545(1.09)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C545(1.00)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C545(1.08)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C545(0.86)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C545(0.95)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C545(1.10)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C545(1.16)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C545(1.11)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C545(0.98)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C545(1.17)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C545(1.11)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C545(1.20)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C545(0.90)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C545(1.12)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C545(1.17)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C545(1.04)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C545(1.25)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C545(1.15)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C545(1.01)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C545(1.46)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C545(1.16)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C545(1.33)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C545(1.56)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C545(1.25)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C545(0.98)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C545(1.15)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C545(1.54)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C545(1.02)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C545(1.16)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C545(1.23)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C545(1.39)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C545(1.23)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C545(1.08)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C545(1.40)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C545(1.08)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C545(1.00)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C545(1.11)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C545(0.95)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C545(0.92)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C545(1.07)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C545(1.16)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C545(0.90)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C545(0.94)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C545(1.07)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C545(1.24)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C545(0.93)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C545(0.92)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C545(1.20)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C545(0.84)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C545(1.23)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C545(1.42)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C545(1.05)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C545(1.29)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C545(1.44)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C545(1.12)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C545(1.08)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C545(1.09)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C545(0.94)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C545(1.10)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C545(0.99)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C545(1.15)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C545(0.89)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C545(1.52)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C545(1.02)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C545(1.37)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C545(0.82)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C545(0.85)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C545(1.01)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C545(1.01)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C545(0.98)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C545(1.15)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C545(1.00)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C545(0.98)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C545(1.06)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C545(1.11)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C545(0.96)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C545(1.06)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C545(0.95)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C545(1.08)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C545(1.04)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C545(0.96)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C545(0.88)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C545(1.09)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C545(1.31)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C545(1.05)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C545(1.15)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C545(1.03)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C545(1.27)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C545(1.21)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C545(1.13)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C545(0.95)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C545(1.02)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C545(1.12)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C545(1.06)  LDD1025  [1]
 LDCM0022  KB02 HEK-293T C545(1.05)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C545(1.00)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C545(1.01)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Tob1 (TOB1) BTG family P50616

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402