Details of the Target

General Information of Target

Target ID LDTP06401
Target Name Regucalcin (RGN)
Gene Name RGN
Gene ID 9104
Synonyms
SMP30; Regucalcin; RC; Gluconolactonase; GNL; EC 3.1.1.17; Senescence marker protein 30; SMP-30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSIKIECVLPENCRCGESPVWEEVSNSLLFVDIPAKKVCRWDSFTKQVQRVTMDAPVSS
VALRQSGGYVATIGTKFCALNWKEQSAVVLATVDNDKKNNRFNDGKVDPAGRYFAGTMAE
ETAPAVLERHQGALYSLFPDHHVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYSVDAFDY
DLQTGQISNRRSVYKLEKEEQIPDGMCIDAEGKLWVACYNGGRVIRLDPVTGKRLQTVKL
PVDKTTSCCFGGKNYSEMYVTCARDGMDPEGLLRQPEAGGIFKITGLGVKGIAPYSYAG
Target Bioclass
Enzyme
Family
SMP-30/CGR1 family
Subcellular location
Cytoplasm
Function
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities.
Uniprot ID
Q15493
Ensemble ID
ENST00000336169.3
HGNC ID
HGNC:9989

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
UACC62 SNV: p.G205R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C248(3.78)  LDD1699  [1]
IPM
 Probe Info  		C249(10.62)  LDD1701  [1]
DBIA
 Probe Info  		C248(0.96)  LDD0812  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C248(0.96)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C248(0.76)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C248(1.02)  LDD0824  [2]
 LDCM0237  AC12 HEK-293T C248(0.74)  LDD0835  [2]
 LDCM0259  AC14 HEK-293T C248(0.86)  LDD0857  [2]
 LDCM0263  AC143 HEK-293T C248(0.98)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C248(0.84)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C248(1.30)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C248(1.27)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C248(0.97)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C248(0.55)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C248(0.76)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C248(0.86)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C248(1.03)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C248(0.90)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C248(1.22)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C248(0.86)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C248(1.35)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C248(0.80)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C248(0.97)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C248(1.37)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C248(1.55)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C248(1.15)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C248(1.37)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C248(1.13)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C248(1.84)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C248(1.50)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C248(1.63)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C248(1.74)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C248(1.46)  LDD0882  [2]
 LDCM0288  AC28 HEK-293T C248(1.01)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C248(1.02)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C248(1.02)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C248(1.01)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C248(1.08)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C248(0.99)  LDD1532  [3]
 LDCM0297  AC36 HEK-293T C248(1.16)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C248(1.04)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C248(1.03)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C248(1.02)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C248(0.89)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C248(1.10)  LDD1541  [3]
 LDCM0306  AC44 HEK-293T C248(1.07)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C248(1.07)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C248(0.82)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C248(1.06)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C248(1.04)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C248(1.34)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C248(1.57)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C248(1.36)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C248(0.99)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C248(1.37)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C248(1.22)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C248(0.74)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C248(1.40)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C248(1.23)  LDD0917  [2]
 LDCM0323  AC6 HEK-293T C248(1.29)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C248(1.01)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C248(1.12)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C248(1.02)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C248(1.00)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C248(1.02)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C248(0.87)  LDD0932  [2]
 LDCM0345  AC8 HEK-293T C248(1.66)  LDD0943  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C248(1.00)  LDD2113  [1]
 LDCM0248  AKOS034007472 HEK-293T C248(0.91)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C248(0.88)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C248(1.06)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C248(1.18)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C248(1.35)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C248(1.22)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C248(1.89)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C248(1.16)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C248(1.61)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C248(1.56)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C248(1.58)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C248(1.00)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C248(1.34)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C248(1.21)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C248(1.19)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C248(1.13)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C248(1.30)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C248(1.83)  LDD0979  [2]
 LDCM0383  CL113 HEK-293T C248(1.12)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C248(0.99)  LDD1591  [3]
 LDCM0390  CL12 HEK-293T C248(1.01)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C248(1.49)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C248(1.02)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C248(0.63)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C248(1.21)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C248(1.00)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C248(1.03)  LDD1604  [3]
 LDCM0403  CL16 HEK-293T C248(2.05)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C248(0.94)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C248(0.98)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C248(0.93)  LDD1004  [2]
 LDCM0408  CL20 HEK-293T C248(0.81)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C248(0.99)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C248(0.96)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C248(0.69)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C248(0.79)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C248(0.87)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C248(1.02)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C248(0.96)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C248(0.87)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C248(0.90)  LDD1015  [2]
 LDCM0419  CL30 HEK-293T C248(1.06)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C248(2.78)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C248(1.76)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C248(3.90)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C248(1.55)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C248(1.70)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C248(1.07)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C248(1.71)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C248(1.76)  LDD1026  [2]
 LDCM0430  CL40 HEK-293T C248(1.66)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C248(1.68)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C248(1.49)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C248(1.55)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C248(1.86)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C248(1.57)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C248(1.07)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C248(0.90)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C248(0.89)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C248(0.78)  LDD1037  [2]
 LDCM0441  CL50 HEK-293T C248(1.04)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C248(0.62)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C248(0.79)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C248(0.94)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C248(0.81)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C248(0.90)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C248(0.77)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C248(0.81)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C248(0.59)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C248(1.17)  LDD1048  [2]
 LDCM0452  CL60 HEK-293T C248(1.21)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C248(1.46)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C248(1.72)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C248(1.84)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C248(1.86)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C248(1.56)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C248(1.34)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C248(1.23)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C248(1.31)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C248(1.20)  LDD1059  [2]
 LDCM0463  CL70 HEK-293T C248(1.28)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C248(1.28)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C248(2.18)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C248(1.12)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C248(2.01)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C248(1.43)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C248(1.37)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C248(3.70)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C248(1.54)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C248(1.31)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C248(1.31)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C248(1.04)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C248(0.71)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C248(0.89)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C248(1.54)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C248(1.29)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C248(1.21)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C248(2.40)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C248(1.63)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C248(1.53)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C248(1.08)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C248(1.11)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C248(1.75)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C248(1.12)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C248(1.13)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C248(1.84)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C248(1.85)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C248(1.43)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C248(1.50)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C248(1.19)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C248(1.06)  LDD1092  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C249(3.33)  LDD1702  [1]
 LDCM0468  Fragment33 HEK-293T C248(1.92)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C248(1.44)  LDD1025  [2]
 LDCM0023  KB03 MDA-MB-231 C249(10.62)  LDD1701  [1]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C248(1.01)  LDD2097  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C248(1.63); C249(1.24)  LDD2101  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C248(0.81)  LDD2115  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C249(0.62)  LDD2134  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C248(0.61)  LDD2148  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402