Details of the Target

General Information of Target

Target ID LDTP06079
Target Name Dihydropyrimidinase-related protein 3 (DPYSL3)
Gene Name DPYSL3
Gene ID 1809
Synonyms
CRMP4; DRP3; ULIP; ULIP1; Dihydropyrimidinase-related protein 3; DRP-3; Collapsin response mediator protein 4; CRMP-4; Unc-33-like phosphoprotein 1; ULIP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEA
NGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAY
EKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTE
LYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAI
TIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAA
FVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEE
RMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIV
SAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYK
RIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPNPPVRNLHQSGFSL
SGTQVDEGVRSASKRIVAPPGGRSNITSLS
Target Bioclass
Enzyme
Family
Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
Subcellular location
Cytoplasm
Function Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
Uniprot ID
Q14195
Ensemble ID
ENST00000343218.10
HGNC ID
HGNC:3015

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C362(2.10); C562(2.25)  LDD3311  [2]
HHS-482
 Probe Info  		Y32(3.41)  LDD0288  [3]
HHS-475
 Probe Info  		Y32(1.00)  LDD0264  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
HHS-465
 Probe Info  		N.A.  LDD2240  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C277
 Probe Info  		7.46  LDD1947  [8]
STS-2
 Probe Info  		1.00  LDD0139  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 11.77  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0116  HHS-0101 DM93 Y32(1.00)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y32(0.91)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y32(0.76)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y32(0.76)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y32(0.83)  LDD0268  [4]
 LDCM0126  JWB150 DM93 Y32(3.41)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y32(3.29)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y32(2.98)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y32(0.55)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y32(1.01)  LDD0292  [3]
 LDCM0022  KB02 22RV1 C362(2.49); C562(1.74); C39(1.87)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C362(2.94); C562(2.53); C39(1.68)  LDD2660  [2]
 LDCM0024  KB05 G361 C362(2.10); C562(2.25)  LDD3311  [2]
 LDCM0109  NEM HeLa N.A.  LDD0231  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydropyrimidinase-related protein 1 (CRMP1) Hydantoinase/dihydropyrimidinase family Q14194
Dihydropyrimidinase-related protein 5 (DPYSL5) Hydantoinase/dihydropyrimidinase family Q9BPU6
OTU domain-containing protein 6A (OTUD6A) . Q7L8S5
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydropyrimidinase-related protein 2 (DPYSL2) Hydantoinase/dihydropyrimidinase family Q16555
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adrenocortical dysplasia protein homolog (ACD) . Q96AP0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.