Details of the Target

General Information of Target

Target ID LDTP05869
Target Name Zinc transporter ZIP6 (SLC39A6)
Gene Name SLC39A6
Gene ID 25800
Synonyms
LIV1; ZIP6; Zinc transporter ZIP6; Estrogen-regulated protein LIV-1; Solute carrier family 39 member 6; Zrt- and Irt-like protein 6; ZIP-6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQL
FYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEH
EHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKD
SVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKT
NESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDA
RSCLIHTSEKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSF
LVALAVGTLSGDAFLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDS
TWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTN
EEKVDTDDRTEGYLRADSQEPSHFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKC
HSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGVATLAWMVI
MGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLY
NALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCS
RWGYFFLQNAGMLLGFGIMLLISIFEHKIVFRINF
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
ZIP transporter (TC 2.A.5) family
Subcellular location
Cell membrane
Function
Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) . When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition.
TTD ID
T25739
Uniprot ID
Q13433
DrugMap ID
TTZN1CF
Ensemble ID
ENST00000269187.10
HGNC ID
HGNC:18607
ChEMBL ID
CHEMBL4523581

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.C540S .
HEC1 SNV: p.A694V .
HEC1B SNV: p.A694V .
HT115 SNV: p.D716G .
LNCaP clone FGC SNV: p.A590V .
MDAMB157 SNV: p.I678T .
MFE319 SNV: p.L304P .
OVK18 SNV: p.A510V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C303(2.23)  LDD1699  [1]
OPA-S-S-alkyne
 Probe Info  		K156(3.23); K249(3.95); K143(4.18); K164(7.08)  LDD3494  [2]
Probe 1
 Probe Info  		Y473(25.10); Y493(48.47)  LDD3495  [3]
DBIA
 Probe Info  		C303(2.82)  LDD3369  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
NAIA_5
 Probe Info  		C146(0.00); C303(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C303(1.16)  LDD2152  [1]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C303(0.60)  LDD2132  [1]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C303(0.59)  LDD2131  [1]
 LDCM0214  AC1 HEK-293T C146(0.99); C264(1.27)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C146(0.98)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C146(1.05); C303(0.97)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C146(0.94)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C146(0.97)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C146(1.02)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C146(0.97); C264(1.17)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C146(0.99)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C146(1.05); C303(1.26)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C146(1.06)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C146(0.96)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C146(1.01)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C146(0.93)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C146(0.95)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C146(1.02); C264(1.00)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C146(1.02); C264(1.46)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C146(1.03)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C146(0.96); C303(1.02)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C146(0.90)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C146(1.03)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C146(0.95); C303(0.97)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C146(0.92)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C146(1.02)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C146(0.93); C264(1.17)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C146(1.18); C264(1.01)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C146(1.06)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C146(1.01); C303(0.93)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C146(0.98)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C146(1.08)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C146(0.92)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C146(1.01)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C146(1.06)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C146(0.99); C264(0.97)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C146(1.14); C264(1.45)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C146(0.95)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C146(1.06); C303(1.00)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C146(0.84)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C146(1.09)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C146(1.03)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C146(1.02)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C146(0.94); C264(1.09)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C146(1.00); C264(1.30)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C146(1.02)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C146(0.94)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C146(0.94); C303(0.98)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C146(0.95)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C146(1.07)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C146(0.86)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C146(0.95)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C146(0.92); C264(1.14)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C146(0.99); C264(1.26)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C146(0.94)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C146(0.87); C303(0.92)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C146(0.96)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C146(0.80)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C146(0.92)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C146(0.84)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C146(0.91)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C146(0.87); C264(1.10)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C146(0.93)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C146(1.03); C264(0.88)  LDD1569  [9]
 LDCM0545  Acetamide MDA-MB-231 C303(0.55)  LDD2138  [1]
 LDCM0248  AKOS034007472 HEK-293T C146(1.00)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C146(1.09); C264(1.42)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C146(1.00); C264(1.28)  LDD1514  [9]
 LDCM0498  BS-3668 MDA-MB-231 C303(0.63)  LDD2091  [1]
 LDCM0632  CL-Sc Hep-G2 C146(20.00); C303(0.94); C303(0.78)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C146(0.76)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C146(1.56)  LDD1572  [9]
 LDCM0370  CL101 HEK-293T C146(0.86)  LDD1574  [9]
 LDCM0372  CL103 HEK-293T C146(0.89)  LDD1576  [9]
 LDCM0374  CL105 HEK-293T C146(0.86)  LDD1578  [9]
 LDCM0376  CL107 HEK-293T C146(0.98)  LDD1580  [9]
 LDCM0378  CL109 HEK-293T C146(0.83)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C146(1.21)  LDD1583  [9]
 LDCM0381  CL111 HEK-293T C146(0.89)  LDD1585  [9]
 LDCM0383  CL113 HEK-293T C146(0.85)  LDD1587  [9]
 LDCM0385  CL115 HEK-293T C146(0.95)  LDD1589  [9]
 LDCM0387  CL117 HEK-293T C146(0.81)  LDD1591  [9]
 LDCM0389  CL119 HEK-293T C146(0.98)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C146(1.20); C264(0.93)  LDD1594  [9]
 LDCM0392  CL121 HEK-293T C146(0.86)  LDD1596  [9]
 LDCM0394  CL123 HEK-293T C146(0.88)  LDD1598  [9]
 LDCM0396  CL125 HEK-293T C146(0.56)  LDD1600  [9]
 LDCM0398  CL127 HEK-293T C146(0.69)  LDD1602  [9]
 LDCM0400  CL13 HEK-293T C146(0.72)  LDD1604  [9]
 LDCM0402  CL15 HEK-293T C146(1.04)  LDD1606  [9]
 LDCM0404  CL17 HEK-293T C146(1.04); C264(1.14)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C146(1.02)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C146(0.92); C303(1.07)  LDD1610  [9]
 LDCM0408  CL20 HEK-293T C146(0.90)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C146(1.14)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C146(1.33)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C146(1.19)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C146(1.41); C264(1.03)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C146(0.69)  LDD1617  [9]
 LDCM0415  CL27 HEK-293T C146(1.06)  LDD1619  [9]
 LDCM0417  CL29 HEK-293T C146(1.10); C264(1.47)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C146(0.88)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C146(0.95)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C146(1.01); C303(1.06)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C146(0.92)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C146(1.00)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C146(1.16)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C146(1.33)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C146(1.43); C264(1.21)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C146(0.61)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C146(0.94)  LDD1632  [9]
 LDCM0431  CL41 HEK-293T C146(1.08); C264(1.41)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C146(1.03)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C146(1.04); C303(0.99)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C146(1.00)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C146(1.22)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C146(1.52)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C146(1.42)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C146(1.43); C264(0.93)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C146(0.61)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C146(1.03); C264(1.27)  LDD1644  [9]
 LDCM0444  CL53 HEK-293T C146(1.15); C264(1.11)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C146(0.96)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C146(1.17); C303(0.92)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C146(0.96)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C146(1.24)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C146(1.17)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C146(1.26)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C146(0.89)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C146(1.40); C264(1.01)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C146(0.63)  LDD1656  [9]
 LDCM0455  CL63 HEK-293T C146(0.93)  LDD1658  [9]
 LDCM0457  CL65 HEK-293T C146(1.13); C264(1.45)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C146(1.08)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C146(1.18); C303(0.98)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C146(1.04)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C146(1.08)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C146(0.94); C303(1.00)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C146(1.29)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C146(1.23)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C146(1.29); C264(1.11)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C146(0.62)  LDD1669  [9]
 LDCM0470  CL77 HEK-293T C146(1.06); C264(1.25)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C146(1.04)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C146(1.01); C303(1.00)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C146(0.73)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C146(0.90)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C146(1.06)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C146(1.17)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C146(1.13)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C146(1.00); C264(1.19)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C146(0.47)  LDD1682  [9]
 LDCM0481  CL87 HEK-293T C146(0.73)  LDD1684  [9]
 LDCM0483  CL89 HEK-293T C146(0.89); C264(1.10)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C146(0.99)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C146(0.91)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C146(0.86); C303(0.90)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C146(0.94)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C146(0.94)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C146(1.13)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C146(1.07)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C146(0.64); C264(1.15)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C146(0.67)  LDD1695  [9]
 LDCM0494  CL99 HEK-293T C146(1.20)  LDD1697  [9]
 LDCM0634  CY-0357 Hep-G2 C303(2.23)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C146(1.07)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C146(0.81)  LDD1671  [9]
 LDCM0022  KB02 HEK-293T C146(0.99)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C146(0.95)  LDD1497  [9]
 LDCM0024  KB05 OAW-42 C303(2.82)  LDD3369  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C303(0.87)  LDD2089  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C303(1.44)  LDD2093  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C303(0.47)  LDD2100  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C303(0.74)  LDD2104  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C303(1.08)  LDD2109  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C303(1.12)  LDD2111  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C303(0.43)  LDD2120  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C303(0.89)  LDD2123  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C303(1.31)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C303(1.10)  LDD2127  [1]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C303(0.40)  LDD2128  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C303(0.70)  LDD2133  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C303(0.91)  LDD2134  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C303(1.89)  LDD2135  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C303(4.05)  LDD1700  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C303(1.16)  LDD2140  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C303(0.83)  LDD2146  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sgn-liv1a Antibody drug conjugate DS6B1L
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sgn Liv1a Antibody D06JBV

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402