Details of the Target

General Information of Target

Target ID LDTP05693
Target Name Receptor-type tyrosine-protein phosphatase eta (PTPRJ)
Gene Name PTPRJ
Gene ID 5795
Synonyms
DEP1; Receptor-type tyrosine-protein phosphatase eta; Protein-tyrosine phosphatase eta; R-PTP-eta; EC 3.1.3.48; Density-enhanced phosphatase 1; DEP-1; HPTP eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; CD antigen CD148
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQ
ISSTAESFHKQNGTGTPQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPS
PVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTITVVHQPWCNITGLRPAT
SYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSR
AGSPTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAI
EFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV
IPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVP
SAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGT
LYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFDDASPTYSYCLL
IEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA
SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEV
TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF
EASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKGRSQSLSE
VLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY
SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKL
IRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDIS
RVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTK
CVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF
TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIE
NENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIY
ENLAPVTTFGKTNGYIA
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Receptor class 3 subfamily
Subcellular location
Cell membrane
Function
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.; [Isoform 2]: Activates angiogenesis and cell migration. Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1.
TTD ID
T94449
Uniprot ID
Q12913
DrugMap ID
TTWMKXP
Ensemble ID
ENST00000418331.7
HGNC ID
HGNC:9673
ChEMBL ID
CHEMBL3692

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 Insertion: p.N501Ter .
CORL88 SNV: p.D1210G DBIA    Probe Info 
HCC1187 SNV: p.H1104D .
HCT116 Deletion: p.I813del .
IPC298 SNV: p.Q71Ter DBIA    Probe Info 
KMCH1 SNV: p.K140R .
KYSE30 SNV: p.G893R .
MEWO SNV: p.P1115L DBIA    Probe Info 
SUPT1 SNV: p.Y1272H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1148(10.00); K154(2.27); K202(6.48)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K281(0.91); K202(2.90); K876(3.12)  LDD3494  [2]
Acrolein
 Probe Info  		N.A.  LDD0224  [3]
DBIA
 Probe Info  		C1039(0.88)  LDD0078  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1039(1.32)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C1039(1.34)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C1039(1.16)  LDD1105  [4]
 LDCM0237  AC12 PaTu 8988t C1039(1.06)  LDD1116  [4]
 LDCM0259  AC14 PaTu 8988t C1039(1.15)  LDD1138  [4]
 LDCM0263  AC143 PaTu 8988t C1039(0.95)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C1039(0.79)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C1039(1.12)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C1039(0.78)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C1039(0.98)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C1039(1.09)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C1039(0.87)  LDD1148  [4]
 LDCM0270  AC15 PaTu 8988t C1039(1.12)  LDD1149  [4]
 LDCM0271  AC150 PaTu 8988t C1039(1.02)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C1039(0.96)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C1039(0.91)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C1039(0.96)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C1039(0.94)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C1039(0.92)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C1039(1.02)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C1039(0.90)  LDD2169  [4]
 LDCM0276  AC17 PaTu 8988t C1149(1.08)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C1149(1.19)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C1149(1.25)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C1039(1.19)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C1149(1.22)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C1149(1.35)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C1149(1.07)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C1149(1.16)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C1149(1.16)  LDD1163  [4]
 LDCM0285  AC25 PaTu 8988t C1149(1.00); C1039(1.03)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C1149(1.10); C1039(0.98)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C1149(1.09); C1039(1.05)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C1149(0.98); C1039(1.02)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C1149(1.11); C1039(0.89)  LDD1168  [4]
 LDCM0290  AC3 PaTu 8988t C1039(0.94)  LDD1169  [4]
 LDCM0291  AC30 PaTu 8988t C1149(1.14); C1039(1.02)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C1149(1.01); C1039(1.14)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C1149(1.00); C1039(0.95)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C1149(1.13); C1039(1.02)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C1149(1.16); C1039(1.00)  LDD1174  [4]
 LDCM0296  AC35 PaTu 8988t C1149(0.92); C1039(0.94)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C1149(0.84); C1039(0.79)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C1149(0.88); C1039(0.98)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C1149(0.92); C1039(0.97)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C1149(0.91); C1039(0.86)  LDD1179  [4]
 LDCM0301  AC4 PaTu 8988t C1039(1.21)  LDD1180  [4]
 LDCM0302  AC40 PaTu 8988t C1149(0.84); C1039(0.92)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C1149(0.79); C1039(0.83)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C1149(0.86); C1039(0.91)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C1149(0.82); C1039(0.98)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C1149(0.97); C1039(1.14)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C1149(0.91); C1039(0.87)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C1149(1.02); C1039(0.95)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C1149(1.11); C1039(0.89)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C1149(1.24); C1039(0.97)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C1149(1.31); C1039(1.05)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C1039(1.26)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C1149(1.12); C1039(1.14)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C1149(1.07); C1039(0.32)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C1149(1.13); C1039(0.97)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C1149(1.34); C1039(1.06)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C1149(1.42); C1039(1.07)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C1149(1.19); C1039(1.29)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C1149(1.36); C1039(1.00)  LDD1198  [4]
 LDCM0320  AC57 PaTu 8988t C1039(0.84)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C1039(0.94)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C1039(0.85)  LDD1201  [4]
 LDCM0323  AC6 PaTu 8988t C1039(1.28)  LDD1202  [4]
 LDCM0324  AC60 PaTu 8988t C1039(0.88)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C1039(1.15)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C1039(0.94)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C1039(0.94)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C1039(0.95)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C1039(1.03)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C1039(1.06)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C1039(0.91)  LDD1210  [4]
 LDCM0332  AC68 PaTu 8988t C1039(0.92)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C1039(0.90)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C1039(1.05)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C1039(0.91)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C1039(0.93)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C1039(1.09)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C1039(0.80)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C1039(0.99)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C1039(1.05)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C1039(0.95)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C1039(1.03)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C1039(0.82)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C1039(1.20)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C1039(1.25)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C1039(0.85)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C1039(0.86)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C1039(0.95)  LDD1227  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C1039(1.33)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C1039(1.33)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C1039(1.10)  LDD1154  [4]
 LDCM0020  ARS-1620 HCC44 C1039(0.88)  LDD0078  [4]
 LDCM0367  CL1 PaTu 8988t C1149(1.21); C1039(1.14)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C1149(1.09); C1039(1.08)  LDD1247  [4]
 LDCM0369  CL100 PaTu 8988t C1039(1.30)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C1039(1.27)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C1039(0.85)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C1039(1.27)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C1039(1.14)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C1149(1.19)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C1149(1.09)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C1149(1.18)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C1149(1.17)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C1149(1.35)  LDD1257  [4]
 LDCM0379  CL11 PaTu 8988t C1149(0.94); C1039(0.88)  LDD1258  [4]
 LDCM0380  CL110 PaTu 8988t C1149(1.09)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C1149(1.18)  LDD1260  [4]
 LDCM0382  CL112 PaTu 8988t C1149(1.09); C1039(0.99)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C1149(1.12); C1039(1.00)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C1149(0.98); C1039(0.88)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C1149(1.02); C1039(0.97)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C1149(1.50); C1039(1.16)  LDD1265  [4]
 LDCM0387  CL117 PaTu 8988t C1149(0.86); C1039(0.95)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C1149(1.00); C1039(1.23)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C1149(0.87); C1039(0.97)  LDD1268  [4]
 LDCM0390  CL12 PaTu 8988t C1149(0.99); C1039(0.88)  LDD1269  [4]
 LDCM0391  CL120 PaTu 8988t C1149(0.79); C1039(0.89)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C1149(1.29); C1039(1.07)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C1149(1.31); C1039(0.98)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C1149(1.10); C1039(0.87)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C1149(1.13); C1039(0.89)  LDD1274  [4]
 LDCM0396  CL125 PaTu 8988t C1039(0.89)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C1039(0.95)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C1039(1.01)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C1039(0.79)  LDD1278  [4]
 LDCM0400  CL13 PaTu 8988t C1149(1.08); C1039(0.96)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C1149(1.05); C1039(0.92)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C1149(0.83); C1039(0.80)  LDD1281  [4]
 LDCM0403  CL16 PaTu 8988t C1039(1.05)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C1039(1.02)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C1039(0.92)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C1039(0.95)  LDD1285  [4]
 LDCM0407  CL2 PaTu 8988t C1149(1.10); C1039(0.87)  LDD1286  [4]
 LDCM0408  CL20 PaTu 8988t C1039(0.94)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C1039(0.90)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C1039(0.94)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C1039(1.13)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C1039(1.21)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C1039(1.02)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C1039(0.92)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C1039(1.01)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C1039(1.13)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C1039(1.01)  LDD1296  [4]
 LDCM0418  CL3 PaTu 8988t C1149(1.28); C1039(1.09)  LDD1297  [4]
 LDCM0419  CL30 PaTu 8988t C1039(1.05)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C1149(0.96); C1039(1.10)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C1149(1.03); C1039(0.88)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C1149(1.00); C1039(0.90)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C1149(0.88); C1039(0.96)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C1039(1.11); C1149(0.94)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C1149(0.63); C1039(0.44)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C1149(1.11); C1039(1.00)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C1149(1.24); C1039(1.16)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C1149(1.28); C1039(1.14)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C1149(1.03); C1039(1.20)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C1149(0.79); C1039(0.84)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C1149(0.91); C1039(1.02)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C1149(0.96); C1039(1.08)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C1149(1.08); C1039(1.26)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C1149(1.02); C1039(1.00)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C1149(1.07)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C1149(0.95)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C1149(1.20)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C1149(1.18)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C1149(1.11); C1039(1.09)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C1149(1.14)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C1149(1.26)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C1149(1.05)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C1149(1.04)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C1149(1.01)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C1149(1.23)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C1149(0.20)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C1149(1.18)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C1149(1.19)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C1149(1.27)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C1149(1.02); C1039(0.90)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C1149(1.17)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C1039(1.15)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C1039(1.28)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C1039(1.14)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C1039(0.98)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C1039(1.08)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C1039(1.21)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C1039(1.29)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C1039(1.34)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C1039(1.23)  LDD1340  [4]
 LDCM0462  CL7 PaTu 8988t C1149(1.03); C1039(0.96)  LDD1341  [4]
 LDCM0463  CL70 PaTu 8988t C1039(1.50)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C1039(0.99)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C1039(1.11)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C1039(1.24)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C1039(1.21)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C1039(1.09)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C1039(0.79)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C1039(0.96)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C1039(1.03)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C1149(0.94); C1039(0.99)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C1039(0.97)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C1039(1.04)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C1039(1.09)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C1039(1.09)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C1039(1.02)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C1039(0.91)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C1039(0.93)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C1039(0.95)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C1039(0.97)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C1039(0.96)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C1149(0.99); C1039(0.86)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C1039(0.81)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C1039(1.09)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C1039(1.08)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C1039(1.07)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C1039(1.11)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C1039(0.98)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C1039(0.92)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C1039(1.24)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C1039(1.42)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C1039(1.14)  LDD1373  [4]
 LDCM0468  Fragment33 PaTu 8988t C1039(1.05)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C1149(0.97); C1039(1.12)  LDD1306  [4]
 LDCM0022  KB02 786-O C1149(1.90)  LDD2247  [5]
 LDCM0023  KB03 786-O C1149(2.34)  LDD2664  [5]
 LDCM0024  KB05 COLO792 C516(1.87)  LDD3310  [5]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
Mitogen-activated protein kinase 3 (MAPK3) CMGC Ser/Thr protein kinase family P27361
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
Vascular endothelial growth factor receptor 1 (FLT1) Tyr protein kinase family P17948
Vascular endothelial growth factor receptor 2 (KDR) Tyr protein kinase family P35968
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Angiopoietin-1 receptor (TEK) Tyr protein kinase family Q02763
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin delta-1 (CTNND1) Beta-catenin family O60716
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth hormone receptor (GHR) Type I cytokine receptor family P10912
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480

The Drug(s) Related To This Target

Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us9340574, 7 Small molecular drug D0H6LK

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840