Details of the Target

General Information of Target

Target ID LDTP05676
Target Name Chromodomain-helicase-DNA-binding protein 3 (CHD3)
Gene Name CHD3
Gene ID 1107
Synonyms
Chromodomain-helicase-DNA-binding protein 3; CHD-3; EC 3.6.4.12; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKAADTVILWARSKNDQLRISFPPGLCWGDRMPDKDDIRLLPSALGVKKRKRGPKKQKEN
KPGKPRKRKKRDSEEEFGSERDEYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKK
GEGDGGQKQVEQKSSATLLLTWGLEDVEHVFSEEDYHTLTNYKAFSQFMRPLIAKKNPKI
PMSKMMTILGAKWREFSANNPFKGSAAAVAAAAAAAAAAVAEQVSAAVSSATPIAPSGPP
ALPPPPAADIQPPPIRRAKTKEGKGPGHKRRSKSPRVPDGRKKLRGKKMAPLKIKLGLLG
GKRKKGGSYVFQSDEGPEPEAEESDLDSGSVHSASGRPDGPVRTKKLKRGRPGRKKKKVL
GCPAVAGEEEVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELDRAPEGKWSC
PHCEKEGVQWEAKEEEEEYEEEGEEEGEKEEEDDHMEYCRVCKDGGELLCCDACISSYHI
HCLNPPLPDIPNGEWLCPRCTCPVLKGRVQKILHWRWGEPPVAVPAPQQADGNPDVPPPR
PLQGRSEREFFVKWVGLSYWHCSWAKELQLEIFHLVMYRNYQRKNDMDEPPPLDYGSGED
DGKSDKRKVKDPHYAEMEEKYYRFGIKPEWMTVHRIINHSVDKKGNYHYLVKWRDLPYDQ
STWEEDEMNIPEYEEHKQSYWRHRELIMGEDPAQPRKYKKKKKELQGDGPPSSPTNDPTV
KYETQPRFITATGGTLHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYK
EGHTKGPFLVSAPLSTIINWEREFQMWAPKFYVVTYTGDKDSRAIIRENEFSFEDNAIKG
GKKAFKMKREAQVKFHVLLTSYELITIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLN
GYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLL
GPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYYKYILTRNFEALNSRGGGNQVSLLN
IMMDLKKCCNHPYLFPVAAMESPKLPSGAYEGGALIKSSGKLMLLQKMLRKLKEQGHRVL
IFSQMTKMLDLLEDFLDYEGYKYERIDGGITGALRQEAIDRFNAPGAQQFCFLLSTRAGG
LGINLATADTVIIFDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRASVEERITQVAKR
KMMLTHLVVRPGLGSKAGSMSKQELDDILKFGTEELFKDENEGENKEEDSSVIHYDNEAI
ARLLDRNQDATEDTDVQNMNEYLSSFKVAQYVVREEDKIEEIEREIIKQEENVDPDYWEK
LLRHHYEQQQEDLARNLGKGKRVRKQVNYNDAAQEDQDNQSEYSVGSEEEDEDFDERPEG
RRQSKRQLRNEKDKPLPPLLARVGGNIEVLGFNTRQRKAFLNAVMRWGMPPQDAFTTQWL
VRDLRGKTEKEFKAYVSLFMRHLCEPGADGSETFADGVPREGLSRQQVLTRIGVMSLVKK
KVQEFEHINGRWSMPELMPDPSADSKRSSRASSPTKTSPTTPEASATNSPCTSKPATPAP
SEKGEGIRTPLEKEEAENQEEKPEKNSRIGEKMETEADAPSPAPSLGERLEPRKIPLEDE
VPGVPGEMEPEPGYRGDREKSATESTPGERGEEKPLDGQEHRERPEGETGDLGKREDVKG
DRELRPGPRDEPRSNGRREEKTEKPRFMFNIADGGFTELHTLWQNEERAAISSGKLNEIW
HRRHDYWLLAGIVLHGYARWQDIQNDAQFAIINEPFKTEANKGNFLEMKNKFLARRFKLL
EQALVIEEQLRRAAYLNLSQEPAHPAMALHARFAEAECLAESHQHLSKESLAGNKPANAV
LHKVLNQLEELLSDMKADVTRLPATLSRIPPIAARLQMSERSILSRLASKGTEPHPTPAY
PPGPYATPPGYGAAFSAAPVGALAAAGANYSQMPAGSFITAATNGPPVLVKKEKEMVGAL
VSDGLDRKEPRAGEVICIDD
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family
Subcellular location
Nucleus, PML body
Function
ATP-dependent helicase that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Involved in transcriptional repression as part of the NuRD complex. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Uniprot ID
Q12873
Ensemble ID
ENST00000330494.12
HGNC ID
HGNC:1918

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.R540VfsTer16 .
A673 SNV: p.Q386E DBIA    Probe Info 
CAL148 SNV: p.I1143M .
CAL27 SNV: p.A1188E .
CASKI SNV: p.D279N DBIA    Probe Info 
CCK81 SNV: p.R1491C DBIA    Probe Info 
COLO800 Deletion: p.A212GfsTer10
SNV: p.A211G		 DBIA    Probe Info 
EFO27 Deletion: p.I234Ter .
HCT116 SNV: p.P246L .
HCT15 SNV: p.A174D .
HEC1 SNV: p.R748C .
JURKAT Deletion: p.R276EfsTer19 .
LS123 SNV: p.L41V; p.N60K; p.A211G DBIA    Probe Info 
MCC13 Substitution: p.S1528F .
MFE319 Deletion: p.E368RfsTer116 .
NCIH1048 SNV: p.G1667R .
NCIH1155 Deletion: p.R276EfsTer19 .
NCIH358 SNV: p.W495L .
NCIH716 SNV: p.E1611G .
OVK18 SNV: p.R256Ter .
PF382 SNV: p.R1294W DBIA    Probe Info 
SNGM SNV: p.P498L; p.R1461C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y1326(20.00)  LDD0260  [1]
ONAyne
 Probe Info  		K969(0.48)  LDD0274  [2]
Probe 1
 Probe Info  		Y1291(16.32); Y1326(26.17)  LDD3495  [3]
m-APA
 Probe Info  		15.00  LDD0403  [4]
DBIA
 Probe Info  		C1523(1.64)  LDD3323  [5]
BTD
 Probe Info  		C1551(0.92)  LDD2124  [6]
HHS-475
 Probe Info  		Y1326(1.10)  LDD0264  [7]
HHS-465
 Probe Info  		Y1326(10.00)  LDD2237  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1464(0.00); C879(0.00); C405(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C1464(0.00); C879(0.00)  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0025  [13]
NAIA_5
 Probe Info  		C1997(0.00); C1838(0.00)  LDD2224  [14]
TFBX
 Probe Info  		C1997(0.00); C1838(0.00)  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
Acrolein
 Probe Info  		C1838(0.00); C1464(0.00); C879(0.00); C405(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		C1838(0.00); C879(0.00); C1464(0.00)  LDD0218  [16]
HHS-482
 Probe Info  		Y1326(0.76)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [17]
STS-2
 Probe Info  		N.A.  LDD0138  [17]
EN
 Probe Info  		3.29  LDD0418  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1464(0.96); C1551(0.99); C879(1.03); C423(0.96)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C1464(1.05); C459(1.37); C1131(1.38); C1551(1.12)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C1464(1.01); C1551(1.06); C879(1.05); C502(1.10)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C1464(0.94); C459(0.95); C1551(1.01); C879(0.95)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C1464(0.88); C459(1.05); C1131(1.00); C879(0.98)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C1464(1.19); C1131(0.99); C1551(0.94); C879(1.10)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C1464(0.97); C1551(0.89); C879(0.90); C423(1.02)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C1464(1.22); C459(1.25); C1131(1.17); C1551(1.15)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C1464(0.96); C1551(1.15); C879(1.13); C502(1.75)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C1464(0.95); C459(1.03); C1131(0.99); C1551(1.03)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C1464(1.12); C459(1.26); C1551(0.92); C879(0.93)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C1464(0.99); C1131(0.85); C1551(1.14); C879(1.03)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C1464(0.91); C459(1.31); C1131(0.93); C879(0.93)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C1464(1.26); C1131(0.95); C1551(0.94); C879(1.11)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C1464(0.91); C459(1.30); C1131(1.20); C879(1.03)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C1464(0.98); C1551(1.00); C879(0.98); C423(1.03)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C1464(1.29); C459(1.19); C1131(1.00); C1551(1.01)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C1464(1.02); C1551(0.94); C879(0.95); C502(0.99)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C1464(0.80); C459(1.07); C1551(1.06); C879(0.94)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C1464(1.04); C1131(1.03); C1551(1.11); C879(1.00)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C1464(1.00); C1551(1.09); C879(1.03); C502(1.05)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C1464(1.00); C459(1.10); C1131(1.11); C879(1.01)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C1464(1.17); C1131(0.95); C1551(1.03); C879(1.10)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C1464(1.09); C459(1.25); C1131(1.21); C879(1.09)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C1464(0.95); C1551(0.93); C879(1.03); C423(1.02)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C1464(0.87); C459(1.40); C1131(1.00); C1551(1.13)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C1464(0.99); C1551(1.03); C879(0.98); C502(1.11)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C1464(0.96); C459(1.13); C1551(0.95); C879(0.98)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C1464(1.09); C1131(1.08); C1551(1.08); C879(1.02)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C1464(0.88); C459(1.06); C1131(1.24); C879(0.96)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C1464(1.11); C1131(0.87); C1551(1.06); C879(1.06)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C1464(0.91); C459(1.11); C1551(1.08); C879(0.93)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C1464(1.05); C459(1.40); C1131(1.03); C879(0.98)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C1464(0.99); C1551(0.80); C879(0.94); C423(1.00)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C1464(1.00); C459(1.32); C1131(0.96); C1551(1.14)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C1464(1.16); C1551(1.10); C879(0.99); C502(1.10)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C1464(1.01); C459(1.02); C1551(0.95); C879(1.01)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C1464(0.97); C1131(0.90); C1551(1.20); C879(1.07)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C1464(0.97); C459(1.17); C1131(1.22); C879(1.07)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C1464(1.20); C1131(1.12); C1551(1.15); C879(1.02)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C1464(1.08); C459(1.50); C1131(1.01); C879(0.97)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C1464(0.99); C1551(0.94); C879(0.93); C423(1.05)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C1464(1.01); C1131(1.11); C1551(1.01); C879(0.99)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C1464(1.32); C459(1.34); C1131(1.20); C1551(1.18)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C1464(1.07); C1551(1.08); C879(0.99); C502(1.03)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C1464(0.99); C459(0.75); C1551(0.87); C879(0.95)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C1464(1.01); C1131(0.96); C1551(1.14); C879(0.96)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C1464(0.98); C459(1.20); C1131(1.19); C879(1.00)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C1464(1.26); C1131(1.04); C1551(0.95); C879(1.11)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C1464(1.02); C459(1.51); C1131(1.05); C879(0.98)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C1464(0.93); C1551(0.97); C879(1.02); C423(0.94)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C1464(1.09); C459(1.35); C1131(1.10); C1551(1.07)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C1464(1.00); C1551(1.12); C879(1.00); C502(1.02)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C1464(0.99); C459(0.85); C1131(1.07); C879(0.95)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C1464(1.15); C459(0.93); C1551(0.85); C879(1.02)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C1464(1.01); C1131(1.07); C1551(1.07); C879(1.04)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C1464(0.95); C459(1.07); C1131(1.20); C879(0.96)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C1464(1.18); C1131(1.14); C1551(1.21); C879(1.10)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C1464(1.04); C459(1.09); C1131(1.18); C879(0.89)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C1464(1.35); C1131(0.92); C1551(1.03); C879(1.08)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C1464(1.06); C459(1.11); C1131(1.02); C879(0.90)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C1464(1.01); C1131(1.04); C1551(1.12); C879(0.94)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C1464(0.96); C1551(0.95); C879(0.95); C423(0.99)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C1464(1.03); C459(1.30); C1131(0.97); C879(0.96)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [4]
 LDCM0108  Chloroacetamide HeLa C1838(0.00); C879(0.00); C405(0.00); C1464(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C1464(1.07); C459(0.88); C1131(1.17); C1551(0.98)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C1464(1.06); C459(0.70); C1131(0.88); C879(1.26)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C1464(0.92); C1551(0.79); C879(0.92); C502(1.00)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C1464(1.15); C459(1.14); C1131(1.03); C1551(1.12)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C1464(0.88); C459(0.93); C1131(1.00); C879(0.68)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C1464(1.04); C459(1.39); C1551(0.99); C879(0.99)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C1464(1.17); C1551(0.82); C879(0.98); C502(1.03)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C1464(1.02); C459(1.15); C1131(1.01); C1551(1.05)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C1464(0.81); C459(1.21); C1131(1.06); C879(0.99)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C1464(1.00); C459(1.24); C1551(0.92); C879(1.02)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C1464(1.10); C1551(1.12); C879(1.06); C502(1.01)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C1464(0.96); C459(1.16); C1131(1.09); C1551(1.18)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C1464(1.23); C1131(0.70); C1551(1.18); C879(1.44)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C1464(0.91); C459(1.08); C1131(1.03); C879(1.01)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C1464(1.03); C459(1.06); C1551(0.84); C879(1.03)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C1464(1.07); C1551(1.05); C879(0.98); C502(1.08)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C1464(1.03); C459(1.17); C1131(1.11); C1551(1.26)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C1464(0.88); C459(1.33); C1131(1.19); C879(1.10)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C1464(1.05); C459(1.10); C1551(0.84); C879(0.98)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C1464(0.85); C1551(0.95); C879(0.95); C502(0.95)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C1464(1.07); C459(1.39); C1131(1.12); C1551(0.95)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C1464(0.96); C459(1.30); C1131(0.93); C879(1.01)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C1464(1.09); C459(1.20); C1551(1.04); C879(1.10)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C1464(1.06); C459(1.16); C1131(0.84); C879(1.16)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C1464(1.08); C1551(0.99); C879(0.98); C502(0.96)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C1464(1.12); C459(1.15); C1131(1.16); C1551(1.03)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C1464(0.99); C459(1.46); C1131(1.17); C879(0.95)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C1464(0.96); C459(1.29); C1551(0.97); C879(1.16)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C1464(0.94); C1551(0.87); C879(1.00); C502(1.15)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C1464(1.02); C459(0.93); C1131(1.24); C1551(1.06)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C1464(0.91); C459(1.05); C1131(1.11); C879(0.96)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C1464(0.99); C459(1.13); C1551(0.93); C879(0.97)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C1464(1.00); C1551(0.89); C879(0.94); C502(0.99)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C1464(1.15); C459(0.93); C1131(1.05); C1551(1.07)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C1464(0.93); C459(1.26); C1131(0.98); C879(0.93)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C1464(1.01); C459(1.06); C1551(0.90); C879(1.13)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C1464(0.87); C1551(1.16); C879(0.98); C502(0.97)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C1464(0.96); C1551(0.84); C879(1.01); C423(0.94)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C1464(1.04); C459(1.26); C1131(0.95); C1551(1.06)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C1464(1.05); C1551(1.26); C879(1.20); C502(1.14)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C1464(1.03); C459(0.99); C1131(0.93); C879(0.99)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C1464(0.91); C459(0.98); C1551(1.06); C879(1.11)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C1464(0.99); C1131(0.70); C1551(1.11); C879(1.29)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C1464(0.92); C459(0.92); C1131(0.73); C879(1.05)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C1464(1.27); C1131(0.69); C1551(1.37); C879(1.28)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C1464(1.18); C459(1.23); C1131(0.78); C879(1.04)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C1464(1.15); C459(1.38); C1131(1.12); C1551(1.04)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C1464(0.98); C459(1.53); C1131(0.97); C879(0.96)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C1464(0.98); C459(1.20); C1551(1.03); C879(1.05)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C1464(0.84); C1551(1.03); C879(1.06); C502(1.12)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C1464(1.02); C1551(0.89); C879(0.97); C423(0.92)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C1464(1.04); C459(1.11); C1551(0.92); C879(1.03)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C1464(1.23); C459(1.37); C1131(0.86); C1551(1.02)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C1464(1.05); C1551(1.15); C879(1.07); C502(1.19)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C1464(1.17); C459(1.12); C1551(1.00); C879(0.95)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C1464(1.06); C1131(0.81); C1551(1.19); C879(1.21)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C1464(0.92); C459(0.83); C1131(0.72); C879(1.02)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C1464(1.43); C1131(0.62); C1551(1.03); C879(1.13)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C1464(1.08); C459(1.01); C1131(0.77); C879(1.02)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C1464(1.15); C459(1.34); C1131(1.19); C1551(0.86)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C1464(0.95); C459(1.20); C1551(0.89); C879(1.03)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C1464(1.13); C1551(1.04); C879(0.97); C502(1.01)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C1464(1.03); C1551(0.84); C879(1.00); C502(1.03)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C1464(0.86); C1551(0.92); C879(1.01); C423(0.96)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C1464(0.93); C459(1.06); C1131(0.88); C1551(1.29)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C1464(0.99); C1551(1.03); C879(1.14); C502(1.01)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C1464(1.05); C459(0.76); C1551(1.09); C879(0.92)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C1464(1.08); C1131(0.68); C1551(1.14); C879(1.18)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C1464(0.93); C459(0.91); C1131(0.76); C879(1.01)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C1464(1.42); C1131(0.56); C1551(1.04); C879(1.15)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C1464(0.94); C459(0.70); C1131(0.83); C879(1.11)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C1464(1.16); C459(1.04); C1131(1.19); C1551(0.94)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C1464(0.93); C1551(0.87); C879(0.97); C423(1.11)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C1464(0.88); C459(1.12); C1131(1.07); C879(1.00)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C1464(0.99); C1551(0.92); C879(1.04); C502(1.05)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C1464(0.99); C1551(0.80); C879(1.04); C423(0.91)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C1464(1.05); C459(1.43); C1131(0.81); C1551(1.08)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C1464(1.06); C1551(1.19); C879(1.24); C502(1.12)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C1464(0.95); C459(0.75); C1551(1.01); C879(1.04)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C1464(1.11); C1131(0.59); C1551(1.23); C879(1.07)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C1464(0.91); C459(1.44); C1131(0.79); C879(1.07)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C1464(1.16); C1131(0.62); C1551(1.37); C879(1.16)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C1464(0.92); C459(0.97); C1131(1.02); C1551(1.22)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C1464(1.04); C459(0.91); C1131(0.72); C879(1.02)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C1464(1.08); C459(1.32); C1131(1.37); C1551(0.92)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C1464(1.02); C459(1.21); C1131(1.00); C879(0.97)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C1464(1.11); C459(1.11); C1551(0.95); C879(1.02)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C1464(0.88); C1551(0.73); C879(0.97); C502(1.20)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C1464(0.90); C1551(0.88); C879(1.08); C423(0.99)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C1464(1.05); C459(1.27); C1131(0.89); C1551(1.34)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C1464(1.07); C1551(1.06); C879(1.12); C502(1.07)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C1464(1.01); C459(0.87); C1551(0.91); C879(1.07)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C1464(1.12); C1131(0.66); C1551(1.19); C879(1.13)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C1464(1.09); C1551(1.19); C879(1.23); C502(1.22)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C1464(0.92); C459(0.99); C1131(0.70); C879(1.07)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C1464(1.24); C1131(0.60); C1551(1.14); C879(1.15)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C1464(1.20); C459(1.07); C1131(0.72); C879(0.94)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C1464(1.06); C459(1.01); C1131(1.30); C1551(0.89)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C1464(0.99); C459(1.32); C1131(0.98); C879(0.93)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C1464(0.97); C1551(0.83); C879(1.00); C502(1.06)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C1464(0.94); C1551(0.89); C879(1.04); C423(0.89)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C1464(0.98); C459(1.37); C1131(0.94); C1551(1.33)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C1464(1.06); C1551(1.07); C879(1.21); C502(1.02)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C1464(0.88); C459(0.58); C1551(0.72); C879(1.20)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C1464(1.28); C459(0.77); C1551(1.07); C879(1.00)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C1464(1.11); C1131(0.71); C1551(1.18); C879(1.04)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C1464(0.87); C459(0.92); C1131(0.73); C879(1.08)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C1464(1.25); C1131(0.72); C1551(1.03); C879(1.19)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C1464(1.09); C459(0.85); C1131(0.79); C879(1.00)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C1464(1.21); C459(1.55); C1131(1.45); C1551(0.73)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C1464(1.03); C459(1.14); C1131(1.18); C879(1.00)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C1464(1.02); C459(1.19); C1551(0.93); C879(0.97)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C1464(0.98); C1551(0.91); C879(0.95); C502(0.98)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C1464(1.14); C1551(0.94); C879(1.07); C423(0.98)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C1464(1.09); C1131(0.64); C1551(1.09); C879(1.10)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C1464(1.17); C459(0.88); C1131(1.13); C1551(0.93)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C1464(0.98); C1551(1.15); C879(1.08); C502(1.04)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C1464(0.92); C459(0.73); C1551(0.99); C879(0.98)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C1464(1.14); C1131(0.82); C1551(1.06); C879(1.14)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C1464(0.95); C459(0.85); C1131(0.84); C879(1.17)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C1464(1.21); C1131(0.65); C1551(0.99); C879(1.08)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C1464(1.02); C459(0.97); C1131(0.83); C879(1.14)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C1464(1.05); C459(0.96); C1131(1.18); C1551(0.90)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C1464(0.87); C459(1.05); C1131(0.91); C879(0.98)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C1464(0.99); C459(1.01); C1551(0.99); C879(0.95)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C1464(1.01); C459(1.17); C1551(0.90); C879(1.02)  LDD1698  [19]
 LDCM0163  Entinostat Hep-G2 3.29  LDD0418  [18]
 LDCM0468  Fragment33 HEK-293T C1464(1.00); C459(1.37); C1551(0.93); C879(1.08)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C1464(0.87); C459(0.99); C1131(0.83); C879(1.03)  LDD1631  [19]
 LDCM0116  HHS-0101 DM93 Y1326(1.10)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y1326(0.96)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y1326(0.77)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y1326(0.98)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y1326(1.23)  LDD0268  [7]
 LDCM0107  IAA HeLa H957(0.00); H1462(0.00); C879(0.00)  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C1551(1.04); C1464(0.97); C879(0.88); C1997(1.02)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C1551(1.21); C1464(1.07); C879(0.96); C1997(1.10)  LDD1497  [19]
 LDCM0024  KB05 SKMEL24 C1523(1.64)  LDD3323  [5]
 LDCM0109  NEM HeLa N.A.  LDD0224  [16]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1551(0.92)  LDD2124  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX5 (DDX5) DEAD box helicase family P17844
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Transcription intermediary factor 1-beta (TRIM28) TRIM/RBCC family Q13263
BRCA1-associated RING domain protein 1 (BARD1) . Q99728
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 7A (ZBTB7A) . O95365
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-mRNA-processing factor 40 homolog A (PRPF40A) PRPF40 family O75400
Small ubiquitin-related modifier 2 (SUMO2) Ubiquitin family P61956
ARF GTPase-activating protein GIT1 (GIT1) . Q9Y2X7
SERPINE1 mRNA-binding protein 1 (SERBP1) . Q8NC51

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Expanding the "minimalist" small molecule tagging approach to different bioactive compounds. Org Biomol Chem. 2019 Mar 13;17(11):3010-3017. doi: 10.1039/c8ob03175d.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402