Details of the Target

General Information of Target

Target ID LDTP05354
Target Name Transcription factor Sp4 (SP4)
Gene Name SP4
Gene ID 6671
Synonyms
Transcription factor Sp4; SPR-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDQKKEEEEEAAAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGT
PGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQP
ASSSSSSSSSNNGSASPTKTKSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQ
INPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIP
LQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAAGGGTGQVGQPAATADSGTSNGNQL
VSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIE
ESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAI
PPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSL
SNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVAN
LGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQ
VHLQQGQQTSDQEVQPGKRLRRVACSCPNCREGEGRGSNEPGKKKQHICHIEGCGKVYGK
TSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSD
HLSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTN
MEEF
Target Bioclass
Transcription factor
Family
Sp1 C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Uniprot ID
Q02446
Ensemble ID
ENST00000222584.8
HGNC ID
HGNC:11209

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C55(2.97)  LDD3339  [1]
IA-alkyne
 Probe Info  		C625, C627, C630(20.00)  LDD1704  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C55(1.01)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C55(0.96)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C55(1.08)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C55(1.11); C627(1.06)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C55(0.99)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C55(1.00)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C55(1.06)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C55(0.99)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C55(1.15)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C55(0.87)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C55(1.12); C627(0.70)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C55(0.93)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C55(1.19)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C55(1.17)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C55(0.98); C627(0.91)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C55(0.99)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C55(0.94)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C55(1.02)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C55(0.92); C627(0.99)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C55(0.98)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C55(1.03)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C55(0.86)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C55(1.00)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C55(1.05); C627(1.25)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C55(1.02)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C55(0.94)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C55(1.09)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C55(0.96); C627(1.51)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C55(1.02)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C55(1.03)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C55(1.09)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C55(0.85); C627(1.18)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C55(1.03); C627(0.93)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C55(1.06)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C55(1.09)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C55(1.19)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C55(1.09); C627(0.92)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C55(1.05)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C55(0.99)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C55(1.05)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C55(1.09); C627(1.06)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C55(1.06)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C55(1.00)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C55(0.93)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C55(1.06)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C55(1.13); C627(1.10)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C55(1.01)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C55(1.07)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C55(1.21)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C55(0.97); C627(0.90)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C55(1.07)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C55(0.98)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C55(1.04)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C55(1.18)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C55(1.04); C627(1.07)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C55(1.00)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C55(1.00)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C55(1.00)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C55(1.09); C627(0.75)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C55(1.00)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C55(0.92); C627(1.14)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C55(1.01)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C55(1.11)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C55(1.02); C627(0.96)  LDD1514  [8]
 LDCM0020  ARS-1620 HCC44 C654(0.89)  LDD2171  [9]
 LDCM0632  CL-Sc Hep-G2 C55(0.43)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C55(0.99)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C55(0.79)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C55(1.03)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C55(1.00)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C55(1.10)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C55(1.09)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C55(0.95)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C55(1.06)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C55(1.01)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C55(1.05)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C55(1.04)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C55(0.91)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C55(0.91)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C55(0.95)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C55(0.88)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C55(1.03)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C55(1.11)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C55(0.98)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C55(0.97)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C55(0.96)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C55(1.01)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C55(1.08)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C55(0.97)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C55(0.94); C627(0.78)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C55(1.10)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C55(1.01)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C55(1.02)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C55(0.90)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C55(1.13)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C55(1.04)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C55(1.00)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C55(0.99)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C55(1.12)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C55(1.11)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C55(1.05)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C55(1.00)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C55(0.97)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C55(1.19)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C55(0.98)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C55(1.17)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C55(1.08)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C55(1.21); C627(0.98)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C55(1.05)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C55(1.09)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C55(1.04)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C55(0.97); C627(0.98)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C55(1.04)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C55(1.01)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C55(1.00)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C55(1.02)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C55(0.95)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C55(0.91)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C55(0.88)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C55(1.19)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C55(1.16); C627(1.18)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C55(1.04)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C55(1.16)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C55(1.24)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C55(0.93); C627(0.92)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C55(0.95)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C55(1.12)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C55(1.06)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C55(1.01)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C55(1.03)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C55(0.96)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C55(0.98)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C55(1.07); C627(0.98)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C55(1.08)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C55(1.32)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C55(1.13)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C55(0.89); C627(0.96)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C55(0.98)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C55(1.04)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C55(1.11)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C55(1.07)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C55(1.08)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C55(0.99)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C55(1.10)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C55(1.12); C627(0.75)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C55(0.91)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C55(0.99)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C55(0.99)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C55(0.96)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C55(0.99); C627(0.78)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C55(1.07)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C55(1.03)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C55(0.88)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C55(1.07)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C55(0.99)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C55(0.98)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C55(1.14)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C55(0.95); C627(1.02)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C55(1.01)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C55(0.98)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C55(1.08)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C55(1.01)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C55(1.01); C627(1.01)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C55(0.99)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C55(1.07)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C55(1.03)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C55(0.98)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C55(0.87)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C55(0.92)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C55(0.82); C627(0.68)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C55(0.87); C627(1.26)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C55(0.94)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C55(0.86)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C55(0.99)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C55(0.93); C627(0.91)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C55(1.06)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C55(1.03)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C55(1.05)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C55(0.97)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C55(1.12)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C55(0.98)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C55(0.90)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C55(0.98)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C55(0.96); C627(0.87)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C55(0.97)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C55(1.16)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C55(1.04)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C55(0.94); C627(0.99)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C55(0.92)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C55(1.02)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C55(0.99)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C55(1.03)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C55(1.17)  LDD1702  [10]
 LDCM0572  Fragment10 Ramos C55(0.74)  LDD2189  [11]
 LDCM0574  Fragment12 Ramos C55(0.76)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C55(1.40)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C55(0.46)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C55(0.91)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C55(1.05)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C55(1.30)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C55(1.18)  LDD2197  [11]
 LDCM0588  Fragment30 Ramos C55(1.12)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C55(0.99)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C55(1.10)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C55(0.93)  LDD1671  [8]
 LDCM0596  Fragment38 Ramos C55(0.83)  LDD2203  [11]
 LDCM0427  Fragment51 HEK-293T C55(1.08)  LDD1631  [8]
 LDCM0610  Fragment52 Ramos C55(1.20)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C55(1.06)  LDD2205  [11]
 LDCM0571  Fragment9 Ramos C55(0.99)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C55(0.91); C627(0.74)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C55(1.02); C627(0.97)  LDD1497  [8]
 LDCM0024  KB05 NALM-6 C55(2.97)  LDD3339  [1]
 LDCM0021  THZ1 HCT 116 C654(0.89)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) Pellino family Q9HAT8
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) . Q13444
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Sperm protein associated with the nucleus on the X chromosome N2 (SPANXN2) SPAN-X family Q5MJ10
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ETS domain-containing protein Elk-3 (ELK3) ETS family P41970
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Nuclear respiratory factor 1 (NRF1) NRF1/Ewg family Q16656
POU domain, class 2, transcription factor 1 (POU2F1) POU transcription factor family P14859
Transcription factor Sp4 (SP4) Sp1 C2H2-type zinc-finger protein family Q02446
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proline-rich protein 20C (PRR20C) PRR20 family P86479
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Sperm protein associated with the nucleus on the X chromosome N3 (SPANXN3) SPAN-X family Q5MJ09
Transcription initiation factor IIA subunit 1 (GTF2A1) TFIIA subunit 1 family P52655
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Collagen alpha-1(VIII) chain (COL8A1) . P27658
LIM domain only protein 3 (LMO3) . Q8TAP4
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578