Details of the Target

General Information of Target

Target ID LDTP05151
Target Name Proline-rich protein 3 (PRR3)
Gene Name PRR3
Gene ID 80742
Synonyms
CAT56; Proline-rich protein 3; MHC class I region proline-rich protein CAT56
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKRKKQNHHQPPTQQQPPLPEREETGDEEDGSPIGPPSLLGPPPMANGKPGDPKSALHR
GPPGSRGPLIPPLLSLPPPPWGRGPIRRGLGPRSSPYGRGWWGVNAEPPFPGPGHGGPTR
GSFHKEQRNPRRLKSWSLIKNTCPPKDDPQVMEDKSDRPVCRHFAKKGHCRYEDLCAFYH
PGVNGPPL
Target Bioclass
Other
Uniprot ID
P79522
Ensemble ID
ENST00000376557.3
HGNC ID
HGNC:21149

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 Deletion: p.K167RfsTer38 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C143(2.22)  LDD3332  [1]
IA-alkyne
 Probe Info  		C143(2.13)  LDD0372  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C143(2.13)  LDD0372  [2]
 LDCM0214  AC1 HEK-293T C143(1.19)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C143(1.29)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C143(1.21)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C143(1.05)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C143(1.28); C161(1.33)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C143(1.14)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C143(1.18)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C143(1.09)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C143(1.29)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C143(1.24)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C143(1.05)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C143(1.05)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C143(1.08); C161(1.28)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C143(1.15)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C143(1.07)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C143(1.18)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C143(1.18)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C143(1.10)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C143(1.26)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C143(1.12)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C143(1.18)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C143(1.01); C161(1.11)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C143(1.00)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C143(1.12)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C143(1.23)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C143(1.23)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C143(1.10)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C143(0.92)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C143(1.07)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C143(1.09); C161(1.08)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C143(0.90)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C143(1.12)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C143(1.01)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C143(1.24)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C143(1.27)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C143(1.09)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C143(0.86)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C143(1.07)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C143(1.15); C161(1.52)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C143(1.12)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C143(1.08)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C143(1.19)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C143(1.14)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C143(1.19)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C143(1.20)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C143(1.02)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C143(1.14)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C143(1.17); C161(1.30)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C143(0.99)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C143(1.09)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C143(1.17)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C143(1.14)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C143(1.09)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C143(1.09); C161(1.33)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C143(0.91)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C143(1.10)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C143(1.12); C161(0.96)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C143(1.02)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C143(1.09)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C143(1.15)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C143(1.10)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C143(1.06)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C143(1.17)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C143(1.08)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C143(0.96)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C143(0.68); C161(0.72)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C143(1.15)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C143(1.02)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C143(0.97)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C143(1.25)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C143(1.12)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C143(1.04)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C143(1.02)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C143(1.12)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C143(1.23)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C143(1.00)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C143(0.71)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C143(0.99)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C143(1.08)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C143(1.29)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C143(0.93)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C143(0.99)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C143(1.10)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C143(1.08)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C143(0.93)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C143(1.01)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C143(1.07)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C143(0.78)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C143(1.13)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C143(1.12)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C143(1.16)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C143(1.00)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C143(1.17)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C143(1.21)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C143(1.02)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C143(1.05)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C143(1.16)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C143(1.07)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C143(1.03)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C143(1.02)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C143(1.07)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C143(1.06)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C143(1.09)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C143(0.98)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C143(1.06)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C143(0.72)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C143(0.75)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C143(0.80); C161(1.27)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C143(0.74)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C143(0.76)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C143(1.04)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C143(0.98)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C143(1.15)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C143(1.20)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C143(1.07)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C143(1.02)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C143(0.95)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C143(0.95)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C143(0.89)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C143(0.76)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C143(0.73); C161(1.29)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C143(0.72)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C143(0.78)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C143(1.04)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C143(0.99)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C143(0.98)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C143(0.96)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C143(1.04)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C143(0.91)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C143(0.91)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C143(0.81)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C143(0.83)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C143(0.75); C161(1.38)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C143(0.79)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C143(0.75)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C143(1.04)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C143(1.17)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C143(0.99)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C143(1.01)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C143(1.00)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C143(0.98)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C143(0.80)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C143(0.70)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C143(0.80)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C143(0.76); C161(0.96)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C143(0.79)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C143(0.95)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C143(0.78)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C143(1.08)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C143(0.99)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C143(1.07)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C143(1.06)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C143(1.08)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C143(1.02)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C143(0.93)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C143(0.80)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C143(0.81)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C143(0.94)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C143(0.83); C161(1.65)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C143(0.79)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C143(0.78)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C143(1.01)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C143(1.05)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C143(1.10)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C143(1.10)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C143(1.04)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C143(0.94)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C143(0.56)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C143(0.78)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C143(0.90)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C143(0.77); C161(1.13)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C143(0.76)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C143(0.80)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C143(1.09)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C143(1.07)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C143(1.09)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C143(1.13)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C143(1.15)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C143(0.78)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C143(0.93)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C143(0.96)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C143(0.75)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C143(0.85)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C143(0.85); C161(1.08)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C143(0.66)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C143(0.89)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C143(0.91)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C143(1.02)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C143(1.06)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C143(0.97)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C143(1.05)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C143(0.97)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C143(0.97); C161(0.89)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C143(1.06); C161(0.90)  LDD1497  [6]
 LDCM0024  KB05 MKN45 C143(2.22)  LDD3332  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine--tRNA ligase, cytoplasmic (SARS1) Class-II aminoacyl-tRNA synthetase family P49591
Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1) Clp1 family Q92989
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) Cytidine and deoxycytidylate deaminase family Q9NRW3
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 1 (KLF1) Krueppel C2H2-type zinc-finger protein family Q13351
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone chaperone ASF1A (ASF1A) ASF1 family Q9Y294
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
RNA-binding motif protein, X chromosome (RBMX) . P38159
RNA-binding motif protein, Y chromosome, family 1 member A1 (RBMY1A1) . P0DJD3
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
RNA-binding protein 3 (RBM3) . P98179

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402