Details of the Target

General Information of Target

Target ID LDTP05141
Target Name Protein BTG2 (BTG2)
Gene Name BTG2
Gene ID 7832
Synonyms
PC3; Protein BTG2; BTG family member 2; NGF-inducible anti-proliferative protein PC3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSHGKGTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSGALQEALTEHYKHHWFPEKPS
KGSGYRCIRINHKMDPIISRVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSIC
VLYEEAPLAASCGLLTCKNQVLLGRSSPSKNYVMAVSS
Target Bioclass
Other
Family
BTG family
Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
Uniprot ID
P78543
Ensemble ID
ENST00000290551.5
HGNC ID
HGNC:1131

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C29(11.05)  LDD1704  [1]
DBIA
 Probe Info  		C29(0.97)  LDD0637  [2]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C29(0.82)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C29(0.75)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C29(0.92)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C29(0.84)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C29(0.89)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C29(0.98)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C29(1.07)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C29(0.94)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C29(0.76)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C29(0.66)  LDD0823  [2]
 LDCM0227  AC110 HEK-293T C29(0.97)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C29(1.00)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C29(1.10)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C29(0.67)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C29(0.73)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C29(1.18)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C29(0.84)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C29(0.86)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C29(0.74)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C29(0.81)  LDD0834  [2]
 LDCM0238  AC120 HEK-293T C29(0.99)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C29(1.17)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C29(1.33)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C29(0.96)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C29(0.59)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C29(0.80)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C29(1.35)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C29(1.16)  LDD0843  [2]
 LDCM0320  AC57 HCT 116 C29(0.97)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C29(1.29)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C29(1.24)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C29(0.99)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C29(0.97)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C29(0.87)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C29(1.13)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C29(1.37)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C29(1.07)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C29(0.94)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C29(1.26)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C29(1.01)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C29(0.87)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C29(0.91)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C29(1.26)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C29(1.17)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C29(1.23)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C29(1.34)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C29(0.88)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C29(0.90)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C29(0.95)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C29(1.05)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C29(1.32)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C29(1.08)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C29(0.80)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C29(1.48)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C29(0.61)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C29(1.18)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C29(0.84)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C29(0.67)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C29(0.65)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C29(0.78)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C29(0.93)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C29(0.71)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C29(0.55)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C29(0.68)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C29(0.72)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C29(0.61)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C29(0.83)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C29(0.48)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C29(0.72)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C29(0.75)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C29(0.83)  LDD0964  [2]
 LDCM0367  CL1 HCT 116 C29(1.06)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C29(1.28)  LDD0685  [2]
 LDCM0379  CL11 HCT 116 C29(1.21)  LDD0696  [2]
 LDCM0390  CL12 HCT 116 C29(1.13)  LDD0707  [2]
 LDCM0396  CL125 HCT 116 C29(0.96)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C29(0.72)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C29(1.15)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C29(0.84)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C29(1.68)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C29(1.50)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C29(1.06)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C29(1.12)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C29(1.04)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C29(1.00)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C29(1.07)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C29(1.04)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C29(1.20)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C29(1.22)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C29(1.22)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C29(1.33)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C29(1.54)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C29(1.31)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C29(1.15)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C29(1.34)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C29(0.97)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C29(1.41)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C29(1.14)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C29(1.44)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C29(1.73)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C29(1.04)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C29(1.02)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C29(1.38)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C29(1.10)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C29(0.99)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C29(1.07)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C29(1.27)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C29(2.23)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C29(0.87)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C29(0.84)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C29(1.04)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C29(1.01)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C29(1.37)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C29(1.09)  LDD0752  [2]
 LDCM0440  CL5 HCT 116 C29(0.97)  LDD0757  [2]
 LDCM0451  CL6 HCT 116 C29(1.47)  LDD0768  [2]
 LDCM0462  CL7 HCT 116 C29(1.10)  LDD0779  [2]
 LDCM0473  CL8 HCT 116 C29(1.33)  LDD0790  [2]
 LDCM0484  CL9 HCT 116 C29(1.55)  LDD0801  [2]
 LDCM0625  F8 Ramos C29(1.53)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C29(0.27)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C29(4.84)  LDD2190  [4]
 LDCM0575  Fragment13 Ramos C29(1.56)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C29(0.13)  LDD2193  [4]
 LDCM0580  Fragment21 Ramos C29(1.69)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C29(1.25)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C29(1.04)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C29(0.89)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C29(2.44)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C29(2.17)  LDD2200  [4]
 LDCM0468  Fragment33 Ramos C29(1.66)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C29(2.50)  LDD2203  [4]
 LDCM0427  Fragment51 HCT 116 C29(1.58)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C29(1.99)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C29(1.39)  LDD2205  [4]
 LDCM0022  KB02 T cell-activated C29(11.05)  LDD1704  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 7 (CNOT7) CAF1 family Q9UIV1
CCR4-NOT transcription complex subunit 8 (CNOT8) CAF1 family Q9UFF9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578