Details of the Target

General Information of Target

Target ID LDTP05115
Target Name UDP-galactose translocator (SLC35A2)
Gene Name SLC35A2
Gene ID 7355
Synonyms
UGALT; UGT; UGTL; UDP-galactose translocator; Solute carrier family 35 member A2; UDP-galactose transporter; UDP-Gal-Tr; UGT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVGAGGSTAAPGPGAVSAGALEPGTASAAHRRLKYISLAVLVVQNASLILSIRYARTL
PGDRFFATTAVVMAEVLKGLTCLLLLFAQKRGNVKHLVLFLHEAVLVQYVDTLKLAVPSL
IYTLQNNLQYVAISNLPAATFQVTYQLKILTTALFSVLMLNRSLSRLQWASLLLLFTGVA
IVQAQQAGGGGPRPLDQNPGAGLAAVVASCLSSGFAGVYFEKILKGSSGSVWLRNLQLGL
FGTALGLVGLWWAEGTAVATRGFFFGYTPAVWGVVLNQAFGGLLVAVVVKYADNILKGFA
TSLSIVLSTVASIRLFGFHVDPLFALGAGLVIGAVYLYSLPRGAAKAIASASASASGPCV
HQQPPGQPPPPQLSSHRGDLITEPFLPKLLTKVKGS
Target Bioclass
Transporter and channel
Family
Nucleotide-sugar transporter family, SLC35A subfamily
Subcellular location
Endoplasmic reticulum membrane; Golgi apparatus membrane
Function
Transports uridine diphosphate galactose (UDP-galactose) from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges UDP-galactose for UMP. It is also able to exchange UDP-galactose for AMP and CMP, and to transport UDP-N-acetylgalactosamine (UDP-GalNAc) and other nucleotide sugars. As a provider of UDP-galactose to galactosyltransferases present in the Golgi apparatus, it is necessary for globotriaosylceramide/globoside (Gb3Cer) synthesis from lactosylceramide.
Uniprot ID
P78381
Ensemble ID
ENST00000247138.11
HGNC ID
HGNC:11022
ChEMBL ID
CHEMBL3430867

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HSC3 SNV: p.A257T .
JURKAT SNV: p.A17V .
NCIH1048 SNV: p.R34C .
SW620 Substitution: p.A22T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C82(2.04)  LDD3337  [1]
AHL-Pu-1
 Probe Info  		C359(9.66)  LDD0171  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C359(9.66)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C359(1.04)  LDD1507  [5]
 LDCM0237  AC12 HEK-293T C359(0.93)  LDD1510  [5]
 LDCM0270  AC15 HEK-293T C359(0.97)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C359(1.12)  LDD1515  [5]
 LDCM0280  AC20 HEK-293T C359(0.99)  LDD1519  [5]
 LDCM0283  AC23 HEK-293T C359(1.02)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C359(1.17)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C359(1.02)  LDD1524  [5]
 LDCM0288  AC28 HEK-293T C359(0.97)  LDD1527  [5]
 LDCM0292  AC31 HEK-293T C359(1.14)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C359(0.80)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C359(0.93)  LDD1533  [5]
 LDCM0297  AC36 HEK-293T C359(1.10)  LDD1536  [5]
 LDCM0300  AC39 HEK-293T C359(1.01)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C359(0.88)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C359(1.13)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C359(1.01)  LDD1542  [5]
 LDCM0306  AC44 HEK-293T C359(1.07)  LDD1545  [5]
 LDCM0309  AC47 HEK-293T C359(1.14)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C359(1.24)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C359(0.96)  LDD1550  [5]
 LDCM0315  AC52 HEK-293T C359(1.05)  LDD1554  [5]
 LDCM0318  AC55 HEK-293T C359(0.84)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C359(1.43)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C359(0.98)  LDD1559  [5]
 LDCM0324  AC60 HEK-293T C359(1.06)  LDD1563  [5]
 LDCM0327  AC63 HEK-293T C359(0.80)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C359(1.27)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C359(0.82)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C359(1.75)  LDD1569  [5]
 LDCM0356  AKOS034007680 HEK-293T C359(1.14)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C359(0.72)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C359(1.26)  LDD1571  [5]
 LDCM0369  CL100 HEK-293T C359(0.84)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C359(1.33)  LDD1574  [5]
 LDCM0373  CL104 HEK-293T C359(0.89)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C359(0.86)  LDD1578  [5]
 LDCM0377  CL108 HEK-293T C359(0.68)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C359(0.73)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C359(1.52)  LDD1583  [5]
 LDCM0382  CL112 HEK-293T C359(0.99)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C359(0.70)  LDD1587  [5]
 LDCM0386  CL116 HEK-293T C359(0.85)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C359(0.86)  LDD1591  [5]
 LDCM0390  CL12 HEK-293T C359(0.98)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C359(0.95)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C359(0.98)  LDD1596  [5]
 LDCM0395  CL124 HEK-293T C359(0.98)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C359(0.89)  LDD1600  [5]
 LDCM0399  CL128 HEK-293T C359(0.67)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C359(1.36)  LDD1604  [5]
 LDCM0403  CL16 HEK-293T C359(1.03)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C359(0.83)  LDD1608  [5]
 LDCM0408  CL20 HEK-293T C359(1.04)  LDD1612  [5]
 LDCM0411  CL23 HEK-293T C359(0.92)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C359(1.04)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C359(0.80)  LDD1617  [5]
 LDCM0416  CL28 HEK-293T C359(0.98)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C359(0.83)  LDD1621  [5]
 LDCM0421  CL32 HEK-293T C359(1.12)  LDD1625  [5]
 LDCM0424  CL35 HEK-293T C359(1.05)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C359(0.88)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C359(0.89)  LDD1630  [5]
 LDCM0429  CL4 HEK-293T C359(0.74)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C359(0.69)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C359(1.34)  LDD1635  [5]
 LDCM0434  CL44 HEK-293T C359(0.91)  LDD1638  [5]
 LDCM0437  CL47 HEK-293T C359(1.04)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C359(1.51)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C359(0.71)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C359(0.83)  LDD1644  [5]
 LDCM0443  CL52 HEK-293T C359(0.79)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C359(1.06)  LDD1647  [5]
 LDCM0447  CL56 HEK-293T C359(0.90)  LDD1650  [5]
 LDCM0450  CL59 HEK-293T C359(0.92)  LDD1653  [5]
 LDCM0452  CL60 HEK-293T C359(1.68)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C359(0.71)  LDD1656  [5]
 LDCM0456  CL64 HEK-293T C359(0.79)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C359(0.87)  LDD1660  [5]
 LDCM0460  CL68 HEK-293T C359(1.13)  LDD1663  [5]
 LDCM0464  CL71 HEK-293T C359(1.23)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C359(1.09)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C359(1.07)  LDD1669  [5]
 LDCM0469  CL76 HEK-293T C359(0.80)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C359(1.17)  LDD1673  [5]
 LDCM0473  CL8 HEK-293T C359(1.15)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C359(0.85)  LDD1677  [5]
 LDCM0477  CL83 HEK-293T C359(1.45)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C359(0.83)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C359(0.55)  LDD1682  [5]
 LDCM0482  CL88 HEK-293T C359(0.59)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C359(0.91)  LDD1686  [5]
 LDCM0487  CL92 HEK-293T C359(1.06)  LDD1690  [5]
 LDCM0490  CL95 HEK-293T C359(1.07)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C359(0.71)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C359(1.03)  LDD1695  [5]
 LDCM0625  F8 Ramos C359(1.81)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C359(1.73)  LDD2189  [6]
 LDCM0573  Fragment11 Ramos C359(11.51)  LDD2190  [6]
 LDCM0574  Fragment12 Ramos C359(1.26)  LDD2191  [6]
 LDCM0575  Fragment13 Ramos C359(0.69)  LDD2192  [6]
 LDCM0576  Fragment14 Ramos C359(2.68)  LDD2193  [6]
 LDCM0580  Fragment21 Ramos C359(0.57)  LDD2195  [6]
 LDCM0582  Fragment23 Ramos C359(0.46)  LDD2196  [6]
 LDCM0578  Fragment27 Ramos C359(0.49)  LDD2197  [6]
 LDCM0586  Fragment28 Ramos C359(0.54)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C359(0.75)  LDD2199  [6]
 LDCM0589  Fragment31 Ramos C359(0.49)  LDD2200  [6]
 LDCM0590  Fragment32 Ramos C359(1.74)  LDD2201  [6]
 LDCM0468  Fragment33 Ramos C359(0.68)  LDD2202  [6]
 LDCM0596  Fragment38 Ramos C359(0.85)  LDD2203  [6]
 LDCM0566  Fragment4 Ramos C359(2.14)  LDD2184  [6]
 LDCM0610  Fragment52 Ramos C359(1.18)  LDD2204  [6]
 LDCM0614  Fragment56 Ramos C359(0.60)  LDD2205  [6]
 LDCM0569  Fragment7 Ramos C359(2.56)  LDD2186  [6]
 LDCM0571  Fragment9 Ramos C359(2.18)  LDD2188  [6]
 LDCM0022  KB02 Ramos C359(4.58)  LDD2182  [6]
 LDCM0023  KB03 Ramos C359(1.88)  LDD2183  [6]
 LDCM0024  KB05 MSTO-211H C82(2.04)  LDD3337  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UDP-N-acetylglucosamine transporter (SLC35A3) Nucleotide-sugar transporter family Q9Y2D2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Collagen alpha-1(VIII) chain (COL8A1) . P27658

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578