Details of the Target

General Information of Target

Target ID LDTP05109
Target Name Polyhomeotic-like protein 1 (PHC1)
Gene Name PHC1
Gene ID 1911
Synonyms
EDR1; PH1; Polyhomeotic-like protein 1; hPH1; Early development regulatory protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METESEQNSNSTNGSSSSGGSSRPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQ
QLSNAQLHSLAAVQQATIAASRQASSPNTSTTQQQTTTTQASINLATTSAAQLISRSQSV
SSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPN
GAVAAVQQEVPSAQSPGVHADADQVQNLAVRNQQASAQGPQMQGSTQKAIPPGASPVSSL
SQASSQALAVAQASSGATNQSLNLSQAGGGSGNSIPGSMGPGGGGQAHGGLGQLPSSGMG
GGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQNVGMNLTRTATPA
PSQTLISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATH
LQLAQQQQQQQQQQQQQQQPQATTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSS
PLSLPPDAAPKPPIPIQSKPPVAPIKPPQLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQA
QALGLAQLAAAVPTSRGMPGTVQSGQAHLASSPPSSQAPGALQECPPTLAPGMTLAPVQG
TAHVVKGGATTSSPVVAQVPAAFYMQSVHLPGKPQTLAVKRKADSEEERDDVSTLGSMLP
AKASPVAESPKVMDEKSSLGEKAESVANVNANTPSSELVALTPAPSVPPPTLAMVSRQMG
DSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQLLKESEKPLQTGLPTGLTENQSGG
PLGVDSPSAELDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRK
KMKEFQEANYARVRRRGPRRSSSDIARAKIQGKCHRGQEDSSRGSDNSSYDEALSPTSPG
PLSVRAGHGERDLGNPNTAPPTPELHGINPVFLSSNPSRWSVEEVYEFIASLQGCQEIAE
EFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKET
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Uniprot ID
P78364
Ensemble ID
ENST00000543824.5
HGNC ID
HGNC:3182

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.67  LDD0402  [1]
DBIA
 Probe Info  		C831(1.00)  LDD3380  [2]
NAIA_5
 Probe Info  		C831(0.78)  LDD2227  [3]
AHL-Pu-1
 Probe Info  		C831(2.44)  LDD0168  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
1d-yne
 Probe Info  		N.A.  LDD0356  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		C819(0.00); C874(0.00)  LDD0018  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C831(2.44)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C831(2.45)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C819(1.14); C823(1.14)  LDD0812  [10]
 LDCM0215  AC10 HEK-293T C831(1.00)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C831(0.97); C819(1.04)  LDD1509  [11]
 LDCM0230  AC113 HEK-293T C819(1.21); C823(1.18)  LDD0828  [10]
 LDCM0231  AC114 HEK-293T C819(1.20); C823(1.10)  LDD0829  [10]
 LDCM0232  AC115 HEK-293T C819(1.03); C823(0.99)  LDD0830  [10]
 LDCM0233  AC116 HEK-293T C819(1.06); C823(1.02)  LDD0831  [10]
 LDCM0234  AC117 HEK-293T C819(1.22); C823(1.09)  LDD0832  [10]
 LDCM0235  AC118 HEK-293T C819(1.39); C823(1.17)  LDD0833  [10]
 LDCM0236  AC119 HEK-293T C819(1.44); C823(1.15)  LDD0834  [10]
 LDCM0237  AC12 HEK-293T C831(1.06)  LDD1510  [11]
 LDCM0238  AC120 HEK-293T C819(1.46); C823(1.21)  LDD0836  [10]
 LDCM0239  AC121 HEK-293T C819(1.85); C823(1.36)  LDD0837  [10]
 LDCM0240  AC122 HEK-293T C819(1.31); C823(1.01)  LDD0838  [10]
 LDCM0241  AC123 HEK-293T C819(1.13); C823(0.96)  LDD0839  [10]
 LDCM0242  AC124 HEK-293T C819(1.39); C823(1.11)  LDD0840  [10]
 LDCM0243  AC125 HEK-293T C819(1.54); C823(1.15)  LDD0841  [10]
 LDCM0244  AC126 HEK-293T C819(1.43); C823(1.00)  LDD0842  [10]
 LDCM0245  AC127 HEK-293T C819(1.40); C823(0.93)  LDD0843  [10]
 LDCM0259  AC14 HEK-293T C831(1.01); C819(1.05)  LDD1512  [11]
 LDCM0276  AC17 HEK-293T C819(1.43); C823(1.43)  LDD0874  [10]
 LDCM0277  AC18 HEK-293T C819(1.35); C823(1.35)  LDD0875  [10]
 LDCM0278  AC19 HEK-293T C819(1.18); C823(1.18)  LDD0876  [10]
 LDCM0279  AC2 HEK-293T C819(1.31); C823(1.31)  LDD0877  [10]
 LDCM0280  AC20 HEK-293T C819(1.24); C823(1.24)  LDD0878  [10]
 LDCM0281  AC21 HEK-293T C819(1.15); C823(1.15)  LDD0879  [10]
 LDCM0282  AC22 HEK-293T C819(1.13); C823(1.13)  LDD0880  [10]
 LDCM0283  AC23 HEK-293T C819(1.14); C823(1.14)  LDD0881  [10]
 LDCM0284  AC24 HEK-293T C819(1.04); C823(1.04)  LDD0882  [10]
 LDCM0285  AC25 HEK-293T C819(0.88); C823(0.88)  LDD0883  [10]
 LDCM0286  AC26 HEK-293T C819(0.95); C823(0.95)  LDD0884  [10]
 LDCM0287  AC27 HEK-293T C819(0.86); C823(0.86)  LDD0885  [10]
 LDCM0288  AC28 HEK-293T C819(0.78); C823(0.78)  LDD0886  [10]
 LDCM0289  AC29 HEK-293T C819(0.77); C823(0.77)  LDD0887  [10]
 LDCM0290  AC3 HEK-293T C819(0.97); C823(0.97)  LDD0888  [10]
 LDCM0291  AC30 HEK-293T C819(0.81); C823(0.81)  LDD0889  [10]
 LDCM0292  AC31 HEK-293T C819(0.88); C823(0.88)  LDD0890  [10]
 LDCM0293  AC32 HEK-293T C819(1.01); C823(1.01)  LDD0891  [10]
 LDCM0294  AC33 HEK-293T C819(0.87); C823(0.87)  LDD0892  [10]
 LDCM0295  AC34 HEK-293T C819(0.81); C823(0.81)  LDD0893  [10]
 LDCM0296  AC35 HEK-293T C831(0.96); C819(1.03)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C831(1.19)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C831(0.97); C754(0.80); C819(1.14)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C831(1.06); C819(1.04)  LDD1538  [11]
 LDCM0301  AC4 HEK-293T C819(1.03); C823(1.03)  LDD0899  [10]
 LDCM0302  AC40 HEK-293T C831(1.04); C819(0.97)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C831(1.22)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C831(1.28)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C831(1.16); C819(1.01)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C831(1.11)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C831(1.05); C754(1.06); C819(1.20)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C819(1.32)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C819(1.33)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C819(1.41)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C819(1.22)  LDD0909  [10]
 LDCM0312  AC5 HEK-293T C819(1.05); C823(1.05)  LDD0910  [10]
 LDCM0313  AC50 HEK-293T C819(1.00)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C819(1.23)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C819(1.52)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C819(1.36)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C819(1.35)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C819(1.25)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C819(1.27)  LDD0917  [10]
 LDCM0320  AC57 HEK-293T C819(1.08); C823(1.16)  LDD0918  [10]
 LDCM0321  AC58 HEK-293T C819(0.98); C823(1.24)  LDD0919  [10]
 LDCM0322  AC59 HEK-293T C819(0.97); C823(1.14)  LDD0920  [10]
 LDCM0323  AC6 HEK-293T C831(0.65); C819(0.98)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C819(0.65); C823(0.82)  LDD0922  [10]
 LDCM0325  AC61 HEK-293T C819(0.61); C823(0.67)  LDD0923  [10]
 LDCM0326  AC62 HEK-293T C819(0.59); C823(0.92)  LDD0924  [10]
 LDCM0327  AC63 HEK-293T C819(0.60); C823(0.76)  LDD0925  [10]
 LDCM0328  AC64 HEK-293T C819(0.63); C823(0.87)  LDD0926  [10]
 LDCM0329  AC65 HEK-293T C819(0.67); C823(0.75)  LDD0927  [10]
 LDCM0330  AC66 HEK-293T C819(0.56); C823(1.00)  LDD0928  [10]
 LDCM0331  AC67 HEK-293T C819(0.72); C823(0.87)  LDD0929  [10]
 LDCM0332  AC68 HEK-293T C819(1.07)  LDD0930  [10]
 LDCM0333  AC69 HEK-293T C819(1.11)  LDD0931  [10]
 LDCM0335  AC70 HEK-293T C819(1.15)  LDD0933  [10]
 LDCM0336  AC71 HEK-293T C819(1.09)  LDD0934  [10]
 LDCM0337  AC72 HEK-293T C819(1.16)  LDD0935  [10]
 LDCM0338  AC73 HEK-293T C819(0.95)  LDD0936  [10]
 LDCM0339  AC74 HEK-293T C819(1.14)  LDD0937  [10]
 LDCM0340  AC75 HEK-293T C819(1.18)  LDD0938  [10]
 LDCM0341  AC76 HEK-293T C819(1.10)  LDD0939  [10]
 LDCM0342  AC77 HEK-293T C819(1.21)  LDD0940  [10]
 LDCM0343  AC78 HEK-293T C819(1.25)  LDD0941  [10]
 LDCM0344  AC79 HEK-293T C819(1.07)  LDD0942  [10]
 LDCM0345  AC8 HEK-293T C831(1.00); C819(0.99)  LDD1569  [11]
 LDCM0346  AC80 HEK-293T C819(1.10)  LDD0944  [10]
 LDCM0347  AC81 HEK-293T C819(1.18)  LDD0945  [10]
 LDCM0348  AC82 HEK-293T C819(1.36)  LDD0946  [10]
 LDCM0248  AKOS034007472 HEK-293T C831(0.89); C754(1.01); C819(1.00)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C831(1.47)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C831(1.13); C819(1.05)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 13.21  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C831(0.78)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C819(0.87); C823(0.87)  LDD0965  [10]
 LDCM0368  CL10 HEK-293T C819(0.74); C823(0.74)  LDD0966  [10]
 LDCM0369  CL100 HEK-293T C819(0.98); C823(0.98)  LDD0967  [10]
 LDCM0370  CL101 HEK-293T C831(1.01); C819(0.93)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C831(0.84); C819(0.93)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C831(1.01)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C831(0.95); C754(0.94)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C819(0.98); C823(0.98)  LDD0972  [10]
 LDCM0375  CL106 HEK-293T C819(1.04); C823(1.04)  LDD0973  [10]
 LDCM0376  CL107 HEK-293T C819(1.05); C823(1.05)  LDD0974  [10]
 LDCM0377  CL108 HEK-293T C819(1.16); C823(1.16)  LDD0975  [10]
 LDCM0378  CL109 HEK-293T C819(1.24); C823(1.24)  LDD0976  [10]
 LDCM0379  CL11 HEK-293T C819(0.85); C823(0.85)  LDD0977  [10]
 LDCM0380  CL110 HEK-293T C819(1.18); C823(1.18)  LDD0978  [10]
 LDCM0381  CL111 HEK-293T C819(1.05); C823(1.05)  LDD0979  [10]
 LDCM0382  CL112 HEK-293T C819(0.75); C823(0.75)  LDD0980  [10]
 LDCM0383  CL113 HEK-293T C819(0.91); C823(0.91)  LDD0981  [10]
 LDCM0384  CL114 HEK-293T C819(0.84); C823(0.84)  LDD0982  [10]
 LDCM0385  CL115 HEK-293T C819(0.81); C823(0.81)  LDD0983  [10]
 LDCM0386  CL116 HEK-293T C819(0.77); C823(0.77)  LDD0984  [10]
 LDCM0387  CL117 HEK-293T C831(1.01); C819(0.97)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C831(0.97); C819(0.96)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C831(0.82)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C819(1.14); C823(1.14)  LDD0988  [10]
 LDCM0391  CL120 HEK-293T C831(1.07); C754(1.25)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C819(1.23)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C819(1.22)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C819(1.05)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C819(1.15)  LDD0993  [10]
 LDCM0396  CL125 HEK-293T C819(1.09); C823(1.25)  LDD0994  [10]
 LDCM0397  CL126 HEK-293T C819(1.22); C823(1.14)  LDD0995  [10]
 LDCM0398  CL127 HEK-293T C819(1.09); C823(1.08)  LDD0996  [10]
 LDCM0399  CL128 HEK-293T C819(1.44); C823(1.33)  LDD0997  [10]
 LDCM0400  CL13 HEK-293T C819(0.77); C823(0.77)  LDD0998  [10]
 LDCM0401  CL14 HEK-293T C819(0.92); C823(0.92)  LDD0999  [10]
 LDCM0402  CL15 HEK-293T C819(0.75); C823(0.75)  LDD1000  [10]
 LDCM0403  CL16 HEK-293T C819(0.96); C823(0.96)  LDD1001  [10]
 LDCM0404  CL17 HEK-293T C819(0.92); C823(0.92)  LDD1002  [10]
 LDCM0405  CL18 HEK-293T C819(1.02); C823(1.02)  LDD1003  [10]
 LDCM0406  CL19 HEK-293T C819(1.06); C823(1.06)  LDD1004  [10]
 LDCM0407  CL2 HEK-293T C819(0.90); C823(0.90)  LDD1005  [10]
 LDCM0408  CL20 HEK-293T C819(1.12); C823(1.12)  LDD1006  [10]
 LDCM0409  CL21 HEK-293T C819(0.89); C823(0.89)  LDD1007  [10]
 LDCM0410  CL22 HEK-293T C819(1.08); C823(1.08)  LDD1008  [10]
 LDCM0411  CL23 HEK-293T C819(0.91); C823(0.91)  LDD1009  [10]
 LDCM0412  CL24 HEK-293T C819(1.14); C823(1.14)  LDD1010  [10]
 LDCM0413  CL25 HEK-293T C819(0.85); C823(0.85)  LDD1011  [10]
 LDCM0414  CL26 HEK-293T C819(1.14); C823(1.14)  LDD1012  [10]
 LDCM0415  CL27 HEK-293T C819(0.94); C823(0.94)  LDD1013  [10]
 LDCM0416  CL28 HEK-293T C819(1.00); C823(1.00)  LDD1014  [10]
 LDCM0417  CL29 HEK-293T C819(1.27); C823(1.27)  LDD1015  [10]
 LDCM0418  CL3 HEK-293T C819(0.82); C823(0.82)  LDD1016  [10]
 LDCM0419  CL30 HEK-293T C819(1.16); C823(1.16)  LDD1017  [10]
 LDCM0420  CL31 HEK-293T C819(0.93); C823(0.93)  LDD1018  [10]
 LDCM0421  CL32 HEK-293T C819(0.89); C823(0.89)  LDD1019  [10]
 LDCM0422  CL33 HEK-293T C819(0.72); C823(0.72)  LDD1020  [10]
 LDCM0423  CL34 HEK-293T C819(0.95); C823(0.95)  LDD1021  [10]
 LDCM0424  CL35 HEK-293T C819(0.92); C823(0.92)  LDD1022  [10]
 LDCM0425  CL36 HEK-293T C819(0.98); C823(0.98)  LDD1023  [10]
 LDCM0426  CL37 HEK-293T C819(1.01); C823(1.01)  LDD1024  [10]
 LDCM0428  CL39 HEK-293T C819(0.88); C823(0.88)  LDD1026  [10]
 LDCM0429  CL4 HEK-293T C819(1.13); C823(1.13)  LDD1027  [10]
 LDCM0430  CL40 HEK-293T C819(0.92); C823(0.92)  LDD1028  [10]
 LDCM0431  CL41 HEK-293T C819(0.91); C823(0.91)  LDD1029  [10]
 LDCM0432  CL42 HEK-293T C819(0.92); C823(0.92)  LDD1030  [10]
 LDCM0433  CL43 HEK-293T C819(0.89); C823(0.89)  LDD1031  [10]
 LDCM0434  CL44 HEK-293T C819(1.06); C823(1.06)  LDD1032  [10]
 LDCM0435  CL45 HEK-293T C819(0.79); C823(0.79)  LDD1033  [10]
 LDCM0436  CL46 HEK-293T C819(1.04); C823(1.04)  LDD1034  [10]
 LDCM0437  CL47 HEK-293T C819(1.03); C823(1.03)  LDD1035  [10]
 LDCM0438  CL48 HEK-293T C819(1.07); C823(1.07)  LDD1036  [10]
 LDCM0439  CL49 HEK-293T C819(1.11); C823(1.11)  LDD1037  [10]
 LDCM0440  CL5 HEK-293T C819(0.95); C823(0.95)  LDD1038  [10]
 LDCM0441  CL50 HEK-293T C819(0.98); C823(0.98)  LDD1039  [10]
 LDCM0442  CL51 HEK-293T C819(1.05); C823(1.05)  LDD1040  [10]
 LDCM0443  CL52 HEK-293T C819(1.04); C823(1.04)  LDD1041  [10]
 LDCM0444  CL53 HEK-293T C819(0.99); C823(0.99)  LDD1042  [10]
 LDCM0445  CL54 HEK-293T C819(1.10); C823(1.10)  LDD1043  [10]
 LDCM0446  CL55 HEK-293T C819(0.88); C823(0.88)  LDD1044  [10]
 LDCM0447  CL56 HEK-293T C819(0.95); C823(0.95)  LDD1045  [10]
 LDCM0448  CL57 HEK-293T C819(1.02); C823(1.02)  LDD1046  [10]
 LDCM0449  CL58 HEK-293T C819(1.07); C823(1.07)  LDD1047  [10]
 LDCM0450  CL59 HEK-293T C819(1.17); C823(1.17)  LDD1048  [10]
 LDCM0451  CL6 HEK-293T C819(0.98); C823(0.98)  LDD1049  [10]
 LDCM0452  CL60 HEK-293T C819(1.04); C823(1.04)  LDD1050  [10]
 LDCM0453  CL61 HEK-293T C819(1.24); C823(1.24)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C819(1.21); C823(1.21)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C819(0.97); C823(0.97)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C819(1.21); C823(1.21)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C819(1.31); C823(1.31)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C819(1.20); C823(1.20)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C819(1.30); C823(1.30)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C819(1.33); C823(1.33)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C819(1.31); C823(1.31)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C819(0.82); C823(0.82)  LDD1060  [10]
 LDCM0463  CL70 HEK-293T C819(1.37); C823(1.37)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C819(1.31); C823(1.31)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C819(1.32); C823(1.32)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C819(1.29); C823(1.29)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C819(1.26); C823(1.26)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C819(1.00); C823(1.06)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C819(0.85); C823(0.96)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C819(1.07); C823(0.98)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C819(1.32); C823(0.90)  LDD1070  [10]
 LDCM0473  CL8 HEK-293T C819(0.87); C823(1.55)  LDD1071  [10]
 LDCM0474  CL80 HEK-293T C819(1.09); C823(0.96)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C819(1.11); C823(1.04)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C819(0.92); C823(0.92)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C819(0.86); C823(0.91)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C819(0.96); C823(0.98)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C819(0.99); C823(1.00)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C819(1.26); C823(0.96)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C819(0.94); C823(0.99)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C819(1.17); C823(1.18)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C819(1.03); C823(0.94)  LDD1081  [10]
 LDCM0484  CL9 HEK-293T C819(1.15); C823(1.36)  LDD1082  [10]
 LDCM0485  CL90 HEK-293T C819(0.86); C823(0.89)  LDD1083  [10]
 LDCM0486  CL91 HEK-293T C819(1.10); C823(1.10)  LDD1084  [10]
 LDCM0487  CL92 HEK-293T C819(0.97); C823(0.97)  LDD1085  [10]
 LDCM0488  CL93 HEK-293T C819(1.01); C823(1.01)  LDD1086  [10]
 LDCM0489  CL94 HEK-293T C819(1.39); C823(1.39)  LDD1087  [10]
 LDCM0490  CL95 HEK-293T C819(1.10); C823(1.10)  LDD1088  [10]
 LDCM0491  CL96 HEK-293T C819(0.97); C823(0.97)  LDD1089  [10]
 LDCM0492  CL97 HEK-293T C819(1.18); C823(1.18)  LDD1090  [10]
 LDCM0493  CL98 HEK-293T C819(1.18); C823(1.18)  LDD1091  [10]
 LDCM0494  CL99 HEK-293T C819(1.44); C823(1.44)  LDD1092  [10]
 LDCM0495  E2913 HEK-293T C831(0.95)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C819(1.44); C823(1.44)  LDD1066  [10]
 LDCM0427  Fragment51 HEK-293T C819(1.06); C823(1.06)  LDD1025  [10]
 LDCM0022  KB02 HEK-293T C831(0.93)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C831(1.03)  LDD1497  [11]
 LDCM0024  KB05 OV-90 C831(1.00)  LDD3380  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Polycomb complex protein BMI-1 (BMI1) . P35226
Polycomb group RING finger protein 2 (PCGF2) . P35227
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Scm-like with four MBT domains protein 2 (SFMBT2) . Q5VUG0
Syntenin-2 (SDCBP2) . Q9H190

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402