Details of the Target

General Information of Target

Target ID LDTP05107
Target Name SRSF protein kinase 2 (SRPK2)
Gene Name SRPK2
Gene ID 6733
Synonyms
SRSF protein kinase 2; EC 2.7.11.1; SFRS protein kinase 2; Serine/arginine-rich protein-specific kinase 2; SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDP
ADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE
TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQ
KAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERK
IIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIE
KDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPN
AESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQ
EESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKH
FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIA
HIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFT
DFLIPMLEMVPEKRASAGECLRHPWLNS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family
Subcellular location
Cytoplasm
Function
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
TTD ID
T58924
Uniprot ID
P78362
DrugMap ID
TTCZEJ9
Ensemble ID
ENST00000357311.7
HGNC ID
HGNC:11306
ChEMBL ID
CHEMBL5668

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C691(5.02); C673(3.21)  LDD3311  [2]
BTD
 Probe Info  		C680(1.17)  LDD2099  [3]
AHL-Pu-1
 Probe Info  		C535(2.14)  LDD0168  [4]
Acrolein
 Probe Info  		C680(0.00); H612(0.00)  LDD0222  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C680(0.00); C535(0.00); C320(0.00); C223(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C535(0.00); C223(0.00); C680(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C223(0.00); C320(0.00); C680(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
AOyne
 Probe Info  		12.50  LDD0443  [10]
NAIA_5
 Probe Info  		C680(0.00); C535(0.00); C223(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C680(0.86)  LDD2117  [3]
 LDCM0025  4SU-RNA HEK-293T C535(2.14)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C320(2.18)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C535(1.07); C320(0.79)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C535(1.01)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C320(1.01); C223(1.03)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C535(1.02)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C535(1.08); C320(0.92); C680(0.99)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C535(1.01); C320(0.92)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C535(0.96); C320(0.83)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C535(0.99)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C320(1.12); C223(0.98)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C535(0.93)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C535(0.89)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C535(1.01); C320(1.03); C467(0.77)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C535(0.94); C320(0.95); C680(0.98)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C535(1.02); C320(0.93)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C535(0.98); C320(0.98); C680(1.02)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C535(1.00); C320(0.69)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C535(0.94)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C320(0.99); C223(0.99)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C535(0.94)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C535(1.02); C320(0.93); C467(1.14)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C320(1.06); C223(0.97)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C535(1.06); C320(0.93); C680(1.07)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C535(1.06); C320(0.93)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C535(0.98); C320(1.00); C680(0.97)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C535(1.03); C320(0.78)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C535(0.93)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C320(0.98); C223(0.98)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C535(0.95)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C535(1.04); C320(0.92); C467(0.97)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C535(1.06); C320(0.95); C680(1.09)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C535(1.10); C320(0.98)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C535(0.95)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C535(0.98); C320(0.91); C680(0.99)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C535(1.12); C320(0.69)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C535(1.04)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C320(1.05); C223(1.03)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C535(1.01)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C535(1.08); C320(0.86); C467(1.02)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C535(1.05); C320(1.01); C680(1.04)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C535(1.09); C320(0.91)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C535(1.10); C320(1.07); C680(1.01)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C535(0.98); C320(0.81)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C535(1.07); C320(0.82); C467(0.78)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C535(0.96)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C320(0.94); C223(0.98)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C535(0.96)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C535(0.96); C320(0.97); C467(0.79)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C535(1.10); C320(0.91); C680(1.01)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C535(0.95); C320(1.09)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C535(1.08); C320(0.92); C680(0.98)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C535(1.03); C320(0.80)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C535(0.96)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C320(1.05); C223(1.04)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C535(1.11); C320(0.94); C680(0.91)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C535(1.01)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C535(0.98); C320(0.90); C467(0.73)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C535(1.12); C320(0.89); C680(0.98)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C535(1.09); C320(1.28)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C535(1.13); C320(0.97); C680(0.88)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C535(1.21); C320(0.75)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C535(0.99); C320(0.96); C680(0.86)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C535(1.04); C320(1.01); C467(1.16)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C535(0.94); C320(0.86)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C535(1.20); C320(0.96); C680(1.02)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 9.04  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C680(0.00); H612(0.00)  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C535(1.10); C320(0.99)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C535(1.10); C320(0.85); C680(1.09)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C535(1.03); C320(1.11)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C535(0.98); C320(1.11)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C535(1.09); C320(1.17); C467(0.92)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C535(1.03); C320(0.93); C223(1.01)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C535(0.98); C320(1.04)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C535(0.99); C320(1.03)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C535(1.00); C320(0.94); C467(0.89)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C535(1.07); C320(1.11); C223(0.97)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C535(0.99); C320(1.20)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C535(1.00); C320(1.05)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C535(1.18); C320(1.05)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C535(1.00); C320(1.00); C467(0.38)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C535(1.00); C320(0.90); C223(1.00)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C535(1.02); C320(1.12)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C535(1.05); C320(1.16)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C535(1.11); C320(0.95); C467(1.01)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C535(1.05); C320(0.95); C223(0.97)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C535(0.95); C320(1.36)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C535(1.05); C320(1.26)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C535(0.98); C320(1.03); C467(0.97)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C535(1.03); C320(0.92); C223(1.11)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C535(1.18); C320(1.05); C680(0.90)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C535(0.92); C320(1.39)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C535(1.06); C320(1.24)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C535(1.04); C320(1.03); C467(0.99)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C535(1.03); C320(0.76); C223(0.93)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C535(1.01); C320(1.00)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C535(1.02); C320(1.03)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C535(1.06); C320(1.07); C467(0.93)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C535(1.00); C320(0.81); C223(1.01)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C535(1.03); C320(1.17)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C535(1.02); C320(1.01)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C535(1.05); C320(1.20); C467(0.87)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C535(1.05); C320(0.94); C223(0.88)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C535(1.01); C320(1.67)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C535(1.05); C320(0.72)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C535(0.99)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C320(1.00); C223(0.88)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C535(1.11); C320(1.11); C467(0.94)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C535(0.97)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C535(1.06); C320(0.95); C467(0.73)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C535(1.16); C320(1.07); C680(0.99)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C535(1.29); C320(1.22)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C535(1.20); C320(1.08); C680(1.06)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C535(1.08); C320(0.96)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C535(0.99); C320(1.06); C467(0.78)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C535(1.04); C320(0.79); C223(0.92)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C535(1.00); C320(1.22)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C535(0.99); C320(0.61)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C535(1.11); C320(0.89); C223(1.05)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C535(0.89)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C320(1.01); C223(0.99)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C535(1.03)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C535(1.24); C320(0.84); C467(0.78)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C535(1.24); C320(0.96); C680(1.14)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C535(1.18); C320(1.39)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C535(1.11); C320(1.01); C680(1.07)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C535(0.99); C320(1.16)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C535(1.12); C320(0.89); C223(0.90)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C535(0.94); C320(1.19)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C535(1.09); C320(1.10)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C535(1.08); C320(0.64)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C535(1.01)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C320(0.99); C223(1.03)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C535(1.11)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C535(1.23); C320(1.01); C467(1.04)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C535(1.32); C320(1.02); C680(1.14)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C535(1.03); C320(1.03)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C535(1.04); C320(1.09); C680(0.97)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C535(1.16); C320(1.12)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C535(1.14); C320(0.80)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C535(1.11); C320(1.03); C467(0.81)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C535(1.01); C320(1.03)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C535(1.16); C320(0.65)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C535(1.10)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C320(1.00); C223(1.07)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C535(1.06)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C535(1.22); C320(0.96); C467(0.65)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C535(1.28); C320(0.95); C680(1.18)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C535(1.13); C320(1.06)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C535(0.98)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C535(1.34); C320(1.10); C680(0.85)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C535(1.12); C320(1.07)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C535(0.97); C320(1.16); C467(0.89)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C535(1.08); C320(1.06); C223(1.00)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C535(1.05); C320(0.87)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C535(1.02); C320(0.73)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C535(0.97)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C320(0.94); C223(1.04)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C535(0.97)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C535(1.14); C320(1.06); C467(0.85)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C320(1.06); C223(0.96)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C535(1.14); C320(0.90); C680(1.11)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C535(1.18); C320(1.08)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C535(1.18); C320(1.14); C680(0.81)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C535(1.13); C320(1.04)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C535(1.05); C320(1.01); C467(0.92)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C535(1.03); C320(1.01)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C535(1.09); C320(0.87)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C535(1.02)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C320(0.98); C223(1.00)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C535(1.08)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C535(1.12)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C535(1.07); C320(1.02); C467(1.91)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C535(1.20); C320(0.92); C680(1.18)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C535(1.26); C320(1.11)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C535(1.18); C320(0.97); C680(0.97)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C535(0.98); C320(1.07)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C535(1.03); C320(1.05); C467(0.65)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C535(1.10); C320(0.99); C223(0.73)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C535(1.03); C320(0.95)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C535(1.04); C320(0.89)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C535(1.09); C320(0.96); C467(0.79)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C535(1.18)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C320(1.00); C223(0.95)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C535(0.97)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C535(1.22); C320(0.94); C467(0.78)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C535(1.19); C320(0.99); C680(0.97)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C535(1.13); C320(0.92)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C535(1.15); C320(1.01); C680(1.01)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C535(1.07); C320(1.04)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C535(1.07); C320(1.11); C467(0.86)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C535(1.05); C320(0.82); C223(1.09)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C535(1.01); C320(0.97); C223(0.91)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C535(1.12); C320(0.82); C223(1.07)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C535(1.04); C320(1.11); C467(1.25)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C535(0.97); C320(1.04); C223(1.06)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C535(1.02); C320(0.94); C223(0.93)  LDD1497  [11]
 LDCM0024  KB05 G361 C691(5.02); C673(3.21)  LDD3311  [2]
 LDCM0109  NEM HeLa N.A.  LDD0231  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C680(1.17)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C680(0.86)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C680(0.75)  LDD2109  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C535(0.51); C189(0.70)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C680(1.02)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C680(0.91)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C680(0.95)  LDD2127  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C680(1.03)  LDD2137  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C535(1.20)  LDD2144  [3]
 LDCM0131  RA190 MM1.R C320(1.00)  LDD0304  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX46 (DDX46) DEAD box helicase family Q7L014
Cyclin-dependent kinase 7 (CDK7) CMGC Ser/Thr protein kinase family P50613
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Dual specificity protein kinase CLK3 (CLK3) CMGC Ser/Thr protein kinase family P49761
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein 8A (RBM8A) RBM8A family Q9Y5S9
RNA-binding protein with serine-rich domain 1 (RNPS1) Splicing factor SR family Q15287
Serine/arginine repetitive matrix protein 1 (SRRM1) Splicing factor SR family Q8IYB3
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B6 (HOXB6) Antp homeobox family P17509
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger and SCAN domain-containing protein 9 (ZSCAN9) Krueppel C2H2-type zinc-finger protein family O15535
Other
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein beta/alpha (YWHAB) 14-3-3 family P31946
ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL6IP4) ARL6IP4 family Q66PJ3
Coilin (COIL) Coilin family P38432
Nucleolar MIF4G domain-containing protein 1 (NOM1) CWC22 family Q5C9Z4
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Putative RNA-binding protein Luc7-like 1 (LUC7L) Luc7 family Q9NQ29
Putative RNA-binding protein Luc7-like 2 (LUC7L2) Luc7 family Q9Y383
Pre-mRNA-splicing factor 38A (PRPF38A) PRP38 family Q8NAV1
Proline-rich protein 20D (PRR20D) PRR20 family P86480
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (SNRNP27) SNUT3 family Q8WVK2
Probable RNA-binding protein 23 (RBM23) Splicing factor SR family Q86U06
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Serine/arginine-rich splicing factor 10 (SRSF10) Splicing factor SR family O75494
Serine/arginine-rich splicing factor 5 (SRSF5) Splicing factor SR family Q13243
Serine/arginine-rich splicing factor 7 (SRSF7) Splicing factor SR family Q16629
Serine/arginine-rich splicing factor 8 (SRSF8) Splicing factor SR family Q9BRL6
Splicing factor U2AF 35 kDa subunit (U2AF1) Splicing factor SR family Q01081
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
Splicing regulatory glutamine/lysine-rich protein 1 (SREK1) Splicing factor SR family Q8WXA9
Transformer-2 protein homolog alpha (TRA2A) Splicing factor SR family Q13595
Transformer-2 protein homolog beta (TRA2B) Splicing factor SR family P62995
Arginine and glutamate-rich protein 1 (ARGLU1) UPF0430 family Q9NWB6
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Chromatin target of PRMT1 protein (CHTOP) . Q9Y3Y2
Leucine zipper protein 4 (LUZP4) . Q9P127
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
Smad nuclear-interacting protein 1 (SNIP1) . Q8TAD8
Treacle protein (TCOF1) . Q13428
U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70) . P08621
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (ZRSR2) . Q15696
YTH domain-containing protein 1 (YTHDC1) . Q96MU7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenine Small molecular drug DB00173
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Purvalanol Small molecular drug DB02733
Urmc-099 Small molecular drug D07ADX
Phosphoaminophosphonic Acid-adenylate Ester . DB04395

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.