Details of the Target

General Information of Target

Target ID LDTP04936
Target Name Syntaxin-binding protein 1 (STXBP1)
Gene Name STXBP1
Gene ID 6812
Synonyms
UNC18A; Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVED
INKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVK
SRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLC
ATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPS
SPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVS
QEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQG
TVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITE
ENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTP
IIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIF
ILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
Target Bioclass
Transporter and channel
Family
STXBP/unc-18/SEC1 family
Subcellular location
Cytoplasm, cytosol
Function
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes. May play a role in determining the specificity of intracellular fusion reactions.
Uniprot ID
P61764
Ensemble ID
ENST00000373299.5
HGNC ID
HGNC:11444

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.V362I .
HCC70 SNV: p.T489I .
JURKAT SNV: p.P167L .
LNCaP clone FGC SNV: p.S86Y DBIA    Probe Info 
NCIH1793 SNV: p.S476Ter .
SUPT1 Insertion: p.C110LfsTer7 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K20(1.95); K308(1.06); K314(9.77); K321(8.19)  LDD0277  [1]
Probe 1
 Probe Info  		Y195(53.83); Y337(49.07)  LDD3495  [2]
DBIA
 Probe Info  		C110(1.64)  LDD3312  [3]
AHL-Pu-1
 Probe Info  		C552(15.10)  LDD0170  [4]
HHS-475
 Probe Info  		Y519(0.63); Y358(1.76)  LDD0264  [5]
IPM
 Probe Info  		C110(1.72)  LDD1702  [6]
HHS-465
 Probe Info  		Y519(10.00)  LDD2237  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C110(0.00); C552(0.00); C180(0.00); C354(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C110(0.00); C552(0.00); C366(0.00); C180(0.00)  LDD0036  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C110(0.00); C180(0.00); C354(0.00); C44(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		C45(0.00); C180(0.00)  LDD0148  [11]
Acrolein
 Probe Info  		C180(0.00); H295(0.00); C110(0.00); C354(0.00)  LDD0217  [12]
NAIA_5
 Probe Info  		C110(0.00); C366(0.00); C180(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C552(15.10)  LDD0170  [4]
 LDCM0214  AC1 HEK-293T C552(1.04); C110(1.06); C45(1.08)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C552(0.78); C354(1.23); C110(0.96); C45(1.01)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C552(1.13); C110(0.84); C45(0.95)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C552(1.01); C354(1.05); C110(1.03); C45(0.96)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C552(0.79); C354(0.95); C110(1.05); C45(1.13)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C552(1.01); C354(1.05); C110(0.96); C45(0.98)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C552(1.06); C110(0.96); C45(0.98)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C552(1.11); C354(0.96); C110(1.00); C45(1.01)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C552(0.82); C110(0.75); C45(0.67)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C552(1.06); C354(1.07); C110(0.92); C45(1.02)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C552(1.03); C354(1.04); C110(1.07); C45(0.95)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C552(1.11); C354(0.92); C110(0.94); C45(1.09)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C552(0.85); C354(0.95); C110(1.13); C45(0.82)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C552(1.02); C354(1.13); C110(1.05); C45(0.99)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C552(0.99); C354(0.98); C110(1.02); C45(1.08)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C552(1.04); C110(1.01); C45(1.03)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C552(0.84); C354(1.09); C110(1.01); C45(1.05)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C552(1.05); C110(0.90); C45(1.09)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C552(0.91); C354(1.05); C110(1.07); C45(0.94)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C552(1.01); C354(0.93); C110(0.98); C45(0.90)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C552(1.06); C110(0.99); C45(1.01)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C552(1.00); C354(1.04); C110(1.16); C45(1.17)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C552(1.07); C354(1.00); C110(0.96); C45(1.01)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C552(0.92); C354(0.94); C110(1.00); C45(0.95)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C552(1.04); C110(0.95); C45(1.03)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C552(1.06); C354(1.09); C110(0.97); C45(1.12)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C552(0.90); C110(0.96); C45(1.04)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C552(1.01); C354(1.05); C110(1.09); C45(0.96)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C552(1.01); C354(1.03); C110(1.09); C45(1.01)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C552(0.97); C354(1.01); C110(0.98); C45(1.28)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C552(1.26); C354(1.15); C110(1.00); C45(0.96)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C552(1.01); C354(1.03); C110(1.10); C45(0.97)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C552(0.93); C354(1.07); C110(0.90); C45(1.03)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C552(1.28); C110(1.03); C45(1.04)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C552(0.85); C354(1.04); C110(1.05); C45(1.03)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C552(1.22); C110(0.82); C45(1.05)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C552(1.14); C354(1.05); C110(1.03); C45(0.88)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C552(1.01); C354(1.12); C110(0.90); C45(0.96)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C552(0.99); C354(1.05); C110(1.03); C45(1.14)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C552(0.93); C354(1.12); C110(0.96); C45(0.96)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C552(0.94); C354(0.92); C110(0.99); C45(1.01)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C552(1.15); C110(0.96); C45(0.98)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C552(0.94); C354(1.10); C110(0.96); C45(1.04)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C552(0.94); C354(1.11); C110(0.97); C45(0.97)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C552(1.33); C110(0.86); C45(1.04)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C552(1.13); C354(1.04); C110(1.00); C45(0.98)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C552(0.98); C354(1.02); C110(1.05); C45(1.00)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C552(0.98); C354(1.06); C110(1.02); C45(1.11)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C552(1.16); C354(1.04); C110(1.04); C45(1.00)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C552(0.98); C354(1.05); C110(0.92); C45(0.97)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C552(1.08); C110(0.83); C45(1.15)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C552(1.02); C354(1.12); C110(1.02); C45(1.07)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C552(1.73); C110(1.05); C45(1.07)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C552(0.83); C354(1.03); C110(1.03); C45(1.13)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C552(1.01); C354(1.05); C110(1.06); C45(1.02)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C552(1.07); C354(1.01); C110(1.01); C45(1.05)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C552(0.92); C354(1.02); C110(0.95); C45(1.08)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C552(1.06); C354(1.03); C110(1.00); C45(0.98)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C552(1.10); C354(0.98); C110(0.98); C45(1.13)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C552(1.07); C354(0.96); C110(1.03); C45(0.95)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C552(0.94); C354(1.07); C110(0.97); C45(1.15)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C552(1.08); C354(0.98); C110(1.04); C45(1.01)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C552(1.12); C110(0.97); C45(0.97)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C552(0.91); C354(0.98); C110(1.00); C45(1.04)  LDD1514  [13]
 LDCM0108  Chloroacetamide HeLa C110(0.00); C180(0.00); C354(0.00); H357(0.00)  LDD0222  [12]
 LDCM0367  CL1 HEK-293T C552(1.07); C354(1.06); C110(1.35); C45(0.94)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C552(1.21); C354(1.08); C110(1.46); C45(1.60)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C552(0.92); C110(0.93); C45(1.03)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C552(0.95); C354(1.01); C110(1.19); C45(0.92)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C552(1.02); C354(0.98); C110(0.82); C45(0.95)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C552(1.03); C354(1.03); C110(0.91); C45(1.02)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C552(0.93); C110(0.93); C45(1.05)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C552(0.98); C354(0.95); C110(1.08); C45(0.91)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C552(0.97); C354(0.97); C110(0.98); C45(1.03)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C552(0.93); C354(1.01); C110(0.90); C45(0.93)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C552(1.08); C110(0.95); C45(1.03)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C552(1.01); C354(0.94); C110(0.98); C45(0.94)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C552(1.14); C354(1.22); C110(1.13); C45(0.99)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C552(0.96); C354(1.00); C110(0.91); C45(1.05)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C552(1.02); C354(0.94); C110(1.02); C45(1.02)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C552(1.06); C110(0.95); C45(0.99)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C552(0.95); C354(0.98); C110(1.39); C45(1.09)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C552(0.91); C354(0.96); C110(0.94); C45(1.04)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C552(1.03); C354(1.04); C110(0.99); C45(1.04)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C552(0.86); C110(0.98); C45(1.05)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C552(0.97); C354(1.04); C110(1.09); C45(0.96)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C552(0.94); C354(1.01); C110(0.77); C45(0.93)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C552(1.08); C354(1.04); C110(0.97); C45(1.06)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C552(1.12); C354(0.97); C110(1.00); C45(1.24)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C552(1.25); C110(0.92); C45(0.98)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C552(1.06); C354(0.98); C110(1.09); C45(0.96)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C552(0.99); C354(1.00); C110(0.86); C45(0.98)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C552(1.00); C354(1.06); C110(1.22); C45(1.11)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C552(1.23); C110(0.96); C45(0.99)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C552(1.02); C354(1.06); C110(1.11); C45(1.04)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C552(1.04); C354(1.03); C110(1.09); C45(1.05)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C552(1.07); C354(0.97); C110(1.15); C45(1.05)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C552(1.12); C110(0.96); C45(1.15)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C552(1.09); C354(1.00); C110(1.38); C45(0.91)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C552(1.05); C354(1.01); C110(1.15); C45(0.96)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C552(0.93); C354(1.06); C110(1.03); C45(0.91)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C552(1.05); C110(0.87); C45(1.16)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C552(1.06); C110(1.01); C45(0.92)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C552(0.91); C354(1.18); C110(1.11); C45(1.31)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C552(1.09); C110(1.07); C45(0.89)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C552(0.94); C354(1.03); C110(0.92); C45(0.94)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C552(1.25); C354(1.08); C110(0.99); C45(0.96)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C552(1.16); C354(1.03); C110(0.95); C45(1.06)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C552(0.94); C354(1.03); C110(1.13); C45(1.48)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C552(1.33); C354(1.08); C110(1.01); C45(0.98)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C552(1.02); C354(1.05); C110(0.94); C45(1.02)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C552(1.00); C354(1.00); C110(1.16); C45(0.91)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C552(0.92); C354(1.05); C110(0.77); C45(0.98)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C552(1.03); C354(0.97); C110(0.96); C45(1.02)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C552(0.95); C110(0.94); C45(1.02)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C552(1.09); C110(0.89); C45(1.07)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C552(1.07); C354(1.07); C110(1.03); C45(0.97)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C552(0.95); C354(1.20); C110(1.00); C45(1.13)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C552(0.87); C110(0.98); C45(0.94)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C552(1.31); C354(1.03); C110(1.08); C45(1.01)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C552(0.96); C354(0.99); C110(1.08); C45(1.14)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C552(0.91); C354(0.98); C110(1.12); C45(1.39)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C552(1.29); C354(1.12); C110(1.00); C45(1.10)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C552(1.04); C354(1.00); C110(1.12); C45(1.18)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C552(1.01); C354(0.97); C110(1.41); C45(0.95)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C552(1.11); C354(0.93); C110(1.09); C45(1.08)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C552(0.99); C110(1.03); C45(1.06)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C552(1.04); C110(0.98); C45(1.14)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C552(0.96); C110(0.88); C45(1.09)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C552(1.04); C354(1.13); C110(1.05); C45(1.15)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C552(1.76); C110(1.01); C45(0.99)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C552(0.85); C354(1.04); C110(1.17); C45(1.00)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C552(1.07); C354(0.98); C110(1.33); C45(1.01)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C552(1.21); C354(1.03); C110(1.14); C45(1.39)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C552(1.12); C354(1.06); C110(1.06); C45(1.07)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C552(1.02); C354(0.96); C110(1.00); C45(1.12)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C552(1.03); C354(1.06); C110(1.11); C45(1.03)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C552(1.08); C110(0.95); C45(0.91)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C552(0.98); C354(1.03); C110(0.83); C45(1.02)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C552(0.91); C110(1.09); C45(1.00)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C552(1.20); C110(0.94); C45(1.09)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C552(1.10); C354(1.27); C110(1.18); C45(1.30)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C552(1.26); C110(0.89); C45(1.16)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C552(0.95); C354(1.08); C110(1.14); C45(1.01)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C552(1.05); C354(1.12); C110(1.12); C45(1.10)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C552(1.21); C354(1.07); C110(1.15); C45(1.56)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C552(1.42); C354(1.09); C110(0.99); C45(1.12)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C552(0.98); C354(1.10); C110(1.02); C45(1.32)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C552(0.98); C354(0.99); C110(1.11); C45(1.08)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C552(1.00); C354(1.02); C110(0.93); C45(1.05)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C552(0.95); C354(1.08); C110(0.85); C45(0.88)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C552(1.02); C354(1.00); C110(0.91); C45(1.17)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C552(1.23); C110(1.00); C45(1.04)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C552(1.04); C110(0.94); C45(1.04)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C552(1.08); C354(1.09); C110(1.06); C45(1.09)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C552(1.23); C110(0.93); C45(1.03)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C552(1.17); C354(1.06); C110(1.11); C45(0.99)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C552(1.09); C354(0.90); C110(1.07); C45(1.14)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C552(1.16); C110(0.93); C45(0.96)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C552(0.98); C354(1.08); C110(0.97); C45(1.35)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C552(1.13); C354(1.08); C110(1.11); C45(1.05)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C552(1.17); C354(1.04); C110(1.03); C45(1.02)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C552(0.99); C354(1.04); C110(1.54); C45(1.06)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C552(1.04); C354(1.02); C110(0.94); C45(1.00)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C552(1.17); C110(0.98); C45(0.96)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C552(0.93); C110(1.08); C45(1.00)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C552(0.94); C354(1.03); C110(1.04); C45(1.16)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C552(1.25); C110(0.93); C45(1.04)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C552(1.01); C354(1.21); C110(1.21); C45(1.05)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C552(0.97); C354(1.09); C110(1.14); C45(0.88)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C552(1.10); C354(1.03); C110(0.91); C45(1.05)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C552(1.01); C354(1.00); C110(1.14); C45(1.41)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C552(1.26); C354(1.08); C110(1.04); C45(1.15)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C552(1.02); C354(1.03); C110(0.94); C45(1.24)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C552(1.09); C354(0.99); C110(1.18); C45(1.04)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C552(1.09); C354(1.06); C110(1.08); C45(1.08)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C552(1.10); C354(0.88); C110(1.07); C45(1.12)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C552(0.85); C110(0.86); C45(1.06)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C552(1.31); C110(0.95); C45(0.96)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C552(1.10); C354(1.04); C110(1.09); C45(1.00)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C552(0.75); C354(1.22); C110(1.26); C45(1.32)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C552(0.95); C110(0.97); C45(1.03)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C552(1.09); C354(1.05); C110(1.21); C45(0.97)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C552(1.07); C354(1.04); C110(1.01); C45(1.08)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C552(0.99); C354(1.02); C110(1.29); C45(1.30)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C552(1.08); C354(1.11); C110(1.00); C45(1.03)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C552(1.00); C354(0.86); C110(0.95); C45(1.19)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C552(0.99); C354(0.98); C110(1.31); C45(1.12)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C552(1.01); C354(1.13); C110(1.11); C45(0.98)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C552(0.95); C354(1.01); C110(1.10); C45(1.17)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C552(1.12); C354(1.04); C110(1.05); C45(1.14)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C110(1.72)  LDD1702  [6]
 LDCM0468  Fragment33 HEK-293T C552(1.08); C354(0.99); C110(1.09); C45(1.11)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C552(0.99); C354(1.00); C110(0.89); C45(1.00)  LDD1631  [13]
 LDCM0116  HHS-0101 DM93 Y519(0.63); Y358(1.76)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y519(1.17); Y358(1.52)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y519(0.45); Y358(0.97)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y519(0.83); Y358(1.70)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y519(1.02); Y358(1.50)  LDD0268  [5]
 LDCM0107  IAA HeLa C180(0.00); H357(0.00); H295(0.00)  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C110(1.04); C45(0.84)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C110(0.94); C45(0.84)  LDD1497  [13]
 LDCM0024  KB05 HMCB C110(1.64)  LDD3312  [3]
 LDCM0109  NEM HeLa H295(0.00); H85(0.00); H357(0.00)  LDD0223  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
E3 ubiquitin-protein ligase TRIM38 (TRIM38) . O00635
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Syntaxin-5 (STX5) Syntaxin family Q13190
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor corepressor 1 (NCOR1) N-CoR nuclear receptor corepressors family O75376
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Homeobox protein MOX-2 (MEOX2) . P50222
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
D(4) dopamine receptor (DRD4) G-protein coupled receptor 1 family P21917
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein P (CENPP) CENP-P/CTF19 family Q6IPU0
Syntaxin-11 (STX11) Syntaxin family O75558
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
Spindle and centriole-associated protein 1 (SPICE1) . Q8N0Z3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402