Details of the Target

General Information of Target

Target ID LDTP04781
Target Name Cilia- and flagella-associated protein 298 (CFAP298)
Gene Name CFAP298
Gene ID 56683
Synonyms
C21orf48; C21orf59; Cilia- and flagella-associated protein 298; Protein kurly homolog
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRLCSEMEELAEHGIFLPP
NMQGLTDDQIEELKLKDEWGEKCVPSGGAVFKKDDIGRRNGQAPNEKMKQVLKKTIEEAK
AIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPPYDPIRMEFENKEDLSGTQAG
LNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQRGQGAPAREPIISSEEQK
QLMLYYHRRQEELKRLEENDDDAYLNSPWADNTALKRHFHGVKDIKWRPR
Target Bioclass
Other
Family
CFAP298 family
Subcellular location
Cytoplasm
Function
Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity.
Uniprot ID
P57076
Ensemble ID
ENST00000290155.8
HGNC ID
HGNC:1301

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K283(10.00); K7(9.23)  LDD0277  [1]
Probe 1
 Probe Info  		Y207(9.84)  LDD3495  [2]
HHS-475
 Probe Info  		Y246(0.87)  LDD0264  [3]
HHS-465
 Probe Info  		Y207(10.00); Y245(6.88); Y246(6.23)  LDD2237  [4]
DBIA
 Probe Info  		C83(0.67)  LDD0813  [5]
ATP probe
 Probe Info  		K76(0.00); K82(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		C83(0.00); C45(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C83(0.00); C45(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
NPM
 Probe Info  		N.A.  LDD0016  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
NAIA_5
 Probe Info  		C83(0.00); C133(0.00)  LDD2223  [8]
HHS-482
 Probe Info  		Y246(1.13)  LDD2239  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C45(0.93)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C83(0.67)  LDD0813  [5]
 LDCM0226  AC11 HEK-293T C83(0.81)  LDD0824  [5]
 LDCM0230  AC113 HEK-293T C83(1.17)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C83(1.18)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C83(1.10)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C83(0.97)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C83(1.12)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C83(1.24)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C83(1.27)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C83(0.90)  LDD0835  [5]
 LDCM0238  AC120 HEK-293T C83(1.17)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C83(1.44)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C83(1.38)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C83(1.41)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C83(1.27)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C83(1.23)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C83(1.69)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C83(1.61)  LDD0843  [5]
 LDCM0259  AC14 HEK-293T C83(0.89)  LDD0857  [5]
 LDCM0270  AC15 HEK-293T C83(0.68)  LDD0868  [5]
 LDCM0276  AC17 HEK-293T C45(1.04)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C45(0.89); C83(0.92)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C45(1.08); C83(1.07)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C45(1.01); C83(1.01)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C45(1.04); C83(1.00)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C83(1.05)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C45(1.16); C83(1.08)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C45(1.05); C83(1.00)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C45(1.12); C83(1.07)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C83(0.79)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C83(0.78)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C83(0.90)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C83(0.90)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C83(0.78)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C45(1.05); C83(1.08)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C83(0.81)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C83(0.87)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C83(0.77)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C83(0.83)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C83(0.77)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C45(1.08); C83(1.14)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C45(1.11); C83(0.96)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C83(1.14)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C45(1.24); C83(1.12)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C45(1.34); C83(1.00)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C45(1.05); C83(0.99)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C45(1.24); C83(0.97)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C45(0.95)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C45(1.21); C83(1.00)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C45(1.15); C83(1.07)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C45(1.11); C83(1.11)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C83(1.04)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C45(1.26); C83(1.11)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C45(1.12); C83(1.00)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C45(0.84); C83(1.12)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C45(0.96)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C83(1.03)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C45(0.90); C83(0.99)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C45(1.12); C83(1.19)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C45(1.13); C83(1.06)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C83(1.07)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C45(1.13); C83(1.05)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C45(1.16); C83(0.97)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C45(1.09); C83(1.09)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C45(1.04)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C45(1.10); C83(0.92)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C45(1.20); C83(1.16)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C83(1.61)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C45(1.12); C83(1.05)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C83(1.00)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C45(1.45); C83(1.10)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C45(1.33); C83(1.05)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C45(1.21); C83(1.07)  LDD1567  [12]
 LDCM0332  AC68 HEK-293T C83(1.08)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C83(1.02)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C83(0.76)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C83(1.12)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C83(1.19)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C83(1.01)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C83(1.09)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C83(1.08)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C83(0.98)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C83(0.92)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C83(1.09)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C83(1.22)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C83(0.83)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C83(0.80)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C83(0.92)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C83(1.16)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C83(1.01)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C83(1.08)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C83(1.35)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C83(1.03)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C83(0.98)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C83(1.09)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C83(1.00)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C83(1.02)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C83(1.32)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C83(1.13)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C83(1.25)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C83(1.39)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C83(1.20)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C83(1.06)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C83(1.38)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C83(1.77)  LDD0962  [5]
 LDCM0248  AKOS034007472 HEK-293T C83(1.43)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C83(0.73)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C83(0.81)  LDD0873  [5]
 LDCM0367  CL1 HEK-293T C45(1.28)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C45(1.14); C83(0.99)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C45(0.98); C133(1.03)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C83(1.36)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C83(0.90)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C83(0.74)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C83(1.03)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C45(0.96)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C45(1.08); C83(1.14)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C45(1.25)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C45(1.24); C133(0.98)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C45(0.72)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C45(1.02); C83(0.88)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C45(0.88); C83(1.03)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C45(1.26)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C83(0.79)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C83(0.85)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C83(0.72)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C83(0.80)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C83(0.75)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C45(1.02)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C45(0.88); C83(1.18)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C45(1.32)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C45(1.12); C83(1.19)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C45(1.21); C133(1.18)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C45(0.84)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C45(1.16); C83(1.08)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C45(1.08)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C45(1.21); C133(1.02)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C45(0.96)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C45(1.13); C83(1.12)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C45(1.29)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C45(1.11); C133(0.98)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C45(0.96)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C45(1.18); C83(1.12)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C45(1.08)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C83(0.62)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C83(0.62)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C83(0.81)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C83(0.68)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C45(1.22); C83(1.02)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C83(0.83)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C83(0.86)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C83(1.05)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C83(0.82)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C83(0.71)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C83(0.75)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C83(0.64)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C83(0.77)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C83(0.81)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C83(0.74)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C45(1.25)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C83(0.95)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C45(0.96); C83(1.04)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C45(1.20); C83(1.24)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C83(1.04)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C45(1.20); C83(1.06)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C45(1.04); C83(0.96)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C45(1.22); C83(1.07)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C45(1.16)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C45(1.19)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C45(1.05); C133(1.18)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C45(1.10); C133(1.13)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C45(1.08)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C45(0.86); C83(1.11)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C45(1.05); C83(1.10)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C45(1.26); C83(1.13)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C83(1.04)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C45(1.23); C83(1.09)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C45(0.92); C83(1.04)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C45(1.31); C83(1.11)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C45(0.98)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C45(1.00)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C45(1.01); C83(1.08)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C45(1.05); C133(1.17)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C45(0.95)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C45(1.11); C83(1.01)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C45(1.29); C83(1.07)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C45(1.26); C83(1.13)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C83(1.14)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C45(1.21); C83(1.20)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C45(1.46); C83(0.97)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C45(1.29); C83(1.01)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C45(1.47); C83(1.09)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C45(0.90)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C45(1.20); C83(1.14)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C45(1.28)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C45(1.05); C133(1.16)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C45(0.98)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C45(1.11); C83(0.99)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C45(1.17); C83(1.06)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C45(1.14); C83(0.97)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C83(1.08)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C45(1.26); C83(0.97)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C45(1.21); C83(1.11)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C45(1.46); C83(1.03)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C45(1.16); C83(1.13)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C45(0.90)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C45(1.15); C83(1.14)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C45(1.16); C133(1.12)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C45(0.99)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C45(0.92); C83(0.96)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C45(1.07); C83(1.12)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C45(1.16); C83(0.86)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C45(1.02); C83(1.02)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C83(1.10)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C45(1.34); C83(1.12)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C45(1.04); C83(1.09)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C45(1.29); C83(1.06)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C45(0.92)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C45(1.37); C83(1.07)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C45(1.03)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C45(1.11); C133(1.02)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C45(1.00)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C83(1.12)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C45(1.06); C83(1.00)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C45(1.00); C83(1.07)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C45(1.06); C83(0.97)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C83(1.03)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C45(1.31); C83(1.11)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C45(1.06); C83(1.03)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C45(1.24); C83(1.00)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C45(0.90)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C45(0.95); C83(1.05)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C45(1.27)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C45(1.07)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C45(1.20)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C45(1.27); C83(1.07)  LDD1631  [12]
 LDCM0116  HHS-0101 DM93 Y246(0.87)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y246(1.09)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y246(0.76)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y246(0.98)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y246(0.96)  LDD0268  [3]
 LDCM0022  KB02 HEK-293T C45(1.09); C83(1.00)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C45(1.22); C83(0.97)  LDD1497  [12]
 LDCM0024  KB05 HEK-293T C45(0.98); C83(0.88)  LDD1502  [12]

References

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Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD044402