Details of the Target

General Information of Target

Target ID LDTP04359
Target Name Glycine amidinotransferase, mitochondrial (GATM)
Gene Name GATM
Gene ID 2628
Synonyms
AGAT; Glycine amidinotransferase, mitochondrial; EC 2.1.4.1; L-arginine:glycine amidinotransferase; Transamidinase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLRVRCLRGGSRGAEAVHYIGSRLGRTLTGWVQRTFQSTQAATASSRNSCAADDKATEPL
PKDCPVSSYNEWDPLEEVIVGRAENACVPPFTIEVKANTYEKYWPFYQKQGGHYFPKDHL
KKAVAEIEEMCNILKTEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILIVVGNEII
EAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYNQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPN
PMHIDATFNIIGPGIVLSNPDRPCHQIDLFKKAGWTIITPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRRRGTLQS
YLD
Target Bioclass
Enzyme
Family
Amidinotransferase family
Subcellular location
Cytoplasm; Mitochondrion inner membrane; Intermembrane side; Peripheral membrane protein
Function
Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable).
Uniprot ID
P50440
Ensemble ID
ENST00000396659.8
HGNC ID
HGNC:4175

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC44 SNV: p.K392I .
HEP3B217 SNV: p.D157N .
MCC13 SNV: p.G387S DBIA    Probe Info 
RKO SNV: p.N224K .
SW948 SNV: p.K331N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C50(1.22)  LDD3312  [1]
BTD
 Probe Info  		C407(1.08)  LDD2092  [2]
IPM
 Probe Info  		C324(7.26)  LDD1701  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C50(0.31)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C50(1.80)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C50(1.64)  LDD1105  [4]
 LDCM0230  AC113 PaTu 8988t C50(1.00)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C50(1.64)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C50(1.50)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C50(1.08)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C50(1.16)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C50(1.01)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C50(0.98)  LDD1115  [4]
 LDCM0237  AC12 PaTu 8988t C50(1.42)  LDD1116  [4]
 LDCM0238  AC120 PaTu 8988t C50(1.25)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C50(1.47)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C50(1.05)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C50(0.84)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C50(1.46)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C50(1.13)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C50(1.30)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C50(1.47)  LDD1124  [4]
 LDCM0246  AC128 PaTu 8988t C50(1.60)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C50(1.39)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C50(1.37)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C50(1.52)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C50(1.58)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C50(2.10)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C50(1.50)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C50(2.97)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C50(1.86)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C50(2.43)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C50(1.43)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C50(1.33)  LDD1137  [4]
 LDCM0259  AC14 PaTu 8988t C50(1.15)  LDD1138  [4]
 LDCM0260  AC140 PaTu 8988t C50(1.55)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C50(1.26)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C50(1.42)  LDD1141  [4]
 LDCM0263  AC143 PaTu 8988t C50(1.09)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C50(1.45)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C50(1.02)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C50(0.80)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C50(1.53)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C50(1.11)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C50(0.96)  LDD1148  [4]
 LDCM0270  AC15 PaTu 8988t C50(1.72)  LDD1149  [4]
 LDCM0271  AC150 PaTu 8988t C50(0.93)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C50(1.43)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C50(1.20)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C50(1.25)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C50(1.03)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C50(1.22)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C50(1.43)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C50(0.76)  LDD2169  [4]
 LDCM0276  AC17 PaTu 8988t C50(1.16)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C50(1.37)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C50(1.09)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C50(0.25)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C50(1.34)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C50(1.49)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C50(1.58)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C50(1.63)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C50(1.41)  LDD1163  [4]
 LDCM0285  AC25 PaTu 8988t C50(0.95)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C50(1.68)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C50(1.61)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C50(1.69)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C50(1.57)  LDD1168  [4]
 LDCM0290  AC3 PaTu 8988t C50(0.34)  LDD1169  [4]
 LDCM0291  AC30 PaTu 8988t C50(1.24)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C50(1.18)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C50(1.31)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C50(1.21)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C50(1.46)  LDD1174  [4]
 LDCM0301  AC4 PaTu 8988t C50(0.27)  LDD1180  [4]
 LDCM0308  AC46 PaTu 8988t C50(1.05)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C50(1.24)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C50(1.95)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C50(1.72)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C50(0.35)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C50(1.76)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C50(0.85)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C50(1.49)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C50(2.47)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C50(2.45)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C50(1.82)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C50(1.35)  LDD1198  [4]
 LDCM0320  AC57 PaTu 8988t C50(1.94)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C50(2.13)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C50(1.70)  LDD1201  [4]
 LDCM0323  AC6 PaTu 8988t C50(1.14)  LDD1202  [4]
 LDCM0324  AC60 PaTu 8988t C50(2.04)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C50(2.63)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C50(1.88)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C50(1.56)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C50(1.52)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C50(1.59)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C50(2.09)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C50(1.51)  LDD1210  [4]
 LDCM0332  AC68 PaTu 8988t C50(0.86)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C50(0.99)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C50(0.87)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C50(1.01)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C50(0.96)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C50(0.74)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C50(0.75)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C50(0.94)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C50(2.15)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C50(1.00)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C50(1.37)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C50(1.00)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C50(1.12)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C50(0.88)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C50(1.04)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C50(1.82)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C50(0.83)  LDD1227  [4]
 LDCM0349  AC83 PaTu 8988t C50(0.91)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C50(0.76)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C50(1.09)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C50(1.40)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C50(1.50)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C50(0.98)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C50(0.78)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C50(1.06)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C50(1.24)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C50(1.16)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C50(0.93)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C50(0.85)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C50(0.99)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C50(0.80)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C50(0.81)  LDD1243  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C50(1.53)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C50(1.46)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C50(1.47)  LDD1154  [4]
 LDCM0369  CL100 PaTu 8988t C50(0.23)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C50(1.18)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C50(1.40)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C50(1.92)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C50(1.16)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C50(1.19)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C50(1.13)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C50(1.05)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C50(1.13)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C50(1.45)  LDD1257  [4]
 LDCM0380  CL110 PaTu 8988t C50(1.49)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C50(1.77)  LDD1260  [4]
 LDCM0382  CL112 PaTu 8988t C50(1.62)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C50(1.20)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C50(1.21)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C50(1.00)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C50(1.78)  LDD1265  [4]
 LDCM0392  CL121 PaTu 8988t C50(1.36)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C50(1.51)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C50(2.25)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C50(1.74)  LDD1274  [4]
 LDCM0396  CL125 PaTu 8988t C50(1.46)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C50(2.19)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C50(1.78)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C50(1.91)  LDD1278  [4]
 LDCM0403  CL16 PaTu 8988t C50(0.86)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C50(1.00)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C50(0.93)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C50(1.22)  LDD1285  [4]
 LDCM0408  CL20 PaTu 8988t C50(1.67)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C50(1.31)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C50(1.10)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C50(1.42)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C50(1.31)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C50(1.28)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C50(1.22)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C50(1.28)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C50(1.26)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C50(1.47)  LDD1296  [4]
 LDCM0419  CL30 PaTu 8988t C50(1.31)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C50(1.23)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C50(1.21)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C50(1.35)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C50(1.20)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C50(1.49)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C50(1.88)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C50(1.38)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C50(1.28)  LDD1307  [4]
 LDCM0430  CL40 PaTu 8988t C50(1.24)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C50(1.27)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C50(1.36)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C50(1.29)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C50(1.58)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C50(1.88)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C50(1.14)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C50(1.17)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C50(1.46)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C50(1.22)  LDD1318  [4]
 LDCM0441  CL50 PaTu 8988t C50(1.28)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C50(1.43)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C50(1.33)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C50(1.53)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C50(1.50)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C50(1.34)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C50(0.69)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C50(1.95)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C50(1.41)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C50(2.05)  LDD1329  [4]
 LDCM0452  CL60 PaTu 8988t C50(1.90)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C50(1.46)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C50(1.53)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C50(1.44)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C50(1.59)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C50(1.13)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C50(1.58)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C50(1.68)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C50(2.02)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C50(1.77)  LDD1340  [4]
 LDCM0463  CL70 PaTu 8988t C50(1.44)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C50(1.23)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C50(1.08)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C50(1.96)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C50(1.65)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C50(1.02)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C50(1.01)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C50(1.21)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C50(1.21)  LDD1351  [4]
 LDCM0474  CL80 PaTu 8988t C50(1.18)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C50(1.27)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C50(1.42)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C50(1.80)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C50(1.13)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C50(1.13)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C50(1.23)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C50(1.33)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C50(1.53)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C50(0.99)  LDD1362  [4]
 LDCM0485  CL90 PaTu 8988t C50(1.52)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C50(0.23)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C50(0.26)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C50(0.23)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C50(0.21)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C50(0.36)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C50(0.23)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C50(0.36)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C50(0.33)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C50(0.30)  LDD1373  [4]
 LDCM0468  Fragment33 PaTu 8988t C50(1.43)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C50(1.53)  LDD1306  [4]
 LDCM0022  KB02 697 C50(1.36)  LDD2245  [1]
 LDCM0023  KB03 MDA-MB-231 C324(7.26)  LDD1701  [2]
 LDCM0024  KB05 HMCB C50(1.22)  LDD3312  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C407(1.08)  LDD2092  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C407(1.68)  LDD2098  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C131(1.02)  LDD2118  [2]
 LDCM0131  RA190 MM1.R C50(1.21)  LDD0304  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidate phosphatase LPIN1 (LPIN1) Lipin family Q14693
Pseudouridylate synthase RPUSD4, mitochondrial (RPUSD4) Pseudouridine synthase RluA family Q96CM3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal-regulatory protein gamma (SIRPG) . Q9P1W8
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Uteroglobin (SCGB1A1) Secretoglobin family P11684
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
Translation initiation factor eIF2B subunit delta (EIF2B4) EIF-2B alpha/beta/delta subunits family Q9UI10
Transmembrane protein 185A (TMEM185A) TMEM185 family Q8NFB2
Centromere protein R (ITGB3BP) . Q13352
COMM domain-containing protein 10 (COMMD10) . Q9Y6G5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gamma-aminobutyric Acid Small molecular drug DB02530
Glycine Small molecular drug DB00145
Ornithine Small molecular drug DB00129
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-aminobutyric Acid Small molecular drug DB04454
Delta-amino Valeric Acid Small molecular drug DB02068
Norvaline . DB04185

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.