Details of the Target

General Information of Target

Target ID LDTP04297
Target Name Dual specificity protein kinase CLK1 (CLK1)
Gene Name CLK1
Gene ID 1195
Synonyms
CLK; Dual specificity protein kinase CLK1; EC 2.7.12.1; CDC-like kinase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
KKSI
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily
Subcellular location
Nucleus
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
TTD ID
T46685
Uniprot ID
P49759
DrugMap ID
TTE6YDG
Ensemble ID
ENST00000321356.9
HGNC ID
HGNC:2068
ChEMBL ID
CHEMBL4224

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C273(0.62)  LDD2135  [1]
AHL-Pu-1
 Probe Info  		C84(2.12)  LDD0168  [2]
DBIA
 Probe Info  		C9(138.29)  LDD0209  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
AOyne
 Probe Info  		14.10  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C84(2.12)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C9(3.31); C84(3.58)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C9(0.93)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C9(1.24); C84(1.05); C52(1.11)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C9(1.08); C84(1.06); C52(0.94)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C9(1.07); C273(1.06)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C9(1.09)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C9(1.03)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C9(0.96)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C9(0.84); C84(1.00); C52(1.09)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C9(1.21); C84(1.37); C52(1.32)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C9(1.13); C84(0.93); C52(1.01)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C9(1.03); C273(0.89)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C9(1.03); C84(1.03); C52(1.08)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C9(0.93)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C9(1.03)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C9(0.92)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C9(1.49)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C9(0.97); C84(1.15); C52(1.05)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C9(1.03); C84(1.02); C52(0.98)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C9(1.07); C273(1.45)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C9(1.04); C84(1.09); C52(1.12)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C9(0.91); C84(1.10); C52(0.98)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C9(1.10)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C9(1.08)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C9(1.00)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C9(1.05)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C9(1.30); C84(1.02); C52(1.01)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C9(0.98); C84(1.19); C52(1.03)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C9(1.05); C273(1.05)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C9(1.04); C84(1.05); C52(1.01)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C9(0.95)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C9(1.06)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C9(1.00); C273(1.07)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C9(1.04)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C9(1.09)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C9(1.44); C84(0.99); C52(1.22)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C9(0.89); C84(1.05); C52(1.06)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C9(1.12); C273(0.98)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C9(1.04); C84(1.13); C52(1.08)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C9(1.00)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C9(1.04)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C9(0.97)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C9(1.09)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C9(1.10); C84(1.08); C52(1.03)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C9(1.12); C84(1.11); C52(1.62)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C9(0.81); C84(1.15); C52(0.97)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C9(1.08); C273(1.04)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C9(1.00); C84(1.10); C52(1.06)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C9(0.93)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C9(1.07)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C9(1.02)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C9(1.09)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C9(1.02); C84(0.98); C52(1.11)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C9(0.98); C84(1.10); C52(0.99)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C9(0.88)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C9(1.03); C273(1.13)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C9(1.08); C84(1.02); C52(1.04)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C9(0.97)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C9(1.06)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C9(0.97)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C9(1.07)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C9(0.92)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C9(1.09); C84(1.15); C52(0.98)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C9(0.92)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C9(1.01)  LDD1514  [9]
 LDCM0368  CL10 HEK-293T C9(0.97)  LDD1572  [9]
 LDCM0372  CL103 HEK-293T C9(1.37); C84(1.02)  LDD1576  [9]
 LDCM0376  CL107 HEK-293T C9(1.48); C84(1.27)  LDD1580  [9]
 LDCM0379  CL11 HEK-293T C9(1.01)  LDD1583  [9]
 LDCM0381  CL111 HEK-293T C9(1.12); C84(0.96)  LDD1585  [9]
 LDCM0385  CL115 HEK-293T C9(1.15); C84(1.07)  LDD1589  [9]
 LDCM0389  CL119 HEK-293T C9(1.21); C84(1.13)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C9(0.89)  LDD1594  [9]
 LDCM0394  CL123 HEK-293T C9(0.90); C84(0.95)  LDD1598  [9]
 LDCM0398  CL127 HEK-293T C9(0.93); C84(1.13)  LDD1602  [9]
 LDCM0402  CL15 HEK-293T C9(1.01); C84(1.00)  LDD1606  [9]
 LDCM0404  CL17 HEK-293T C9(0.96)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C9(1.26); C84(1.19); C52(1.00)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C9(1.28); C84(1.48); C52(1.00)  LDD1610  [9]
 LDCM0408  CL20 HEK-293T C9(1.15); C273(1.09)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C9(1.12); C84(1.52); C52(1.00)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C9(0.97)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C9(0.95)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C9(0.88)  LDD1616  [9]
 LDCM0415  CL27 HEK-293T C9(0.93); C84(1.15)  LDD1619  [9]
 LDCM0417  CL29 HEK-293T C9(1.04)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C9(1.01); C84(1.21)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C9(1.14); C84(1.11); C52(0.94)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C9(0.94); C84(1.33); C52(0.98)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C9(1.02); C273(1.00)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C9(1.07); C84(1.14); C52(0.96)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C9(0.86)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C9(0.96)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C9(0.85)  LDD1629  [9]
 LDCM0428  CL39 HEK-293T C9(1.29); C84(0.97)  LDD1632  [9]
 LDCM0431  CL41 HEK-293T C9(1.17)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C9(1.05); C84(0.96); C52(1.16)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C9(0.95); C84(1.32); C52(1.00)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C9(1.03); C273(1.05)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C9(1.10); C84(1.29); C52(0.95)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C9(0.90)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C9(0.97)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C9(0.80)  LDD1642  [9]
 LDCM0440  CL5 HEK-293T C9(0.97)  LDD1644  [9]
 LDCM0444  CL53 HEK-293T C9(0.98)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C9(1.08); C84(1.26); C52(1.37)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C9(0.84); C84(1.18); C52(1.06)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C9(1.10); C273(1.13)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C9(1.13); C84(1.39); C52(1.13)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C9(0.96)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C9(0.94)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C9(1.13); C84(1.05); C52(1.44)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C9(0.83)  LDD1655  [9]
 LDCM0455  CL63 HEK-293T C9(1.68); C84(1.02)  LDD1658  [9]
 LDCM0457  CL65 HEK-293T C9(1.04)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C9(1.36); C84(1.07); C52(1.01)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C9(0.86); C84(1.17); C52(0.96)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C9(1.04); C273(1.12)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C9(1.01); C84(1.24); C52(1.08)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C9(0.98); C84(1.25); C52(1.04)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C9(0.96)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C9(0.96)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C9(0.92)  LDD1668  [9]
 LDCM0470  CL77 HEK-293T C9(0.90)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C9(1.19); C84(1.09); C52(1.20)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C9(0.94); C84(1.35); C52(0.98)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C9(1.00); C273(1.32)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C9(0.99); C273(1.12)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C9(1.09); C84(1.11); C52(1.02)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C9(0.85)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C9(0.87)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C9(0.83)  LDD1681  [9]
 LDCM0481  CL87 HEK-293T C9(0.93); C84(0.83)  LDD1684  [9]
 LDCM0483  CL89 HEK-293T C9(1.04)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C9(0.99); C84(1.17); C52(1.04)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C9(1.38); C84(0.95); C52(1.04)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C9(0.98); C84(1.04); C52(0.92)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C9(0.93); C273(1.04)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C9(0.96); C84(1.23); C52(1.01)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C9(0.83)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C9(0.87)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C9(0.72)  LDD1694  [9]
 LDCM0494  CL99 HEK-293T C9(0.83); C84(0.99)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C9(1.55); C84(1.10)  LDD1698  [9]
 LDCM0625  F8 Ramos C200(1.34)  LDD2187  [10]
 LDCM0573  Fragment11 Ramos C200(0.41)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C200(1.51)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C200(1.11)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C200(0.85)  LDD2193  [10]
 LDCM0580  Fragment21 Ramos C200(0.96)  LDD2195  [10]
 LDCM0578  Fragment27 Ramos C200(1.33)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C200(1.43)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C200(1.21)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C200(1.32)  LDD2200  [10]
 LDCM0468  Fragment33 HEK-293T C9(1.15); C84(1.01)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C200(1.63)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C200(1.52)  LDD2184  [10]
 LDCM0569  Fragment7 Ramos C200(1.95)  LDD2186  [10]
 LDCM0022  KB02 Ramos C200(1.97)  LDD2182  [10]
 LDCM0023  KB03 Jurkat C9(138.29)  LDD0209  [3]
 LDCM0024  KB05 IGR37 C220(1.41)  LDD3314  [11]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C273(0.62)  LDD2135  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A) Cyclic nucleotide phosphodiesterase family O76083
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
CLK4-associating serine/arginine rich protein (CLASRP) Splicing factor SR family Q8N2M8
Serine/arginine-rich splicing factor 1 (SRSF1) Splicing factor SR family Q07955
Serine/arginine-rich splicing factor 10 (SRSF10) Splicing factor SR family O75494
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Serine/arginine-rich splicing factor 7 (SRSF7) Splicing factor SR family Q16629
Transformer-2 protein homolog beta (TRA2B) Splicing factor SR family P62995

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Debromohymenialdisine Small molecular drug DB04367
Ethyl 3-[(E)-2-amino-1-cyanoethenyl]-67-dichloro-1-methyl-1h-indole-2-carboxylate Small molecular drug DB08691
Kh-cb19 Small molecular drug D00BAJ
Leucettine L41 Small molecular drug D04IMY
Ml315 Small molecular drug D0UI7U
Pmid23642479c17 Small molecular drug D06CXU
Chgn111 . DB06376
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tg003 Small molecular drug D06MBI

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840