Details of the Target

General Information of Target

Target ID LDTP04115
Target Name Transcriptional coactivator YAP1 (YAP1)
Gene Name YAP1
Gene ID 10413
Synonyms
YAP65; Transcriptional coactivator YAP1; Yes-associated protein 1; Protein yorkie homolog; Yes-associated protein YAP65 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD
SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP
QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM
TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS
NQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGG
TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV
DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS
DILNDMESVLAATKLDKESFLTWL
Target Type
Literature-reported
Target Bioclass
Other
Family
YAP1 family
Subcellular location
Cytoplasm
Function
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation.; [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3).; [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3).
TTD ID
T94048
Uniprot ID
P46937
DrugMap ID
TT8UN2D
Ensemble ID
ENST00000282441.10
HGNC ID
HGNC:16262
ChEMBL ID
CHEMBL3334415

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.H56Q .
ETK1 SNV: p.Q35K .
HCT15 SNV: p.I246F .
LUDLU1 SNV: p.I249V .
MFE319 SNV: p.I273T DBIA    Probe Info 
WM793 SNV: p.Q357P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K315(1.02); K321(1.83)  LDD0274  [2]
STPyne
 Probe Info  		K315(4.76); K321(7.11); K342(1.11)  LDD0277  [2]
Probe 1
 Probe Info  		Y407(13.62)  LDD3495  [3]
DBIA
 Probe Info  		C347(4.25)  LDD3314  [4]
BTD
 Probe Info  		C343(1.02)  LDD2089  [5]
Sulforaphane-probe2
 Probe Info  		1.64  LDD0160  [6]
HHS-475
 Probe Info  		Y188(0.74)  LDD0264  [7]
Acrolein
 Probe Info  		N.A.  LDD0223  [8]
5E-2FA
 Probe Info  		H159(0.00); H126(0.00); H122(0.00); H392(0.00)  LDD2235  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
IPM
 Probe Info  		N.A.  LDD0005  [12]
NPM
 Probe Info  		N.A.  LDD0016  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C343(1.12)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C343(0.98)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C343(1.14)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C343(1.13)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C343(1.17)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C343(1.17)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C343(1.62)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C343(1.12)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C343(1.18)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C343(0.97)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C343(1.42)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C343(1.12)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C343(1.27)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C343(1.55)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C343(1.47)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C343(1.25)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C343(0.87)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C343(0.98)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C343(1.04)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C343(0.90)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C343(0.92)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C343(0.93)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C343(0.96)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C343(1.24)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C343(1.82)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C343(1.26)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C343(1.34)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C343(1.39)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C343(1.03)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C343(1.50)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C343(1.40)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C343(0.87)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C343(1.19)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C343(1.99)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C343(1.01)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C343(1.57)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C343(1.38)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C343(1.04)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C343(1.26)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C343(1.24)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C343(1.56)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C343(1.37)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C343(0.90)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C343(0.96)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C343(1.28)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C343(1.34)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C343(1.19)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C343(1.48)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C343(1.53)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C343(1.33)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C343(1.22)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C343(1.00)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C343(1.27)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C343(0.94)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C343(1.21)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C343(0.94)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C343(1.34)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C343(1.34)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C343(1.06)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C343(0.91)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C343(0.87)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C343(1.16)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C343(1.32)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C343(1.17)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 12.20  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C343(0.96)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C343(0.81)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C343(1.09)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C343(1.30)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C343(0.90)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C343(1.57)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C343(1.03)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C343(1.10)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C343(1.09)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C343(1.48)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C343(1.34)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C343(0.80)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C343(1.01)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C343(0.96)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C343(0.97)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C343(1.09)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C343(1.04)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C343(0.96)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C343(1.13)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C343(1.40)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C343(1.19)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C343(0.94)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C343(1.09)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C343(1.15)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C343(1.20)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C343(1.49)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C343(1.04)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C343(1.23)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C343(1.27)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C343(0.85)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C343(1.12)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C343(0.99)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C343(1.16)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C343(0.98)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C343(1.06)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C343(1.25)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C343(1.12)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C343(1.26)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C343(0.97)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C343(1.44)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C343(1.00)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C343(1.26)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C343(1.10)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C343(1.10)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C343(1.22)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C343(1.21)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C343(1.30)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C343(1.44)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C343(1.39)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C343(1.22)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C343(1.40)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C343(0.82)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C343(1.02)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C343(1.13)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C343(1.38)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C343(1.12)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C343(1.32)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C343(1.31)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C343(1.39)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C343(1.58)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C343(1.89)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C343(0.84)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C343(1.42)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C343(1.42)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C343(1.04)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C343(1.22)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C343(1.13)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C343(1.28)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C343(1.27)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C343(1.32)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C343(1.57)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C343(1.07)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C343(1.19)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C343(1.27)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C343(1.03)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C343(1.34)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C343(1.04)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C343(1.29)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C343(1.30)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C343(1.08)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C343(1.30)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C343(1.33)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C343(0.80)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C343(1.79)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C343(0.89)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C343(1.20)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C343(1.55)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C343(1.30)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C343(1.81)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C343(1.13)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C343(1.16)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C343(1.43)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C343(1.25)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C343(1.08)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C343(1.59)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C343(1.27)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C343(2.00)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C343(1.10)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C343(1.01)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C343(1.09)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C343(1.19)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C343(0.90)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C343(0.98)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C343(0.90)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C343(0.87)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C343(1.28)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C343(0.98)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C343(0.96)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C343(1.04)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C343(1.02)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C343(1.01)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C343(1.17)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C343(1.20)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C343(1.46)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C343(0.76)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C343(1.08)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C343(1.13)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C343(1.57)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C343(1.08)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C343(1.52)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C343(1.23)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C343(1.22)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C343(0.83)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C343(0.82)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C343(0.91)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C343(2.17)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C343(0.93)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C343(1.22)  LDD1631  [14]
 LDCM0116  HHS-0101 DM93 Y188(0.74)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y188(0.85)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y188(0.81)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y188(1.49)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y188(0.74)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C343(0.97)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C343(1.02)  LDD1497  [14]
 LDCM0024  KB05 IGR37 C347(4.25)  LDD3314  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C343(1.02)  LDD2089  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C343(1.03)  LDD2141  [5]
 LDCM0003  Sulforaphane MDA-MB-231 1.64  LDD0160  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4) Commissureless family Q9BZD6
Probable ATP-dependent RNA helicase DDX17 (DDX17) DEAD box helicase family Q92841
E3 SUMO-protein ligase EGR2 (EGR2) EGR C2H2-type zinc-finger protein family P11161
Serine/threonine-protein kinase LATS1 (LATS1) AGC Ser/Thr protein kinase family O95835
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) STE Ser/Thr protein kinase family Q02750
Receptor tyrosine-protein kinase erbB-4 (ERBB4) Tyr protein kinase family Q15303
Tyrosine-protein phosphatase non-receptor type 14 (PTPN14) Protein-tyrosine phosphatase family Q15678
Ras-related protein Rab-11A (RAB11A) Rab family P62491
E3 ubiquitin-protein ligase RBBP6 (RBBP6) . Q7Z6E9
Transmembrane gamma-carboxyglutamic acid protein 2 (PRRG2) . O14669
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Protein patched homolog 1 (PTCH1) Patched family Q13635
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2) . Q15599
Transmembrane protein 139 (TMEM139) . Q8IV31
Transcription factor
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 1 (SMAD1) Dwarfin/SMAD family Q15797
Mothers against decapentaplegic homolog 7 (SMAD7) Dwarfin/SMAD family O15105
Zinc finger protein GLIS3 (GLIS3) GLI C2H2-type zinc-finger protein family Q8NEA6
Krueppel-like factor 5 (KLF5) Krueppel C2H2-type zinc-finger protein family Q13887
Zinc finger protein 469 (ZNF469) Krueppel C2H2-type zinc-finger protein family Q96JG9
Tumor protein 63 (TP63) P53 family Q9H3D4
Tumor protein p73 (TP73) P53 family O15350
Paired box protein Pax-7 (PAX7) Paired homeobox family P23759
AT-rich interactive domain-containing protein 2 (ARID2) . Q68CP9
Runt-related transcription factor 1 (RUNX1) . Q01196
T-box transcription factor TBX5 (TBX5) . Q99593
Transcriptional enhancer factor TEF-1 (TEAD1) . P28347
Transcriptional enhancer factor TEF-3 (TEAD4) . Q15561
Transcriptional enhancer factor TEF-4 (TEAD2) . Q15562
Transcriptional-regulating factor 1 (TRERF1) . Q96PN7
Trinucleotide repeat-containing gene 18 protein (TNRC18) . O15417
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein beta/alpha (YWHAB) 14-3-3 family P31946
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Cell death-inducing p53-target protein 1 (CDIP1) CDIP1/LITAF family Q9H305
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Protein scribble homolog (SCRIB) LAP (LRR and PDZ) protein family Q14160
Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3) LDLR family Q86YD5
Transmembrane protein 151A (TMEM151A) TMEM151 family Q8N4L1
Tubby-related protein 4 (TULP4) TUB family Q9NRJ4
Atrophin-1 (ATN1) . P54259
Axin-1 (AXIN1) . O15169
InaD-like protein (PATJ) . Q8NI35
NEDD4 family-interacting protein 2 (NDFIP2) . Q9NV92
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
Rap guanine nucleotide exchange factor 6 (RAPGEF6) . Q8TEU7
Suppressor of cytokine signaling 6 (SOCS6) . O14544
WW domain-binding protein 1 (WBP1) . Q96G27
WW domain-binding protein 2 (WBP2) . Q969T9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402