Details of the Target

General Information of Target

Target ID LDTP04003
Target Name Cyclin-dependent kinase 4 inhibitor C (CDKN2C)
Gene Name CDKN2C
Gene ID 1031
Synonyms
CDKN6; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
Target Type
Literature-reported
Target Bioclass
Other
Family
CDKN2 cyclin-dependent kinase inhibitor family
Function Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
TTD ID
T45755
Uniprot ID
P42773
DrugMap ID
TTBRUGA
Ensemble ID
ENST00000262662.5
HGNC ID
HGNC:1789

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K124(1.15)  LDD0277  [1]
DBIA
 Probe Info  		C141(1.20)  LDD3318  [2]
IA-alkyne
 Probe Info  		C141(0.71)  LDD2182  [3]
5E-2FA
 Probe Info  		H135(0.00); H75(0.00)  LDD2235  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C141(0.98)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C141(1.38)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C141(0.90)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C141(1.72)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C141(0.88)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C141(1.47)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C141(0.99)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C141(0.97)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C141(0.99)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C141(1.07)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C141(1.20)  LDD1509  [9]
 LDCM0227  AC110 HEK-293T C141(1.12)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C141(0.71)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C141(1.43)  LDD0827  [8]
 LDCM0237  AC12 HEK-293T C141(1.71)  LDD1510  [9]
 LDCM0246  AC128 HEK-293T C141(0.94)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C141(0.82)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C141(0.97)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C141(0.97)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C141(0.89)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C141(1.07)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C141(1.07)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C141(1.04)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C141(0.94)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C141(0.83)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C141(0.90)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C141(0.96)  LDD0856  [8]
 LDCM0260  AC140 HEK-293T C141(0.90)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C141(0.98)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C141(1.04)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C141(1.08)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C141(1.06)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C141(0.75)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C141(0.87)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C141(1.02)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C141(1.00)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C141(1.06)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C141(1.29)  LDD1513  [9]
 LDCM0271  AC150 HEK-293T C141(1.25)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C141(0.98)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C141(1.26)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C141(1.36)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C141(1.53)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C141(1.31)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C141(0.83)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C141(1.33)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C141(1.23)  LDD0874  [8]
 LDCM0277  AC18 HEK-293T C141(1.18)  LDD0875  [8]
 LDCM0278  AC19 HEK-293T C141(1.03)  LDD0876  [8]
 LDCM0280  AC20 HEK-293T C141(1.06)  LDD0878  [8]
 LDCM0281  AC21 HEK-293T C141(0.89)  LDD0879  [8]
 LDCM0282  AC22 HEK-293T C141(0.97)  LDD0880  [8]
 LDCM0283  AC23 HEK-293T C141(1.27)  LDD0881  [8]
 LDCM0284  AC24 HEK-293T C141(1.27)  LDD0882  [8]
 LDCM0287  AC27 HEK-293T C141(1.00)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C141(1.27)  LDD1527  [9]
 LDCM0290  AC3 HEK-293T C141(1.01)  LDD1529  [9]
 LDCM0292  AC31 HEK-293T C141(1.10)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C141(1.25)  LDD1532  [9]
 LDCM0296  AC35 HEK-293T C141(1.19)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C141(1.53)  LDD1536  [9]
 LDCM0300  AC39 HEK-293T C141(1.39)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C141(1.06)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C141(1.04)  LDD1541  [9]
 LDCM0305  AC43 HEK-293T C141(1.04)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C141(1.38)  LDD1545  [9]
 LDCM0308  AC46 PaTu 8988t C141(0.84)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C141(0.91)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C141(1.55)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C141(0.87)  LDD1190  [8]
 LDCM0313  AC50 PaTu 8988t C141(1.24)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C141(0.83)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C141(1.49)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C141(1.58)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C141(1.64)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C141(0.94)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C141(1.02)  LDD1198  [8]
 LDCM0320  AC57 HEK-293T C141(1.03)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C141(0.84)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C141(1.27)  LDD0920  [8]
 LDCM0324  AC60 HEK-293T C141(1.18)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C141(1.18)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C141(0.94)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C141(1.01)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C141(0.96)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C141(1.19)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C141(1.11)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C141(1.25)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C141(0.87)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C141(0.84)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C141(0.95)  LDD1568  [9]
 LDCM0335  AC70 HEK-293T C141(0.97)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C141(0.99)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C141(0.86)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C141(1.05)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C141(1.28)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C141(0.85)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C141(0.73)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C141(0.83)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C141(0.73)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C141(0.82)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C141(0.85)  LDD1569  [9]
 LDCM0346  AC80 HEK-293T C141(0.83)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C141(0.76)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C141(0.87)  LDD0946  [8]
 LDCM0349  AC83 HEK-293T C141(1.02)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C141(0.69)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C141(0.87)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C141(1.00)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C141(0.95)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C141(0.80)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C141(0.78)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C141(0.85)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C141(0.85)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C141(0.81)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C141(1.04)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C141(0.92)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C141(0.98)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C141(0.95)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C141(0.97)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C141(1.08)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C141(0.72)  LDD0964  [8]
 LDCM0275  AKOS034007705 HEK-293T C141(1.46)  LDD1514  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C141(1.07)  LDD1571  [9]
 LDCM0370  CL101 HEK-293T C141(1.07)  LDD1574  [9]
 LDCM0374  CL105 HEK-293T C141(1.15)  LDD0972  [8]
 LDCM0375  CL106 HEK-293T C141(0.94)  LDD0973  [8]
 LDCM0376  CL107 HEK-293T C141(1.15)  LDD0974  [8]
 LDCM0377  CL108 HEK-293T C141(1.03)  LDD0975  [8]
 LDCM0378  CL109 HEK-293T C141(1.19)  LDD0976  [8]
 LDCM0379  CL11 HEK-293T C141(1.04)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C141(1.16)  LDD0978  [8]
 LDCM0381  CL111 HEK-293T C141(0.93)  LDD0979  [8]
 LDCM0383  CL113 HEK-293T C141(1.01)  LDD1587  [9]
 LDCM0387  CL117 HEK-293T C141(1.00)  LDD1591  [9]
 LDCM0390  CL12 HEK-293T C141(1.32)  LDD1594  [9]
 LDCM0392  CL121 PaTu 8988t C141(1.88)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C141(0.87)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C141(1.39)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C141(1.73)  LDD1274  [8]
 LDCM0396  CL125 HEK-293T C141(1.18)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C141(1.18)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C141(1.12)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C141(1.14)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C141(1.24)  LDD1604  [9]
 LDCM0403  CL16 PaTu 8988t C141(0.93)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C141(0.88)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C141(1.36)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C141(0.85)  LDD1285  [8]
 LDCM0408  CL20 PaTu 8988t C141(0.89)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C141(1.28)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C141(1.05)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C141(1.16)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C141(2.25)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C141(1.25)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C141(1.12)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C141(1.12)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C141(1.60)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C141(1.10)  LDD1296  [8]
 LDCM0419  CL30 PaTu 8988t C141(1.13)  LDD1298  [8]
 LDCM0420  CL31 HEK-293T C141(1.32)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C141(1.03)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C141(1.19)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C141(1.39)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C141(1.17)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C141(1.21)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C141(1.12)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C141(1.28)  LDD1026  [8]
 LDCM0430  CL40 HEK-293T C141(0.99)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C141(1.30)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C141(1.05)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C141(1.10)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C141(1.08)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C141(1.24)  LDD1033  [8]
 LDCM0437  CL47 HEK-293T C141(1.22)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C141(1.14)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C141(1.10)  LDD1643  [9]
 LDCM0446  CL55 HEK-293T C141(1.09)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C141(1.51)  LDD1650  [9]
 LDCM0450  CL59 HEK-293T C141(1.42)  LDD1653  [9]
 LDCM0452  CL60 HEK-293T C141(1.10)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C141(0.83)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C141(0.75)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C141(0.74)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C141(0.55)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C141(0.84)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C141(0.78)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C141(0.76)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C141(0.95)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C141(1.37)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C141(1.05)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C141(0.82)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C141(1.05)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C141(0.71)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C141(0.58)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C141(0.74)  LDD1065  [8]
 LDCM0469  CL76 PaTu 8988t C141(1.42)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C141(1.30)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C141(1.52)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C141(1.22)  LDD1351  [8]
 LDCM0473  CL8 HEK-293T C141(1.29)  LDD1676  [9]
 LDCM0474  CL80 PaTu 8988t C141(0.93)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C141(1.49)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C141(1.49)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C141(1.22)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C141(1.30)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C141(1.13)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C141(1.22)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C141(1.38)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C141(1.18)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C141(0.99)  LDD1362  [8]
 LDCM0485  CL90 PaTu 8988t C141(0.99)  LDD1364  [8]
 LDCM0486  CL91 HEK-293T C141(1.11)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C141(1.40)  LDD1690  [9]
 LDCM0490  CL95 HEK-293T C141(1.26)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C141(1.04)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C141(0.90)  LDD1695  [9]
 LDCM0625  F8 Ramos C141(3.52)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C141(0.30)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C141(12.07)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C141(0.27)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C141(0.97)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C141(0.74)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C141(0.16)  LDD2194  [3]
 LDCM0586  Fragment28 Ramos C141(0.52)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C141(0.39)  LDD2199  [3]
 LDCM0590  Fragment32 Ramos C141(0.46)  LDD2201  [3]
 LDCM0468  Fragment33 HEK-293T C141(0.96)  LDD1066  [8]
 LDCM0566  Fragment4 Ramos C141(0.79)  LDD2184  [3]
 LDCM0427  Fragment51 HEK-293T C141(1.10)  LDD1025  [8]
 LDCM0610  Fragment52 Ramos C141(1.04)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C141(0.22)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C141(0.70)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C141(0.20)  LDD2188  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C141(1.03)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C141(1.39)  LDD1497  [9]
 LDCM0024  KB05 MELHO C141(1.20)  LDD3318  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) Adenosylhomocysteinase family O43865
N-acetyl-D-glucosamine kinase (NAGK) Eukaryotic-type N-acetylglucosamine kinase family Q9UJ70
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Caspase-6 (CASP6) Peptidase C14A family P55212
Cyclin-dependent kinase 4 (CDK4) CMGC Ser/Thr protein kinase family P11802
Cyclin-dependent kinase 6 (CDK6) CMGC Ser/Thr protein kinase family Q00534
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 12 (TCF12) . Q99081
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Puratrophin-1 (PLEKHG4) . Q58EX7
Vinexin (SORBS3) . O60504

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402