Details of the Target

General Information of Target

Target ID LDTP03896
Target Name Pre-B-cell leukemia transcription factor 1 (PBX1)
Gene Name PBX1
Gene ID 5087
Synonyms
PRL; Pre-B-cell leukemia transcription factor 1; Homeobox protein PBX1; Homeobox protein PRL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE
AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP
EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM
NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF
NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE
EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG
AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG
PGSVHSDTSN
Target Bioclass
Transcription factor
Family
TALE/PBX homeobox family
Subcellular location
Nucleus
Function
Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8. Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein. Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4. Acts as a transcriptional activator of PF4 in complex with MEIS1. Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence. In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development. Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression.; [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.
Uniprot ID
P40424
Ensemble ID
ENST00000367897.5
HGNC ID
HGNC:8632

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.E250V .
MIAPACA2 SNV: p.M340V .
MM1S SNV: p.H425D .
NCIH1793 SNV: p.Q56R .
NCIH2170 SNV: p.S385N .
OAW28 SNV: p.S187I .
PF382 SNV: p.E97G; p.R238W .
TOV21G SNV: p.S10F .
WM793 SNV: p.H66Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0224  [1]
DBIA
 Probe Info  		C220(1.22)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C273(0.00); C172(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		C82(0.00); C70(0.00)  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
NAIA_5
 Probe Info  		C273(0.00); C70(0.00); C220(0.00)  LDD2223  [7]
HHS-465
 Probe Info  		N.A.  LDD2240  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C220(1.22)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C273(0.76)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C273(0.84)  LDD0824  [2]
 LDCM0230  AC113 HEK-293T C273(1.30)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C273(0.89)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C273(1.02)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C273(0.83)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C273(1.05)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C273(0.91)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C273(0.94)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C273(1.00)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C273(1.04)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C273(1.01)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C273(1.12)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C273(1.15)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C273(1.19)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C273(1.21)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C273(1.28)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C273(1.19)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C273(1.66)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C273(1.54)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C273(1.50)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C273(1.33)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C273(1.31)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C273(1.61)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C273(1.16)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C273(2.03)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C273(1.16)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C273(1.46)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C273(1.57)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C273(1.74)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C273(0.92)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C273(1.57)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C273(1.26)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C273(1.32)  LDD0860  [2]
 LDCM0270  AC15 HEK-293T C273(0.91)  LDD0868  [2]
 LDCM0276  AC17 HCT 116 C220(1.42)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C220(4.36)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C220(1.87)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C220(0.78)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C220(0.88)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C220(1.25)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C220(1.62)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C220(0.98)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C220(0.93)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C82(1.02); C273(0.87)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C82(1.07); C273(0.99)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C82(1.06)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C82(0.99); C273(1.05)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C82(1.00); C273(1.04)  LDD1528  [9]
 LDCM0290  AC3 HCT 116 C220(1.11)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C82(1.02)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C82(0.99); C273(1.01)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C82(1.00)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C82(1.03); C273(1.09)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C82(1.08); C273(0.82)  LDD1534  [9]
 LDCM0296  AC35 HCT 116 C220(0.72)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C220(0.55)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C220(1.26)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C220(1.12)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C220(0.89)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C220(1.02)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C220(0.95)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C220(0.83)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C220(0.83)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C220(0.77)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C220(0.57)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C220(0.80)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C82(0.99)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C82(0.98); C273(1.10)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C82(0.98)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C82(1.04); C273(0.93)  LDD1550  [9]
 LDCM0312  AC5 HCT 116 C220(1.31)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C82(1.12); C273(0.90)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C82(1.11)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C82(1.03); C273(1.00)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C82(0.99); C273(1.09)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C82(1.04)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C82(1.05); C273(1.17)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C82(1.06)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C273(1.01)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C273(1.17)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C273(1.31)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C273(0.85)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C273(1.11)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C273(1.30)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C273(1.60)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C273(1.34)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C273(1.64)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C273(1.45)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C273(1.35)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C273(1.27)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C273(0.91)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C273(0.90)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C273(1.07)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C273(0.83)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C273(0.93)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C273(0.92)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C273(0.76)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C273(0.71)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C273(0.76)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C273(1.01)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C273(0.78)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C273(0.92)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C273(0.81)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C273(0.93)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C273(0.73)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C273(0.69)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C273(0.66)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C273(0.93)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C273(0.89)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C273(0.89)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C273(0.84)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C273(0.75)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C273(0.96)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C273(0.77)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C273(0.83)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C273(0.84)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C273(1.27)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C273(1.28)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C273(0.94)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C273(0.78)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C273(0.74)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C273(0.94)  LDD0962  [2]
 LDCM0248  AKOS034007472 HEK-293T C273(0.97)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C273(0.89)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C273(0.94)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C82(1.03)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C82(0.90)  LDD1572  [9]
 LDCM0369  CL100 HCT 116 C220(1.32)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C273(0.90)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C273(1.04)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C273(0.91)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C273(0.67)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C220(1.17)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C220(1.50)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C220(2.06)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C220(1.50)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C220(1.12)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C82(0.74); C273(1.26)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C220(1.21)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C220(1.75)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C82(0.98); C273(1.01)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C82(1.11)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C82(0.91)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C82(0.96); C273(0.99)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C82(0.99); C273(0.97)  LDD1590  [9]
 LDCM0387  CL117 HCT 116 C220(1.04)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C220(0.90)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C220(0.63)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C82(0.88)  LDD1594  [9]
 LDCM0391  CL120 HCT 116 C220(0.67)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C82(1.06)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C82(1.05)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C82(1.06); C273(0.98)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C82(0.90); C273(1.03)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C273(1.08)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C273(1.30)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C273(1.13)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C273(1.13)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C82(1.09)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C82(1.05)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C82(1.04); C273(0.88)  LDD1606  [9]
 LDCM0403  CL16 HCT 116 C220(0.91)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C220(2.06)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C220(1.74)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C220(1.65)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C82(1.06)  LDD1611  [9]
 LDCM0408  CL20 HCT 116 C220(1.21)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C220(1.10)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C220(1.58)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C220(1.36)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C220(1.44)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C220(0.96)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C220(0.85)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C220(1.02)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C220(1.02)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C220(1.63)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C82(1.04); C273(1.00)  LDD1622  [9]
 LDCM0419  CL30 HCT 116 C220(1.16)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C82(1.06)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C82(0.92); C273(1.31)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C82(0.77); C273(1.02)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C82(0.79)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C82(0.75); C273(1.73)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C82(0.94)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C82(1.13)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C82(0.95); C273(0.97)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C82(0.97); C273(0.98)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C82(0.98); C273(1.13)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C82(0.97); C273(0.79)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C82(0.98); C273(1.07)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C82(1.06)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C82(0.91); C273(1.14)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C82(0.81); C273(1.19)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C273(0.94)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C273(1.17)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C273(1.35)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C273(1.04)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C82(1.04); C273(0.94)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C273(1.03)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C273(1.46)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C273(1.27)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C273(0.85)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C273(1.60)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C273(1.02)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C273(1.28)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C273(0.89)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C273(1.10)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C273(1.03)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C82(1.04); C273(0.86)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C273(1.17)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C220(0.74)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C220(0.67)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C220(1.26)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C220(1.07)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C220(0.81)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C220(1.16)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C220(1.27)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C220(0.84)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C220(1.12)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C82(1.08)  LDD1665  [9]
 LDCM0463  CL70 HCT 116 C220(0.68)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C220(1.16)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C220(0.98)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C220(0.87)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C220(1.34)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C82(1.05); C273(1.03)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C82(0.97); C273(0.83)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C82(1.09); C273(1.00)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C82(1.15)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C82(1.01); C273(0.73)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C82(0.93); C273(1.15)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C82(0.84); C273(1.26)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C82(0.94)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C82(0.78); C273(1.27)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C82(0.94)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C82(1.05)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C82(1.06)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C82(1.04); C273(0.99)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C82(1.06); C273(0.98)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C82(1.08); C273(1.08)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C82(0.85); C273(1.24)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C82(1.10); C273(0.65)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C220(1.84)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C220(1.50)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C220(0.84)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C220(1.31)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C220(1.18)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C220(0.88)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C220(1.02)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C220(0.87)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C220(0.91)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C82(0.88); C273(1.17)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C220(0.79)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C82(1.04)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C82(1.20)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C82(0.94)  LDD1497  [9]
 LDCM0024  KB05 NB1 C82(1.68)  LDD3340  [10]
 LDCM0109  NEM HeLa N.A.  LDD0224  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Homeobox protein Hox-C5 (HOXC5) Antp homeobox family Q00444
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Homeobox protein Meis1 (MEIS1) TALE/MEIS homeobox family O00470
Homeobox protein PKNOX1 (PKNOX1) TALE/MEIS homeobox family P55347
Forkhead box protein C1 (FOXC1) . Q12948
T-cell leukemia homeobox protein 1 (TLX1) . P31314
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer metastasis-suppressor 1-like protein (BRMS1L) BRMS1 family Q5PSV4
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840