Details of the Target

General Information of Target

Target ID LDTP03821
Target Name Bone morphogenetic protein receptor type-1A (BMPR1A)
Gene Name BMPR1A
Gene ID 657
Synonyms
ACVRLK3; ALK3; Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; EC 2.7.11.30; Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD antigen CD292
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK
CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR
TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC
KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV
GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG
SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH
RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR
PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Subcellular location
Cell membrane
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2.
Uniprot ID
P36894
Ensemble ID
ENST00000372037.8
HGNC ID
HGNC:1076
ChEMBL ID
CHEMBL5275

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C475(4.29)  LDD3386  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C503(1.33)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C503(1.29)  LDD0813  [2]
 LDCM0226  AC11 HEK-293T C503(1.11)  LDD0824  [2]
 LDCM0230  AC113 HEK-293T C503(1.39)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C503(1.49)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C503(2.12)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C503(2.10)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C503(1.86)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C503(2.59)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C503(1.89)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C503(1.49)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C503(2.38)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C503(3.10)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C503(4.78)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C503(3.04)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C503(2.43)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C503(1.99)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C503(3.97)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C503(1.99)  LDD0843  [2]
 LDCM0259  AC14 HEK-293T C503(1.58)  LDD0857  [2]
 LDCM0263  AC143 HEK-293T C503(1.09)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C503(1.56)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C503(1.90)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C503(2.12)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C503(1.82)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C503(1.55)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C503(1.11)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C503(2.47)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C503(1.29)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C503(1.38)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C503(1.44)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C503(1.37)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C503(1.39)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C503(1.32)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C503(1.99)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C503(2.88)  LDD2165  [2]
 LDCM0276  AC17 PaTu 8988t C503(1.14)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C503(1.09)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C503(1.16)  LDD1157  [2]
 LDCM0279  AC2 HEK-293T C503(1.35)  LDD0877  [2]
 LDCM0280  AC20 PaTu 8988t C503(1.13)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C503(1.11)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C503(0.73)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C503(1.20)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C503(1.09)  LDD1163  [2]
 LDCM0285  AC25 HEK-293T C503(1.21)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C503(1.60)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C503(1.35)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C503(1.09)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C503(1.76)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C503(1.23)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C503(1.55)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C503(0.99)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C503(1.19)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C503(1.58)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C503(1.39)  LDD0893  [2]
 LDCM0296  AC35 PaTu 8988t C503(1.02)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C503(1.18)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C503(0.81)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C503(1.13)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C503(1.04)  LDD1179  [2]
 LDCM0301  AC4 HEK-293T C503(1.35)  LDD0899  [2]
 LDCM0302  AC40 PaTu 8988t C503(0.99)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C503(1.00)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C503(0.86)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C503(0.84)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C503(0.83)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C503(0.85)  LDD1186  [2]
 LDCM0308  AC46 HEK-293T C503(0.91)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C503(1.38)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C503(1.45)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C503(1.50)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C503(1.21)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C503(1.25)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C503(1.49)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C503(1.72)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C503(1.63)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C503(1.71)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C503(1.75)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C503(1.60)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C323(1.05); C492(1.10); C503(1.01); C444(0.97)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C323(0.97); C492(0.97); C503(1.03); C110(1.05)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C323(1.02); C492(0.92); C503(1.01); C444(1.02)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C503(1.13)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C323(0.96); C492(1.03); C503(1.00); C444(1.03)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C323(0.97); C492(0.93); C503(0.97); C444(0.95)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C323(1.03); C492(0.98); C503(1.02); C444(1.01)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C323(0.98); C492(0.97); C503(1.05); C444(1.04)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C323(0.99); C492(1.02); C503(0.97); C444(1.12)  LDD1567  [3]
 LDCM0332  AC68 HEK-293T C503(1.00)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C503(1.02)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C503(1.27)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C503(1.36)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C503(1.20)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C503(1.20)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C503(1.54)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C503(1.34)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C503(1.31)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C503(1.33)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C503(1.47)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C503(1.58)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C503(0.98)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C503(1.87)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C503(1.77)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C503(1.39)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C503(2.06)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C503(1.10)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C503(1.67)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C503(1.72)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C503(1.44)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C503(1.47)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C503(1.84)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C503(1.55)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C503(1.45)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C503(1.38)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C503(1.39)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C503(1.48)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C503(1.54)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C503(1.74)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C503(1.56)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C503(3.71)  LDD0962  [2]
 LDCM0248  AKOS034007472 HEK-293T C503(1.29)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C503(1.81)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C503(1.86)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C503(4.60)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C503(4.61)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C503(2.19)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C503(2.75)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C503(2.38)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C503(1.83)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C503(2.08)  LDD0971  [2]
 LDCM0374  CL105 PaTu 8988t C503(0.98)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C503(1.01)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C503(1.04)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C503(0.81)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C503(0.84)  LDD1257  [2]
 LDCM0379  CL11 HEK-293T C503(6.27)  LDD0977  [2]
 LDCM0380  CL110 PaTu 8988t C503(1.02)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C503(1.09)  LDD1260  [2]
 LDCM0382  CL112 HEK-293T C503(2.02)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C503(1.25)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C503(4.48)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C503(2.06)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C503(1.74)  LDD0984  [2]
 LDCM0387  CL117 PaTu 8988t C503(0.88)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C503(0.90)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C503(0.82)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C503(2.83)  LDD0988  [2]
 LDCM0391  CL120 PaTu 8988t C503(0.87)  LDD1270  [2]
 LDCM0392  CL121 HEK-293T C503(1.88)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C503(1.78)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C503(3.10)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C503(2.01)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C323(1.11); C492(0.90); C503(0.97); C340(0.99)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C323(1.00); C492(0.88); C503(1.03); C340(1.05)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C323(1.01); C492(0.97); C503(0.92); C444(0.96)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C323(0.98); C492(1.04); C503(1.00); C444(1.14)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C503(2.60)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C503(3.19)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C503(19.70)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C503(1.34)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C503(3.75)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C503(1.19)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C503(1.40)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C503(1.98)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C503(1.08)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C503(3.81)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C503(2.06)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C503(1.01)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C503(0.95)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C503(2.74)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C503(1.04)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C503(1.26)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C503(1.69)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C503(0.96)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C503(2.67)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C503(1.53)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C503(2.36)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C503(1.65)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C503(12.20)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C503(2.56)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C503(1.87)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C503(2.80)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C503(1.75)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C503(4.94)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C503(3.67)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C503(1.42)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C503(3.03)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C503(2.49)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C503(2.80)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C503(1.49)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C503(4.31)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C503(1.91)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C503(1.55)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C503(1.43)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C503(1.83)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C503(1.40)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C503(2.71)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C503(2.69)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C503(1.23)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C503(1.86)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C503(2.08)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C503(1.26)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C503(1.59)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C503(3.12)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C503(1.00)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C503(1.53)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C503(2.88)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C503(4.04)  LDD1050  [2]
 LDCM0453  CL61 PaTu 8988t C503(1.22)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C503(1.11)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C503(0.99)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C503(0.97)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C503(0.88)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C503(0.97)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C503(1.01)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C503(1.09)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C503(1.13)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C503(1.74)  LDD1060  [2]
 LDCM0463  CL70 PaTu 8988t C503(0.95)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C503(1.02)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C503(1.43)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C503(1.16)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C503(1.13)  LDD1346  [2]
 LDCM0469  CL76 HEK-293T C503(1.31)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C503(2.21)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C503(1.55)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C503(1.53)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C503(1.31)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C503(1.07)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C503(0.98)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C503(1.05)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C503(1.36)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C503(1.63)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C503(1.21)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C503(1.54)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C503(1.33)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C503(1.16)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C503(2.02)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C503(1.03)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C503(5.61)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C503(1.92)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C503(4.14)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C503(2.80)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C503(2.85)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C503(5.60)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C503(2.88)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C503(2.49)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C503(3.13)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C503(1.98)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C323(1.02); C492(0.99); C503(1.01); C444(0.46)  LDD1698  [3]
 LDCM0468  Fragment33 PaTu 8988t C503(0.95)  LDD1347  [2]
 LDCM0427  Fragment51 HEK-293T C503(1.99)  LDD1025  [2]
 LDCM0022  KB02 HEK-293T C323(0.93); C110(1.00); C492(0.81); C503(1.03)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C323(1.01); C110(1.04); C492(0.98); C503(1.03)  LDD1497  [3]
 LDCM0024  KB05 OVK-18 C475(4.29)  LDD3386  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bone morphogenetic protein 2 (BMP2) TGF-beta family P12643
Bone morphogenetic protein 4 (BMP4) TGF-beta family P12644
Growth/differentiation factor 5 (GDF5) TGF-beta family P43026

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dibotermin Alfa . DB11639

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402